RESUMEN
Yellow KK mice carrying the 'yellow obese' gene Ay are a well established polygenic model for human non-insulin dependent diabetes mellitus. These animals develop marked adiposity and decreased glucose tolerance relative to their control littermates, KK mice. The authors monitored glucose tolerance in KK-Ay mice over time and observed a significant (PAsunto(s)
Diabetes Mellitus Tipo 2/metabolismo
, Modelos Animales de Enfermedad
, Glucosa/metabolismo
, Insulina/metabolismo
, Ratones/metabolismo
, Factores de Edad
, Amiloide/sangre
, Animales
, Glucagón/sangre
, Péptido 1 Similar al Glucagón/sangre
, Glucosa/análisis
, Insulina/sangre
, Polipéptido Amiloide de los Islotes Pancreáticos
, Leptina/sangre
, Masculino
, Ratones Endogámicos ICR