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1.
J Environ Manage ; 351: 119645, 2024 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-38048711

RESUMEN

A low cost and green peroxymonosulfate (PMS) activation catalyst (CG-Ca-N) was successfully prepared with coal gangue (CG), calcium chloride, and melamine as activator. Under the optimal conditions, the CG-Ca-N can remove 100 % for benzo(a)pyrene (Bap) in an aqueous solution after 20 min and 72.06 % in soil slurry medium within 60 min, which also display excellent reuse ability toward Bap after three times. The removal of Bap is significantly decreased when the initial pH value was greater than 9 and obviously inhibited in the presence of HCO3- or SO42-. The characterization results indicated that the addition of calcium chloride could stabilize and increase the content of pyridinic N during thermal annealing, resulting in the production of •OH, SO4•- and 1O2. Based on electron paramagnetic resonance (EPR) and active radical scavenging experiments, 1O2 could be identified to be the dominant role in Bap degradation. Overall, this work opened a new perspective for the low cost and green PMS catalysts and offered great promise in the practical remediation of organic pollution of groundwater and soil.


Asunto(s)
Benzo(a)pireno , Peróxidos , Cloruro de Calcio , Peróxidos/química , Suelo
2.
Int Wound J ; 21(4): e14597, 2024 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-38124467

RESUMEN

Macrophages play a crucial role in aiding all phases of the wound-healing process and has garnered increasing attention recently. Although a substantial body of related studies has been published, there remains a lack of comprehensive bibliometric analysis. In this study, we collected 4296 papers from the Web of Science Core Collection database. Three tools including CiteSpace, VOSviewer and one online analytical platform were employed to conduct bibliometric analysis and data visualization. Our results revealed that the annual number of publications related to macrophage and wound healing has increased exponentially with the year. The United States and China stand as the primary driving forces within this field, collectively constituting 58.2% of the total publication output. The application of biomaterials was one of the most concerned research areas in this field. According to references analysis, the current research focus has shifted to diabetic wound healing and regulating macrophage polarization. Based on the keywords analysis, we identified the following research frontiers in the future: exosomes and other extracellular vesicles; bio-derived materials and drug delivery methods such as nanoparticles, scaffolds and hydrogels; immunomodulation and macrophage polarization in the M2-state; chronic wounds, particularly those associated with diabetes; antimicrobial peptides; and antioxidant. Additionally, TNF, IL-6, IL-10, TGF-ß1 and VEGF ranked as the five genes that have garnered the most research attention in the intersection of macrophage and wound healing. All in all, our findings offered researchers a holistic view of the ongoing progress in the field of macrophages and wound healing, serving as a valuable reference for scholars and policymakers in this domain.


Asunto(s)
Antioxidantes , Macrófagos , Humanos , Bibliometría , Materiales Biocompatibles , China
3.
J Obstet Gynaecol Res ; 49(7): 1821-1826, 2023 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-37186345

RESUMEN

AIM: Complete perforation of the bladder caused by an intrauterine device (IUD) is rare. This study examined the characteristics of patients associated with IUD-related bladder perforation and evaluated the relationship between mislocated IUDs and their potential complications. METHODS: From October 2005 to December 2021, 13 reports regarding complete perforations to the bladder by IUDs were retrieved from the National Contraceptives Adverse Reaction Monitoring System of China. The clinical features of these cases were analyzed. RESULTS: The median patient age was 30 (range, 27-46) years. There were four cases (4/13, 30.8%) with IUDs placed during lactation, one case (1/13, 7.7%) with an IUD placed after medical abortion, and eight cases (8/13, 61.5%) placed after menstruation. Seven cases (7/13, 53.9%) were first-time IUD users. The median duration of IUD placement was 47 (range, 1-145) months. Unexpected pregnancy was reported in five cases (5/13, 38.5%). Six cases (6/13, 46.2%) reported bladder stones with varying degrees of abdominal pain or urinary tract infection. Removal methods included laparotomy (four cases), cystoscopy (four cases), laparoscopy (two cases), laparoscopy combined with cystoscopy (two cases), and laparotomy after cystoscopy (one case). All IUDs were successfully removed. CONCLUSIONS: Complete perforation to the bladder by IUDs is a rare adverse event. Regular follow-up is required after the placement of IUDs. The possibility of uterine perforation should be investigated if IUD users encounter persistent lower abdominal pain or urinary tract infection.


