Habitual dietary intake and mediators of the inflammaging process in Brazilian older women.

AIM: This study aimed to assess whether the habitual intake of macronutrients by older women associates with circulating levels of important inflammaging mediators by means of a cross-sectional design with 229 Brazilian elderly women. METHODS: Laboratory tests determined serum IL1α, IL1ß, IL6, IL8, IL10, IL12 and TNFα by specific immunoassays. Food records of three alternate days were decomposed into usual intake of carbohydrates, proteins and lipids (and fractions), as well as total energy value (TEV) per patient. Moreover, the study has identified and controlled results for metabolic conditions known to influence the inflammatory profile: hypercholesterolemia, hypertension and diabetes. RESULTS AND DISCUSSION: Pearson's correlation test revealed that log10IL8 expressed a positive association with levels of saturated fatty acid (FA) (r = 0.173; p = 0.009) and total cholesterol intake (r = 0.223; p = 0.001). Similar analysis of the other mediators revealed no association with dietary intake. CONCLUSION: Higher intakes of total cholesterol and saturated FA seem to correlate with increased serum IL8 levels, being a possible mechanism by which this pro-atherogenic intake pattern may increase the risk of age-related chronic diseases with important inflammatory contribution.

Lack of association between apolipoprotein E genotypes and cognitive performance in the non-demented elderly.

AIM: The ε4 alelle of the apolipoprotein E gene is known to be a key genetic risk factor for Alzheimer's disease and possibly for other neurological disorders. Some evidence in the literature indicates that the ε4 allele interferes with human cognition independently of chronological age and diagnosis of Alzheimer's disease. The present study investigated the correlation of allelic variants of apolipoprotein E with the cognitive performance of elderly individuals without apparent cognitive impairment. METHODS: This was a cross-sectional analysis that included 213 non-demented elderly individuals (age ≥60 years) from the Brazilian Federal District. The analysis assessed the subjects for cognitive domains including short- and long-term episodic memory, processing speed, and attention and executive functions. Sociodemographic and other clinical characteristics were gathered and analyzed as covariates. RESULTS: Being sufficiently powered, the present study did not identify differential performance across apolipoprotein E genotypes. There was no influence of age, gender, marital status, schooling, depressive symptoms or use of central nervous system depressants when the analyses were controlled for such factors. CONCLUSIONS: Our findings suggest that the ε4 allele does not contribute to detectable cognitive decline within the context of non-dementia.

Lifestyle and risk behaviors for chronic noncommunicable diseases among healthcare undergraduates in Midwest, Brazil.

This study aimed to assess the lifestyle of undergraduate university students, and to investigate the prevalence of risk behaviors for chronic noncommunicable diseases. This cross-sectional study took place in Brasilia, with 2.163 healthcare undergraduates. We used a self-administered questionnaire for demographic variables, social class, behavioral data, self-perception of health and self-reported diseases. Given a total of 2.163 students, 69.3% were female, 65.4% were 20-29 years, men smoked more cigarettes (p < 0.01) and used more alcohol than women. We found significant differences in the consumption of beans (p < 0.04) and full-fat milk (p < 0.01) between females and males. Women also had more sedentary lifestyles (p < 0.01) and showed higher prevalences of overweight (33.8%) and obesity (5.0%). Students who did not engage in physical activity were more morbidities, overweight (p = 0.03), consumed more soft drinks (p < 0.01) and meat with excess fat (p = 0.01). University students were found to have unhealthy lifestyles. There is an urgent need for both a formulation and implementation of public health policies to promote health and improve student quality of life (QoL).

