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PURPOSE: Carotid artery stenting (CAS) is an option for carotid restenosis (CR) treatment with favorable outcomes. However, CAS has also emerged as an alternative to carotid endarterectomy (CEA) for the management of patients with primary carotid stenosis. This study aimed to report CR rates after CAS was performed in patients with primary lesions versus restenosis after CEA, to identify predictors of CR, and to report both neurological and overall outcomes. MATERIALS AND METHODS: From January 2000 to September 2018, a total of 782 patients were divided into 2 groups: The CAS (prim) group consisted of 440 patients in whom CAS was performed for primary lesions, and the CAS (res) group consisted of 342 patients with CAS due to restenosis after CEA. Indications for CAS were symptomatic stenosis/restenosis >70% and asymptomatic stenosis/restenosis >85%. A color duplex scan (CDS) of carotid arteries was performed 6 months after CAS, after 1 year, and annually afterward. Follow-up ranged from 12 to 88 months, with a mean follow-up of 34.6±18.0 months. RESULTS: There were no differences in terms of CR rate between the patients in the CAS (prim) and CAS (res) groups (8.7% vs 7.2%, χ2=0.691, p=0.406). The overall CR rate was 7.9%, whereas significant CR (>70%) rate needing re-intervention was 5.6%, but there was no difference between patients in the CAS (prim) and CAS (res) groups (6.4% vs 4.7%, p=0.351). Six independent predictors for CR were smoking, associated previous myocardial infarction and angina pectoris, plaque morphology, spasm after CAS, the use of FilterWire or Spider Fx cerebral protection devices, and time after stenting. A carotid restenosis risk index (CRRI) was created based on these predictors and ranged from -7 (minimal risk) to +10 (maximum risk); patients with a score >-4 were at increased risk for CR. There were no differences in terms of neurological and overall morbidity and mortality between the 2 groups. CONCLUSIONS: There was no difference in CR rate after CAS between the patients with primary stenosis and restenosis after CEA. A CRRI score >-4 is a criterion for identifying high-risk patients for post-CAS CR that should be tested in future randomized trials.
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Estenosis Carotídea , Endarterectomía Carotidea , Accidente Cerebrovascular , Humanos , Estenosis Carotídea/diagnóstico por imagen , Estenosis Carotídea/terapia , Estenosis Carotídea/complicaciones , Constricción Patológica , Resultado del Tratamiento , Stents/efectos adversos , Factores de Tiempo , Endarterectomía Carotidea/efectos adversos , Arterias Carótidas , Factores de Riesgo , Recurrencia , Accidente Cerebrovascular/etiologíaRESUMEN
INTRODUCTION: Anxiety disorders are among the most common mental disorders. Benzodiazepines belong to the group of anxiolytic sedatives and the most prescribed drugs in the world. The aim in ours study was to evaluate the differences in the exposure of the population to benzodiazepines (in period from 2014-2018) between Serbia, Slovenia and Croatia, the three countries of the Southwestern Balkans with varying degrees of socioeconomic development. STUDY DESIGN: A academic investigator initiated, pharmacoepidemiological difference-in-difference time series analysis of population exposure to benzodiazepines between the three, geographically close Balkans countries (Slovenia, Serbia, Croatia) with varying degrees of socioeconomic development has been carried out. Study was conducted as academic investigator initiated, in a retrospective manner on monthly basis international data set from January 2014 to December 2018. RESULTS: At the annual level, during the study period from January 2014 to December 2018, compared to Slovenia, Serbia and Croatia had higher DIDs, from 5 fold (Croatia) to 6 fold (Serbia), for all benzodiazepines in total. By analyzing the differences-in-difference, we have shown that influence of both time (month) and country on DIDs is significant as well as their mutual interaction (the country x month) for all benzodiazepines in total. CONCLUSION: Serbia and Croatia must implement explicit measures of reducing benzodiazepine prescription in health primary care based on evidence-based recommendations in the indications where general medicine practitioners/family doctors most commonly prescribe these medicines. Without providing a realistic supplement/alternative to benzodiazepines such as increasing the availability of psychotherapy and improving the structure of psychiatric professionals in healthcare settings, implicit measures are not recommended for reducing prescription, implementing accountability measures for prolonged prescription of benzodiazepines, and in particular for "masked" somatic diseases. All this comes to the fore by raising economic development and socioeconomic stability.
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Benzodiazepinas/economía , Desarrollo Económico , Factores Socioeconómicos , Peninsula Balcánica , Croacia , Humanos , Estudios Retrospectivos , Serbia , EsloveniaRESUMEN
Breast arterial calcifications (BACs) are common findings on mammography which are associated with an increased risk of the coronary artery disease (CAD). Our aim in the current study was to design measurement instruments of CAD prediction, with or without BACs, and its discriminatory validity in the diagnosis of CAD (expressed by Syntax score) in women. This was observational, prospective study in the women cohort which underwent mammography and angiography. In this study we have demonstrated that the total 'The Breast Arterial Calcification and Coronary Artery Disease Scale' (BACCADS) was good additional diagnostic tool for detection of patients with severe CAD.
