Antipsychotic drug use in Greenland and Denmark: longitudinal and cross-sectional data.

PURPOSE: The aim of this study was to compare the consumption of antipsychotic drugs in Denmark and Greenland between 2014 and 2019. We also investigated the use of antipsychotic medication for schizophrenic and non-affective psychotic patients in both countries. METHODS: This study was performed as a register study using data from the medical register in Denmark and Greenland. A cross-sectional study on the prescription of antipsychotic drugs for psychotic patients (F 20-29) in Greenland in September 2020 was also conducted. RESULTS: The prevalence of antipsychotic drug consumption between 2014 and 2019 was higher in Greenland (average 16.9 DDD/1000/day) compared to Denmark (average 9.3 DDD/1000/day) and the consumption increased in Greenland remarkably. Olanzapine was the most widely used drug in both countries and Clozapine consumption was twice as high in Greenland as in Denmark (1.3 versus 0.6 DDD/1000/day). The mean dose of antipsychotics in schizophrenic and non-affective psychotic patients was higher in Greenland than in Denmark and this difference was greatest among institutional residents. In Greenland, 59% of institutional residents received 2 or 3 DDD/day while only 43% in Denmark received it. Polypharmacy was common in both countries. CONCLUSION: The total consumption and the main dose of antipsychotics in schizophrenic patients was higher in Greenland than in Denmark. Factors contributing to the differences noted appear to be a combination of age and gender differences among patients in the two countries. Socio-economic differences, and differences in treatment options can contribute to the differences and must be investigated further.

Associations between clinical and psychosocial factors and metabolic and cardiovascular risk factors in overweight patients with schizophrenia spectrum disorders - Baseline and two-years findings from the CHANGE trial.

OBJECTIVES: People with severe mental disorders die averagely 15years earlier than people in the Western background population, cardiovascular disease being the most frequent cause of death with unhealthy eating habits and lower levels of physical activity as major contributing risk factors. Understanding possible associations and predictors of the specific cardiovascular risk may permit more targeted and effective prevention. The aim of this study was to investigate the associations between clinical and psychosocial factors and several separate cardiovascular risk factors in a cohort of 428 persons with schizophrenia and abdominal obesity enrolled in the CHANGE trial. METHODS: We used data from baseline and two-year follow-up of 428 individuals with schizophrenia spectrum disorders and abdominal overweight enrolled in the CHANGE trial. By linear regressions we explored the relationships between clinical and psychosocial factors and established cardiovascular risk factors: Dependent variables were baseline and follow-up values of the following: VO2max, waist circumference, high density lipoprotein (HDL), systolic blood pressure and HbA1c. Independent variables were baseline values of the following: negative symptoms, positive symptoms, cognition, level of functioning, antipsychotic medication, duration of illness, employment situation and whether the participants had any friend. RESULTS: Negative symptoms were associated with most baseline- as well as two-years-outcome; negatively with cardiorespiratory fitness and with dietary quality and with HDL, and with increasing values of the variables waist circumference, BMI and HbA1c. Negative symptoms were seen also to predict poorer cardiorespiratory fitness and larger waist circumference, higher HbA1c and lower HDL at two year follow-up. Level of functioning and Cognitive function correlated positively with cardiorespiratory fitness and HDL, and correlated negatively with waist circumference and HbA1c. Both parameters also predicted a better fitness, higher HDL and lower HbA1c at two year follow-up. Isolating the antipsychotic drugs known to give the worst metabolic adverse effects (olanzapine, clozapine, quetiapine), the dosage was positively associated with cholesterol, but not with any other outcome. Psychotic symptoms and duration of illness were not significantly associated with any outcome. Employment of any kind was significantly associated with cardiorespiratory fitness and negatively associated with waist circumference, BMI and systolic blood pressure. At two year follow-up associations were significant for the two year outcomes cardiorespiratory fitness and waist circumference. Friendship relations were negatively associated with waist circumference and positively with HDL cholesterol. None of the two year outcomes were predicted by friendship. CONCLUSIONS: We found various clinical and psychosocial factors to be associated with less healthy lifestyle factors and higher risk of cardiovascular disease, with negative symptoms building the strongest associations, although a possible bidirectional causality needs to be regarded. Reduction of negative symptoms should be investigated further in order to reduce the increased cardiovascular morbidity and mortality in people with schizophrenia spectrum disorders.

The CHANGE trial: no superiority of lifestyle coaching plus care coordination plus treatment as usual compared to treatment as usual alone in reducing risk of cardiovascular disease in adults with schizophrenia spectrum disorders and abdominal obesity.

Life expectancy in patients with schizophrenia is reduced by 20 years for men and 15 years for women compared to the general population. About 60% of the excess mortality is due to physical illnesses, with cardiovascular disease being dominant. CHANGE was a randomized, parallel-group, superiority, multi-centre trial with blinded outcome assessment, testing the efficacy of an intervention aimed to improve cardiovascular risk profile and hereby potentially reduce mortality. A total of 428 patients with schizophrenia spectrum disorders and abdominal obesity were recruited and centrally randomized 1:1:1 to 12 months of lifestyle coaching plus care coordination plus treatment as usual (N=138), or care coordination plus treatment as usual (N=142), or treatment as usual alone (N=148). The primary outcome was 10-year risk of cardiovascular disease assessed post-treatment and standardized to age 60. At follow-up, the mean 10-year risk of cardiovascular disease was 8.4 ± 6.7% in the group receiving lifestyle coaching, 8.5 ± 7.5% in the care coordination group, and 8.0 ± 6.5% in the treatment as usual group (p=0.41). We found no intervention effects for any secondary or exploratory outcomes, including cardiorespiratory fitness, physical activity, weight, diet and smoking. In conclusion, the CHANGE trial did not support superiority of individual lifestyle coaching or care coordination compared to treatment as usual in reducing cardiovascular risk in patients with schizophrenia spectrum disorders and abdominal obesity.

[The Psychiatric Emergency Service in Copenhagen functions as planned]. / Den psykiatriske udrykningstjeneste i Storkøbenhavn fungerer efter hensigten.

The Psychiatric Emergency Service in Copenhagen is unique as the only psychiatric outgoing service in Denmark with medical doctor expertise. The service has been active since 1997 and is serving 1.28 million inhabitants. The target group of the service are psychiatric patients, who are not able to attend the psychiatric emergency rooms, for example because of severe affect, psychosis or substance abuse. A quantitative and qualitative evaluation of the journals from all 1,653 contacts to the service in 2010 and 2011 clearly shows the efficacy and necessity of such a service.