Dopamine dysregulation in Parkinson's disease flattens the pleasurable urge to move to musical rhythms.

The pleasurable urge to move to music (PLUMM) activates motor and reward areas of the brain and is thought to be driven by predictive processes. Dopamine in motor and limbic networks is implicated in beat-based timing and music-induced pleasure, suggesting a central role of basal ganglia (BG) dopaminergic systems in PLUMM. This study tested this hypothesis by comparing PLUMM in participants with Parkinson's disease (PD), age-matched controls, and young controls. Participants listened to musical sequences with varying rhythmic and harmonic complexity (low, medium and high), and rated their experienced pleasure and urge to move to the rhythm. In line with previous results, healthy younger participants showed an inverted U-shaped relationship between rhythmic complexity and ratings, with preference for medium complexity rhythms, while age-matched controls showed a similar, but weaker, inverted U-shaped response. Conversely, PD showed a significantly flattened response for both the urge to move and pleasure. Crucially, this flattened response could not be attributed to differences in rhythm discrimination and did not reflect an overall decrease in ratings. For harmonic complexity, PD showed a negative linear pattern for both the urge to move and pleasure while healthy age-matched controls showed the same pattern for pleasure and an inverted U for the urge to move. This contrasts with the pattern observed in young healthy controls in previous studies, suggesting that both healthy aging and PD also influence affective responses to harmonic complexity. Together, these results support the role of dopamine within cortico-striatal circuits in the predictive processes that form the link between the perceptual processing of rhythmic patterns and the affective and motor responses to rhythmic music.

Abnormal functional neurocircuitry underpinning emotional processing in fibromyalgia.

Fibromyalgia, a condition characterized by chronic pain, is frequently accompanied by emotional disturbances. Here we aimed to study brain activation and functional connectivity (FC) during processing of emotional stimuli in fibromyalgia. Thirty female patients with fibromyalgia and 31 female healthy controls (HC) were included. Psychometric tests were administered to measure alexithymia, affective state, and severity of depressive and anxiety symptoms. Next, participants performed an emotion processing and regulation task during functional magnetic resonance imaging (fMRI). We performed a 2 × 2 ANCOVA to analyze main effects and interactions of the stimuli valence (positive or negative) and group (fibromyalgia or HC) on brain activation. Generalized psychophysiological interaction analysis was used to assess task-dependent FC of brain regions previously associated with emotion processing and fibromyalgia (i.e., hippocampus, amygdala, anterior insula, and pregenual anterior cingulate cortex [pACC]). The left superior lateral occipital cortex showed more activation in fibromyalgia during emotion processing than in HC, irrespective of valence. Moreover, we found an interaction effect (valence x group) in the FC between the left pACC and the precentral and postcentral cortex, and central operculum, and premotor cortex. These results suggest abnormal brain activation and connectivity underlying emotion processing in fibromyalgia, which could help explain the high prevalence of psychopathological symptoms in this condition.

Cortical and subcortical microstructure integrity changes after repetitive transcranial magnetic stimulation therapy in cocaine use disorder and relates to clinical outcomes.

Cocaine use disorder (CUD) is a worldwide public health condition that is suggested to induce pathological changes in macrostructure and microstructure. Repetitive transcranial magnetic stimulation (rTMS) has gained attention as a potential treatment for CUD symptoms. Here, we sought to elucidate whether rTMS induces changes in white matter (WM) microstructure in frontostriatal circuits after 2 weeks of therapy in patients with CUD and to test whether baseline WM microstructure of the same circuits affects clinical improvement. This study consisted of a 2-week, parallel-group, double-blind, randomized controlled clinical trial (acute phase) (sham [n = 23] and active [n = 27]), in which patients received two daily sessions of rTMS on the left dorsolateral prefrontal cortex (lDLPFC) as an add-on treatment. T1-weighted and high angular resolution diffusion-weighted imaging (DWI-HARDI) at baseline and 2 weeks after served to evaluate WM microstructure. After active rTMS, results showed a significant increase in neurite density compared with sham rTMS in WM tracts connecting lDLPFC with left and right ventromedial prefrontal cortex (vmPFC). Similarly, rTMS showed a reduction in orientation dispersion in WM tracts connecting lDLPFC with the left caudate nucleus, left thalamus, and left vmPFC. Results also showed a greater reduction in craving Visual Analogue Scale (VAS) after rTMS when baseline intra-cellular volume fraction (ICVF) was low in WM tracts connecting left caudate nucleus with substantia nigra and left pallidum, as well as left thalamus with substantia nigra and left pallidum. Our results evidence rTMS-induced WM microstructural changes in fronto-striato-thalamic circuits and support its efficacy as a therapeutic tool in treating CUD. Further, individual clinical improvement may rely on the patient's individual structural connectivity integrity.