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Enfermedades de la Mama/diagnóstico por imagen , Angiografía Coronaria , Enfermedad de la Arteria Coronaria/diagnóstico por imagen , Mamografía , Adulto , Femenino , Humanos , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Estudios Prospectivos , Índice de Severidad de la EnfermedadRESUMEN
The nature of mental disorders, the attitudes and prejudices of the social community towards psychiatric patients, the behavior and treatment of mental patients, all bring about numerous dilemmas and prejudices. When a patient is diagnosed with a mental disorder, he may suffer restrictions in the field of general human rights. However, the biggest problems in clinical practice occur in the treatment of patients who, besides their mental disorder also have a somatic disease. We report a 56-years-old female with a severe renal failure who refused to undergo dialysis. Following the patient's refusal to sign an informed consent, a psychiatrist was called in for consultation and diagnosed an acute psychotic reaction. To manage the delusions and acute psychotic reactions, risperidone in the dose of 2 mg was started. After 22 days, the patient still had marked psychotic symptoms. A psychiatrist, a nephrologist and an anesthesiologist, in the presence of the spouse on the grounds of her life-threatening condition, decided to apply the necessary medical procedures even without the patient's consent. A day after the start of dialysis the patient still had delusional ideas, but without the presence of anxiety, and the patient no longer offered resistance to dialysis. Four days after the first dialysis, the patient was calm, had vague memories about the entire previous period, and signed the informed consent concerning her further treatment.
Asunto(s)
Consentimiento Informado , Diálisis Renal/psicología , Insuficiencia Renal/psicología , Trastornos de Ansiedad , Comorbilidad , Femenino , Humanos , Trastornos Mentales , Persona de Mediana Edad , Insuficiencia Renal/terapia , Negativa del Paciente al TratamientoRESUMEN
BACKGROUND: Antimicrobial resistance presents one of the most significant threats to public health. This study aimed to examine antibiotic usage within the general population in the Republic of Serbia and their knowledge, attitudes, and behavior concerning this topic. METHODS: We conducted an online cross-sectional study over two weeks in December 2022, on a sample of 1014 respondents, representative of the Republic of Serbia's population. Predictors of the Antibiotic Knowledge Score (composed of four questions) were analyzed by multivariate ordinal logistic regression. RESULTS: In 2022, 76.8% of the participants from the Serbian population had taken antibiotics, mostly upon a medical prescription, with the most common reasons being upper respiratory tract infections. Only 31.3% of all respondents received any kind of advice about the rational use of antibiotics and half of them changed their opinions on using antibiotics after receiving this information. The average Antibiotic Knowledge Score was 2.6 out of 4, with 32.5% of respondents answering all knowledge questions correctly. The multivariate ordinal logistic regression analysis showed that female gender, higher education level, and the willingness to change opinions regarding the usage of antibiotics after receiving information about the rational use of antibiotics from any available source were significant predictors of better knowledge about antibiotics use. Respondents who were open to changing their opinion after receiving information about the rational use of antibiotics had 28% higher odds of higher antibiotic knowledge scores. CONCLUSION: This is the first population-level study on public knowledge, attitudes, and practices about antibiotic use in Serbia and therefore the baseline for future research and measuring the impact of potential interventions. Our findings underline the importance of taking into account specific population characteristics, knowledge levels, and attitudes when designing educational and intervention strategies for antibiotic use. Policymakers can leverage these findings to target specific groups and enhance the population's knowledge and practices regarding rational antibiotic usage.
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Antibacterianos , Conocimientos, Actitudes y Práctica en Salud , Humanos , Femenino , Estudios Transversales , Serbia , Antibacterianos/uso terapéutico , Encuestas y CuestionariosRESUMEN
BACKGROUND: Cough is frequent symptom in sarcoidosis and its impact on patient's quality of life (QoL) has not been adequately addressed so far. OBJECTIVES: The goal of this study was to determine the significant predictors of cough-specific and generic QoL in sarcoidosis patients. METHODS: In the prospective study 275 sarcoidosis patients administered Patient Reported Outcomes instruments for measurement of dyspnea (Borg and MRC scales) and fatigue (Fatigue Assessment Scale (FAS) and Daily Activity List (DAL)), as well as patients' QoL (cough-specific Leicester Cough Questionnaire (LCQ) and generic tool - 15D). The LCQ contains 3 domains covering physical, psychological and social aspects of chronic cough. Pulmonary function tests (spirometry and diffusing capacity for carbon monoxide) and serum angiotensin converting enzyme (sACE) were also measured. RESULTS: Dyspnea measured by Borg scale and impairment of daily activities determined by DAL instrument as well as sACE were the strongest predictors of all cough-specific QoL domains. Mental aspect of patients' fatigue was significantly correlated with all domains except with psychological LCQ domain. Regarding the generic QoL, the following significant predictors were: dyspnea measured by MRC scale, overall fatigue determined by FAS and physical domain of the LCQ. CONCLUSION: It is important to measure both cough-specific and generic QoL in sarcoidosis patients since they measure different health aspects and their predictors can be different. We demonstrated that physical domain of cough-specific QoL is significant predictor of generic QoL. (Sarcoidosis Vasc Diffuse Lung Dis 2020; 37 (2): 158-168).
