Detalles de la búsqueda
1.
A Phase II randomized controlled trial evaluated antithrombotic treatment with fesomersen in patients with kidney failure on hemodialysis.
Kidney Int
; 2024 Mar 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-38537676
2.
Longitudinal observations of TFPI levels in paediatric Haemophilia A patients.
Haemophilia
; 29(4): 1142-1149, 2023 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-37335569
3.
Associations between model-predicted rivaroxaban exposure and patient characteristics and efficacy and safety outcomes in the prevention of venous thromboembolism.
J Thromb Thrombolysis
; 50(1): 12-19, 2020 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-32323190
4.
Associations between model-predicted rivaroxaban exposure and patient characteristics and efficacy and safety outcomes in the treatment of venous thromboembolism.
J Thromb Thrombolysis
; 50(1): 1-11, 2020 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-32323191
5.
Associations between model-predicted rivaroxaban exposure and patient characteristics and efficacy and safety outcomes in patients with non-valvular atrial fibrillation.
J Thromb Thrombolysis
; 50(1): 20-29, 2020 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-32323192
6.
Pharmacokinetics of rivaroxaban in children using physiologically based and population pharmacokinetic modelling: an EINSTEIN-Jr phase I study.
Thromb J
; 16: 32, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-30534008
7.
Exploratory evaluation of pharmacodynamics, pharmacokinetics and safety of rivaroxaban in children and adolescents: an EINSTEIN-Jr phase I study.
Thromb J
; 16: 31, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-30534007
8.
A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim.
J Pharmacokinet Pharmacodyn
; 45(2): 235-257, 2018 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29234936
9.
Evaluation of changes in oral drug absorption in preterm and term neonates for Biopharmaceutics Classification System (BCS) class I and II compounds.
Br J Clin Pharmacol
; 81(1): 137-47, 2016 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-26302359
10.
Modeling and Simulation of In Vivo Drug Effects.
Handb Exp Pharmacol
; 232: 313-29, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-26578524
11.
Pharmacokinetics, pharmacodynamics, and safety of fesomersen, a novel antisense inhibitor of factor XI, in healthy Chinese, Japanese, and Caucasian volunteers.
Clin Transl Sci
; 17(4): e13784, 2024 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-38563414
12.
The Importance of Assessing Drug Pharmacokinetics and Pharmacodynamics in the Obese Population During Drug Development.
J Clin Pharmacol
; 63 Suppl 2: S78-S84, 2023 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-37942912
13.
Population pharmacokinetics of riociguat in a pediatric population (aged ≥ 6 years) with pulmonary arterial hypertension.
Pediatr Pulmonol
; 58(3): 908-917, 2023 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-36507572
14.
Prediction of a potentially effective dose in humans for BAY 60-5521, a potent inhibitor of cholesteryl ester transfer protein (CETP) by allometric species scaling and combined pharmacodynamic and physiologically-based pharmacokinetic modelling.
Br J Clin Pharmacol
; 73(2): 219-31, 2012 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-21762205
15.
First dose in children: physiological insights into pharmacokinetic scaling approaches and their implications in paediatric drug development.
J Pharmacokinet Pharmacodyn
; 39(2): 195-203, 2012 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-22311388
16.
Nifurtimox for Treatment of Chagas Disease in Pediatric Patients: the Challenges of Applying Pharmacokinetic-Pharmacodynamic Principles to Dose Finding.
AAPS J
; 24(5): 92, 2022 08 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-36002604
17.
Population Pharmacokinetics of Nifurtimox in Adult and Pediatric Patients With Chagas Disease.
J Clin Pharmacol
; 62(10): 1273-1284, 2022 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-35460577
18.
Model-informed bridging of rivaroxaban doses for thromboprophylaxis in pediatric patients aged 9 years and older with congenital heart disease.
CPT Pharmacometrics Syst Pharmacol
; 11(8): 1111-1121, 2022 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35665486
19.
Dosing Regimen Prediction and Confirmation With Rivaroxaban for Thromboprophylaxis in Children After the Fontan Procedure: Insights From the Phase III UNIVERSE Study.
J Clin Pharmacol
; 62(2): 220-231, 2022 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34524700
20.
Anticoagulation in pediatric cancer-associated venous thromboembolism: a subgroup analysis of EINSTEIN-Jr.
Blood Adv
; 6(22): 5821-5828, 2022 11 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-36006613