Fornix volumetric increase and microglia morphology contribute to spatial and recognition-like memory decline in ageing male mice.

Ageing displays a low-grade pro-inflammatory profile in blood and the brain. Accumulation of pro-inflammatory cytokines, microglia activation and volumetric changes in the brain correlate with cognitive decline in ageing models. However, the interplay between them is not totally understood. Here, we aimed to globally identify an age-dependent pro-inflammatory profile and microglia morphological plasticity that favors major volume changes in the brain associated with cognitive decline. Cluster analysis of behavioral data obtained from 2-,12- and 20-month-old male C57BL/6 mice revealed age-dependent cognitive decline after the Y-maze, Barnes maze, object recognition (NORT) and object location tests (OLT). Global magnetic resonance imageing (MRI) analysis by deformation-based morphometry (DBM) in the brain identified a volume increase in the fornix and a decrease in the left medial entorhinal cortex (MEntC) during ageing. Notably, the fornix shows an increase in the accumulation of pro-inflammatory cytokines, whereas the left MEntC displays a decrease. Morphological assessment of microglia also confirms an active and dystrophic phenotype in the fornix and a surveillance phenotype in the left MEntC. Finally, biological modeling revealed that age-related volume increase in the fornix was associated with dystrophic microglia and cognitive impairment, as evidenced by failure on tasks examining memory of object location and novelty. Our results propose that the morphological plasticity of microglia might contribute to volumetric changes in brain regions associated with cognitive decline during physiological ageing.

The Dorsolateral Prefrontal Cortex Presents Structural Variations Associated with Empathy and Emotion Regulation in Psychotherapists.

Empathic abilities have been shown to be linked with brain structural variations. Since psychotherapists constitute a population that tends to display greater empathic abilities, as shown in psychometric differences in cognitive empathy and emotional regulation, we aimed to identify cortical thickness (CT) differences between a group of professional psychotherapists and a control group. In line with the recently emphasized urge to employ more than a single workflow in cortical analyses, we utilized two cortical surface extraction and thickness estimation pipelines-CIVET and FreeSurfer. Eighteen psychotherapists and eighteen controls underwent MRI scanning and completed empathy-related psychometric assessments. We evaluated how CT measures differed between groups and if there was an association with individual empathy-related scores in a series of regions of interest (ROIs). Our analysis with CIVET shows that psychotherapists display a significantly greater CT at a ROI in the left dorsolateral prefrontal cortex (dlPFC; p < 0.05, FDR corrected). With FreeSurfer, a whole-brain vertex-wise analysis identified a statistically significant cluster in the left PFC that partially overlaps with the previous ROI. These results were reinforced by a structural covariance analysis revealing that, in psychotherapists, the left dlPFC ROI seemed to vary independently from the rest of the cortex. These findings are relevant because the dlPFC region importantly participates in the cognitive components of the empathic response, such as emotion regulation and perspective taking. Thus, our findings support the idea that empathic capacity is reflected by brain structural variations while also studying for the first time a sample of subjects for whom empathic responding is crucial in their profession.

Low-Velocity Loss Induces Similar Strength Gains to Moderate-Velocity Loss During Resistance Training.