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Tos/diagnóstico , Pulmón/fisiopatología , Medición de Resultados Informados por el Paciente , Calidad de Vida , Sarcoidosis Pulmonar/diagnóstico , Actividades Cotidianas , Adulto , Anciano , Costo de Enfermedad , Tos/etiología , Tos/fisiopatología , Tos/psicología , Disnea/diagnóstico , Disnea/etiología , Disnea/fisiopatología , Disnea/psicología , Fatiga/diagnóstico , Fatiga/etiología , Fatiga/fisiopatología , Fatiga/psicología , Femenino , Estado de Salud , Humanos , Masculino , Salud Mental , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Estudios Prospectivos , Factores de Riesgo , Sarcoidosis Pulmonar/complicaciones , Sarcoidosis Pulmonar/fisiopatología , Sarcoidosis Pulmonar/psicología , Índice de Severidad de la EnfermedadRESUMEN
INTRODUCTION: Fatigue, anxiety and depression are very frequent symptoms in patients with rheumatoid arthritis (RA). GOALS: In this study we evaluated the influence of socioeconomic characteristics, therapy and comorbidities on the self-reported high fatigue, anxiety and depression in patients with RA. METHOD: Multicenter cross-sectional study was performed in 22 health institutions in Serbia during the period from April-August 2014 in population of older RA patients. Self-reported patients health status was measured by: Fatigue Assessment Scale, Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7. Treatment modalities were defined as: (1) non-steroidal anti-inflammatory drugs (NSAIDs) and/or analgesics and/or corticosteroids; (2) synthetic disease-modifying antirheumatic drugs (DMARDs) alone or in combination with corticosteroids and/or NSAIDs and (3) any RA treatment which includes biologic DMARDs. RESULTS: There were significant predictors of high depression: synthetic DMARDs therapy in combination with corticosteroids and/or NSAIDs, physiotherapist self-payment, frequent taxi use, alternative treatment and employment status. The need for another person's assistance, supplemental calcium therapy and professional qualifications were the predictors of a high fatigue, whereas the age above 65 years had the protective effect on it. Anxiety was an independent high fatigue predictor. The predictors of a high anxiety were: gastroprotection with proton-pump inhibitors and patient occupation. CONCLUSION: Socioeconomic predictors of self-reported high depression, anxiety or fatigue are different for each of the mentioned outcomes, while accompanied with the basic RA treatment they exclusively explain a high depression. The anxiety, jointed with the socioeconomic variables and supplemental therapy, is a significant fatigue predictor in RA patients.
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Ansiedad/etiología , Artritis Reumatoide/psicología , Depresión/etiología , Fatiga/etiología , Factores Socioeconómicos , Corticoesteroides/uso terapéutico , Anciano , Antiinflamatorios no Esteroideos/uso terapéutico , Antirreumáticos/uso terapéutico , Ansiedad/psicología , Artritis Reumatoide/complicaciones , Artritis Reumatoide/tratamiento farmacológico , Factores Biológicos/uso terapéutico , Estudios Transversales , Depresión/psicología , Fatiga/psicología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Calidad de Vida , AutoinformeRESUMEN
BACKGROUND: Exploration of long-term health expenditure and longevity trends across three major sub-regions of Eastern Europe since 1989. METHODS: 24 countries were classified as EU 2004, CIS, or SEE. European Health for All Database (HFA-DB) 1989-2012 data were processed using difference-in-difference (DiD) and data envelopment analysis (DEA). RESULTS: The strongest expenditure growth was recorded in EU 2004 followed by SEE and the CIS. A surprisingly similar longevity increase was present in SEE and EU 2004. In 1989, countries that joined EU in 2004 were relatively inefficient in the number of life-years gained yet had a lower life expectancy than the SEE region and was only slightly higher than the CIS region (DEA). By 2012 the revenue spent was roughly linear to additional life-year expectancies. CONCLUSION: EU 2004 members were the best performers in terms of balanced longevity increase followed by health expenditure growth. The SEE economies' longevity gains were lagging slightly behind at a far lower cost. An extrapolated CIS expenditure to longevity increase ratio has the fastest-growing long-term promise.
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Gastos en Salud/tendencias , Esperanza de Vida/tendencias , Longevidad , Costos y Análisis de Costo , Bases de Datos Factuales , Europa Oriental , Humanos , Estudios RetrospectivosRESUMEN
OBJECTIVE: The aim of this study was to use a Serbian-language version of the disease-specific, self-report Sarcoidosis Health Questionnaire (SHQ), which was designed and originally validated in the United States, to assess health status in sarcoidosis patients in Serbia, as well as validating the instrument for use in the country. METHODS: This was a cross-sectional study of 346 patients with biopsy-confirmed sarcoidosis. To evaluate the health status of the patients, we used the SHQ, which was translated into Serbian for the purposes of this study. We compared SHQ scores by patient gender and age, as well as by disease duration and treatment. Lower SHQ scores indicate poorer health status. RESULTS: The SHQ scores demonstrated differences in health status among subgroups of the sarcoidosis patients evaluated. Health status was found to be significantly poorer among female patients and older patients, as well as among those with chronic sarcoidosis or extrapulmonary manifestations of the disease. Monotherapy with methotrexate was found to be associated with better health status than was monotherapy with prednisone or combination therapy with prednisone and methotrexate. CONCLUSIONS: The SHQ is a reliable, disease-specific, self-report instrument. Although originally designed for use in the United States, the SHQ could be a useful tool for the assessment of health status in various non-English-speaking populations of sarcoidosis patients.
