[Stabilization of antiviral activity of porcine leukocytic interferon]. / Stabilizatsiia protivovirusnoi aktivnosti svinogo leikotsitarnogo interferona.

Unithiol (2,3-dimercaptopropan-sodium sulphonate) has been found to be an effective, nontoxic stabilizer of antiviral activity of labile interferons. The optimum stabilizing concentration of unithiol is 0.07%: at this concentration its protective effect is maximum with the lowest content of the substance. Unithiol at this concentration retains about 66% of the initial antiviral activity in acid medium (pH 2.0) and up to 75% of the initial antiviral activity on mechanical exposure.

[Formation, persistence period and protective role of antihemagglutinins to earlier circulating influenza A viruses]. / Formirovanie, dlitel'nost' sokhraneniia i zashchitnaia rol' antigemagliutininov k ranee tsirkulirovavshim virusam grippa A.

Surveys of the population immunity as well as blood sera from human subjects vaccinated with vaccine strains done by the HI test showed the immunity to previously prevalent influenza A viruses to be maintained by anamnestic stimulation of immunogenesis occuring during circulation of the current agent. The intensity of anamnestic immunity stimulation is determined by the degree of relationship of the current strain hemagglutinin with the similar antigen of previously prevalent viruses. Circulating antibodies have a certain protective effect only against those influenza A viruses which are antigenically related within the drift alteration of hemagglutinin.

[Production of virus-induced and mitogen-induced interferons by canine cells]. / Produktsiia virusindutsirovannogo i mitogenindutsirovannogo interferonov kletkami sobak.

Cells of monocytic-phagocytic series and immunocompetent cells derived from dogs: bone marrow, leukocytes, spleen, thymus, lymph nodes (with the exception of the liver) were found to be capable of producing interferon (IFn) in vitro in response to inoculation of viral and non-viral inducers. This capacity is manifested in different ways: thymus and lymph node cells were less active interferon producers. Studies of physicochemical properties of the resulting interferons confirmed the belonging of the virus-induced IFn to alpha-interferons, PHA-induced IFn to immune alpha-IFn. The above-mentioned refers both to bone marrow and leukocyte interferons.

[Complex study of population immunity to 3 influenza A virus antigens]. / Kompleksnoe izuchenie populiatsionnogo immuniteta k trem antigenam virusa grippa A.

In 5 large cities of the USSR a four-year study of the population immunity to 3 antigens of influenza A virus (hemagglutinin, neuraminidase and ribonucleoprotein antigens) was carried out. The time course of immunity to these antigens had a similar character. The high level of population immunity to actual hemagglutinin and neuraminidase, observed for 2 years, in succession, indicated the possibility of shift-life changes in these surface antigens. Population immunity to ribonucleoproteid antigen had no influence on the epidemic process in influenza A. A method for the study of population immunity, based on the analysis of pooled serum samples from healthy persons, is proposed. This method considerably reduces the time of the test and the number of ingredients.