ABSTRACT: Galiano, C, Pareja-Blanco, F, Hidalgo de Mora, J, and Sáez de Villarreal, E. Low-velocity loss induces similar strength gains to moderate-velocity loss during resistance training. J Strength Cond Res 36(2): 340-345, 2022-This study aimed to analyze the effects of 2 velocity-based resistance training (VBT) programs that used the same relative loading but differed in the velocity loss (VL) throughout the set: 5% (VL5) vs. 20% (VL20). Twenty-eight physically active men (age: 23.0 ± 3.2 years; height: 175.8 ± 4.7 cm; body mass: 73.8 ± 10.8 kg) were randomly assigned to 2 groups: VL5 (n = 15) or VL20 (n = 13). Subjects followed a 7-week (14 sessions) VBT program using the squat exercise while repetition velocity was monitored. The following variables were assessed at pretest and posttest: estimated 1-repetition maximum (1RM); average velocity attained for all absolute loads common to pretest and posttest (AV); average velocity for those loads that were moved faster than 1 m·s-1 (AV > 1); average velocity for those loads that were moved slower than 1 m·s-1 (AV < 1); countermovement jump (CMJ); and 20-m running sprint time (T20). T20 and CMJ height were assessed before each training session to analyze their evolution during the training program. The VL5 group executed only 32.6% of the total repetitions performed by the VL20 group (156.9 ± 25.0 vs. 480.5 ± 162.0 rep). Both groups improved significantly (p < 0.01) in all variables analyzed (1RM, AV, AV > 1, AV < 1, CMJ, and T20) from pretest to posttest, with no significant differences between them. Therefore, a low VL (5%) induced similar gains in strength, jump, and sprint performance to a moderate VL of 20%, despite VL5 performing only 32.6% of the repetitions achieved by the VL20 group.

Effects of Different Loading Conditions During Resisted Sprint Training on Sprint Performance.

ABSTRACT: Rodríguez-Rosell, D, Sáez de Villarreal, E, Mora-Custodio, R, Asián-Clemente, JA, Bachero-Mena, B, Loturco, I, and Pareja-Blanco, F. Effects of different loading conditions during resisted sprint training on sprint performance. J Strength Cond Res 36(10): 2725-2732, 2022-The aim of this study was to compare the effects of 5 loading conditions (0, 20, 40, 60, and 80% of body mass [BM]) during weighted sled sprint training on unresisted and resisted sprint performance and jump ability. Sixty physically active men were randomly assigned into 5 groups according to the overload used during sled sprint training: 0% (G0%, n = 12), 20% (G20%, n = 12), 40% (G40%, n = 12), 60% (G60%, n = 12), and 80% BM (G80%, n = 12). Pretraining and post-training assessments included: countermovement jump (CMJ), 30-m sprint without extra load, and 20-m sprint with 20, 40, 60, and 80% BM. All 5 experimental groups trained once a week for a period of 8 weeks completing the same training program (number of sessions, number of bouts, running distance in each sprint, rest intervals between repetitions, and total running distance), but with different sled loads (0, 20, 40, 60, and 80% BM). There was a significant "time × group" interaction for resisted sprint performance at 80% BM condition, where the G40% group attained improvements in performance and G80% worsened. Moreover, G40% increased performance in unresisted and the rest of loading conditions. In addition, G0% and G60% showed statistically significant increases in unresisted sprint performance. No relevant changes were observed in the other experimental groups. All groups showed significant improvements ( p < 0.05-0.001) in CMJ height. Therefore, our findings suggest that resisted sprint training with moderate loads (i.e., 40% BM) may have a positive effect on unresisted and resisted sprint performance.

Acute Effects of Progressive Sled Loading on Resisted Sprint Performance and Kinematics.

