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Euro Surveill ; 28(1)2023 01.
Artículo en Inglés | MEDLINE | ID: mdl-36695452

RESUMEN

BackgroundSince the beginning of the war in Ukraine in February 2022, Ukrainians have been seeking shelter in other European countries.AimWe aimed to investigate the prevalence and the molecular epidemiology of multidrug-resistant Gram-negative (MDRGN) bacteria and meticillin-resistant Staphylococcus aureus (MRSA) in Ukrainian patients at admittance to the University Hospital Frankfurt, Germany.MethodsWe performed screening and observational analysis of all patients from March until June 2022. Genomes of MDRGN isolates were analysed for antimicrobial resistance, virulence genes and phylogenetic relatedness.ResultsWe included 103 patients (median age: 39 ±â€¯23.7 years), 57 of whom were female (55.3%; 95% confidence interval (CI): 45.2-5.1). Patients were most frequently admitted to the Department of Paediatrics (29/103; 28.2%; 95% CI: 19.7-37.9). We found 34 MDRGN isolates in 17 of 103 patients (16.5%; 95% CI: 9.9-25.1). Ten patients carried 21 carbapenem-resistant (CR) bacteria, five of them more than one CR isolate. Four of six patients with war-related injuries carried eight CR isolates. In six of 10 patients, CR isolates caused infections. Genomic characterisation revealed that the CR isolates harboured at least one carbapenemase gene, bla NDM-1 being the most frequent (n = 10). Core genome and plasmid analysis revealed no epidemiological connection between most of these isolates. Hypervirulence marker genes were found in five of six Klebsiella pneumoniae CR isolates. No MRSA was found.ConclusionHospitals should consider infection control strategies to cover the elevated prevalence of MDRGN bacteria in Ukrainian patients with war-related injuries and/or hospital pre-treatment and to prevent the spread of hypervirulent CR isolates.


Asunto(s)
Infecciones por Klebsiella , Staphylococcus aureus Resistente a Meticilina , Heridas Relacionadas con la Guerra , Humanos , Niño , Femenino , Adolescente , Adulto Joven , Adulto , Persona de Mediana Edad , Masculino , Antibacterianos/farmacología , Antibacterianos/uso terapéutico , Filogenia , Heridas Relacionadas con la Guerra/tratamiento farmacológico , beta-Lactamasas/genética , Bacterias , Hospitales Universitarios , Alemania/epidemiología , Bacterias Gramnegativas/genética , Klebsiella pneumoniae/genética , Infecciones por Klebsiella/tratamiento farmacológico
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