Asunto(s)
Dispositivos Intrauterinos , Laparoscopía , Vejiga Urinaria , Perforación Uterina , Adulto , Femenino , Humanos , Persona de Mediana Edad , Embarazo , Cistoscopía , Dispositivos Intrauterinos/efectos adversos , Laparoscopía/efectos adversos , Vejiga Urinaria/lesiones , Perforación Uterina/epidemiología , Perforación Uterina/etiología , Perforación Uterina/cirugía , Cuerpos Extraños
4.
J Environ Manage ; 328: 116894, 2023 Feb 15.
Artículo en Inglés | MEDLINE | ID: mdl-36527804

RESUMEN

Combing the assisted dispersion strategy of support with the wet chemical reduction method, a novel nano-zero valent iron/microsilica (nZVI/M) composite was successfully fabricated, where the 2D nZVI nanosheets were uniformly anchored and covered on the surface of microsilica. The introduction of microsilica notably relieved the agglomeration effect of nZVI nanosheets, which induced the improvement of specific surface area (45.68 m2/g) and pore volume (0.172 cm3/g), and thereby exposing more active sites for bisphenol A (BPA) removal. The optimized nZVI/M-0.6 displayed the superior catalytic performance in the presence of peroxymonosulfate (PMS) with the degradation rate of BPA reached above 97% within 3 min and a higher constant rate of 0.659 min-1, which was approximately 3.9 times as high as that of nZVI/PMS system. The homogeneously dispersion of nZVI nanosheets on microsilica benefited for the assembly of the pollutants and boosting the kinetics of the catalytic degradation process. As a highly efficient PMS activator, it could well maintain the catalytic activity in different real water samples. The quenching experiments verified that SO4•- played the dominate role for BPA removal. This work offered novel insights for designing and preparing iron-based persulfate activator for wastewater treatment.


Asunto(s)
Hierro , Contaminantes Químicos del Agua , Hierro/química , Contaminantes Químicos del Agua/química , Fenoles
5.
Small ; 18(52): e2204793, 2022 12.
Artículo en Inglés | MEDLINE | ID: mdl-36344427

RESUMEN

Single-atom catalysts (SACs) feature maximum atomic utilization efficiency; however, the loading amount, dispersibility, synthesis cost, and regulation of the electronic structure are factors that need to be considered in water treatment. In this study, kaolinite, a natural layered clay mineral, is applied as the support for g-C3 N4 and single Fe atoms (FeSA-NGK). The FeSA-NGK composite exhibits an impressive degradation performance toward the target pollutant (>98% degradation rate in 10 min), and catalytic stability across consecutive runs (90% reactivity maintained after three runs in a fluidized-bed catalytic unit) under peroxymonosulfate (PMS)/visible light (Vis) synergetic system. The introduction of kaolinite promotes the loading amount of single Fe atoms (2.57 wt.%), which is a 14.2% increase compared to using a bare catalyst without kaolinite, and improved the concentration of N vacancies, thereby optimizing the regulation of the electronic structure of the single Fe atoms. It is discovered that the single Fe atoms successfully occupied five coordinated N atoms and combined with a neighboring N vacancy. Consequently, this regulated the local electronic structure of single Fe atoms, which drives the electrons of N atoms to accumulate on the Fe centers. This study opens an avenue for the design of clay-based SACs for water purification.