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Estado de Salud , Sarcoidosis/fisiopatología , Autoinforme/normas , Encuestas y Cuestionarios , Adulto , Análisis de Varianza , Estudios Transversales , Femenino , Humanos , Lenguaje , Masculino , Persona de Mediana Edad , Calidad de Vida , Reproducibilidad de los Resultados , Sarcoidosis/psicología , Sarcoidosis/terapia , Serbia , Estadísticas no Paramétricas , TraduccionesRESUMEN
BACKGROUND: Serbia, as the largest market of the Western Balkans, has entered socioeconomic transition with substantial delay compared to most of Eastern Europe. Its health system reform efforts were bold during the past 15 years, but their results were inconsistent in various areas. The two waves of global recession that hit Balkan economies ultimately reflected to the financial situation of healthcare. Serious difficulties in providing accessible medical care to the citizens became a reality. A large part of the unbearable expenses actually belongs to the overt prescription of pharmaceuticals and various laboratory and imaging diagnostic procedures requested by physicians. Therefore, a broad national survey was conducted at all levels of the healthcare system hierarchy to distinguish the ability of cost containment strategies to reshape clinician's mindsets and decision-making in practice. AIMS: Assessment of healthcare professionals' judgment on economic consequences of prescribed medical interventions and evaluation of responsiveness of healthcare professionals to policy measures targeted at increasing cost-consciousness. STUDY DESIGN: Cross-sectional study. METHODS: A nationwide cross-sectional survey was conducted through a hierarchy of medical facilities across diverse geographical regions before and after policy action, from January 2010 to April 2013. In the middle of the observed period, the National Health Insurance Fund (RFZO) adopted severe cost-containment measures. Independently, pharmacoeconomic guidelines targeted at prescribers were disseminated. Administration in large hospitals and community pharmacies was forced to restrict access to high budget-impact medical care. Economic Awareness of Healthcare Professionals Questionnaire-29 (EAHPQ-29), developed in Serbian language, was used in face-to-face interviews. The questionnaire documented clinician's attitudes on: Clinical-Decision-Making-between-Alternative-Interventions (CDMAI), Quality-of-Health-Care (QHC), and Cost-Containment-Policy (CCP). The authors randomly and anonymously recruited 2000 healthcare experts, with a total of 1487 responding; after eliminating incomplete surveys, 649 participants were considered before and 651 after policy intervention. RESULTS: Dentists (1.195±0.560) had a higher mean CDMAI score compared to physicians (1.017±0.453). The surgical group compared to the internist group had a higher total EAHPQ-29 score, CCP score and CDMAI score. Policy intervention had a statistically significant negative impact on the QHC score (F=4.958; df=1; p=0.027). There was no substantial impact of policy interventions on professional behavior and judgment with regard to the CDMAI, CCP, and total EAHPQ-29 scores. CONCLUSION: Although cost savings were forcibly imposed in practice, the effects on clinical decision-making were modest. Clinicians' perceptions of quality of medical care were explained in a less effective manner due to the severely constrained resources allocated to the providers. This pioneering effort in the Balkans exposes the inefficiency of current policies to expand clinicians' cost consciousness.
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INTRODUCTION: Administration of human serum albumin (HSA) solutions for the resuscitation of critically ill patients remains controversial. The objective of this study was to assess the effect of continuing medical education (CME) on health care professionals' clinical decision making with regard to HSA administration and the costs of quality (COQ). A quasi-experimental study of time series association of CME intervention with COQ and use of HSA solution was conducted at the Surgery Department of the Hospital Valjevo, Serbia. The CME contained evidence-based criteria for HSA solution administration in surgical patients. The preintervention period was defined as January 2009 to May 2011. CME was provided in June 2011, with the postintervention period June 2011 to May 2012. METHODS: Total mortality rate, the rate of nonsurgical mortality, the rate of surgical mortality, the rate of sepsis patient mortality, index of irrational use of HSA solutions, and number of hospital days per hospitalized patient were collected for each month as quality indicators. Statistical analysis was performed by multivariate autoregressive integrated moving average (MARIMA) modeling. The specification of the COQ was performed according to a traditional COQ model. RESULTS: The CME intervention resulted in an average monthly reduction of the hospital days per hospitalized patient, the rate of sepsis patient mortality, index of irrational use of HSA solutions, and COQ for $593,890.77 per year. DISCUSSION: Didactic CME presenting evidence-based criteria for HSA administration was associated with improvements in clinical decisions and COQ. In addition, this study demonstrates that models combining MARIMA and traditional COQ models can be useful in the evaluation of CME interventions aimed at reducing COQ.
