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1.
Pediatr Crit Care Med ; 12(6): 635-42, 2011 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-21499186

RESUMEN

OBJECTIVE: Critically ill children are at risk for psychological sequelae following pediatric intensive care unit hospitalization. This article reports on the psychometric testing of the first self-report measure of psychological distress for 6-12-yr-old children post-pediatric intensive care unit hospitalization: The Children's Critical Illness Impact Scale. This 23-item scale takes approximately 15 mins for children to complete. DESIGN: Psychometric testing based on Classic Test Theory and guidelines for health measurement scale development. SETTING: The pediatric intensive care units of four Canadian pediatric hospitals and the ear, nose, and throat clinic of one participating hospital. PATIENTS: A total of 172 children (pediatric intensive care unit group, n = 84; ear, nose, and throat group, n = 88) aged 6-12 yrs and their parents. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: We assessed the factor structure, internal consistency, and test-retest reliability of the Children's Critical Illness Impact Scale and conducted contrasted group comparisons and convergent and concurrent validation testing. Fit indices and internal consistency were best for a three-factor solution, suggesting three dimensions of psychological distress: 1) worries about getting sick again, 2) feeling things have changed, and 3) feeling anxious and fearful about hospitalization. As expected, Children's Critical Illness Impact Scale scores were positively correlated with child anxiety and medical fear scores. The ear, nose, and throat group scores were higher than expected. Higher Children's Critical Illness Impact Scale scores in older children may reflect a better understanding of the situation and its complexity and meaning, and younger children's tendency to provide more positive self-evaluation. CONCLUSIONS: The Children's Critical Illness Impact Scale is a promising new self-report measure of psychological distress with demonstrated reliability and validation testing in 6-12-yr-old children post-pediatric intensive care unit hospitalization. This new measure has potential to advance the evidence base for pediatric intensive care unit and post-pediatric intensive care unit health promotion interventions.


Asunto(s)
Hospitalización , Unidades de Cuidado Intensivo Pediátrico , Evaluación de Resultado en la Atención de Salud , Pacientes/psicología , Encuestas y Cuestionarios/normas , Canadá , Niño , Femenino , Humanos , Masculino , Psicometría
2.
Int J Pediatr Otorhinolaryngol ; 69(9): 1247-52, 2005 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-15927272

RESUMEN

In this article, we describe a patient with Pai syndrome. This infant was born with an unusual median cleft of the upper lip, a pedunculated cutaneous mass that protruded from the right nostril, double frenulum of the upper lip, and median alveolar cleft. MRI showed a midline corpus callosal lipoma. Mental development was normal and chromosomal analysis revealed a normal male 46, XY karyotype.


Asunto(s)
Neoplasias Encefálicas , Labio Leporino , Fisura del Paladar , Cuerpo Calloso , Lipoma , Pólipos Nasales , Neoplasias Encefálicas/diagnóstico , Neoplasias Encefálicas/etiología , Labio Leporino/etiología , Labio Leporino/cirugía , Fisura del Paladar/etiología , Fisura del Paladar/cirugía , Cuerpo Calloso/patología , Humanos , Recién Nacido , Lipoma/diagnóstico , Lipoma/etiología , Imagen por Resonancia Magnética , Masculino , Pólipos Nasales/etiología , Pólipos Nasales/cirugía , Síndrome , Tomografía Computarizada por Rayos X
3.
Arch Otolaryngol Head Neck Surg ; 128(2): 156-60, 2002 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-11843724

RESUMEN

OBJECTIVES: To establish and characterize the first pediatric normative database for the Multi-Dimensional Voice Program, a computerized voice analysis system, and to compare the normative data with the vocal profiles of patients with vocal fold nodules. DESIGN: A cross-sectional, observational design was used to establish the normative database. The comparative study was completed using a case-control design. SETTING: University-based outpatient pediatric otolaryngology clinic. PARTICIPANTS: One hundred control subjects (50 boys and 50 girls) aged 4 to 18 years contributed to the normative database. The voices of 26 patients (19 boys and 7 girls) with bilateral vocal fold nodules were also analyzed. MAIN OUTCOME MEASURES: Demographic data, including sex, age, height, weight, body mass index, and cigarette smoke exposure, were obtained. The Multi-Dimensional Voice Program extracted up to 33 acoustic variables from each voice analysis. RESULTS: The mean (SEM) values of each of the acoustic variables are presented. At age 12 years, boys experience a dramatic decrease in fundamental frequency measurements. The voices of patients with vocal fold nodules had significantly elevated frequency perturbation measurements compared with control subjects (P<.001). CONCLUSIONS: The vocal profile of children is uniform across all girls and prepubescent boys. Patients with vocal fold nodules demonstrated a consistent acoustic profile characterized by an elevation in frequency perturbation measurements. Normal acoustic reference ranges may be used to detect various vocal fold pathologic abnormalities and to monitor the effects of voice therapy.