Asunto(s)
Hierro , Caolín , Hierro/química , Arcilla , Oxidación-Reducción
6.
J Arthroplasty ; 37(5): 974-984, 2022 05.
Artículo en Inglés | MEDLINE | ID: mdl-35065213

RESUMEN

BACKGROUND: As the number of primary hip and knee arthroplasties increases, revision cases correspondingly demonstrate high relative growth, gaining increasing attention. The present research aimed to investigate subject characteristics in revision hip and knee arthroplasty (RHKA) research using a bibliometric approach. METHODS: Publications related to RHKA from 2000 to 2020 were searched in the Web of Science database. WPS Office, CiteSpace, VOSviewer, and Bibliometrix were used to analyze the results. RESULTS: Bibliometric analysis revealed 3290 records. Fifty-nine countries published manuscripts on RHKA. The United States contributed most and also had the highest number of international collaborations. The most relevant institution was the Mayo Clinic. Berry DJ and Parvizi J were the most productive and academic influential authors in RHKA, respectively. The most productive journal was the Journal of Arthroplasty. Co-occurrence analysis demonstrated "infection" to be the trend in RHKA. Thematic analysis displayed 16 keywords in hip arthroplasty and 14 keywords in knee arthroplasty. CONCLUSION: The present study observed an increasing trend of research papers in RHKA. Institutions and scholars from the United States were found to dominate the field. Periprosthetic joint infection was likely a potential development trend and hotspot of RHKA.


Asunto(s)
Artroplastia de Reemplazo de Rodilla , Bibliometría , Bases de Datos Factuales , Humanos , Articulación de la Rodilla , Extremidad Inferior , Estados Unidos
7.
Langmuir ; 36(10): 2601-2611, 2020 03 17.
Artículo en Inglés | MEDLINE | ID: mdl-32083882

RESUMEN

Understanding surface and interfacial information, which has a close relationship to the structures and properties of materials, helps guide the design of materials for specific applications. This study focuses on the surface functionalization of montmorillonite (Mt) with chitosan (CTS) and exploring the role of surface properties on its adsorptive performance. Two prototypical products, namely, 180-Htc@Mt and 250-Htc@Mt, were fabricated via the hydrothermal method at 180 and 250 °C, respectively. Field emission scanning electron microscopy revealed that hydrothermal carbon (Htc) derived from CTS anchored on the surface of Mt uniformly with a spherical morphology. The introduction of Htc endowed the surface of Mt with abundant hydroxy, amine, and amide groups; organic carbon; developed porosity; and hydrophobic interfacial property. Hydrothermal temperature has huge impacts on the surface system, and smaller particles (average size of 27 vs 53 nm) with deeper carbonization, higher content of carbonaceous and nitrogenous functional groups, more developed porosity (66.149 vs 39.434 m2/g of specific surface area, 0.115 vs 0.090 cm3/g of pore volume), and slightly decreased hydrophobicity can be readily achieved at a higher temperature. The incoming surface protonated amine and amide functional groups show an ion-dipolar interaction to polar aflatoxin B1 (AFB1), and the increased organic carbon content as well as interfacial hydrophobicity generate a hydrophobic interaction to weak polar zearalenone (ZER). Consequently, the surface functionalization affords Mt enhanced adsorption capacity for AFB1, approximately two times compared with Mt, and superior adsorption ability for ZER (10 mg/g). The present work provides sufficient evidence of "surface directs application" of Mt, which encourages researchers to focus on studies of the surface science of clay minerals.

8.
J Physiol ; 596(19): 4729-4752, 2018 10.
Artículo en Inglés | MEDLINE | ID: mdl-30016551

RESUMEN

KEY POINTS: ERG3 channels have a high expression level in the central nervous system. Knockdown of ERG3 channels enhances neuronal intrinsic excitability (caused by decreased fast afterhyperpolarization, shortened delay time to the generation of an action potential and enhanced summation of somatic excitatory postsynaptic potentials) in hippocampal CA1 pyramidal neurons and dentate gyrus granule cells. The expression of ERG3 protein is reduced in human and mouse hippocampal epileptogenic foci. Knockdown of ERG3 channels in hippocampus enhanced seizure susceptibility, while mice treated with the ERG channel activator NS-1643 were less prone to epileptogenesis. The results provide strong evidence that ERG3 channels have a crucial role in the regulation of neuronal intrinsic excitability in hippocampal CA1 pyramidal neurons and dentate gyrus granule cells and are critically involved in the onset and development of epilepsy. ABSTRACT: The input-output relationship of neuronal networks depends heavily on the intrinsic properties of their neuronal elements. Profound changes in intrinsic properties have been observed in various physiological and pathological processes, such as learning, memory and epilepsy. However, the cellular and molecular mechanisms underlying acquired changes in intrinsic excitability are still not fully understood. Here, we demonstrate that ERG3 channels are critically involved in the regulation of intrinsic excitability in hippocampal CA1 pyramidal neurons and dentate gyrus granule cells. Knock-down of ERG3 channels significantly increases neuronal intrinsic excitability, which is mainly caused by decreased fast afterhyperpolarization, shortened delay time to the generation of an action potential and enhanced summation of somatic excitatory postsynaptic potentials. Interestingly, the expression level of ERG3 protein is significantly reduced in human and mouse brain tissues with temporal lobe epilepsy. Moreover, ERG3 channel knockdown in hippocampus significantly enhanced seizure susceptibility, while mice treated with the ERG channel activator NS-1643 were less prone to epileptogenesis. Taken together, our results suggest ERG3 channels play an important role in determining the excitability of hippocampal neurons and dysregulation of these channels may be involved in the generation of epilepsy. ERG3 channels may thus be a novel therapeutic target for the prevention of epilepsy.


