Novel methodology for detection and prediction of mild cognitive impairment using resting-state EEG.

BACKGROUND: Early discrimination and prediction of cognitive decline are crucial for the study of neurodegenerative mechanisms and interventions to promote cognitive resiliency. METHODS: Our research is based on resting-state electroencephalography (EEG) and the current dataset includes 137 consensus-diagnosed, community-dwelling Black Americans (ages 60-90 years, 84 healthy controls [HC]; 53 mild cognitive impairment [MCI]) recruited through Wayne State University and Michigan Alzheimer's Disease Research Center. We conducted multiscale analysis on time-varying brain functional connectivity and developed an innovative soft discrimination model in which each decision on HC or MCI also comes with a connectivity-based score. RESULTS: The leave-one-out cross-validation accuracy is 91.97% and 3-fold accuracy is 91.17%. The 9 to 18 months' progression trend prediction accuracy over an availability-limited subset sample is 84.61%. CONCLUSION: The EEG-based soft discrimination model demonstrates high sensitivity and reliability for MCI detection and shows promising capability in proactive prediction of people at risk of MCI before clinical symptoms may occur.

Causalized convergent cross-mapping and its approximate equivalence with directed information in causality analysis.

Convergent cross-mapping (CCM) has attracted increased attention recently due to its capability to detect causality in nonseparable systems under deterministic settings, which may not be covered by the traditional Granger causality. From an information-theoretic perspective, causality is often characterized as the directed information (DI) flowing from one side to the other. As information is essentially nondeterministic, a natural question is: does CCM measure DI flow? Here, we first causalize CCM so that it aligns with the presumption in causality analysis-the future values of one process cannot influence the past of the other, and then establish and validate the approximate equivalence of causalized CCM (cCCM) and DI under Gaussian variables through both theoretical derivations and fMRI-based brain network causality analysis. Our simulation result indicates that, in general, cCCM tends to be more robust than DI in causality detection. The underlying argument is that DI relies heavily on probability estimation, which is sensitive to data size as well as digitization procedures; cCCM, on the other hand, gets around this problem through geometric cross-mapping between the manifolds involved. Overall, our analysis demonstrates that cross-mapping provides an alternative way to evaluate DI and is potentially an effective technique for identifying both linear and nonlinear causal coupling in brain neural networks and other settings, either random or deterministic, or both.

MAG-Res2Net: a novel deep learning network for human activity recognition.

Objective.Human activity recognition (HAR) has become increasingly important in healthcare, sports, and fitness domains due to its wide range of applications. However, existing deep learning based HAR methods often overlook the challenges posed by the diversity of human activities and data quality, which can make feature extraction difficult. To address these issues, we propose a new neural network model called MAG-Res2Net, which incorporates the Borderline-SMOTE data upsampling algorithm, a loss function combination algorithm based on metric learning, and the Lion optimization algorithm.Approach.We evaluated the proposed method on two commonly utilized public datasets, UCI-HAR and WISDM, and leveraged the CSL-SHARE multimodal human activity recognition dataset for comparison with state-of-the-art models.Main results.On the UCI-HAR dataset, our model achieved accuracy, F1-macro, and F1-weighted scores of 94.44%, 94.38%, and 94.26%, respectively. On the WISDM dataset, the corresponding scores were 98.32%, 97.26%, and 98.42%, respectively.Significance.The proposed MAG-Res2Net model demonstrates robust multimodal performance, with each module successfully enhancing model capabilities. Additionally, our model surpasses current human activity recognition neural networks on both evaluation metrics and training efficiency. Source code of this work is available at:https://github.com/LHY1007/MAG-Res2Net.