Detalles de la búsqueda
1.
Low molecular weight acids and OATP1B mediated hepatic clearance: In vitro and in vivo evaluation using novel hypoxia-inducible factor prolyl hydroxylase inhibitors (Dustats).
Drug Metab Dispos
; 2024 Feb 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-38388380
2.
The Comparison of Machine Learning and Mechanistic In Vitro-In Vivo Extrapolation Models for the Prediction of Human Intrinsic Clearance.
Mol Pharm
; 20(11): 5616-5630, 2023 11 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-37812508
3.
Transporter-Enzyme Interplay in the Pharmacokinetics of PF-06835919, A First-in-class Ketohexokinase Inhibitor for Metabolic Disorders and Non-alcoholic Fatty Liver Disease.
Drug Metab Dispos
; 2022 Jul 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-35779864
4.
In Vitro - in Vivo Extrapolation of Hepatic Clearance in Preclinical Species.
Pharm Res
; 39(7): 1615-1632, 2022 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-35257289
5.
Organic Anion-Transporting Polypeptide 1B1/1B3-Mediated Hepatic Uptake Determines the Pharmacokinetics of Large Lipophilic Acids: In Vitro-In Vivo Evaluation in Cynomolgus Monkey.
J Pharmacol Exp Ther
; 377(1): 169-180, 2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33509903
6.
Effect of Human Plasma on Hepatic Uptake of Organic Anion-Transporting Polypeptide 1B Substrates: Studies Using Transfected Cells and Primary Human Hepatocytes.
Drug Metab Dispos
; 49(1): 72-83, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33139461
7.
Static and Dynamic Projections of Drug-Drug Interactions Caused by Cytochrome P450 3A Time-Dependent Inhibitors Measured in Human Liver Microsomes and Hepatocytes.
Drug Metab Dispos
; 49(10): 947-960, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34326140
8.
Quantitative Contribution of Six Major Transporters to the Hepatic Uptake of Drugs: "SLC-Phenotyping" Using Primary Human Hepatocytes.
J Pharmacol Exp Ther
; 370(1): 72-83, 2019 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-30975793
9.
A Novel Unified Approach to Predict Human Hepatic Clearance for Both Enzyme- and Transporter-Mediated Mechanisms Using Suspended Human Hepatocytes.
Drug Metab Dispos
; 47(5): 484-492, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30787098
10.
Organic Anion Transporter 2-Mediated Hepatic Uptake Contributes to the Clearance of High-Permeability-Low-Molecular-Weight Acid and Zwitterion Drugs: Evaluation Using 25 Drugs.
J Pharmacol Exp Ther
; 367(2): 322-334, 2018 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30135178
11.
A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 2: Prospectively Predicting Systemic and Liver Exposure in Healthy Subjects.
Drug Metab Dispos
; 46(4): 357-366, 2018 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29330219
12.
Comparison of Species and Cell-Type Differences in Fraction Unbound of Liver Tissues, Hepatocytes, and Cell Lines.
Drug Metab Dispos
; 46(4): 415-421, 2018 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29437874
13.
A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy Subjects.
Drug Metab Dispos
; 46(4): 346-356, 2018 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29330218
14.
Selective Activation of AMPK ß1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy.
J Pharmacol Exp Ther
; 361(2): 303-311, 2017 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28289077
15.
Quantitative Prediction of Human Renal Clearance and Drug-Drug Interactions of Organic Anion Transporter Substrates Using In Vitro Transport Data: A Relative Activity Factor Approach.
Drug Metab Dispos
; 45(4): 409-417, 2017 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-28179375
16.
Correction: In Vitro-In Vivo Extrapolation of Hepatic Clearance in Preclinical Species.
Pharm Res
; 39(7): 1659, 2022 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-35315000
17.
Study of the ketohexokinase inhibitor PF-06835919 as a clinical cytochrome P450 3A inducer: Integrated use of oral midazolam and liquid biopsy.
Clin Transl Sci
; 17(1): e13644, 2024 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-38108609
18.
Characterization and Applications of Permeabilized Hepatocytes in Drug Discovery.
AAPS J
; 26(3): 38, 2024 03 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-38548986
19.
Relationship of binding-site occupancy, transthyretin stabilisation and disease modification in patients with tafamidis-treated transthyretin amyloid cardiomyopathy.
Amyloid
; 30(2): 208-219, 2023 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-36399070
20.
In Vitro-In Vivo Extrapolation and Scaling Factors for Clearance of Human and Preclinical Species with Liver Microsomes and Hepatocytes.
AAPS J
; 25(3): 40, 2023 04 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-37052732