Asunto(s)
Giro Dentado/fisiología , Epilepsia del Lóbulo Temporal/prevención & control , Canales de Potasio Éter-A-Go-Go/metabolismo , Hipocampo/fisiología , Canales de Potasio/metabolismo , Células Piramidales/fisiología , Convulsiones/prevención & control , Potenciales de Acción , Adulto , Animales , Estudios de Casos y Controles , Epilepsia del Lóbulo Temporal/metabolismo , Epilepsia del Lóbulo Temporal/patología , Canales de Potasio Éter-A-Go-Go/genética , Femenino , Humanos , Masculino , Ratones , Persona de Mediana Edad , Canales de Potasio/genética , Convulsiones/metabolismo , Convulsiones/patología
9.
J Environ Sci (China) ; 57: 62-71, 2017 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-28647266

RESUMEN

A novel illite@carbon (I@C) nanocomposite adsorbent has been synthesized via a facile hydrothermal carbonization process (HTC) using glucose as carbonaceous source and illite as the carrier. The morphology, microstructure and surface properties of the prepared nanocomposite adsorbent were analyzed by FESEM, TGA, XRD, FT-IR and Zeta potential measurements. Batch experiments were carried out on the adsorption of Cr(VI) to determine the adsorption properties of the composite. The adsorption of Cr(VI) onto the I@C nanocomposite was well described by the pseudo-second-order kinetic model and Langmuir isotherm. Compared with the illite and carbon material (SC) separately, the prepared I@C nanocomposite adsorbent exhibited enhanced adsorption performance for Cr(VI) with a maximum adsorption capacity of 149.25mg/g, which was higher than that of most reported adsorbents. In addition, the adsorption process was spontaneous and endothermic based on the adsorption thermodynamics study. The adsorption of Cr(VI) by I@C was highly pH-dependent and the optimum adsorption occurred at pH2.0. The Zeta potential analysis results indicated that the electrostatic interactions between anionic Cr(VI) and the positively charged surface of the adsorbent might be critical to the adsorption mechanism. This study demonstrated that the I@C nanocomposite should be a promising candidate for a low-cost, environmental friendly and highly efficient adsorbent for the removal of toxic Cr(VI) from wastewater.


Asunto(s)
Cromo/química , Nanocompuestos/química , Aguas Residuales/química , Contaminantes Químicos del Agua/química , Purificación del Agua/métodos , Adsorción , Cromo/análisis , Cinética , Minerales , Contaminantes Químicos del Agua/análisis
10.
Sci Total Environ ; 942: 173834, 2024 Sep 10.
Artículo en Inglés | MEDLINE | ID: mdl-38851354