ABSTRACT: Pareja-Blanco, F, Pereira, LA, Freitas, TT, Alcaraz, PE, Reis, VP, Guerriero, A, Arruda, AFS, Zabaloy, S, De Villarreal, ES, and Loturco, I. Acute effects of progressive sled loading on resisted sprint performance and kinematics. J Strength Cond Res 36(6): 1524-1531, 2022-We examined the effects of 5 loading conditions (0, 20, 40, 60, and 80% of body-mass [BM]) on resisted sprint performance and kinematics in male rugby players over different distances. Ten players from the Brazilian National Team (20.1 ± 3.3 years; 88.7 ± 18.8 kg; 178.3 ± 6.2 cm) performed 20-m sprints under the 5 loading conditions. Sprint times in 5, 10, and 20 m were recorded. Stride length (SL), and hip, knee, and ankle angles were measured using an eight-sensor motion analysis system. The kinematic parameters were calculated over the different distances. Heavier loads led to significantly greater velocity loss (p < 0.001-0.05). Significant reductions in SL were also observed when comparing 0% BM and all resisted sprints in all assessed distances (p < 0.001-0.05, effect size [ES]: 1.35-4.99). Very heavy (80% BM) sled load provoked significantly greater decreases in SL than the rest of loading conditions (p < 0.01-0.05). Important kinematic alterations were observed for all loading conditions and sprint distances when compared with 0% BM (ES: 0.76-1.79, for hip-angle; 0.20-1.40, for knee-angle; and 0.73-1.88, for ankle-angle). Moreover, 80% BM induced significantly higher hip flexion, lower knee flexion, and higher ankle dorsiflexion than 20% BM condition at 5-10 and 10-20 m distances (p < 0.05). Lighter sled loads (<40% BM) seem to be more adequate to improve speed ability without provoking drastic changes in the unloaded sprinting technique, whereas heavier loads may be more suitable for optimizing horizontal force production and thus, acceleration performance.

PREEMACS: Pipeline for preprocessing and extraction of the macaque brain surface.

Accurate extraction of the cortical brain surface is critical for cortical thickness estimation and a key element to perform multimodal imaging analysis, where different metrics are integrated and compared in a common space. While brain surface extraction has become widespread practice in human studies, several challenges unique to neuroimaging of non-human primates (NHP) have hindered its adoption for the study of macaques. Although, some of these difficulties can be addressed at the acquisition stage, several common artifacts can be minimized through image preprocessing. Likewise, there are several image analysis pipelines for human MRIs, but very few automated methods for extraction of cortical surfaces have been reported for NHPs and none have been tested on data from diverse sources. We present PREEMACS, a pipeline that standardizes the preprocessing of structural MRI images (T1- and T2-weighted) and carries out an automatic surface extraction of the macaque brain. Building upon and extending pre-existing tools, the first module performs volume orientation, image cropping, intensity non-uniformity correction, and volume averaging, before skull-stripping through a convolutional neural network. The second module performs quality control using an adaptation of MRIqc method to extract objective quality metrics that are then used to determine the likelihood of accurate brain surface estimation. The third and final module estimates the white matter (wm) and pial surfaces from the T1-weighted volume (T1w) using an NHP customized version of FreeSurfer aided by the T2-weighted volumes (T2w). To evaluate the generalizability of PREEMACS, we tested the pipeline using 57 T1w/T2w NHP volumes acquired at 11 different sites from the PRIME-DE public dataset. Results showed an accurate and robust automatic brain surface extraction from images that passed the quality control segment of our pipeline. This work offers a robust, efficient and generalizable pipeline for the automatic standardization of MRI surface analysis on NHP.

The Subcortical Atlas of the Rhesus Macaque (SARM) for neuroimaging.

Digitized neuroanatomical atlases that can be overlaid onto functional data are crucial for localizing brain structures and analyzing functional networks identified by neuroimaging techniques. To aid in functional and structural data analysis, we have created a comprehensive parcellation of the rhesus macaque subcortex using a high-resolution ex vivo structural imaging scan. This anatomical scan and its parcellation were warped to the updated NIMH Macaque Template (NMT v2), an in vivo population template, where the parcellation was refined to produce the Subcortical Atlas of the Rhesus Macaque (SARM) with 210 primary regions-of-interest (ROIs). The subcortical parcellation and nomenclature reflect those of the 4th edition of the Rhesus Monkey Brain in Stereotaxic Coordinates (Paxinos et al., in preparation), rather than proposing yet another novel atlas. The primary ROIs are organized across six spatial hierarchical scales from small, fine-grained ROIs to broader composites of multiple ROIs, making the SARM suitable for analysis at different resolutions and allowing broader labeling of functional signals when more accurate localization is not possible. As an example application of this atlas, we have included a functional localizer for the dorsal lateral geniculate (DLG) nucleus in three macaques using a visual flickering checkerboard stimulus, identifying and quantifying significant fMRI activation in this atlas region. The SARM has been made openly available to the neuroimaging community and can easily be used with common MRI data processing software, such as AFNI, where the atlas has been embedded into the software alongside cortical macaque atlases.