Asunto(s)
Bases de Datos como Asunto , Diagnóstico por Computador , Pliegues Vocales/fisiopatología , Trastornos de la Voz/diagnóstico , Trastornos de la Voz/fisiopatología , Adolescente , Estudios de Casos y Controles , Niño , Preescolar , Estudios Transversales , Femenino , Humanos , Masculino , Valores de Referencia , Sensibilidad y Especificidad , Acústica del Lenguaje
4.
Int J Pediatr Otorhinolaryngol ; 68(4): 495-501, 2004 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-15013619

RESUMEN

Acrocephalosyndactyly Type I, or Apert syndrome is a congenital disorder characterized by craniosynostosis and syndactyly. When hearing loss occurs, it is usually bilateral and conductive, often attributable to congenital stapes fixation. In determining treatment, the risk of gusher with stapedectomy becomes an important consideration. We present an adult with Apert syndrome and hearing loss, with particular emphasis on a progressive conductive component in one ear. Surgical exploration failed to reveal any definite middle ear abnormality and no stapedectomy was performed. A theory on the pathogenesis of the conductive loss in our patient follows a brief review of the literature on gusher in patients with ear malformations.


Asunto(s)
Acrocefalosindactilia/complicaciones , Oído/anomalías , Pérdida Auditiva Conductiva/etiología , Adulto , Audiometría de Tonos Puros , Umbral Auditivo , Oído Interno/anomalías , Femenino , Humanos , Tomografía Computarizada por Rayos X
5.
Mcgill J Med ; 13(1): 10, 2011 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-22363177

RESUMEN

In this report we describe a newborn with a rare case of Type II tracheal agenesis and bronchoesophageal fistula. Polyhydramnios and suspected esophageal atresia were identified during routine pre-natal ultrasound screening. Upon delivery, rigid bronchoscopy, esophagoscopy, and intraoperative fluoroscopy were performed, where both bronchi and the carina showed unusual horizontal orientation making it difficult to identify the fistula. However, a post mortem CT confirmed the diagnosis of an isolated Type II tracheal agenesis with bronchoesophageal fistula.

6.
Pediatrics ; 125(1): e162-8, 2010 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-20026494

RESUMEN

BACKGROUND: Polysomnography is the best tool available for diagnosing obstructive sleep apnea (OSA) in children. However, polysomnography is relatively inaccessible and costly, and studies are needed to evaluate other diagnostic approaches. It has been suggested that the OSA-18 quality-of-life questionnaire (OSA-18) is a useful measure that could replace polysomnography. The purpose of our study was to determine if the OSA-18, is an accurate measure for the detection of moderate-to-severe OSA. PATIENTS AND METHODS: Children who were referred to our sleep laboratory for evaluation of suspected OSA and who had a nocturnal pulse oximetry study were included in our cross-sectional study. The results of the oximetry study were interpreted by using the McGill oximetry score (MOS). Abnormal scores were consistent with moderate-to-severe OSA. We analyzed demographic and medical data in addition to the OSA-18 results. We estimated sensitivity and negative predictive values for the OSA-18 to detect an abnormal MOS. We also conducted logistic regression analyses with MOS as the dependent variable and the OSA-18 score, age, gender, comorbidities, and race as independent variables. RESULTS: We studied 334 children (mean age: 4.6 years; 58% male). The OSA-18 had a sensitivity of 40% and a negative predictive value of 73% for detecting an abnormal MOS. While controlling for other variables in the regression model, for each unit increase in the OSA-18 score, the odds of having an abnormal MOS were increased by 2%. For each 1-year increase in age, the odds of having an abnormal MOS were decreased by 17%. CONCLUSIONS: Among children who are referred to a sleep laboratory, the OSA-18 does not accurately detect which children will have an abnormal MOS and cannot be used to exclude moderate-to-severe OSA. The OSA-18 should not be used in the place of objective testing to identify moderate-to-severe OSA in children.