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Toma de Decisiones Clínicas , Ahorro de Costo , Educación Médica Continua , Calidad de la Atención de Salud/economía , Enfermedad Crítica , Medicina Basada en la Evidencia , Humanos , Cuerpo Médico de Hospitales/educación , Mejoramiento de la Calidad/economía , Resucitación/métodos , Serbia , Albúmina Sérica/administración & dosificación , Servicio de Cirugía en HospitalRESUMEN
INTRODUCTION: Over the last several years, during the economic crisis, the Ministry of Health and the Republican Health Insurance Fund (RHIF) have been faced with new challenges in the sphere of healthcare services financing both in the primary as well as other types of health insurance in the Republic of Serbia (RS). OBJECTIVE: Analysis of cost-effectiveness of two models of organization of home treatment and healthcare in the primary insurance, with evaluation of the cost sustainability of a single visit by the in-home therapy team. METHODS: Economic evaluation of the cost of home treatment and healthcare provision in 2011 was performed. In statistical analysis, the methods of descriptive statistics were employed. The structure of fixed costs of home healthcare was developed according to the RS official norms, as well as fixed costs of providing services of home therapy by the Healthcare Centre "New Belgrade". The statement of account for provided home therapy services was made utilizing the RHIF price list. RESULTS: The results showed that the cost of home healthcare and therapy of the heterogeneous population of patients in the Healthcare Centre "New Belgrade" was more cost-effective in relation to the cost of providing home therapy services according to the RS official norms. CONCLUSION: Approved costs utilized when making a contract for services of home therapy and healthcare with the RHIF are not financially sustainable. It was shown that the price of 10 EUR for each home visit by the in-home therapy team enables sustainability of this form of providing healthcare services in RS.
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Costos y Análisis de Costo , Servicios de Atención de Salud a Domicilio/economía , Análisis Costo-Beneficio , Servicios de Atención de Salud a Domicilio/organización & administración , Humanos , SerbiaRESUMEN
Abstract Introduction: Fatigue, anxiety and depression are very frequent symptoms in patients with rheumatoid arthritis (RA). Goals: In this study we evaluated the influence of socioeconomic characteristics, therapy and comorbidities on the self-reported high fatigue, anxiety and depression in patients with RA. Method: Multicenter cross-sectional study was performed in 22 health institutions in Serbia during the period from April-August 2014 in population of older RA patients. Self-reported patients health status was measured by: Fatigue Assessment Scale, Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7. Treatment modalities were defined as: (1) non-steroidal anti-inflammatory drugs (NSAIDs) and/or analgesics and/or corticosteroids; (2) synthetic disease-modifying antirheumatic drugs (DMARDs) alone or in combination with corticosteroids and/or NSAIDs and (3) any RA treatment which includes biologic DMARDs. Results: There were significant predictors of high depression: synthetic DMARDs therapy in combination with corticosteroids and/or NSAIDs, physiotherapist self-payment, frequent taxi use, alternative treatment and employment status. The need for another person's assistance, supplemental calcium therapy and professional qualifications were the predictors of a high fatigue, whereas the age above 65 years had the protective effect on it. Anxiety was an independent high fatigue predictor. The predictors of a high anxiety were: gastroprotection with proton-pump inhibitors and patient occupation. Conclusion Socioeconomic predictors of self-reported high depression, anxiety or fatigue are different for each of the mentioned outcomes, while accompanied with the basic RA treatment they exclusively explain a high depression. The anxiety, jointed with the socioeconomic variables and supplemental therapy, is a significant fatigue predictor in RA patients.
Resumo Introdução: A fadiga, a ansiedade e a depressão são sintomas muito frequentes em pacientes com artrite reumatoide (AR). Objetivos: Neste estudo, avaliou-se a influência de características socioeconômicas, características de tratamento e comorbidades na elevação na fadiga, ansiedade e depressão autorrelatadas em pacientes com AR. Método: Este estudo transversal multicêntrico foi feito em 22 instituições de saúde na Sérvia de abril a agosto de 2014 na população de pacientes idosos com AR. O status de saúde autorrelatado dos pacientes foi medido pelos instrumentos Fatigue Assessment Scale, Patient Health Questionnaire-9 e Generalized Anxiety Disorder-7. As modalidades de tratamento foram definidas como: 1) anti-inflamatórios não esteroides (AINE) e/ou analgésicos e/ou corticosteroides; 2) fármacos antirreumáticos modificadores da doença sintéticos (DMARD) isoladamente ou em combinação com corticosteroides e/ou AINE e 3) qualquer tratamento para a AR que incluísse DMARD biológicos. Resultados: Houve preditores significativos de depressão elevada: tratamento com DMARD sintéticos em combinação com corticosteroides e/ou AINE, pagamento particular de fisioterapia, uso frequente de serviços de táxi, terapias alternativas e status ocupacional. A necessidade de assistência de outra pessoa, o tratamento suplementar com cálcio e as qualificações profissionais foram os preditores de fadiga elevada. A idade acima de 65 anos teve um efeito protetor sobre a fadiga elevada. A ansiedade foi um preditor independente de fadiga elevada. Os preditores ansiedade elevada foram: gastroproteção com inibidores da bomba de prótons e ocupação do paciente. Conclusão: Os preditores socioeconômicos de níveis elevados de depressão, ansiedade ou fadiga autorrelatadas são diferentes para cada um dos desfechos mencionados; quando acompanhados do tratamento básico para a AR, esses preditores socioeconômicos explicam exclusivamente uma depressão elevada. A ansiedade, associada às variáveis socioeconômicas e ao tratamento complementar, é um importante preditor da fadiga em pacientes com AR.