RESUMEN

Developing technologies aimed at ecologically restoring is of great significance in addressing the problem of heavy metal pollution. In this study, NaA zeolites (FAZ) originated from fly ash with outstanding performance were prepared by alkali fusion hydrothermal method and used for the solidification and stabilization of heavy metals in soil. After systematic evaluation, it was found that FAZ may lower the leaching concentration of lead (Pb) in soil to <1 mg/kg and increase the stabilization rate of Pb to 80 % in the single Pb-contaminated soil, lower the leaching concentration of cadmium (Cd) in soil to <3 mg/kg and increase the stabilization rate of Cd to 60 % in the single Cd-contaminated soil, and lower the leaching concentration of Pb to 0.15 mg/kg and the leaching concentration of Cd to 0.74 mg/kg in PbCd complex polluted soil. Additionally, Pb stabilization rates reach 60 % and Cd stabilization rates reach 30 %, respectively. Ion exchange is primarily responsible for the adsorption and solidification of Pb and Cd in soil by FAZ. Generally, FAZ has a wide range of applications in the rehabilitation of contaminated soil and significantly lowers the level of heavy metal pollution in soil.

11.
J Orthop Surg Res ; 19(1): 204, 2024 Mar 27.
Artículo en Inglés | MEDLINE | ID: mdl-38539216

RESUMEN

Osteofibrous dysplasia (OFD) is a rare, benign, self-limited bone disorder with a relatively low incidence, accounting for approximately 0.2% of all primary bone tumors. It was frequently found intra-cortical of the mid-shaft of the tibia. OFD can also occur in other skeletal regions, including the fibula, ulna, radius, femur, humerus, ischium, rib, tarsus, metatarsals, vertebral, and capitate. OFD can present with asymptomatic, mass, pain, swelling, deformity, and even pathological fracture. OFD might be misdiagnosed as adamantinoma (AD) and because they are three subtypes origin from the same family of bone tumors and have similar imaging features. Moreover, pathology could provide evidence for an accurate diagnosis of OFD, but misdiagnosis may occur due to small sampling materials. To date, few studies have comprehensively introduced the epidemiology, clinical manifestations, pathogenesis, radiological features, pathology, and treatment for OFD. We herein discuss clinical signs, diagnosis methods, and treatment options of OFD to improve the understanding of OFD, which is helpful for accurate diagnosis and appropriate treatment.


Asunto(s)
Adamantinoma , Enfermedades del Desarrollo Óseo , Neoplasias Óseas , Displasia Fibrosa Ósea , Humanos , Adamantinoma/patología , Neoplasias Óseas/patología , Tibia/patología , Enfermedades del Desarrollo Óseo/diagnóstico por imagen , Enfermedades del Desarrollo Óseo/terapia , Displasia Fibrosa Ósea/diagnóstico por imagen , Displasia Fibrosa Ósea/patología
12.
J Colloid Interface Sci ; 666: 547-559, 2024 Jul 15.
Artículo en Inglés | MEDLINE | ID: mdl-38613977

RESUMEN

Efficient degradation of organic pollutants in complex media via advanced oxidation processes (AOPs) is still critical and challenging. Herein, nitrogen (N)-doped coal gangue (CG) catalysts (N-CG) with economic competitiveness and environmental friendliness were successfully synthesized to activate peroxymonosulfate (PMS), exhibiting ultrafast degradation performance toward benzo(a)pyrene (BaP) with 100.00 % and 93.21 % in contaminated solution and soil under optimized condition, respectively. In addition, 0.4 N-CG possessed excellent reusability toward BaP degradation with over 80.00 % after five cycles. However, BaP removal efficiency was significantly affected by some co-existing anions (HCO3- and SO42-) and humic acid (HA) in solution and soil, as well as inhibited under alkaline conditions, especially pH ≥ 9. According to the characterizations, N-doping could promote the generation of pyridinic N and graphitic N in N-CG via high-temperature calcination, which was conducive to produce hydroxyl radical (•OH), sulfate radical (SO4•-), superoxide radical (•O2-) and single oxygen (1O2). In 0.4 N-CG/PMS system, 1O2 and •O2- were proved to be the predominant reactive oxygen species (ROSs) in BaP degradation, as well as •OH and SO4•- made certain contributions. To sum up, this work provided a promising strategy for synthesis of CG-based catalysts by chemical inertness conversion of carbon fracture via N-doping for PMS activation and opened a novel perspective for environmental remediation of hydrophobic and hydrophilic contaminants pollution.

