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1.
Visualizing and Modulating Mitophagy for Therapeutic Studies of Neurodegeneration.
Cell
; 181(5): 1176-1187.e16, 2020 05 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-32437660
2.
Discovery of a novel series of GPR119 agonists: Design, synthesis, and biological evaluation of N-(Piperidin-4-yl)-N-(trifluoromethyl)pyrimidin-4-amine derivatives.
Bioorg Med Chem
; 41: 116208, 2021 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34010766
3.
Discovery of a novel series of indolinylpyrimidine-based GPR119 agonists: Elimination of ether-a-go-go-related gene liability using a hydrogen bond acceptor-focused approach.
Bioorg Med Chem
; 34: 116034, 2021 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33548803
4.
SCO-267, a GPR40 Full Agonist, Improves Glycemic and Body Weight Control in Rat Models of Diabetes and Obesity.
J Pharmacol Exp Ther
; 370(2): 172-181, 2019 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-31182471
5.
Fasiglifam/TAK-875, a Selective GPR40 Agonist, Improves Hyperglycemia in Rats Unresponsive to Sulfonylureas and Acts Additively with Sulfonylureas.
J Pharmacol Exp Ther
; 357(1): 217-27, 2016 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-26813930
6.
Discovery of a novel series of indoline carbamate and indolinylpyrimidine derivatives as potent GPR119 agonists.
Bioorg Med Chem
; 22(5): 1649-66, 2014 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24508142
7.
The effects of TAK-875, a selective G protein-coupled receptor 40/free fatty acid 1 agonist, on insulin and glucagon secretion in isolated rat and human islets.
J Pharmacol Exp Ther
; 340(2): 483-9, 2012 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-22106100
8.
Rapid and selective generation of H2S within mitochondria protects against cardiac ischemia-reperfusion injury.
Redox Biol
; 55: 102429, 2022 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-35961099
9.
TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats.
J Pharmacol Exp Ther
; 339(1): 228-37, 2011 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-21752941
10.
GPR40 full agonism exerts feeding suppression and weight loss through afferent vagal nerve.
PLoS One
; 14(9): e0222653, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31525244
11.
Antihypertrophic Effects of Small Molecules that Maintain Mitochondrial ATP Levels Under Hypoxia.
EBioMedicine
; 24: 147-158, 2017 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-28942281
12.
Fasiglifam (TAK-875) has dual potentiating mechanisms via Gαq-GPR40/FFAR1 signaling branches on glucose-dependent insulin secretion.
Pharmacol Res Perspect
; 4(3): e00237, 2016 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-27433346
13.
A novel antidiabetic drug, fasiglifam/TAK-875, acts as an ago-allosteric modulator of FFAR1.
PLoS One
; 8(10): e76280, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-24130766
14.
Identification of fused-ring alkanoic acids with improved pharmacokinetic profiles that act as G protein-coupled receptor 40/free fatty acid receptor 1 agonists.
J Med Chem
; 55(4): 1538-52, 2012 Feb 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-22242551
15.
Optimization of (2,3-dihydro-1-benzofuran-3-yl)acetic acids: discovery of a non-free fatty acid-like, highly bioavailable G protein-coupled receptor 40/free fatty acid receptor 1 agonist as a glucose-dependent insulinotropic agent.
J Med Chem
; 55(8): 3960-74, 2012 Apr 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-22490067
16.
Discovery of phenylpropanoic acid derivatives containing polar functionalities as potent and orally bioavailable G protein-coupled receptor 40 agonists for the treatment of type 2 diabetes.
J Med Chem
; 55(8): 3756-76, 2012 Apr 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-22428944
17.
Design, synthesis, and biological activity of potent and orally available G protein-coupled receptor 40 agonists.
J Med Chem
; 54(5): 1365-78, 2011 Mar 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-21319751
18.
Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist.
ACS Med Chem Lett
; 1(6): 290-4, 2010 Sep 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900210
19.
[Discovery and development of a selective GPR40/FFAR1 agonist, fasiglifam, for treatment of type 2 diabetes mellitus].
Nihon Yakurigaku Zasshi
; 144(2): 59-63, 2014 Aug.
Artículo
en Japonés
| MEDLINE | ID: mdl-25109517
20.
B-cell repertoire specific for an unfolded self-determinant of mouse lysozyme escape tolerance and dominantly participate in the autoantibody response.
Immunology
; 107(4): 394-402, 2002 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-12460183
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