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1.

Central androgen action reverses hypothalamic astrogliosis and atherogenic risk factors induced by orchiectomy and high-fat diet feeding in male mice.

Dorfman, Mauricio D; Monfeuga, Thomas; Melhorn, Susan J; Kanter, Jenny E; Frey, Jeremy M; Fasnacht, Rachael D; Chandran, Anandhakumar; Lala, Emaad; Velasco, Inmaculada; Rubinow, Katya B; Meek, Thomas H; Schur, Ellen A; Bornfeldt, Karin E; Thaler, Joshua P.

Am J Physiol Endocrinol Metab ; 324(5): E461-E475, 2023 05 01.

Artículo en Inglés | MEDLINE | ID: mdl-37053049

2.

CX3CL1 Action on Microglia Protects from Diet-Induced Obesity by Restoring POMC Neuronal Excitability and Melanocortin System Activity Impaired by High-Fat Diet Feeding.

Banerjee, Jineta; Dorfman, Mauricio D; Fasnacht, Rachael; Douglass, John D; Wyse-Jackson, Alice C; Barria, Andres; Thaler, Joshua P.

Int J Mol Sci ; 23(12)2022 Jun 07.

Artículo en Inglés | MEDLINE | ID: mdl-35742824

3.

Functional identification of a neurocircuit regulating blood glucose.

Meek, Thomas H; Nelson, Jarrell T; Matsen, Miles E; Dorfman, Mauricio D; Guyenet, Stephan J; Damian, Vincent; Allison, Margaret B; Scarlett, Jarrad M; Nguyen, Hong T; Thaler, Joshua P; Olson, David P; Myers, Martin G; Schwartz, Michael W; Morton, Gregory J.

Proc Natl Acad Sci U S A ; 113(14): E2073-82, 2016 Apr 05.

Artículo en Inglés | MEDLINE | ID: mdl-27001850

4.

Glia: silent partners in energy homeostasis and obesity pathogenesis.

Douglass, John D; Dorfman, Mauricio D; Thaler, Joshua P.

Diabetologia ; 60(2): 226-236, 2017 02.

Artículo en Inglés | MEDLINE | ID: mdl-27986987

5.

Food for thought: hormonal, experiential, and neural influences on feeding and obesity.

Karatsoreos, Ilia N; Thaler, Joshua P; Borgland, Stephanie L; Champagne, Frances A; Hurd, Yasmin L; Hill, Matthew N.

J Neurosci ; 33(45): 17610-6, 2013 Nov 06.

Artículo en Inglés | MEDLINE | ID: mdl-24198352

6.

Hormones and diet, but not body weight, control hypothalamic microglial activity.

Gao, Yuanqing; Ottaway, Nickki; Schriever, Sonja C; Legutko, Beata; García-Cáceres, Cristina; de la Fuente, Esther; Mergen, Clarita; Bour, Susanne; Thaler, Joshua P; Seeley, Randy J; Filosa, Jessica; Stern, Javier E; Perez-Tilve, Diego; Schwartz, Michael W; Tschöp, Matthias H; Yi, Chun-Xia.

Glia ; 62(1): 17-25, 2014 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-24166765

7.

Longer T(2) relaxation time is a marker of hypothalamic gliosis in mice with diet-induced obesity.

Lee, Donghoon; Thaler, Joshua P; Berkseth, Kathryn E; Melhorn, Susan J; Schwartz, Michael W; Schur, Ellen A.

Am J Physiol Endocrinol Metab ; 304(11): E1245-50, 2013 Jun 01.

Artículo en Inglés | MEDLINE | ID: mdl-23548614

8.

In uncontrolled diabetes, thyroid hormone and sympathetic activators induce thermogenesis without increasing glucose uptake in brown adipose tissue.

Matsen, Miles E; Thaler, Joshua P; Wisse, Brent E; Guyenet, Stephan J; Meek, Thomas H; Ogimoto, Kayoko; Cubelo, Alex; Fischer, Jonathan D; Kaiyala, Karl J; Schwartz, Michael W; Morton, Gregory J.

Am J Physiol Endocrinol Metab ; 304(7): E734-46, 2013 Apr 01.

Artículo en Inglés | MEDLINE | ID: mdl-23384771

9.

Prostaglandin PGE2 Receptor EP4 Regulates Microglial Phagocytosis and Increases Susceptibility to Diet-Induced Obesity.

Niraula, Anzela; Fasnacht, Rachael D; Ness, Kelly M; Frey, Jeremy M; Cuschieri, Sophia A; Dorfman, Mauricio D; Thaler, Joshua P.