13.
Eur J Pharmacol ; 974: 176604, 2024 Jul 05.
Artículo en Inglés | MEDLINE | ID: mdl-38649090

RESUMEN

Osteoporosis (OP) is a metabolic bone disease with a high incidence rate worldwide. Its main features are decreased bone mass, increased bone fragility and deterioration of bone microstructure. It is caused by an imbalance between bone formation and bone resorption. Ginsenoside is a safe and effective traditional Chinese medicine (TCM) usually extracted from ginseng plants, having various therapeutic effects, of which the effect against osteoporosis has been extensively studied. We searched a total of 44 relevant articles with using keywords including osteoporosis, ginsenosides, bone mesenchymal cells, osteoblasts, osteoclasts and bone remodeling, all of which investigated the cellular mechanisms of different types of ginsenosides affecting the activity of bone remodeling by mesenchymal stem cells, osteoblasts and osteoclasts to counteract osteoporosis. This review describes the different types of ginsenosides used to treat osteoporosis from different perspectives, providing a solid theoretical basis for future clinical applications.


Asunto(s)
Ginsenósidos , Osteoporosis , Ginsenósidos/farmacología , Ginsenósidos/uso terapéutico , Osteoporosis/tratamiento farmacológico , Humanos , Animales , Remodelación Ósea/efectos de los fármacos , Osteoblastos/efectos de los fármacos , Osteoclastos/efectos de los fármacos
14.
Endocrine ; 2024 May 29.
Artículo en Inglés | MEDLINE | ID: mdl-38809347

RESUMEN

PURPOSE: This study aims to develop a non-invasive diagnosis model using machine learning (ML) for identifying high-risk IgG4 Hashimoto's thyroiditis (HT) patients. METHODS: A retrospective cohort of 93 HT patients and a prospective cohort of 179 HT patients were collected. According to the immunohistochemical and pathological results, the patients were divided into IgG4 HT group and non-IgG4 HT group. Serum TgAb IgG4 and TPOAb IgG4 were detected by ELISAs. A logistic regression model, support vector machine (SVM) and random forest (RF) were used to establish a clinical diagnosis model for IgG4 HT. RESULTS: Among these 272 patients, 40 (14.7%) were diagnosed with IgG4 HT. Patients with IgG4 HT were younger than those with non-IgG4 HT (P < 0.05). Serum levels of TgAb IgG4 and TPOAb IgG4 in IgG4 HT group were significantly higher than those in non-IgG4 HT group (P < 0.05). There were no significant differences in gender, disease duration, goiter, preoperative thyroid function status, preoperative TgAb or TPOAb levels, and thyroid ultrasound characteristics between the two groups (all P > 0.05). The accuracy, sensitivity, and specificity were 57%, 78%, and 79% for logistic regression model of IgG4 HT, 80 ± 7%, 84.7% ± 2.6%, and 75.4% ± 9.6% for the RF model and 78 ± 5%, 89.8% ± 5.7%, and 64.7% ± 5.7% for the SVM model. The RF model works better than SVM. The area under the ROC curve of RF ranged 0.87 to 0.92. CONCLUSION: A clinical diagnosis model for IgG4 HT established by RF model might help the early recognition of the high-risk patients of IgG4 HT.

15.
Phys Chem Chem Phys ; 15(40): 17250-6, 2013 Oct 28.
Artículo en Inglés | MEDLINE | ID: mdl-24018865

RESUMEN

Novel molecularly imprinted photonic crystals (IPCs) for the highly sensitive label-free detection of L-proline and for the chiral recognition of L/D-proline were reported. A series of L-proline imprinted polyacrylamide photonic crystals (PAM-LPIPCs) and poly(acrylamide-co-acrylic acid) photonic crystals (PAM-co-AA-LPIPCs) were fabricated via the in situ polymerization of polystyrene opal. The PAM-LPIPCs exhibit good molecular response in L-proline solutions and can be visualized by the naked eye much like a pH test paper. The concentration of imprinted molecules (L-proline) in aqueous solution can be detected by the chromatic signal (structural color) or the optical signal (λmax). Furthermore, the responsivity and sensitivity of the PAM-co-AA-LPIPCs can be improved by increasing the amount of the imprinted content or the proportion of AA, or by decreasing the ratio of the cross-linking agent. When all these factors were balanced, a PAM2-co-AA0.4-LP0.5 IPC with good strength, high responsivity, high sensitivity and specific molecular recognition was obtained. It is found that the presented crystals can show obvious response to L-proline solution even at a low concentration of 1%. The PAM2-co-AA0.4-LP0.5 IPC not only very selectively distinguishes between L-proline and nicotinic acid, but it is also good at chiral recognition between L-proline and D-proline. What is more, the response is rapid and reversible and the IPC is recyclable.