Asunto(s)
Humanos , Masculino , Femenino , Anciano , Ansiedad/etiología , Artritis Reumatoide/psicología , Factores Socioeconómicos , Depresión/etiología , Fatiga/etiología , Ansiedad/psicología , Artritis Reumatoide/complicaciones , Artritis Reumatoide/tratamiento farmacológico , Calidad de Vida , Factores Biológicos/uso terapéutico , Antiinflamatorios no Esteroideos/uso terapéutico , Estudios Transversales , Corticoesteroides/uso terapéutico , Antirreumáticos/uso terapéutico , Depresión/psicología , Fatiga/psicología , Autoinforme , Persona de Mediana EdadRESUMEN
INTRODUCTION: Nurse/patient relationship as a complex interrelation or as an interaction of the factor patient and factor nurse has been a subject of a number of studies during the past ten years. Nurse/patient communication is a special entity, usually observed within a framework of the wider nurse/patient relationship. In that regard, we wanted to develop a standardized questionnaire that could reliably measure the quality of communication between nurse and patient, and be used by nurses. OBJECTIVES: The main goal of this study was to develop and evaluate construct validity of the Nurse Quality of Communication with Patient Questionnaire (NQCPQ), as well as to evaluate its reliability. The goal was also to establish a measure of inter-raters reliability, using two repeated measurements of results by items and scores of the NQCPQ, on the same observed units by two assessors. METHODS: The starting NQCPQ that consists of 25 items, was filled in by two groups of nurses. Each nurse was questioned during morning and afternoon shifts, in order to evaluate their communication with hospitalized patients, using marks from 1 to 6. To evaluate construct validity, we used the analysis of main components, while reliability was assessed using intraclass correlation coefficient and Cronbach-alpha coefficient. To evaluate interraters reliability, we used Pearson correlation coefficient. RESULTS: Using a group of 118 patients, we explained 86% of the unknown, regarding the investigated phenomenon (communication nurse/patient), using one component by which we separated 6 items of the questionnaire. Inter-item correlation (alpha) in this component was 0.96. Pearson correlation coefficient was highly significant, value 0.7 by item, and correlation coefficient for scores at repeated measurements was 0.84. CONCLUSION: NQCPQ is 6-item instrument with high construct validity. It can be used to measure quality of nurse/patient communication in a simple, fast and reliable way. It could contribute to more adequate research and defining of this problem, and as such could be used in studies of interaction of psychometric, clinical, biochemical, socio-cultural, demographic and other parameters as well.
Asunto(s)
Comunicación , Relaciones Enfermero-Paciente , Personal de Enfermería en Hospital , Encuestas y Cuestionarios , Femenino , Humanos , Masculino , Persona de Mediana EdadRESUMEN
The nature of mental disorders, the attitudes and prejudices of the social community towards psychiatric patients, the behavior and treatment of mental patients, all bring about numerous dilemmas and prejudices. When a patient is diagnosed with a mental disorder, he may suffer restrictions in the field of general human rights. However, the biggest problems in clinical practice occur in the treatment of patients who, besides their mental disorder also have a somatic disease. We report a 56-years-old female with a severe renal failure who refused to undergo dialysis. Following the patient's refusal to sign an informed consent, a psychiatrist was called in for consultation and diagnosed an acute psychotic reaction. To manage the delusions and acute psychotic reactions, risperidone in the dose of 2 mg was started. After 22 days, the patient still had marked psychotic symptoms. A psychiatrist, a nephrologist and an anesthesiologist, in the presence of the spouse on the grounds of her life-threatening condition, decided to apply the necessary medical procedures even without the patient's consent. A day after the start of dialysis the patient still had delusional ideas, but without the presence of anxiety, and the patient no longer offered resistance to dialysis. Four days after the first dialysis, the patient was calm, had vague memories about the entire previous period, and signed the informed consent concerning her further treatment.
Se generan muchos dilemas y prejuicios debido a la naturaleza de las enfermedades mentales. Cuando a un paciente se le diagnostica un cuadro mental, sus derechos humanos pueden verse perjudicados. Sin embargo, los mayores problemas se suscitan en pacientes que además de tener un trastorno mental, tienen una enfermedad somática. Presentamos una mujer de 56 años con una falla renal que rechazó ser dializada. Después que la paciente no firmó el consentimiento informado, se pidió una interconsulta a psiquiatría y se diagnosticó una reacción psicótica aguda. Se indicó risperidona para tratar las alucinaciones. Después de 22 días de tratamiento la paciente aún tenía síntomas psicóticos. Una junta médica efectuada en la presencia del cónyuge de la paciente, decidió efectuar la diálisis a pesar del rechazo de la paciente. Un día después de dializarse, la paciente aún tenía alucinaciones pero menos ansiedad y dejó de rechazar la diálisis. Cuatro días más tarde la paciente no recordaba lo ocurrido y firmó el consentimiento para dializarse.