A collaborative resource platform for non-human primate neuroimaging.

Neuroimaging non-human primates (NHPs) is a growing, yet highly specialized field of neuroscience. Resources that were primarily developed for human neuroimaging often need to be significantly adapted for use with NHPs or other animals, which has led to an abundance of custom, in-house solutions. In recent years, the global NHP neuroimaging community has made significant efforts to transform the field towards more open and collaborative practices. Here we present the PRIMatE Resource Exchange (PRIME-RE), a new collaborative online platform for NHP neuroimaging. PRIME-RE is a dynamic community-driven hub for the exchange of practical knowledge, specialized analytical tools, and open data repositories, specifically related to NHP neuroimaging. PRIME-RE caters to both researchers and developers who are either new to the field, looking to stay abreast of the latest developments, or seeking to collaboratively advance the field .

Combined Squat and Light-Load Resisted Sprint Training for Improving Athletic Performance.

ABSTRACT: Pareja-Blanco, F, Asián-Clemente, JA, and Sáez de Villarreal, E. Combined squat and light-load resisted sprint training for improving athletic performance. J Strength Cond Res 35(9): 2457-2463, 2021-This study aimed to analyze the effects of 5 training methods: squat (SQ), light-load sled towing (LST), heavy-load sled towing (HST), squat combined with LST (SQ + LST), and squat combined with HST (SQ + HST) on physical performance. Ninety-one physically active men were randomly assigned to one of the aforementioned training methods or a control group. Before and after the training period, a battery of tests was completed: 30-m sprint; change of direction (COD); countermovement jump (CMJ) and Abalakov jump (ABK); and estimated 1 repetition maximum (1RM) in squat. Training took place once per week for 8 weeks. SQ trained the squat exercise, HST trained resisted sprints with 80% body mass (BM) load, LST trained resisted sprints with 12.5% BM load, SQ + HST combined squat with 80% BM load resisted sprint, and SQ + LST combined squat with 12.5% BM load resisted sprint. The loads used in squat ranged from 40 to 55% 1RM. After the training program, SQ + LST showed improvements in 0- to 30-, 10- to 20-, and 10- to 30-m sprint times, whereas SQ + HST did not achieve significant enhancements over any sprint time. LST and HST improved over 0-20 and 10-30 m, respectively. SQ showed improvements in 20- to 30-m sprint time. Change of direction and CMJ performance were increased for HST, SQ + HST, and SQ + LST, whereas only SQ + LST improved ABK height. SQ, HST, SQ + HST, and SQ + LST increased 1RM. Squat training with low/moderate loads combined with LST (12.5% BM) may be an effective stimulus for improving leg strength, jump ability, COD, and sprint performance.

Acute Effects of Ballistic vs. Passive Static Stretching Involved in a Prematch Warm-up on Vertical Jump and Linear Sprint Performance in Soccer Players.

ABSTRACT: López Mariscal, S, Sánchez Garcia, V, Fernández-García, JC, and Sáez de Villarreal, E. Acute effects of ballistic vs. passive static stretching involved in a prematch warm-up on vertical jump and linear sprint performance in soccer players. J Strength Cond Res 35(1): 147-153, 2021-The purpose of this study was to compare the effects of introducing passive static and ballistic stretching in a standard soccer match warm-up. The variables addressed were the counter movement jump (CMJ), Abalakov jump, and the 40-m linear sprint. The sample was composed of 33 male subjects, divided into 2 age groups. U16 and adult players formed the groups, to cross check whether there were differences between them. Each group was further subdivided into 2 groups regarding the type of stretching carried out during the stretching phase. Before the warm-up, the tests previously described were assessed. In the experimental phase, standard stretching was carried out, consisting of an initial phase in which players had to execute continuous running; a general phase in which players had to make articulate moves; a technical phase in which players had to execute exercises with the ball; a 5 vs. 5 small-sided game was carried out during the tactical phase; and in the final phase, activation exercises and sprints were carried out by the players. Eventually, the same variables were assessed again once the warm-up was finished. There were no statistically significant differences between the 2 types of stretching included in the prematch warm-up. It can be concluded that ballistic and passive static stretching (<10 seconds) did not cause, under these circumstances, any effect in the assessed variables related to soccer performance (linear sprint, CMJ, and Abalakov). This has to be considered by coaches when devising soccer-related warm-ups.