Asunto(s)
Técnicas de Química Analítica/métodos , Impresión Molecular , Fotones , Prolina/química , Coloides/química , Límite de Detección , Estructura Molecular , Poliestirenos/química , Coloración y Etiquetado , Estereoisomerismo
16.
J Orthop Surg Res ; 18(1): 358, 2023 May 15.
Artículo en Inglés | MEDLINE | ID: mdl-37183257

RESUMEN

OBJECTIVE: To explore the efficacy and safety of the posterior paramedian approach combined with a novel inverted V-shaped surgical access for the treatment of intraspinal schwannomas. METHODS: This study retrospectively reviewed consecutive patients who underwent surgical resection of the intraspinal schwannomas via the inverted V-shaped approach at our center between January 2016 and May 2021. Changes between the preoperative and postoperative visual analog scale (VAS) scores and neurological function Japan Orthopaedic Association (JOA) scores were assessed. Secondary outcomes such as success rate of tumor resection, operation time, blood loss, spinal stability, and disruption degree of intervertebral joints. Postoperative complications were also investigated. RESULTS: Of these 36 consecutive patients, there were 6 cases in the cervical spine, 2 cases at the cervical-thoracic junction, 11 cases in the thoracic spine, 4 cases at the thoracic-lumbar junction and 13 cases in the lumbar spine. The average operation time was 99 min, and the average blood loss was 95.4 mL. The tumor removal rate was 100%. Postoperative CT re-examination showed that the spinous processes were intact in all cases, the facet joint surfaces were intact in 32 cases. At the time of last follow-up, the median JOA score was 25 (9-27), which was significantly improved compared to the preoperative median JOA score of 15 (10-22) (P < 0.01). The overall excellent and good rate were 88.9 %. The median VAS score at post-surgery was 0 (0-2), which was significantly improved compared to the preoperative median VAS score of 4 (2-8) (P < 0.01). As for complications, there were no cases of cerebrospinal fluid leakage or spinal instability. Three patients who had a postoperative fever finally recovered after lumbar cistern drainage. CONCLUSION: The inverted V-shaped surgical access via the posterior paramedian approach is an effective and safe method for the treatment of intraspinal schwannomas.


Asunto(s)
Neurilemoma , Fusión Vertebral , Humanos , Estudios Retrospectivos , Resultado del Tratamiento , Vértebras Cervicales/diagnóstico por imagen , Vértebras Cervicales/cirugía , Vértebras Lumbares/diagnóstico por imagen , Vértebras Lumbares/cirugía , Neurilemoma/diagnóstico por imagen , Neurilemoma/cirugía
17.
Ann Transl Med ; 11(6): 255, 2023 Mar 31.
Artículo en Inglés | MEDLINE | ID: mdl-37082685

RESUMEN

Background: With the growing awareness of postoperative infection, increasing focus has been placed on infection after spinal implant surgery (IASIS). This study aimed to explore the development and trends of research regarding IASIS using bibliometric analysis. Methods: Scientific articles on IASIS research published between February 1, 2000, and December 31, 2020 were retrieved from the Web of Science database. Results: A total of 820 publications were included in the bibliometric analysis, with studies originating from 46 countries and 6 languages. Researchers from the United States published the highest number of articles and collaborated closely with researchers in Canada, Germany, and Japan. The author with the most publications was Alexander R. Vaccaro. The journal with the most articles and citations was Spine. Most of the research was performed on risk factors and the incidence of IASIS. Co-occurrence analysis revealed that the most recent research trend was likely related to the management of IASIS and the international consensus meeting. Three clusters of research were identified through a thematic map: diagnosis and treatment of IASIS, scoliosis-related infection, and risk factors and prevention of IASIS. Conclusions: Research on IASIS increasingly grew between 2000 and 2020. Spinal surgeons and institutes from the United States had the highest number of publications and academic impact in this field. Diagnosis-related problems and multidisciplinary work on IASIS require further attention in the future. Current trends in IASIS are likely associated with IASIS management and the international consensus meeting.