High prevalence of risk factors for non-communicable diseases in university students of a nursing course / Elevada prevalência de fatores de risco para doenças crônicas não transmissíveis em universitários de enfermagem

Abstract Background The inadequate lifestyle of university students can contribute to the occurrence of chronic noncommunicable diseases (NCD). Objective To evaluate the prevalence of NCD risk and prevention factors and verify gender differences for healthy habits among nursing students. Method A cross-sectional study with 974 nursing students. A self-administered questionnaire on health-related life habits was used in the study. Results Of the 974 students, 78.7% were women, 62.6% were between 20-29 years of age, 65.1% consumed alcohol, 57.4% did not do physical activity, and 34.7% were overweight. The women (41.9%) drank more full-fat milk, while the men drank more soft drinks and routinely consumed more meat with fat. The students who did not engage in physical activity smoked more (p<0.01), consumed less fruit (p<0.01), less salad (p<0.01), and less vegetables (p<0.01), and consumed more soft drinks (p=0.03), and meat with fat (p=0.04). In the physically inactive students, a high prevalence of diabetes mellitus (p=0.03) and high cholesterol (p<0.01) was observed. Conclusion The results show a clear profile of NCD risk factors among university students, highlighting the need to implement educational programs to reduce these factors.

Resumo Introdução O estilo de vida inadequado dos universitários pode contribuir para o aparecimento de doenças crônicas não transmissíveis (DCNT). Objetivo Avaliar a prevalência de fatores de risco e proteção para DCNT e verificar as diferenças de gêneros em hábitos saudáveis de estudantes de enfermagem. Método Estudo transversal com 974 estudantes. Foi utilizado um questionário sobre os hábitos de vida relacionados à saúde. Resultados Dos 974 alunos, 78,7% eram mulheres, 62,6% com idade entre 20-29 anos, 65,1% consumiam álcool, 57,4% não realizavam atividade física (AF), e 34,7% tinham sobrepeso. As mulheres (41,9%) apresentavam maior prevalência no consumo de leite com gordura, e os homens consumiam mais refrigerante e tinham o hábito de comer mais carne com gordura. Os universitários que não realizavam AF fumavam mais (p<0,01), apresentavam consumo baixo de frutas (p<0,01), saladas (p<0,01) e verduras (p<0,01), e consumiam mais refrigerante (p=0,03) e carne com gordura (p=0,04). Observamos que os estudantes fisicamente inativos tinham elevada prevalência para desenvolverem diabetes mellitus (p=0,03) e colesterol elevado (p<0,01). Conclusão Os resultados mostram um perfil elevado de fatores de risco para DCNT entre os universitários, mostrando assim a necessidade de implementar programas educacionais, a fim de reduzir esses fatores.

Lifestyle and risk behaviors for chronic noncommunicable diseases among healthcare undergraduates in Midwest, Brazil / Estilo de vida e comportamentos de risco para doenças crônicas não transmissíveis entre universitários da saúde na região Centro-Oeste, Brasil

Abstract This study aimed to assess the lifestyle of undergraduate university students, and to investigate the prevalence of risk behaviors for chronic noncommunicable diseases. This cross-sectional study took place in Brasilia, with 2.163 healthcare undergraduates. We used a self-administered questionnaire for demographic variables, social class, behavioral data, self-perception of health and self-reported diseases. Given a total of 2.163 students, 69.3% were female, 65.4% were 20-29 years, men smoked more cigarettes (p < 0.01) and used more alcohol than women. We found significant differences in the consumption of beans (p < 0.04) and full-fat milk (p < 0.01) between females and males. Women also had more sedentary lifestyles (p < 0.01) and showed higher prevalences of overweight (33.8%) and obesity (5.0%). Students who did not engage in physical activity were more morbidities, overweight (p = 0.03), consumed more soft drinks (p < 0.01) and meat with excess fat (p = 0.01). University students were found to have unhealthy lifestyles. There is an urgent need for both a formulation and implementation of public health policies to promote health and improve student quality of life (QoL).

Resumo Este estudo teve como objetivo avaliar o estilo de vida dos universitários e investigar a prevalência de comportamentos de risco para doenças crônicas não transmissíveis. Estudo transversal com 2.163 universitários da área de saúde da cidade de Brasília. Foi aplicado um questionário sobre as variáveis demográficas, classe social, comportamentos e autopercepção de saúde e doenças autorreferidas. Dos 2.163, 69,3% eram mulheres, 65,4% idade entre 20 a 29 anos, 66,8% consumiam álcool e 44,2% não realizavam atividade física. Os homens fumavam (p <0,01) e consumiam mais álcool do que as mulheres. Encontramos diferenças no consumo de feijão (p <0,04) e leite integral (p <0,01) entre homens e mulheres. Elas também apresentaram estilos de vida mais sedentários (p <0,01) e elevada prevalência de sobrepeso (33,8%) e obesidade (5,0%). Os estudantes que não praticavam atividade física tinham mais morbidades, estavam acima do peso (p = 0,03), consumiam mais refrigerantes (p <0,01) e carne com excesso de gordura (p = 0,01). Os estudantes têm adotado um estilo de vida pouco saudável. Observa-se a necessidade da elaboração e implantação de políticas públicas de promoção da saúde dentro da Universidade, com vistas à melhoria da saúde e da qualidade de vida dos universitários.

