1.
J Org Chem
; 85(4): 1894-1905, 2020 02 21.
Artículo
en Inglés
| MEDLINE
| ID: mdl-31905290
RESUMEN
Herein we show a novel approach toward the allylation of indoles. Thereby, we explore a class of bench-stable allylboronates and fine-tune their reactivity. The allylations of different substituted indoles proceed with negligible diastereo- and excellent enantioselectivities. This surprising selectivity (up to 99:1 er, up to ≈60:40 dr) is rationalized by DFT calculations.