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Femenino , Humanos , Persona de Mediana Edad , Consentimiento Informado , Diálisis Renal/psicología , Insuficiencia Renal/psicología , Trastornos de Ansiedad , Comorbilidad , Trastornos Mentales , Insuficiencia Renal/terapia , Negativa del Paciente al TratamientoRESUMEN
INTRODUCTION: The main causes of reduced glucose levels during metformin therapy appear to be an increase in insulin action in peripheral tissues and reduced hepatic glucose output due to inhibition gluconeogenesis. OBJECTIVE: The purpose of the study was to establish the effect of metformin on fasting and postprandial insulin secretion. METHOD: The study carried out was double blind, controlled, comparative, randomized, multicentric, including two groups of out-patient department (OPD) patients. 43 patients were administered metformin (Tefor ICN Canada), and 46 patients were given placebo. Patients enrolled in the study were newly diagnosed with diabetes mellitus (DM) type 2, glycaemia < 12 mmol/l, and had the Body Mass Index (BMI) > 30 kg/m2. Before treatment, blood biochemistry was done: fasting and postprandial glycaemia, glycosylated haemoglobin (HbA1c) value, fasting and postprandial insulinaemia, blood lipids (total cholesterol, total triglycerides, HDL cholesterol, and LDL cholesterol), and gamma glutaryl transferase (GGT) level. BMI was also established. After 42 days of treatment, fasting and postprandial insulinaemia were tested again. Analysis of the effects of therapy, and identification of co-variants for fasting and postprandial insulinaemia, were done by ANOVA two way and ANCOVA method. RESULTS: It was shown that metformin accompanied by diet, as compared to placebo accompanied by diet, lowered the fasting insulinaemia value during six weeks of therapy in obese patients with DM type 2 (24.392 mU/l vs. 25.667 mU/l), interacting both with BMI pre-therapy, and interacting with fasting insulinaemia pre-therapy (p < 0.001). A significant effect of the interaction of covariants BMI and GGT was defined. As for the effect of therapy on postprandial insulinaemia, it was found that there was a high statistical significance of the effect of BMI interacting with initial values for postprandial insulinaemia before therapy, and interacting with therapy (p < 0.01). Adjusted mean values for postprandial insulinaemia after therapy in the placebo group were lower as compared to the metformin group (44.807 mU/l vs. 47.114 mU/l). CONCLUSION: It can be concluded that, as compared to place- bo, metformin is more efficient in reducing insulin resistance in obese patients with DM type 2. In addition, as compared to placebo, metformin maintains more efficient productive insulin secretion, indicating that metformin protects the pancreas from beta cell depletion.
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Diabetes Mellitus Tipo 2/tratamiento farmacológico , Hipoglucemiantes/uso terapéutico , Insulina/metabolismo , Metformina/uso terapéutico , Periodo Posprandial , Diabetes Mellitus Tipo 2/sangre , Método Doble Ciego , Ayuno , Humanos , Secreción de InsulinaRESUMEN
INTRODUCTION: In a chain of cardiovascular episodes, risk factors (RF) and bad habits represent the first link. OBJECTIVE: The purpose of the study was to determine, during six months, on four examinations (the first, and three follow-ups after the second, fourth and sixth month), the following: physical activity (PA) alteration and the number of cigarettes smoked; the effect of antihypertensive beta-blockers and ACE inhibitors on systolic and diastolic arterial tension; the effect of metmorfin therapy on BMI, glycaemia, total cholesterol level (TCL) and triglycerides in diabetics compared to healthy individuals; the effect of hypolipidaemics on blood TCL and triglycerides in patients with angina pectoris (AP); the effect of betablocker therapy on TCL. METHOD: This was a multicentric interventional study. Secondary prevention of coronary disease and cerebrovascular conditions was applied in the first half of 2005. There were 185 general practitioners from 38 health centres in Serbia, and patients of both sexes were included with the verified diagnosis of coronary disease and/or cerebrovascular condition. They had demographic data verified as well as data of being genetically (non)predisposed for AP, hypertension, myocardial infarction, stroke and diabetes mellitus. Descriptive and differential statistical methods were used for study result analysis. RESULTS: Out of 1189 patients, there were 51.4% of women and 48.6% of men. The average age was 59.45 +/- 9.77 years. The population was homogeneous by sex and the factor of being genetically (non)predisposed for AP. There was a significant difference in examinations in four contacts in PA and cigarette smoking (p < 0.0001). Systolic and diastolic pressure, TCL and triglycerides were significantly decreased by medicaments (p < 0.05) and more significantly so associated with nonmedicamentous measures (p < 0.001). Metmorfin significantly decreased the glycaemic level (p < 0.001) both in diabetics and patients with a reduced tolerance level to glucose. In patients who took betablockers, there was lowering of TCL. CONCLUSION: Taking medicaments significantly lowers RF, and more significantly so when associated with a non-medicamentous therapy.
