Anthropometric data peculiarities in early school children population.

The anthropometric data were studied in early school aged (6-7 years old) children and the degree of harmonization during physical development was evaluated. Representative population of 400 otherwise healthy early school aged children was included in study group. Study period covered the end of school year. In the selected under observation focused population the level of individual anthropometric data was determined in percentile intervals according its position. Anthropometric data assessments by using percentile method it was revealed in early school aged (6-7 years of old children) excess in body height and weight in comparison with normal values. This phenomenon indicates the prevalence of acceleration and weight gain. Anthropometric data in boys were increased while comparing with physical development data in girls. This result difference has the tendency to statistically insignificant. Physical development harmonization values were studied in 200 children. Harmonized physical development revealed in 50 children (25%); disharmonized physical development I 50 children (15%), among them with I degree weight gain were 48 (24%), and with I degree weight deficit were 2 (1%). Markedly disharmonized development had 100 children (50%), among them with II degree weight gain were 98 (49%), and with II degree weight deficit were 2 (1%). According to the children's anthropometric data and assessment by physical development harmonization percentiles tables three groups of children were organized: main, risk group and the group with deviation in physical development. On the basis of resulted data the study of early school age children's physical development gives possibility for risk groups stratification, which in turn itself makes a strong basis for reasonable preventive measurements and stepwise monitoring implementation.

Clinical and psychological characteristics of school adaptation.

70 girls and 50 boys--totally 120 practically healthy children were examined; Three age-specific groups with equal number of children were chosen. Goal of the research was to evaluate the adaptation ability and analyse the disadaptive derangements in primary school age children. Cross-sectional, one moment research was carried out according to D. Stot's "Map of Observation". Adaptive potential determination and evaluation of vegetative nervous system functional state was done. Special charts for children were filled in. 56% of pupils were practically healthy and well adapted to school obligations. In the rest of cases different degree and form of school dysadaptation derangements were revealed. The dysadaptation contingent with cognitive function was seen in 14% of children. Emotional attitude derangements to learning process was revealed in 18% of children.; and hard to cope with the derangements correction in behavior was seen in 12% of children. The study results enabled us to reveal different types of school dysadaptation in primary school age children as well as to study the main reasons for their formation on the basis of age-specific characteristics. The above-mentioned fact should be taken into consideration while elaborating complex rehabilitation actions and school disadaptation prevention.

[Troponin-I and creatinkinase-mb values for detection of cardiovascular system damage in children with recurrent respiratory tract disease].

84 patients 3-15 years of age were observed at the department of cardio-rheumatology of the Research Institute of Pediatrics, the laboratory "Test" and the laboratory department of the clinic "Guli". The patients with tonsillitis and recurrent respiratory tract disease were investigated. The patients were divided into study and control groups; The study group included children with signs of cardiovascular system damage according to the clinical and instrumental findings. Cross-sectional study was conducted. Cardiac Troponin-I was measured in serum by ELISA. Ck-MB was measured by colorimetric method. In the cases of cardiovascular system damage significant rise of Tp-I levels in 48,2%; and Ck-MB levels in 36.5% has been found. In 39% of cases positive was only Tp-I, (Ck-MB was negative in this 39% of cases). The study allows to use investigated markers as the diagnostic criteria of cardiovascular damage, to reveal the high risk group in children with tonsillitis and recurrent respiratory tract disease, as they really represent the candidates for future meaningful damage to cardiovascular system, which will require itself further monitoring of clinical and laboratory parameters and including of prevention activities in their life style.

[Monitoring of neopterin and INF-gamma in children with recurrent respiratory tract infection].

The upper and lover respiratory tract infections are usually mild and self-limited. Owing to their frequency recurrent upper and lower respiratory tract infection in children and adults constitute a major global health problem. The goal of our study was to observe 30 children with recurrent respiratory tract infection, 17 boy and 13 girl, they were treated with Ribomunyl. The control group consisted of 15 children who received only basic therapy (10 boys and 5 girls). The age of the children ranged between 8 months and 6 years. The study was conducted by the simply randomization method. Clinical and laboratory examinations were evaluated before and after treatment. The concentration of INF-gamma was rather low in study group in comparison with control group before the beginning of the treatment, that indicates insufficient stimulation of T-lymphocytes in children with recurrent infection. INF-gamma lever significantly increased after treatment (Statistically significantly P<0.05) in study group in comparison with control group. Neopterin level unlike INF-gamma in study group was higher than in the control group, before and after treatment. This fact can be explained that neopterin as a slowly acting biologically active substance remains high during the presence of recurrent infections. Ribomunyl treatment significantly increased the level of neopterin. The efficacy of the product is primarily confirmed by significant reductions in the number of recurrent infections episodes and the use of antibacterials. Combined immunostimulating effect of Ribomunyl makes it possible to use Ribomunyl to create a longterm postvaccinal protection of the child.

[New method for the study of the cation center of the Na,K-ATPase system]. / Novyi metod analiza kationnykh tsentrov Na,K-ATPaznoi sistemy.

An analysis of the shapes of the kinetic curves for the cationic sites of the Na,K-ATPase system revealed four completely activated Na-sites. Free ATP can change the so-called operation regime of Na,K-ATPase. At ATP excess two completely activated K-sites are detected, whereas at low ATP concentrations only one incompletely activated site is observed.

[Kinetic research on the Na, K-ATPase system]. / Kineticheskoe issledovanie Na, K-ATFaznoi sistemy.

The velocity of Na, K-ATPase is studied as a function of MgATP, ATP and MG2+ concentrations. The kinetic analysis is used to substantiate the inclusion of certain intermediates and steps of their interconversion into the minimal model for Na, K-ATPase.

[Regulation of the number of k-binding sites of Na,K-ATPase by adenosine triphosphate]. / Reguliatsiia kolichestva K-sviazyvaiushchikh tsentrov Na,K-ATPazy adenozintrifosfatom.

A possible existence of two functional states of Na,K-ATPase with different electrogenic coefficients has been experimentally proved. Regulation of electrogenicity is achieved by alteration in the number of K+ transport sites. A transition of Na,K-ATPase from one functional state to the other has been shown to occur during the binding of ATP free ions.