Injury Profile of Elite Male Young Soccer Players in a Spanish Professional Soccer Club: A Prospective Study During 4 Consecutive Seasons.

CONTEXT: As the number of injuries in young soccer players increases, an epidemiological study is the first step in improving preventive strategies. OBJECTIVES: To analyze the injury profile of a Spanish professional soccer club's academy during 4 consecutive seasons and to examine the injury incidence across different chronological age groups. DESIGN: Prospective cohort design. SETTING: Aggregate injury and exposure data collected during 4 consecutive seasons. PARTICIPANTS: Three hundred nine elite male young soccer players. MAIN OUTCOMES MEASURES: Injuries that led to participation time missed from training and match play prospectively reported by medical or coaching staff of the club. RESULTS: A total of 464 time-loss injuries were observed during this study period. The overall injury incidence was 2.93 injuries per 1000 hours, with higher incidence during matches than during training (10.16 vs 2.10 injuries/1000 h; rate ratio [RR] = 0.21; 95% confidence interval [CI], 0.17-0.25; P < .05), with the U14 age group presenting the lowest injury rate (2.39 injuries/1000 h; RR = 1.15-1.57; P < .05). In terms of injury severity, moderate injuries were the most frequent (1.42 injuries/1000 h). Muscle injuries were the most common type of injuries (57.7%; 2.75 injuries/1000 h; RR = 1.84-13.4; P < .05), and hamstrings (93/268) were the most affected muscle group (0.58 injuries/1000 h; RR = 1.58-2.91; P < .05). Injury incidence showed a seasonal variation as indicated by peaks in August and October. In matches, specifically, the match period between 75 and 90 minutes showed the highest injury incidence (10.29 injuries/1000 h; RR = 1.89-6.38; P < .01). CONCLUSIONS: The findings of this study suggest that specific preventive strategies must be implemented to try to reduce the injury incidence in Spanish elite young soccer players attending to the characteristics of each age group.

Comorbid personality disorders and their impact on severe dissociative experiences in Mexican patients with borderline personality disorder.

Objective: To identify personality disorders comorbid with borderline personality disorder (BPD) that may confer greater risk for the presence of severe dissociative experiences. Method: Three hundred and one outpatients with a primary diagnosis of BPD were evaluated using the Structured Clinical Interview for DSM-IV Axis II personality disorders, the Borderline Evaluation of Severity Over Time (BEST) and the Dissociative Experiences Scale (DES). Results: The most frequent personality disorders comorbid to BPD were paranoid (83.2%, n = 263) and depressive (81.3%, n = 257). The mean BEST and DES total score were 43.3 (SD = 11.4, range 15-69) and 28.6 (SD = 19.8, range 0-98), respectively. We categorized the sample into patients with and without severe dissociative experiences (41% were positive). A logistic regression model revealed that Schizotypal, Obsessive-compulsive and Antisocial personality disorders conferred greater risk for the presence of severe dissociative experiences. Discussion: Our results suggest that a large proportion of patients with BPD present a high rate of severe dissociative experiences and that some clinical factors such as personality comorbidity confer greater risk for severe dissociation, which is related to greater dysfunction and suffering, as well as a worse progression of the BPD.

The effects of maturation on jumping ability and sprint adaptations to plyometric training in youth soccer players.