Asunto(s)
Oximetría/métodos , Calidad de Vida , Apnea Obstructiva del Sueño/diagnóstico , Encuestas y Cuestionarios , Niño , Preescolar , Intervalos de Confianza , Estudios Transversales , Reacciones Falso Negativas , Femenino , Humanos , Modelos Logísticos , Masculino , Oportunidad Relativa , Polisomnografía , Probabilidad , Quebec , Medición de Riesgo , Sensibilidad y Especificidad , Índice de Severidad de la Enfermedad
7.
J Otolaryngol Head Neck Surg ; 37(4): 565-71, 2008 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-19128594

RESUMEN

HYPOTHESIS/OBJECTIVES: Laryngopharyngeal reflux (LPR) was recently implicated in the etiology of otitis media with effusion (OME). To study the hypothesis that gastric juice reaches the middle ear through the nasopharynx and eustachian tube, we evaluated the presence of pepsinogen in the adenoid tissues of children with otitis media with effusion (OME) and compared them with the tissues of a control group of children without OME. METHODS: In the study group, middle ear effusions (MEEs) and adenoidal tissue biopsies were obtained from patients undergoing simultaneous tympanostomy tube placement and adenoidectomy. In the control group, adenoid specimens were taken during adenoidectomy (+/- tonsillectomy) from children with no history of OME. The adenoid tissues were analyzed immunohistochemically to confirm the presence of pepsinogen. Normal gastric tissue was used as a positive control and lymphatic tissue as a negative control. Total pepsinogen levels of MEE were measured with enzyme-linked immunosorbent assay. RESULTS: Adenoid tissue of the OME group (n = 25) demonstrated significantly higher pepsinogen immunoreactivity when compared with the adenoid tissue of the control group (n = 29), specifically in staining of both the epithelia (p < .0001) and the subepithelia, (p < .001). The presence of pepsinogen was detected in 84% of MEEs from the OME group, at concentrations 1.86 to 12.5 times higher than that of serum. Pepsinogen messenger ribonucleic acid was not demonstrated in any of the adenoid tissues of the OME group. CONCLUSION: LPR plays an important role in the pathogenesis of OME as gastric reflux reaches the middle ear through the nasopharynx and eustachian tube to cause OME.


Asunto(s)
Reflujo Gastroesofágico/complicaciones , Reflujo Gastroesofágico/diagnóstico , Otitis Media con Derrame/etiología , Pepsinógeno A/análisis , Tonsila Faríngea/patología , Biomarcadores/análisis , Distribución de Chi-Cuadrado , Niño , Preescolar , Ensayo de Inmunoadsorción Enzimática , Exudados y Transudados/química , Femenino , Humanos , Técnicas para Inmunoenzimas , Lactante , Masculino
8.
Curr Opin Otolaryngol Head Neck Surg ; 14(3): 187-90, 2006 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-16728898

RESUMEN

PURPOSE OF REVIEW: In this review we will examine evidence indicating that allergic inflammation is present in middle ear effusion. We will also discuss several of the problems relating to the diagnosis of allergy and allergic sensitization, and why anti-allergy treatments have been unsuccessful. This will provide a rationale for future studies in the field linking allergic inflammation with otitis media with effusion. RECENT FINDINGS: Recent findings in atopic children demonstrated higher levels of eosinophils, T lymphocytes, and interleukin-4+ and interleukin-5+ cells compared with nonatopic patients. T-helper 2 cells and cytokines were found not only in middle ear effusions in atopic children but also in specimens from adenoid tissue. This demonstrates a strong correlation between allergic reaction in the middle ear and the upper airway. SUMMARY: In summary, as our knowledge of the allergic and nonallergic influences on inflammation broadens, the paradigms of treatment may be altered. The accumulating experimental and clinical data suggest that it may be wiser to screen every child with otitis media with effusion for allergic rhinitis and ultimately to manage those with allergic inflammation differently to nonatopic individuals with otitis media with effusion.


Asunto(s)
Hipersensibilidad/inmunología , Otitis Media con Derrame/inmunología , Humanos , Hipersensibilidad/complicaciones , Otitis Media con Derrame/complicaciones
9.
J Otolaryngol ; 35(3): 180-5, 2006 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-16929994

RESUMEN

OBJECTIVE: To document the most important postoperative adenotonsillectomy morbidities, with an emphasis on prolonged hospitalization and readmissions. DESIGN: Retrospective chart analysis. METHODS: We reviewed 2067 cases of adenotonsillectomies performed at our institution over a period of 6 years. RESULTS: Of these cases, 1927 patients had undergone tonsillectomy by electrocautery and adenoidectomy by suction-coagulator, of whom 9.3% required admission. The incidence of admissions owing to bleeding was 1.7%, whereas admissions owing to respiratory and gastrointestinal complications represented 3.7% and 5.2%, respectively. Compared with the literature and our institution's previous results, these morbidity values were found to be either comparable or significantly lower (p < .05). CONCLUSION: We attribute this improvement to our use of electrocautery-based techniques not only for tonsillectomy but also for adenoidectomy.


