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Bioorg Med Chem Lett
; 92: 129410, 2023 08 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-37478957
RESUMEN
A collection of ß-carbolines based on the natural product harmine, a compound known to target the heat shock 90 protein of Plasmodium falciparum, was synthesized and tested for antimalarial activity and potential toxicity. Several of these novel compounds display promising bioactivity, providing a new potential therapeutic with a mode of action that differs versus any currently available clinical treatment.