Recurrent giant cystic lymphangioma of peritoneum: a case report and literature review.

Cystic lymphangioma (CL) is a rare benign tumor of the lymphatic system, most commonly found in the neck, head, and armpits. The incidence of lymphangiomas in the abdominal cavity is less than 5%, and the incidence of retroperitoneal tumors is even lower. We report here a case of recurrent giant CL that recurred 20 years after the first complete surgical resection. Pelvic MRI at 6 months follow-up after the second complete surgical resection indicated a recurrence of the tumor. The main purpose of this article is to explore the treatment and follow-up strategies for recurrent lymphangioma.

Machine learning-aided understanding of the structure-activity relationship: a case study of MoS2 supported metal-nonmetal pairs for the hydrogen evolution reaction.

Understanding the structure-performance relationship is crucial for designing highly active electrocatalysts, yet this remains a challenge. Using MoS2 supported metal-nonmetal atom pairs (XTM@MoS2, TM = Sc-Ni, and X = B, C, N, O, P, Se, Te, and S) for the hydrogen evolution reaction (HER) as an example, we successfully uncovered the structure-activity relationship with the help of density functional theory (DFT) calculations and integrated machine learning (ML) methods. An ML model based on random forest regression was used to predict the activity, and the trained model exhibited excellent performance with minimal error. SHapley Additive exPlanations analysis revealed that the atom mass and covalent radius of the X atom (m_X and R_X) dominate the activity, and their higher values usually lead to better activity. In addition, four promising candidates, i.e., PCr@MoS2, SV@MoS2, SeTi@MoS2, and SeSc@MoS2, with excellent activity are selected. This work provides several promising catalysts for the HER but, more importantly, offers a workflow to explore the structure-activity relationship.

Spatiotemporal Analysis of the Coupling Relationship between Habitat Quality and Urbanization in the Lower Yellow River.

Natural habitats are damaged by human interference to varying degrees during the urbanization process, which can impede a region's high-quality development. In this study, we examined the spatial-temporal evolution characteristics of habitat quality and urbanization in the Lower Yellow River from 2000 to 2020 using the integrated valuation of ecosystem services and tradeoffs (InVEST) model and the comprehensive indicator method. We also evaluated the coupling relationship between the habitat quality and urbanization using the coupling coordination degree model. The findings indicate the following aspects: (1) Between 2000 and 2020, the Lower Yellow River's habitat quality was typically mediocre, with a steady declining trend. The majority of cities displayed a trend toward declining habitat quality. (2) Both the urbanization subsystem and the urbanization level in 34 cities have demonstrated a consistent growth tendency. The urbanization level is most affected by economic urbanization among the subsystems. (3) The coupling coordination degree have revealed an ongoing trend of growth. In most cities, the relationship between habitat quality and urbanization has been evolving toward coordination. The results of this study have some reference value for ameliorating the habitat quality of the Lower Yellow River and solving the coupling coordination relationship between habitat quality and urbanization.

Theoretical exploration of the nitrogen fixation mechanism of two-dimensional dual-metal TM1TM2@C9N4 electrocatalysts.

The electrochemical nitrogen reduction reaction (eNRR) to NH3 has become an alternative to traditional NH3 production techniques, while developing NRR catalysts with high activity and high selectivity is of great importance. In this study, we systematically investigated the potentiality of dual transition metal (TM) atom anchored electrocatalysts, TM1TM2@C9N4 (TM1, TM2 = 3(4)d TM atoms), for the NRR through the first principles high-throughput screening method. A total of 78 TM1TM2@C9N4 candidates were designed to evaluate their stability, catalytic activity, and selectivity for the NRR. Four TM1TM2@C9N4 candidates (TM1TM2 = NiRu, FeNi, TiNi, and NiZr) with an end-on N2 adsorption configuration, and two candidates (TM1TM2 = TiNi and TiFe) with a side-on adsorption configuration, were screened out with the advantage of suppressing the hydrogen evolution reaction (HER) and exhibiting high NRR activity. Moreover, the catalysts with end-on and side-on N2 adsorption configurations were determined to favor distal and consecutive reaction pathways, respectively, with favorable limiting potentials of only -0.33 V to -0.53 V. Detailed analysis showed that the N2 adsorption and activation are primarily ascribed to the strong back-donation interactions between the d-electrons of TM atoms and the anti-orbitals of an N2 molecule. Our findings pave a way for the rational design and rapid screening of highly active C9N4-based catalysts for the NRR.

Anti-tumor activity and safety evaluation of fisetin-loaded methoxy poly(ethylene glycol)-poly(epsilon-caprolactone) nanoparticles.

Fisetin (3,3',4',7-tetrahydroxyflavone) is a potential anti-tumor agent but poor water solubility hinders its application and complicates direct parenteral administration. Nanoparticle encapsulation is an efficient way to enhance the solubility of some hydrophobic drugs. In this study, methoxy poly(ethylene glycol)-polycaprolactone (MPEG-PCL) nanoparticles were successfully prepared for fisetin delivery in vitro and in vivo. Narrow distribution fisetin-loaded MPEG-PCL NPs (aproximately100 nm) were obtained via emulsification (O/W) and displayed a sustained release behavior in vitro. Moreover, hemolysis and cell cytotoxicity testing showed that MPEG-PCL is biocompatible and safe for intravenous injection. Most importantly, NPs encapsulation enhanced the anti-cancer activity of fisetin as shown in a subcutaneous LL/2 tumor model, and reduced the hepatotoxicity of fisetin. Therefore, our data demonstrate that fisetin-loaded MPEG-PCL NPs have potential application in cancer chemotherapy.