Pro-inflammatory cytokines correlate with classical risk factors for atherosclerosis in the admixed Brazilian older women.

AIM: Measurement of inflammatory markers for risk stratification of vascular disorders has been the focus of numerous investigations worldwide, and usually reveals augmented levels of circulating cytokines/chemokines among carriers of classic risk factors for atherosclerosis. Nonetheless, this low-grade inflammatory milieu detected in aged individuals tends to be influenced by body composition. Moreover, cardiovascular risk factors have a complex genetic etiology, and disregarding the genetic heritage may produce spurious results owing to interethnic differences. In this complex scenario, our study was designed to verify the existence and strength of the association between selected mediators of systemic inflammation and classic risk factors of cardiovascular diseases (CVD). METHODS: In a sample of post-menopausal older women, correlation analyses explored the association of circulating levels of IL1α, IL1ß, IL8, IL10 and IL12 with atherosclerosis-related clinical/metabolic parameters, using age, body mass index (BMI), genetic ancestry estimates as standard correction factors. Further adjustment for use of therapeutic agents was applied when appropriate. RESULTS: Our analyses revealed association of log10-transformed IL-12 titers with VLDL-c levels (r=.192; p=.002) and with SBP (r-.185; p=.003), and of log10-transformed IL-8 titers with GLY (r=.235; p<.001). CONCLUSION: Interpretation to the results account to a possible dysregulation of the PPAR signaling pathway to explain the association of IL12 and VLDL-c, and to IL8-driven mechanisms to promote dysglycemia. No previous report sought to investigate the relationship between this set of inflammatory markers and classic risk factors for atherosclerosis correcting for the heterogeneity in genetic admixture and body composition of Brazilian post-menopausal women.

Nível de ansiedade e fatores associados: Estudantes de Farmácia de uma faculdade privada / Anxiety Level and Associated Factors: Pharmacy Students from a Private College

Objetivo: Avaliar o perfil de ansiedade de estudantes do curso de Farmácia em uma Instituição particular do Distrito Federal e verificar fatores associados. Método: Trata-se de um estudo transversal, realizado, entre novembro de 2018 a abril de 2019, com 200 estudantes de graduação do curso de Farmácia de uma faculdade particular do Distrito Federal. O instrumento utilizado foi o Inventário de Ansiedade de Beck (BAI), validado no Brasil, composto por 21 perguntas de múltipla escolha, referentes ao estado emocional, fisiológico e cognitivo da última semana. Foram também avaliados dados sociodemográficos e hábitos de vida. Resultados: A amostra foi constituída por maioria mulheres (76%), sem companheiro (64%), com baixa classe econômica (62%), baixa ingesta de álcool (59%), estado nutricional (56% sobrepeso), inatividade física (66%) e percepção de saúde regular (32%). A maioria dos estudantes apresentaram elevado nível de ansiedade, sendo relacionado com sexo (p=0,02), estado civil (p=0,04), etilismo (0<0,01) e atividade física (p=0,03). Os estudantes que apresentaram o maior nível de ansiedade foram os etilistas, os inativos fisicamente e com sobrepeso. Conclusão: Os alunos de farmácia apresentaram elevados níveis de ansiedade e hábitos de vida inadequados. Assim, são necessárias intervenções que propiciem uma melhora desses níveis, impactando positivamente a formação acadêmica e a qualidade de vida dos estudantes