Asunto(s)
Adenoidectomía/efectos adversos , Electrocoagulación/efectos adversos , Tonsilectomía/efectos adversos , Adenoidectomía/métodos , Adolescente , Procedimientos Quirúrgicos Ambulatorios/efectos adversos , Niño , Preescolar , Femenino , Humanos , Lactante , Tiempo de Internación , Masculino , Readmisión del Paciente , Estudios Retrospectivos , Tonsilectomía/métodos
10.
J Otolaryngol ; 35(4): 235-41, 2006 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-17176798

RESUMEN

BACKGROUND: Day surgery constitutes an important part of modern otolaryngology practice. However, high rates of unplanned admissions remain an issue. OBJECTIVE: To determine the incidence, reasons, and predictive factors for unanticipated admission after ambulatory otolaryngologic surgery. METHODS: A retrospective review of all cases of unplanned admission following otolaryngology day surgery at a tertiary care centre over a 4-year period from 2000 to 2004. Data relating to patient demographics, physical status, surgical procedure, perioperative complications, and reasons for hospital admission were recorded. A case-control analysis of these parameters with nonadmitted day surgery patients was used for comparison. RESULTS: During the above period, 1106 patients underwent otolaryngologic day surgery, of whom 74 (6.7%) required admission. Fifty-seven percent of the patients were male, and the average age was 48.9 years. The three most common procedures with unplanned admission were open neck biopsy (27%), functional endoscopic sinus surgery (20.3%), and panendoscopy (16.2%). The reasons for admission could be divided into airway monitoring (37.7%), postoperative bleeding (28.6%), the need for supportive or pain management (19.5%), anesthetic complication (5.2%), cardiovascular complication (3.9%), clerical error (3.9%), and suspicion of a cerebrospinal fluid leak (1.3%). Risk factors for admission were determined to be an American Society of Anesthesiologists' class of 3 or greater, open neck surgical procedures, and a length of surgery of 60 minutes or greater. Minor factors included the use of general anesthesia, male gender, advanced age, and living far from a hospital. CONCLUSIONS: This study suggests strategies to reduce the rate of unplanned admission by means of careful preoperative assessment and planning, patient selection, careful scheduling of higher-risk patients, and appropriate postoperative observation and management.


Asunto(s)
Procedimientos Quirúrgicos Ambulatorios/efectos adversos , Hospitalización/estadística & datos numéricos , Procedimientos Quirúrgicos Otorrinolaringológicos/efectos adversos , Admisión del Paciente/estadística & datos numéricos , Adolescente , Adulto , Anciano , Análisis de Varianza , Estudios de Casos y Controles , Distribución de Chi-Cuadrado , Femenino , Humanos , Incidencia , Masculino , Persona de Mediana Edad , Planificación de Atención al Paciente , Selección de Paciente , Complicaciones Posoperatorias/epidemiología , Estudios Retrospectivos , Factores de Riesgo
11.
J Otolaryngol ; 34 Suppl 1: S45-9, 2005 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-16089240

RESUMEN

Tonsillopharyngitis is an extremely common infection seen in adults and children. Although the symptoms and signs of this disease are usually sufficient to make a diagnosis, it is often difficult to make a distinction between bacterial and viral etiology on clinical grounds alone. The complications of tonsillopharyngitis may be classified into suppurative and nonsuppurative complications. The nonsuppurative complications include scarlet fever, acute rheumatic fever, and post-streptococcal glomerulonephritis. Suppurative complications include peritonsillar, parapharyngeal, and retropharyngeal cellulites and/or abscess. Features suggestive of viral bacterial (GABHS) etiologies, the medical and surgical guidelines for managing tonsillopharyngitis, and its complications are highlighted in this article.


