Detalles de la búsqueda
1.
Phosphodiesterase 2A Inhibitor TAK-915 Ameliorates Cognitive Impairments and Social Withdrawal in N-Methyl-d-Aspartate Receptor Antagonist-Induced Rat Models of Schizophrenia.
J Pharmacol Exp Ther
; 365(1): 179-188, 2018 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29440309
2.
Discovery of a Novel Series of Pyrazolo[1,5-a]pyrimidine-Based Phosphodiesterase 2A Inhibitors Structurally Different from N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915), for the Treatment of Cognitive Disorders.
Chem Pharm Bull (Tokyo)
; 65(11): 1058-1077, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-29093293
3.
Design and synthesis of potent and selective pyridazin-4(1H)-one-based PDE10A inhibitors interacting with Tyr683 in the PDE10A selectivity pocket.
Bioorg Med Chem
; 24(16): 3447-55, 2016 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27301679
4.
Evaluation of a novel PDE10A PET radioligand, [(11) C]T-773, in nonhuman primates: brain and whole body PET and brain autoradiography.
Synapse
; 69(7): 345-55, 2015 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-25892433
5.
Design and synthesis of a novel 2-oxindole scaffold as a highly potent and brain-penetrant phosphodiesterase 10A inhibitor.
Bioorg Med Chem
; 23(22): 7138-49, 2015 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26494583
6.
Development of a series of novel carbon-11 labeled PDE10A inhibitors.
J Labelled Comp Radiopharm
; 58(5): 202-8, 2015 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25891816
7.
Simple and Practical Method for the Quantitative High-Sensitivity Analysis of N-Nitroso Duloxetine in Duloxetine Drug Products Utilizing LC-MS/MS.
ACS Omega
; 9(11): 13440-13446, 2024 Mar 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-38524415
8.
A case of spinal cord infarction presenting with unilateral C5 palsy.
Rinsho Shinkeigaku
; 64(2): 105-108, 2024 Feb 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-38246605
9.
Preliminary Experience of the Surpass Streamline Flow Diverter for Large and Giant Unruptured Internal Carotid Artery Aneurysms.
Neurol Med Chir (Tokyo)
; 62(10): 451-457, 2022 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36070961
10.
Ruptured Dissecting Aneurysm of the Carotid Artery 12 Years after Gamma Knife Therapy for Pituitary Adenoma.
J Neuroendovasc Ther
; 15(1): 32-37, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-37503454
11.
Direct and Regioselective Monofluorination of N-Protected Pyridone Derivatives using N-Fluorobenzenesulfonimide (NFSI).
Org Lett
; 21(18): 7254-7257, 2019 09 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-31490083
12.
Development of two fluorine-18 labeled PET radioligands targeting PDE10A and in vivo PET evaluation in nonhuman primates.
Nucl Med Biol
; 57: 12-19, 2018 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29223715
13.
Whole Genome Sequencing of Influenza A and B Viruses With the MinION Sequencer in the Clinical Setting: A Pilot Study.
Front Microbiol
; 9: 2748, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-30483243
14.
Discovery of an Orally Bioavailable, Brain-Penetrating, in Vivo Active Phosphodiesterase 2A Inhibitor Lead Series for the Treatment of Cognitive Disorders.
J Med Chem
; 60(18): 7658-7676, 2017 09 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-28759228
15.
Discovery of Clinical Candidate N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders.
J Med Chem
; 60(18): 7677-7702, 2017 09 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-28796496
16.
Characterization of binding and inhibitory properties of TAK-063, a novel phosphodiesterase 10A inhibitor.
PLoS One
; 10(3): e0122197, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25815469
17.
Characterization of the binding properties of T-773 as a PET radioligand for phosphodiesterase 10A.
Nucl Med Biol
; 42(2): 146-54, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25451212
18.
Molecular Imaging of PDE10A Knockout Mice with a Novel PET Radiotracer: [(11)C]T-773.
Mol Imaging Biol
; 17(4): 445-9, 2015 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-25622810
19.
Extremely Facile and Selective Nickel-Catalyzed Allyl Ether Cleavage.
Angew Chem Int Ed Engl
; 37(8): 1136-1137, 1998 May 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29711026
20.
Discovery of 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a highly potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor.
J Med Chem
; 57(22): 9627-43, 2014 Nov 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-25384088