Objective: To evaluate the anxiety profile of students of the Pharmacy course in a private institution of the Federal District and to verify associated factors. Methods: This is a cross-sectional study, carried out between November 2018 and April 2019, with 200 undergraduate students of the Pharmacy course of a private college in the Federal District. The instrument used was the Beck Anxiety Inventory (BAI), validated in Brazil, composed of 21 multiple-choice questions concerning the emotional, physiological and cognitive state of last week. Sociodemographic data and life habits were also evaluated. Results: The sample consisted of a majority of women (76%), with no partner (64%), low economic class (62%), low alcohol intake (59%), nutritional status (56% overweight), physical inactivity 66%) and regular health perception (32%). (P = 0.02), marital status (p = 0.04), alcoholism (0 <0.01) and physical activity (p = 0.03) . The students who presented the highest level of anxiety were the alcoholics, the physically inactive and overweight. Conclusion: Pharmacy students presented high levels of anxiety and inadequate life habits. Thus, interventions are necessary to improve these levels, positively impacting the academic formation and quality of life of the students.

Perfil de sono, variáveis clínicas e jornada de trabalho de caminhoneiros idosos e de meia-idade em rodovias / Sleep profile, clinical variables, and working hours in elderly and middle-aged long-haul truck drivers

Este trabalho objetivou investigar a associação de variáveis representativas do perfil sociodemográfico, da jornada de trabalho e das condições gerais de saúde de profissionais do transporte de cargas em rodovias com o regime de sono relatado. Tratou-se de um estudo transversal com análise de questionários cedidos pelo Serviço Social do Transporte e pelo Serviço Nacional de Aprendizagem do Transporte, em que foram averiguados dados relativos aos profissionais com idade ≥ 45 anos. Os resultados encontrados permitem inferir que o perfil de sono exibido pelos profissionais de transporte de cargas parece correlacionar-se negativamente com a condição geral de saúde (ocorrência de hipertensão arterial sistêmica e consumo de medicamentos) e a extensão da jornada de trabalho.

This cross-sectional study aimed to investigate the association of variables representative of the sociodemographic profile, working hours, and general health status of long-haul truck drivers with their reported sleep regimen. Questionnaires provided by the Transportation Social Service and the National Transportation Learning Service, in which data were collected from professional truckers aged ≥ 45 years, were analyzed. The results found allow us to infer that the sleep profile of these ground freight transportation workers seems to correlate negatively with general health (prevalence of arterial hypertension and drug use) and the number of working hours per day.

Implication of the G145C polymorphism (rs713598) of the TAS2r38 gene on food consumption by Brazilian older women.

To evaluate the capacity to perceive bitter taste in a sample of the elderly population of the Brazilian Federal District, and to investigate its association with the consumption profile of distinct food groups. A total of 255 female outpatients aged 60 years or older took part in this cross-sectional study. The following data were determined for all the volunteers: alimentary frequency by clinical dieticians; genotyping of the G145C polymorphism in the TAS2r38 gene; cognitive status; sensorial (visual and hearing) acuity and drugs related to ageusia or dysgeusia. Sensitivity to bitter taste was assessed using phenylthiocarbamide (PTC) in a subset. Non-parametric tests confirmed the remarkable effect of the C allele in determining sensitivity to PTC (p<0.001). C allele carriers displayed diminished consumption of type B vegetables as well as of some vegetables generally recognized as bitter: arugula (p=0.044) and chard (p=0.006). No associations were observed for the remaining food classes. The present findings suggest that the G145C genetic variation in the TAS2r38 gene modestly influenced food consumption habits of Brazilian older women. Nonetheless, the results do not rule out possible effects of past experiences on choices of elderly individuals.

Risk of glycemic disorder in elderly women adjusted by anthropometric parameters and cytokine genotypes.

OBJECTIVE: The objective of the present study was to examine the association of glucose intolerance and type-2 diabetes mellitus with the -174 G > C and -308 G > A allelic variations of IL-6 and TNF-α, respectively, through anthropometric measurements and age strata. METHODS: This is a cross-sectional study using data from 285 community dwelling elderly women who underwent physical, biochemical, and genetic examinations. RESULT: Genotype-unadjusted analysis revealed that the risk of glucose intolerance and diabetes in elderly women with elevated BMI was 1.71 and 2.82 times higher, respectively, whereas age and conicity index did not show predictive value. Prevalence ratios for glucose intolerance and diabetes across allelic variants of IL-6 and TNF-α did not associate IL-6 with unbalanced glucose levels, despite adjustment for BMI, age, and conicity index. Conversely, carriers of the TNF-α A allele were 2.06 and 5.58 times more likely to exhibit glucose intolerance and diabetes, respectively, compared to GG homozygotes. CONCLUSION: Our results suggest that bearing the A allele of the -308 G > A polymorphism of TNF-α predisposes to anthropometric measure-sensitive impaired glucose metabolism in older women.