Asunto(s)
Faringitis/diagnóstico , Faringitis/terapia , Tonsilitis/diagnóstico , Tonsilitis/terapia , Algoritmos , Celulitis (Flemón)/etiología , Celulitis (Flemón)/terapia , Niño , Humanos , Tonsila Palatina/inmunología , Tonsila Palatina/patología , Absceso Peritonsilar/etiología , Faringitis/complicaciones , Faringitis/microbiología , Escarlatina/etiología , Tonsilitis/complicaciones , Tonsilitis/microbiología
12.
J Otolaryngol ; 34(3): 178-82, 2005 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-16089221

RESUMEN

OBJECTIVE: To compare the analgesic efficacy of hydrogen peroxide (H2O2) mouth rinse with control for post-tonsillectomy pain management. DESIGN: Double-blinded, prospective, randomized, controlled clinical trial. PATIENTS AND METHODS: Thirty-seven patients from 5 to 14 years old undergoing electrocautery tonsillectomy were randomized to either the H2O2 mouth rinse or the water rinse (control) group. For 14 days, patients recorded pain levels twice daily using a visual analogue scale. Analgesic uses, as well as any complications, were also noted by the patients. RESULTS: Thirty-seven patients completed the study, 21 in the treatment group and 16 in the control group. Mean postoperative days of pain were 10.3 and 8.3, respectively, and differed significantly (p = .008). Mean postoperative days of analgesic use were 9.0 and 6.7, respectively, and differed significantly (p = .005). Only one incidence of postoperative hemorrhage occurred in the study group. CONCLUSION: In our study, the H2O2 mouth rinse does not provide a better analgesic effect than the water rinse for post-tonsillectomy pain relief.


Asunto(s)
Antiinfecciosos Locales/uso terapéutico , Peróxido de Hidrógeno/uso terapéutico , Dolor Postoperatorio/prevención & control , Tonsilectomía , Niño , Femenino , Humanos , Masculino , Antisépticos Bucales , Dimensión del Dolor , Estudios Prospectivos
13.
Ann Allergy Asthma Immunol ; 88(6): 601-8, 2002 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-12086368

RESUMEN

BACKGROUND: Vocal cord dysfunction (VCD) can present with signs and symptoms that mimic asthma. This may lead to unnecessary pharmacologic treatment or more invasive measures including intubation. Presently, the diagnosis of VCD can only be confirmed when a patient is symptomatic, via pulmonary function testing (PFT) or visualization of adduction of the vocal cords during inspiration by direct laryngoscopy. OBJECTIVE: Multidimensional Voice Program (MDVP) analysis. a computer program which analyzes various aspects of voice, can detect abnormal voice patterns of patients with upper airway pathology. We determined whether MDVP analysis was useful in the diagnosis of VCD. METHODS: We conducted chart reviews of patients referred to our department from 1995 to 1998 with the presumed diagnosis of VCD who had undergone MDVP analysis. The diagnosis of VCD was based on the presenting history, PFT results, laryngoscopy results, as well as voice evaluation conducted by a speech-language pathologist. We analyzed six consecutive patients referred for this investigation. We delineated common trends in the variables measured on MDVP analysis in VCD patients. and compared these with controls and other vocal cord pathology. RESULTS: Five cases of possible VCD had abnormalities in the MDVP variable of soft phonation index (SPI). All five also had abnormalities in the variation in fundamental frequency (vFo). In one case, MDVP analysis was conducted pre- and posttreatment for VCD, and SPI and vFo both normalized. In a sixth case of possible VCD. the diagnosis was not confirmed as the patient had normal PFTs and laryngoscopy. MDVP analysis was normal in this individual. The pattern of abnormal SPI and vFo was not seen in a group of normal controls or in patients with vocal cord nodules. CONCLUSIONS: MDVP analysis may be a useful tool when diagnosingVCD, as well as in evaluating response to treatment.


Asunto(s)
Espectrografía del Sonido/métodos , Pliegues Vocales/fisiopatología , Trastornos de la Voz/diagnóstico , Adolescente , Asma/complicaciones , Niño , Diagnóstico por Computador , Femenino , Humanos , Laringoscopía , Masculino , Terapia por Relajación , Pruebas de Función Respiratoria , Pruebas Cutáneas , Trastornos de la Voz/complicaciones , Trastornos de la Voz/fisiopatología , Trastornos de la Voz/terapia , Calidad de la Voz
14.
J Otolaryngol ; 33(3): 189-92, 2004 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-15841999

RESUMEN

OBJECTIVE: The etiology of hearing loss is heterogeneous and falls into the two broad categories of genetic and environmental. In the genetic subgroup, 70% are non syndromic. Fifty percent of nonsyndromic sensorineural deafness is due to a mutation in the connexin 26 gene. This article presents the detection rate of connexin mutations in a multiethnic Canadian population. METHODS: A study of patients with nonsyndromic hearing loss seen over a period of 2 years who had connexin 26 mutation testing. RESULTS: Nine of the 18 patients had connexin 26 mutations. CONCLUSION: The majority of our patients with connexin 26 mutations had moderate to profound hearing loss. Testing for connexin mutations should be standard care because it accounts for a large proportion of individuals with nonsyndromic hearing loss. Reasons for testing include ruling out a syndromic cause, predicting moderate to profound hearing loss, and the need for language intervention, cochlear implants, and genetic counselling.


