RESUMEN
The predictor of hematopoietic stem cells (HSCs) mobilized in peripheral blood (PB) remains unknown. We retrospectively examined the relationship between serum cholesterol level and CD34-positive cells mobilized with granulocyte stimulating factor in PB. PB- mobilized CD34-positive cells were significantly higher in patients with high titers of total cholesterol and low-density lipoprotein cholesterol (LDL-C) than in patients with normal levels (average total cholesterol, 122.94 vs. 51.03/µL, p<0.05; average LDL-C 130.07 vs. 53.77, p<0.05). Multivariable analysis showed that LDL-C significantly influenced PB-mobilized CD34-positive cells, suggesting that LDL-C may be an effective biomarker for mobilization of HSCs in PB.
Asunto(s)
Células Madre Hematopoyéticas/metabolismo , Lipoproteínas LDL/sangre , Adulto , Anciano , Biomarcadores/sangre , Colesterol/sangre , Femenino , Trasplante de Células Madre Hematopoyéticas/métodos , Humanos , Masculino , Persona de Mediana Edad , Acondicionamiento Pretrasplante/métodos , Trasplante Autólogo , Adulto JovenRESUMEN
Linezolid (LZD)-induced myelosuppression has been reported in adults; however, LZD-induced pure red cell precursor toxicity rarely occurs. A 2-year-old boy diagnosed with infective endocarditis by Streptococcus mitis received LZD after developing resistance to multiple antibiotics. Although his infective symptoms were improved by LZD, progressive anemia was noticed 2 weeks after LZD therapy. Four weeks after LZD administration, his hemoglobin level was 6.5 g/dL and reticulocytes less than 0.1%. Bone marrow examination revealed markedly decreased erythropoiesis with cytoplasmic vacuolation of erythroblasts. Anemia recovered 19 days after cessation of LZD. Elevated protoporphyrin and a high LZD level in the blood suggested that mitochondrial disturbance by high-dose and long-term treatment with LZD may have been responsible for LZD-induced pure red cell precursor toxicity.