Diabetes ; 72(2): 233-244, 2023 02 01.

Artículo en Inglés | MEDLINE | ID: mdl-36318114

10.

Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance.

Douglass, John D; Ness, Kelly M; Valdearcos, Martin; Wyse-Jackson, Alice; Dorfman, Mauricio D; Frey, Jeremy M; Fasnacht, Rachael D; Santiago, Olivia D; Niraula, Anzela; Banerjee, Jineta; Robblee, Megan; Koliwad, Suneil K; Thaler, Joshua P.

Cell Metab ; 35(9): 1613-1629.e8, 2023 09 05.

Artículo en Inglés | MEDLINE | ID: mdl-37572666

11.

Hypothalamic inflammation and energy homeostasis: resolving the paradox.

Thaler, Joshua P; Choi, Sun Ju; Schwartz, Michael W; Wisse, Brent E.

Front Neuroendocrinol ; 31(1): 79-84, 2010 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-19822168

12.

Instructive role of aPKCzeta subcellular localization in the assembly of adherens junctions in neural progenitors.

Ghosh, Sourav; Marquardt, Till; Thaler, Joshua P; Carter, Nigel; Andrews, Shane E; Pfaff, Samuel L; Hunter, Tony.

Proc Natl Acad Sci U S A ; 105(1): 335-40, 2008 Jan 08.

Artículo en Inglés | MEDLINE | ID: mdl-18162555

13.

Central administration of interleukin-4 exacerbates hypothalamic inflammation and weight gain during high-fat feeding.

Oh-I, Shinsuke; Thaler, Joshua P; Ogimoto, Kayoko; Wisse, Brent E; Morton, Gregory J; Schwartz, Michael W.

Am J Physiol Endocrinol Metab ; 299(1): E47-53, 2010 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-20371733

14.

Metabolism: food alert.

Thaler, Joshua P; Cummings, David E.

Nature ; 452(7190): 941-2, 2008 Apr 24.

Artículo en Inglés | MEDLINE | ID: mdl-18432230

15.

A postmitotic role for Isl-class LIM homeodomain proteins in the assignment of visceral spinal motor neuron identity.

Thaler, Joshua P; Koo, Sonya J; Kania, Artur; Lettieri, Karen; Andrews, Shane; Cox, Christopher; Jessell, Thomas M; Pfaff, Samuel L.

Neuron ; 41(3): 337-50, 2004 Feb 05.

Artículo en Inglés | MEDLINE | ID: mdl-14766174

16.

Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice.

Dorfman, Mauricio D; Krull, Jordan E; Douglass, John D; Fasnacht, Rachael; Lara-Lince, Fernando; Meek, Thomas H; Shi, Xiaogang; Damian, Vincent; Nguyen, Hong T; Matsen, Miles E; Morton, Gregory J; Thaler, Joshua P.

Nat Commun ; 8: 14556, 2017 02 22.

Artículo en Inglés | MEDLINE | ID: mdl-28223698

17.

Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity.

Dorfman, Mauricio D; Krull, Jordan E; Scarlett, Jarrad M; Guyenet, Stephan J; Sajan, Mini P; Damian, Vincent; Nguyen, Hong T; Leitges, Michael; Morton, Gregory J; Farese, Robert V; Schwartz, Michael W; Thaler, Joshua P.

Diabetes ; 66(4): 920-934, 2017 04.

Artículo en Inglés | MEDLINE | ID: mdl-28073831

18.

Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility.

Valdearcos, Martin; Douglass, John D; Robblee, Megan M; Dorfman, Mauricio D; Stifler, Daniel R; Bennett, Mariko L; Gerritse, Irene; Fasnacht, Rachael; Barres, Ben A; Thaler, Joshua P; Koliwad, Suneil K.

Cell Metab ; 26(1): 185-197.e3, 2017 Jul 05.

Artículo en Inglés | MEDLINE | ID: mdl-28683286

19.

Hypothalamic inflammation and gliosis in obesity.

Dorfman, Mauricio D; Thaler, Joshua P.

Curr Opin Endocrinol Diabetes Obes ; 22(5): 325-30, 2015 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-26192704

20.

Hypothalamic gliosis associated with high-fat diet feeding is reversible in mice: a combined immunohistochemical and magnetic resonance imaging study.

Berkseth, Kathryn E; Guyenet, Stephan J; Melhorn, Susan J; Lee, Donghoon; Thaler, Joshua P; Schur, Ellen A; Schwartz, Michael W.

Endocrinology ; 155(8): 2858-67, 2014 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-24914942

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