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Fármacos Cardiovasculares/uso terapéutico , Trastornos Cerebrovasculares/prevención & control , Enfermedad Coronaria/prevención & control , Agonistas Adrenérgicos beta/uso terapéutico , Anciano de 80 o más Años , Inhibidores de la Enzima Convertidora de Angiotensina/uso terapéutico , Complicaciones de la Diabetes , Femenino , Conductas Relacionadas con la Salud , Humanos , Inhibidores de Hidroximetilglutaril-CoA Reductasas/uso terapéutico , Hipoglucemiantes/uso terapéutico , Masculino , Metoprolol/uso terapéutico , Factores de RiesgoRESUMEN
INTRODUCTION: It is known that pentoxifylline is the only medicament to date which has been clinically proven to lead to nitrogen conversion in uremic patients. Positive results of application of pentoxifylline in prevention of systemic inflammatory response syndrome have also been published, as well as in prevention and treatment of the acute respiratory distress syndrome. OBJECTIVE: The goal of our study was to investigate the effect of four-day treatment with pentoxifylline in a dose of 300 mg dissolved in 500 ml of normal saline, administered as 20-hour intravenous infusion per day, on the conversion of nitrogen in 11 patients suffering from diabetic phlegmona of the foot, and with pathological values of urea and creatinine. METHOD: All patients had 3 repeated negative blood cultures, and at least one positive out of three wound swabs. Seven patients were insulin independent, and 4 insulin dependent. Before treatment, all patients had pathological findings of white blood cells, in the form of granulocytosis, with appearance of young cells. Patients were prescribed adequate antibiotics according to drug susceptibility test, and glycemia was monitored every 6 hours, with correction of diabetes therapy. Patient's dressings were changed once a day, while urea and creatinine were checked immediately before the onset of pentoxifylline therapy, as well as after four days of therapy. Statistical analysis was done using the McNemar test for linked sample. RESULTS: The results showed that pathological values of white blood cells persisted in all patients, and after four days of therapy, blood urea restored to normal in 9 patients (Z = -3; p = 0.003), and blood creatinine in 10 patients (Z = -3, 162; p = 0.002). There was no need to make corrections of diabetes therapy. CONCLUSION: It can be concluded that pentoxifylline can prevent further degradation of nitrogen in patients suffering from phlegmona of the foot, decreasing the catabolic effect of infection, most probably by inhibiting the effect of TNF-alpha, interleukin-1 and interleukin-6, without any significant effect on leukocytosis during four days of treatment.
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Celulitis (Flemón)/tratamiento farmacológico , Pie Diabético/tratamiento farmacológico , Nitrógeno/metabolismo , Pentoxifilina/administración & dosificación , Adulto , Celulitis (Flemón)/metabolismo , Creatinina/metabolismo , Pie Diabético/metabolismo , Femenino , Humanos , Infusiones Intravenosas , Masculino , Urea/metabolismoRESUMEN
INTRODUCTION: World Health Organization (WHO) Articles of Association defines health as the state of complete physical, mental and social well-being and not merely the absence of disease. According to this definition, the concept of health is enlarged and consists of public and personal needs, motives and psychological nature of a person, education, culture, tradition, religion, etc. All these needs do not have the same rank on life valuation scale. OBJECTIVE: The objective of our study was ranking 6 most important values of life out of 12 suggested. METHOD: Questionnaire about Life Valuation Scale was used as method in our study. This questionnaire was created by the Serbian Medical Association and Department of General Medicine, School of Medicine, University of Belgrade. It analyzed 10% of all citizens in 18 places in Serbia, aged from 25 to 64 years, including Belgrade commune Vozdovac. Survey was performed in health institutions and in citizens' residencies in 1995/96 by doctors, nurses and field nurses. RESULTS: A total of 14,801 citizens was questioned in Serbia (42.57% of men, 57.25% of women), and 852 citizens in Vozdovac commune (34.62% of men, 65.38% of women). People differently value things in their lives. On the basis of life values scoring, the most important thing in people's life was health. In Serbia, public rank of health was 4.79%, and 4.4% in Vozdovac commune. Relations in family were on the second place, and engagement in politics was on the last place. CONCLUSION: The results of our study in the whole Serbia and in Vozdovac commune do not differ significantly from each other, and all of them demonstrated that people attached the greatest importance to health on the scale of proposed values. Relationships in family were on the second place, and political activity was on the last place. High ranking of health and relationships in family generally shows that general practitioners in Serbia take important part in primary health care and promotion of health care management. They have responsibility to preserve and enhance health of a person, family and society as a whole.
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Calidad de Vida , Valores Sociales , Encuestas y Cuestionarios , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Satisfacción Personal , Psicometría , YugoslaviaRESUMEN
INTRODUCTION: Asthma is the chronic inflammatory disease of the airways, and the inhalation treatment is the most convenient way to deliver the medication directly to the airways. OBJECTIVE: The aim of our study was to evaluate the relationship between respiratory symptom scores in asthmatic outpatients and their satisfaction with inhaled asthma medication. METHOD: In 124 patients, (39 males; mean age 45 +/- 18 years; mean forced expiratory volume in one second (FEV) 71.8 +/- 23.4% predicted), respiratory symptoms were determined by 4-item questionnaire for most frequent asthma symptoms--cough, wheezing, dyspnea and chest tightness (all of them graded from 1--without symptoms, 2--mild, 3--moderate, and 4--severe symptoms), with overall score (from 4 to 16), as well as by scale for assessment of sinonasal symptoms--the 20-item sinonasal outcome test (SNOT-20) (in 65 out of 124 patients). SNOT-20 scores ranged from 0 to 5, where higher score indicated more manifested symptom. Patients' satisfaction was measured by standardized "Satisfaction with Inhaled Asthma Treatment Questionnaire" (SATQ), which scores were calculated for the overall satisfaction as well as for individual domains (effectiveness of treatment, easy application, medication burden, and side-effects and related worries). The bigger the score the better the satisfaction, and vice versa. RESULTS: The highest degree of correlation with overall satisfaction scores was found (using the Pearson's coefficient of linear correlation) for the scores of wheezing (r = -0.271; p = 0.002). SNOT-20 scores best correlated with side-effects and worries domain scores. CONCLUSION: The severity of respiratory symptoms in the asthmatics is strongly correlated with satisfaction with inhaled medication. Improving the asthmatic symptoms results in enhancement of their satisfaction with inhaled medication and compliance.