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Biochemistry ; 54(27): 4163-6, 2015 Jul 14.
Artículo en Inglés | MEDLINE | ID: mdl-26115234

RESUMEN

CCL19 and CCL21 are chemokines involved in the trafficking of immune cells, particularly within the lymphatic system, through activation of CCR7. Concurrent expression of PSGL-1 and CCR7 in naive T-cells enhances recruitment of these cells to secondary lymphoid organs by CCL19 and CCL21. Here the solution structure of CCL19 is reported. It contains a canonical chemokine domain. Chemical shift mapping shows the N-termini of PSGL-1 and CCR7 have overlapping binding sites for CCL19 and binding is competitive. Implications for the mechanism of PSGL-1's enhancement of resting T-cell recruitment are discussed.


Asunto(s)
Quimiocina CCL19/química , Quimiocina CCL19/metabolismo , Glicoproteínas de Membrana/metabolismo , Receptores CCR7/metabolismo , Sitios de Unión , Humanos , Modelos Moleculares , Conformación Proteica
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