1.
Chem Commun (Camb)
; 59(37): 5555-5558, 2023 May 04.
Artículo
en Inglés
| MEDLINE
| ID: mdl-37071468
RESUMEN
A comprehensive structure-activity relationship study on antibody Fc-glycosylation has been performed using the chimeric anti-SSEA4 antibody chMC813-70 as a model. The α-2,6 sialylated biantennary complex type glycan was identified as the optimal Fc-glycan with significant enhancement in antibody effector functions, including binding to different Fc receptors and ADCC.