18.
Front Cell Dev Biol ; 11: 1270383, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37719884

RESUMEN

[This corrects the article DOI: 10.3389/fcell.2021.646311.].

19.
Front Public Health ; 11: 1204497, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37448662

RESUMEN

Objective: Falls in older people have become a major public health, economic and societal problem. Osteoporosis predisposes older adults to high risk of falls, which were the most common outcome attributable to low bone mineral density (LBMD). In this study, we analyze the long-term trends in falls burden attributable to LBMD among people aged 60 years and over from 1990 to 2019, using data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019). Methods: Data from GBD 2019 were used to assess the long-term trends in mortality and disability-adjusted life-year (DALY) rates by Joinpoint regression. The age-period-cohort (APC) model was used to evaluate the effects of age, period and cohort on mortality rate of falls attributable to LBMD. Results: The mortality and DALYs rates of falls attributable to LBMD among people aged 60 years and over increased from 1990 to 2019, with average annual percentage changes (AAPCs) of 1.74% (95% CI: -1.47 to 2.01%) and 0.99% (95% CI: 0.80-1.19%), respectively. APC analysis revealed that the mortality rate due to LBMD significantly increased among the older people over the age of 75 years. The risk of falls mortality due to LBMD during the period of 1990-2019 initially declined but later elevated. An overall increasing risk for falls death attributable to LBMD was presented across birth cohorts, but in cohorts born after 1930, the upward trend has slowed down. The overall net drift per year attributable to LBMD was above 0. The corresponding results showed that the negative impact of period and cohort effects among males was more pronounced than those among females. Conclusions: Falls attributable to LBMD remain an ongoing health burden in the older people in China, and the mortality has been on the rise from 1990 to 2019, especially among the older people aged 80+ years group. The prevention and treatment of LBMD should be emphasized, especially among males and oldest-old people. Furthermore, there is an urgent need to strengthen the implementation of system-wide, integrated and effective public health policies and other health interventions in China.


Asunto(s)
Accidentes por Caídas , Osteoporosis , Masculino , Femenino , Humanos , Persona de Mediana Edad , Anciano , Anciano de 80 o más Años , Años de Vida Ajustados por Calidad de Vida , Osteoporosis/epidemiología , Factores de Riesgo , China/epidemiología
20.
ACS Appl Bio Mater ; 6(11): 4961-4971, 2023 11 20.
Artículo en Inglés | MEDLINE | ID: mdl-37832028

RESUMEN

By intercalating montmorillonite (MMT) with Cu2+ and benzalkonium chloride (BAC), the present work constructed a synergistic promotion system (Cu2+/BAC/MMT). MMT not only enhances the thermal stability of Cu2+ and BAC but also facilitates the controlled release of Cu2+ and BAC. Concurrently, the introduction of BAC improves the material's organic compatibility. In vitro assays show that the "MIC+" of Cu2+/BAC/MMT against Staphylococcus aureus is merely 7.32 mg/L and 55.56 mg/L against Escherichia coli. At concentrations of 10 and 25 mg/L, Cu2+/BAC/MMT inactivates 100% of S. aureus and E. coli within 2 h, respectively. Furthermore, it is confirmed that the prepared Cu2+/BAC/MMT exhibits a long-term antibacterial ability through antibacterial experiments and release tests. Also, the biosafety of this material was also substantiated by in vitro cytotoxicity tests. These comprehensive findings indisputably portend that Cu2+/BAC/MMT holds promise to supplant antibiotics as an efficacious treatment modality for bacterial infections.


Asunto(s)
Bentonita , Compuestos de Benzalconio , Bentonita/farmacología , Compuestos de Benzalconio/farmacología , Escherichia coli , Staphylococcus aureus , Antibacterianos/farmacología
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