Risco de distúrbio glicêmico em mulheres idosas ajustado por antropometria e genótipos de citocinas / Risk of glycemic disorder in elderly women adjusted by anthropometric parameters and cytokine genotypes

OBJETIVO: Analisar a associação da intolerância à glicose e do diabetes mellitus tipo 2 com as variações alélicas -174 G > C e -308 G > A de IL-6 e TNF-α, respectivamente, à luz de indicadores antropométricos e faixa etária. MÉTODOS: Trata-se de um estudo transversal com dados obtidos de 285 mulheres idosas da comunidade, submetidas a exames físicos, bioquímicos e genéticos. RESULTADOS: Análise não ajustada para genótipos revelou que idosas com IMC elevado apresentaram risco 1,71 e 2,82 vezes maior para intolerância à glicose e diabetes, respectivamente, enquanto faixa etária e índice de conicidade não apresentaram qualquer valor preditivo. Razões de prevalência para intolerância à glicose e diabetes conforme variantes alélicas de IL-6 e TNF-α não associam genótipos de IL-6 com desregulação glicêmica, a despeito de ajustes para IMC, idade e índice de conicidade. Por outro lado, portadores do alelo A de TNF-α apresentaram 2,06 e 5,58 vezes mais chance de intolerância à glicose e diabetes, respectivamente, comparadas a homozigotas GG no estrato com IMC < 27 kg/m². CONCLUSÃO: Os resultados sugerem que o alelo A do polimorfismo -308 G > A de TNF-α predispõe a distúrbios do metabolismo glicêmico em mulheres idosas de um modo sensível a medidas antropométricas.

OBJECTIVE: The objective of the present study was to examine the association of glucose intolerance and type-2 diabetes mellitus with the -174 G > C and -308 G > A allelic variations of IL-6 and TNF-α, respectively, through anthropometric measurements and age strata. METHODS: This is a cross-sectional study using data from 285 community dwelling elderly women who underwent physical, biochemical, and genetic examinations. RESULT: Genotype-unadjusted analysis revealed that the risk of glucose intolerance and diabetes in elderly women with elevated BMI was 1.71 and 2.82 times higher, respectively, whereas age and conicity index did not show predictive value. Prevalence ratios for glucose intolerance and diabetes across allelic variants of IL-6 and TNF-α did not associate IL-6 with unbalanced glucose levels, despite adjustment for BMI, age, and conicity index. Conversely, carriers of the TNF-α A allele were 2.06 and 5.58 times more likely to exhibit glucose intolerance and diabetes, respectively, compared to GG homozygotes. CONCLUSION: Our results suggest that bearing the A allele of the -308 G > A polymorphism of TNF-α predisposes to anthropometric measure-sensitive impaired glucose metabolism in older women.

Alterações gustativas no envelhecimento / Gustatory alterations in aging

Neste artigo são discutidos alguns dos aspectos mais relevantes na literatura científica sobre o sistema gustativo, transmissão dos sinais gustativos e combinações dos sentidos, além de focar as alterações gustativas no envelhecimento, tratamento paliativo e métodos para a avaliação da percepção gustativa. É imprescindível atentar para as queixas dos idosos quanto às alterações gustativas, pois podem acarretar outras intercorrências na saúde e na qualidade de vida do idoso.

In this article, we revise the most relevant aspects considered in the scientific literature on the gustatory system, on transmission of gustatory signals and sense combinations. In addition, the article focuses on gustatory alterations in aging, palliative care and methods to evaluate taste threshold. It is important to pay attention to complaints from the elderly concerning taste alterations since this may account for other clinical events in health and quality of life of elderly adults.