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1.
An integrative genomics approach to infer causal associations between gene expression and disease.
Nat Genet
; 37(7): 710-7, 2005 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-15965475
2.
11ß-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature.
Physiol Genomics
; 45(1): 47-57, 2013 Jan 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-23170035
3.
Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers.
Mol Syst Biol
; 8: 594, 2012 Jul 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-22806142
4.
11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice.
J Exp Med
; 202(4): 517-27, 2005 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16103409
5.
Bicyclo[2.2.2]octyltriazole inhibitors of 11ß-hydoxysteroid dehydrogenase type 1. Pharmacological agents for the treatment of metabolic syndrome.
Bioorg Med Chem Lett
; 21(8): 2568-72, 2011 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21421311
6.
4-Methyl-5-phenyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.
Bioorg Med Chem Lett
; 18(11): 3405-11, 2008 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18440811
7.
Phenylcyclobutyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.
Bioorg Med Chem Lett
; 18(11): 3412-6, 2008 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18440812
8.
Bis-aryl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
Bioorg Med Chem Lett
; 18(9): 2799-804, 2008 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18434143
9.
Depot-specific modulation of rat intraabdominal adipose tissue lipid metabolism by pharmacological inhibition of 11beta-hydroxysteroid dehydrogenase type 1.
Endocrinology
; 148(5): 2391-7, 2007 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-17272400
10.
Preliminary report: pharmacologic 11beta-hydroxysteroid dehydrogenase type 1 inhibition increases hepatic fat oxidation in vivo and expression of related genes in rats fed an obesogenic diet.
Metabolism
; 59(1): 114-7, 2010 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-19766266
11.
Identification and validation of genes affecting aortic lesions in mice.
J Clin Invest
; 120(7): 2414-22, 2010 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-20577049
12.
11beta-HSD1 inhibition improves triglyceridemia through reduced liver VLDL secretion and partitions lipids toward oxidative tissues.
Am J Physiol Endocrinol Metab
; 293(4): E1045-52, 2007 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-17666487
13.
Inhibition of 11beta-HSD1 as a novel treatment for the metabolic syndrome: do glucocorticoids play a role?
Expert Rev Cardiovasc Ther
; 3(5): 911-24, 2005 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-16181035
14.
Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11beta-HSD1: novel therapeutic agents for the treatment of metabolic syndrome.
Bioorg Med Chem Lett
; 15(23): 5266-9, 2005 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16185866
15.
Adamantyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
Bioorg Med Chem Lett
; 15(19): 4359-62, 2005 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16039856
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