Asunto(s)
Conexinas/genética , Pérdida Auditiva Sensorineural/genética , Mutación/genética , Canadá , Niño , Preescolar , Conexina 26 , Sordera/genética , Progresión de la Enfermedad , Etnicidad/genética , Femenino , Estudios de Seguimiento , Genes Recesivos/genética , Pérdida Auditiva Bilateral/genética , Heterocigoto , Humanos , Lactante , Masculino
15.
J Otolaryngol ; 31(3): 131-6, 2002 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-12121013

RESUMEN

BACKGROUND: Orbital complications of sinusitis are uncommon but can result in significant morbidity if not appropriately managed. OBJECTIVE: This study was conducted to evaluate the clinical presentation, diagnosis, management, and outcome of orbital complications of sinusitis in children treated at our institution over a 10-year period. METHODS: The study retrospectively reviewed cases of 139 children with evidence of orbital complications of sinusitis admitted to the Montreal Children's Hospital between January 1990 and March 2000. Factors assessed included the clinical presentation, radiologic findings, management, and outcome (length of admission, complications). Complications were classified as preseptal if they did not penetrate the periorbita. Postseptal complications were defined as those penetrating the periorbita and were further subdivided into cellulitis and abscess categories. RESULTS: Seventy-two percent of patients presented with preseptal cellulitis, 19% with orbital cellulitis, and 9% with subperiosteal abscess. Ophthalmoplegia and proptosis at presentation were found to be predictors of postseptal disease, although computed tomography (CT) was necessary to differentiate between cellulitis and abscess. Preseptal disease resolved with antibiotics in all cases. Postseptal disease was treated medically and in some cases surgically, although surgery did not affect outcome. CONCLUSION: Preseptal complications of sinusitis can be diagnosed clinically without a CT scan and should be treated with an appropriate course of intravenous antibiotics. Postseptal complications of sinusitis can be diagnosed by the presence of ophthalmoplegia or proptosis and mandate a CT scan to differentiate abscess from orbital cellulitis. Management of these patients should include intravenous antibiotics, reserving surgery for selected cases.


Asunto(s)
Enfermedades Orbitales/etiología , Sinusitis/complicaciones , Absceso/etiología , Adolescente , Algoritmos , Celulitis (Flemón)/etiología , Niño , Preescolar , Diagnóstico Diferencial , Femenino , Humanos , Lactante , Masculino , Enfermedades Orbitales/diagnóstico , Enfermedades Orbitales/terapia , Estudios Retrospectivos
16.
J Otolaryngol ; 33(6): 352-5, 2004 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-15971649

RESUMEN

OBJECTIVE: Retrospective analysis of all patients treated for retropharyngeal infection in a tertiary care pediatric hospital. METHODS: Charts were reviewed for demographic data, duration of symptoms, radiologic workup, antibiotic choice, microbiologic findings, surgical approach, complications, and duration of medical therapy. Surgical findings were correlated with computed tomographic (CT) scans. RESULTS: Sixty-eight patients were included in the study. Empirical intravenous clindamycin was started for a trial of conservative medical therapy. Fifty-one patients (75%) responded to medical treatment, and only 17 patients (25%) required surgical intervention. The CT scan showed a sensitivity of 43% and a specificity of 63% in this series. None of the patients with retropharyngeal infection died, had a major complication, or had a recurrence. CONCLUSION: Based on the current study, we propose that all patients should be given a trial of medical treatment with intravenous clindamycin. Surgery should be reserved for those who do not respond. An extensive review of the literature is presented.