The aim of this study was to investigate the effects of maturation on power and sprint performance adaptations following 6 weeks of plyometric training in youth soccer players during pre-season. Sixty male soccer players were categorized into 3 maturity groups (Pre, Mid and Post peak height velocity [PHV]) and then randomly assigned to plyometric group and control group. Vertical jump, standing long jump, and 20-m sprint (with and without ball) tests were collected before- and after-intervention. After the intervention, the Pre, Mid and Post-PHV groups showed significant (P ≤ 0.05) and small to moderate effect size (ES) improvement in vertical jump (ES = 0.48; 0.57; 0.73), peak power output (E = 0.60; 0.64; 0.76), standing long jump (ES = 0.62; 0.65; 0.7), 20-m sprint (ES = -0.58; -0.66), and 20-m sprint with ball (ES = -0.44; -0.8; -0.55) performances. The Post-PHV soccer players indicated greater gains than Pre-PHV in vertical jump and sprint performance after training (P ≤ 0.05). Short-term plyometric training had positive effects on sprinting and jumping-power which are important determinants of match-winning actions in soccer. These results indicate that a sixty foot contact, twice per week program, seems effective in improving power and sprint performance in youth soccer players.

Does Flywheel Paradigm Training Improve Muscle Volume and Force? A Meta-Analysis.

Núñez Sanchez, FJ and Sáez de Villarreal, E. Does flywheel paradigm training improve muscle volume and force? A meta-analysis. J Strength Cond Res 31(11): 3177-3186, 2017-Several studies have confirmed the efficacy of flywheel paradigm training for improving or benefiting muscle volume and force. A meta-analysis of 13 studies with a total of 18 effect sizes was performed to analyse the role of various factors on the effectiveness of flywheel paradigm training. The following inclusion criteria were employed for the analysis: (a) randomized studies; (b) high validity and reliability instruments; (c) published in a high quality peer-reviewed journal; (d) healthy participants; (e) studies where the eccentric programme were described; and (f) studies where increases in muscle volume and force were measured before and after training. Increases in muscle volume and force were noted through the use of flywheel systems during short periods of training. The increase in muscle mass appears was not influenced by the existence of eccentric overload during the exercise. The increase in force was significantly higher with the existence of eccentric overload during the exercise. The responses identified in this analysis are essential and should be considered by strength and conditioning professionals regarding the most appropriate dose response trends for flywheel paradigm systems to optimize the increase in muscle volume and force.

Off-Season Effects on Functional Performance, Body Composition, and Blood Parameters in Top-Level Professional Soccer Players.

Requena, B, García, I, Suárez-Arrones, L, Sáez de Villarreal, E, Naranjo Orellana, J, and Santalla, A. Off-season effects on functional performance, body composition, and blood parameters in top-level professional soccer players. J Strength Cond Res 31(4): 939-946, 2017-To examine the effects of a standard off-season period (OSP) on aerobic, sprint, and jumping performances, and body and blood composition in a top-level soccer team. Nineteen soccer players were measured. The OSP included to 2 weeks of no training (resting phase) and a 4-week period of moderate-training load (phase in which each player performed the vacation exercise plan). Player's functional performance (15- and 30-m sprint times [seconds], vertical jump [meter], and incremental field test Vam-Eval [kilometer per hour]), percentage of body fat (%) and blood composition (hematological and biochemical data) were measured at mid-season, end-season, and after the OSP. The percentage of body fat was nonaltered during the competitive season (10.8 ± 3.6 and 10.5 ± 3.5%) and increased significantly after the OSP (11.6 ± 3.6%, p ≤ 0.05). Similarly, the maximal aerobic speed (VVam-Eval) velocity (kilometer per hour) decreased (p ≤ 0.05) from 17.4 ± 1 and 17.3 ± 1.2 during the competitive season to 16.6 ± 0.9 after the OSP. The hematocrit and blood hemoglobin concentration increased (p ≤ 0.05) during the OSP, showing a blood hemoconcentration adaptation. However, sprint time (seconds) and jump height (meters) showed no significant changes after the OSP. Soccer players maintained their functional performance during high-intensity activities such as jumping or sprinting after the OSP proposed. By contrast, there was a decrease in aerobic performance (VVam-Eval) accompanied by a blood hemoconcentration, and an increase of body fat mass associated with a reduction of fat-free mass of the lower limbs. Our data suggest that an end-season evaluation is needed to design holiday training programs focused on regaining aerobic capacity and body composition.