Should the Proximal Part of a Bifurcated Aortic Graft be Kept as Short as Possible? A Computational Study Elucidates on Aortic Graft Hemodynamics for Various Main Body Lengths.

BACKGROUND: It is accepted that surgically placed bifurcated aortic grafts should be shaped as a short proximal main tube with two long distal limbs. We aim to investigate the hemodynamic effect of different main body lengths in bifurcated aortic grafts using 3D computer models. METHODS: Five different idealized models are generated to represent an aorto-bifemoral graft. Distance from renal to femoral arteries is set at 25cm and distance between the femoral arteries is set at 14cm. Values of the main body length taken into account to build the idealized models are 3cm, 6cm, 9cm, 12cm and 15cm. Blood flow resistance, Time Average Wall Shear Stress (TAWSS), Oscillatory Shear Index (OSI) and Relative Residence Time (RRT) are estimated using the constructed 3D models. RESULTS: The total resistance decreased monotonically by as far as 40% as the main body length increased. Appropriate hemodynamic simulations show a maximum TAWSS decrease and a corresponding maximum OSI and RRT increase with elongated main body configurations, indicating a hemodynamic benefit of the "Short" main body configuration. Nevertheless, the differences in these later variables are small, affecting a limited portion of the geometries. CONCLUSION: A long main body of a bifurcated aortic graft results in significantly reduced total resistance in idealized models designed to represent an aorto-bifemoral surgical graft, while the differences observed in TAWSS, OSI and RRT between models are small.

Anatomical variability in the upper tracheobronchial tree: sex-based differences and implications for personalized inhalation therapies.

The morphometry of the large conducting airways is presumed to have a strong effect on the regional deposition of inhaled aerosol particles. Nevertheless, sex-based differences have not been fully quantified and are still largely ignored in designing inhalation therapies. To this end, we retrospectively analyzed high-resolution computed tomography scans for 185 individuals (90 women, 95 men) in the age range of 12-89 yr to determine airway luminal areas, airway lengths, and bifurcation angles. Only subjects free of chronic airway disease were considered. In men, luminal areas of the upper conducting airways were, on average, ∼30%-50% larger when compared with those in women, with the largest differences found in the trachea (289.72 ± 54.25 vs. 193.50 ± 42.37 mm2 for men and women, respectively). The ratio of the largest luminal area in men to the smallest luminal area in women (in any given segment) ranged between 4.5 and 8.6, the largest differences being found in the lobar bronchi. Sex-based differences were minor in the case of bifurcation angles (e.g., average main bifurcation angle: 93.04 ± 9.58° vs. 91.03 ± 9.81° for men and women, respectively), but large intersubject variability was found irrespective of sex (e.g., range of main bifurcation angle: 65.04°-122.01° vs. 69.46°-113.94° for men and women, respectively). Bronchial segments were shorter by ∼5%-20% in women relative to men, the largest differences being located in the upper lobes. False discovery rate analysis revealed statistically significant associations among morphometric measures of the right lung in women (but not in men), suggesting two phenotypes among women that we attribute to the smaller female thoracic volume.NEW & NOTEWORTHY We found significant sex-based morphometric differences in the central airways of healthy men and women that were only mildly attenuated in subsets matched for lung volume. Lumen areas were significantly larger in men (∼30%-50%). Large variability (∼75%-87%) in airway bifurcation angles (60°-122°) was found irrespective of sex. The branching pattern of the right main and right upper bronchi in women (but not in men) follows two phenotypes modulated by lung volume.