Asunto(s)
Absceso Retrofaríngeo , Antibacterianos/uso terapéutico , Niño , Preescolar , Clindamicina/uso terapéutico , Demografía , Hospitalización , Hospitales Pediátricos , Humanos , Inyecciones Intravenosas , Cuello , Absceso Retrofaríngeo/diagnóstico por imagen , Absceso Retrofaríngeo/microbiología , Absceso Retrofaríngeo/terapia , Estudios Retrospectivos , Sensibilidad y Especificidad , Infecciones Estreptocócicas/complicaciones , Tomografía Computarizada por Rayos X
17.
J Allergy Clin Immunol ; 114(5): 1110-5, 2004 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-15536418

RESUMEN

BACKGROUND: Otitis media with effusion (OME) is a chronic inflammatory disease of the middle ear space characterized by the accumulation of fluid. Previous investigations have suggested that the immunopathologic mechanism underlying the development of middle ear effusion in patients with allergy is largely due to the effects of T(H)2 mediators. The composition of the inflammatory substrate in the effusions of allergic otitis media is similar to the late-phase allergic response seen elsewhere in the respiratory tract, such as in asthma and in allergic rhinitis. OBJECTIVE: To determine whether the middle ear compartment may be a component of the united airways in allergic disease by comparing the inflammatory profiles of the middle ear to the upper airway. METHODS: Middle ear effusions, torus tubaris (Eustachian tube mucosa at the nasopharyngeal orifice), and adenoidal tissue biopsies were obtained from 45 patients undergoing simultaneous tympanostomy tube placement for OME and adenoidectomy for adenoid hypertrophy. The cellular and cytokine profiles of each site were investigated by using immunocytochemistry (elastase, CD3, major basic protein) and in situ hybridization (IL-4, IL-5, IFN-gamma mRNA). Atopic status was determined for each patient by using skin prick testing. RESULTS: Eleven of the 45 patients with OME (24%) were atopic. The middle ear effusions of atopic patients had significantly higher levels of eosinophils, T lymphocytes, and IL-4 mRNA + cells ( P < .01) and significantly lower levels of neutrophils and IFN-gamma mRNA + cells ( P < .01) compared with nonatopic patients. The nasopharyngeal tissue biopsies revealed similar cellular and cytokine profiles. CONCLUSION: In atopic patients with OME, the allergic inflammation occurs on both sides of the Eustachian tube, both in the middle ear and in the nasopharynx. The results of this study support the concept that the middle ear may be part of the united airway in atopic individuals.


Asunto(s)
Oído Medio/inmunología , Hipersensibilidad/inmunología , Nasofaringe/inmunología , Otitis Media con Derrame/inmunología , Tonsila Faríngea/inmunología , Adolescente , Niño , Preescolar , Femenino , Humanos , Lactante , Interferón gamma/análisis , Masculino , Estudios Prospectivos
18.
J Pediatr Surg ; 37(5): 685-90, 2002 May.
Artículo en Inglés | MEDLINE | ID: mdl-11987078

RESUMEN

BACKGROUND: Third and fourth branchial remnants may result in cysts and abscesses that are in close contact with the thyroid gland. These anomalies are rare and often present diagnostic and therapeutic challenges. METHODS: The charts of patients diagnosed with a branchial anomaly between July 1991 and July 2001 at the Montreal Children's Hospital were reviewed. All cases of third and fourth branchial remnants or pyriform sinus fistulae were identified. Clinical presentation, imaging, treatment, and outcome were recorded. RESULTS: Eight patients with a third or fourth branchial anomaly were identified and ranged in age from birth to 13 years. All anomalies were left sided. Presenting symptoms consisted of an asymptomatic cervical mass (n = 1), an infected mass (n = 5), neonatal respiratory distress (n = 1), and 1 incidental cyst found on magnetic resonance imaging. Ultrasonography was useful in suggesting the diagnosis in 7 cases. Barium swallow was performed in 3 patients with 2 positive results. Pharyngoscopy results showed the internal opening in 2 of 7 patients. A portion of the thyroid gland was resected in 6 patients. One patient has not yet undergone a definitive procedure. There was 1 recurrence in a patient whose pathology did not confirm a branchial remnant. CONCLUSIONS: The diagnosis and management of pyriform sinus anomalies are challenging. Ultrasound scan, computed tomography scan, barium swallow, and pharyngoscopy are all useful. The portion of thyroid involved in the fistula must be excised en bloc with the inflammatory mass, and the tract should be ligated at the level of the pharynx to minimize recurrence.


Asunto(s)
Región Branquial/anomalías , Adolescente , Región Branquial/diagnóstico por imagen , Región Branquial/cirugía , Niño , Preescolar , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Tomografía Computarizada por Rayos X , Resultado del Tratamiento , Ultrasonografía
19.
J Allergy Clin Immunol ; 110(1): 125-30, 2002 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-12110831

RESUMEN

BACKGROUND: Otitis media with effusion (OME) is more common in atopic children. Few studies have looked for the presence of inflammatory mediators in the middle-ear effusions of this population. OBJECTIVE: We hypothesize that atopic children with OME have a different inflammatory cell and cytokine profile than nonatopic patients with the disease. METHODS: Twenty-six patients with OME undergoing myringotomy and ventilation tube placement were recruited at the McGill University Hospital Center. The atopic status was determined for each patient by using standard skin testing. By means of immunocytochemistry, fluid specimens were assessed for T lymphocytes (CD3), eosinophils (major basic protein), neutrophils (elastase), mast cells (tryptase), and basophils (BB1). By using in situ hybridization, the expression of IL-4, IL-5, and IFN-gamma was assessed. RESULTS: There is a higher percentage of eosinophils and T lymphocytes in atopic patients with OME (n = 8) compared with that seen in nonatopic patients (n = 18, P <.01). There is a higher percentage of neutrophils in nonatopic patients with OME compared with that seen in atopic patients (P <.01). In examining cytokine profiles, there is a higher percentage of cells expressing IL-4 and IL-5 in atopic patients with OME compared with that seen in nonatopic patients (P <.01). CONCLUSION: The predominance of eosinophils, T lymphocytes, and T(H)2 mediators in the middle-ear effusions of atopic children provides evidence that allergy might play a role in the pathogenesis of OME.


Asunto(s)
Citocinas/biosíntesis , Hipersensibilidad Inmediata/inmunología , Otitis Media con Derrame/fisiopatología , Células Th2/inmunología , Basófilos/inmunología , Complejo CD3/metabolismo , Niño , Preescolar , Eosinófilos/inmunología , Humanos , Inmunohistoquímica , Hibridación in Situ , Lactante , Mastocitos/inmunología , Neutrófilos/inmunología , Otitis Media con Derrame/inmunología , Células Th2/metabolismo
20.
J Otolaryngol ; 33(6): 360-5, 2004 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-15971651

RESUMEN

OBJECTIVE: To evaluate the usefulness of adynamic lateral neck radiographs and dynamic video rhinoscopy in assessing adenoid size and the relationship of these methods to associated symptoms and thus the severity of the disease. METHODS: Children with suspected adenoid hypertrophy underwent standard lateral neck soft tissue radiographs: the percentage of airway occlusion, adenoid to nasopharynx (AN) ratio, airway to soft palate ratio, and adenoid thickness were assessed by a radiologist. The percentage of airway closure was assessed by direct fibre-optic rhinoscopy in an ear, nose, and throat clinic. Associated clinical symptoms were assessed by parents using a standardized questionnaire, evaluating the severity of symptoms (snoring, sleep apnea, mouth breathing, and otitis media) to give a total symptom score out of 16. RESULTS: Nonparametric statistical analysis using Spearman's correlation coefficients was performed on 32 patients. There was a weak correlation, which approaches significance, between the percentage of airway occlusion assessed by fibre-optic rhinoscopy and the total symptom score (r = .344, p = .054). However, this correlation becomes significant when the frequency of otitis media is omitted (r = .367, p = .039). There was also a significant correlation between airway occlusion assessed by rhinoscopy and the percentage of airway occlusion as determined by lateral neck radiography (r = .431, p = .014). There was no correlation between any of the measurements taken by lateral soft tissue neck radiography and total symptom score. CONCLUSION: Dynamic video rhinoscopy is more accurate at assessing adenoid hypertrophy, and the percentage of airway occlusion, as estimated by video rhinoscopy, is better correlated to the severity of symptoms than are values obtained by lateral neck radiography.


Asunto(s)
Tonsila Faríngea/diagnóstico por imagen , Endoscopía/métodos , Grabación de Cinta de Video , Adenoidectomía , Tonsila Faríngea/patología , Tonsila Faríngea/cirugía , Niño , Preescolar , Tecnología de Fibra Óptica/instrumentación , Humanos , Hipertrofia/diagnóstico por imagen , Hipertrofia/patología , Hipertrofia/cirugía , Lactante , Obstrucción Nasal/complicaciones , Obstrucción Nasal/diagnóstico por imagen , Obstrucción Nasal/patología , Cuello , Radiografía , Índice de Severidad de la Enfermedad , Ronquido/diagnóstico , Ronquido/etiología , Encuestas y Cuestionarios
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