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We report an extensive experimental investigation on the transition from flat-band localization (FBL) to Anderson localization (AL) in a one-dimensional synthetic lattice in the momentum dimension. By driving multiple Bragg processes between designated momentum states, an effective one-dimensional Tasaki lattice is implemented with highly tunable parameters, including nearest-neighbor and next-nearest-neighbor coupling coefficients and onsite energy potentials. With that, a flat-band localization phase is realized and demonstrated via the evolution dynamics of the particle population over different momentum states. The localization effect is undermined when a moderate disorder is introduced to the onsite potential and restored under a strong disorder. We find clear signatures of the FBL-AL transition in the density profile evolution, the inverse participation ratio, and the von Neumann entropy, where good agreement is obtained with theoretical predictions.
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The oxygen evolution reaction (OER) has significant effects on the water-splitting process and rechargeable metal-air batteries; however, the sluggish reaction kinetics caused by the four-electron transfer process for transition metal catalysts hinder large-scale commercialization in highly efficient electrochemical energy conversion devices. Herein, a magnetic heating-assisted enhancement design for low-cost carbonized wood with high OER activity is proposed, in which Ni nanoparticles are encapsulated in amorphous NiFe hydroxide nanosheets (a-NiFe@Ni-CW) via direct calcination and electroplating. The introduction of amorphous NiFe hydroxide nanosheets optimizes the electronic structure of a-NiFe@Ni-CW, accelerating electron transfer and reducing the energy barrier in the OER. More importantly, the Ni nanoparticles located on carbonized wood can function as magnetic heating centers under the effect of an alternating current (AC) magnetic field, further promoting the adsorption of reaction intermediates. Consequently, a-NiFe@Ni-CW demonstrated an overpotential of 268 mV at 100 mA cm-2 for the OER under an AC magnetic field, which is superior to that of most reported transition metal catalysts. Starting with sustainable and abundant wood, this work provides a reference for highly effective and low-cost electrocatalyst design with the assistance of a magnetic field.
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PURPOSE: Complications in facial plastic surgery can lead to pain, suffering, and permanent harm. Yet, the etiology and outcomes of adverse events are understudied. This study aims to determine the etiology and outcomes of adverse events reported in aesthetic facial plastic surgery and identify quality improvement opportunities. MATERIAL AND METHODS: A cross-sectional survey analysis was conducted using an anonymous 22-item questionnaire distributed to members of the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) and American Academy of Facial Plastic and Reconstructive Surgery (AAFPRS). Participants were queried on demographics, practice type, and adverse events related to aesthetic facial surgeries. RESULTS: Two hundred fifty-three individuals participated; nearly half of respondents (49.0%) held membership in both AAO-HNS and AAFPRS. Of these, 40.8% of respondents reported at least one adverse event within the past 12 months of practice. A total of 194 adverse events were reported, most commonly related to facelift (n = 59/194, 30.4%), rhinoplasty (n = 55/194, 28.4%), and injection procedures (n = 38/194, 19.6%), with hematoma or seroma being the most commonly described. Most adverse events were self-limited, but approximately 68% resulted in further procedures. Surgeon error or poor judgement (n = 42) and patient non-adherence (n = 18) were the most commonly ascribed reasons for adverse events; 37.1% of participants reported a change in clinical practice after the incident. CONCLUSIONS: Adverse events were not infrequent in facial plastic surgery. Understanding these adverse events can provide impetus for tracking outcomes, standardization, and engagement with lifelong learning, self-assessment, and evaluation of practice performance.
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Cara/cirugía , Mejoramiento de la Calidad , Calidad de la Atención de Salud , Autoevaluación (Psicología) , Cirujanos/psicología , Cirugía Plástica/efectos adversos , Estudios Transversales , Femenino , Humanos , Aprendizaje , Masculino , Seguridad del Paciente , Complicaciones Posoperatorias , Pautas de la Práctica en Medicina , Encuestas y Cuestionarios , Estados UnidosRESUMEN
Successful management of lip and perioral trauma requires a nuanced understanding of anatomy and surgical techniques. Surgical correction is particularly challenging in instances of tissue loss, due to a narrow tolerance for aesthetic deformity and highly specialized functions of the perioral region, including facial expression, communication, and oral competence. Restoring continuity of the orbicularis oris musculature is critical for dynamic sphincter function of the upper and lower lips. Lip and perioral tissue symmetry are also critical for aesthetic balance, and failure to restore a natural appearance can adversely affect personal identity, with attendant psychological trauma. This discussion of lip and perioral trauma management encompasses lip and perioral anatomy, evaluation of injuries, reconstructive techniques, and prevention and management of complications. Perioral injuries are classified by size, depth, and extent of injury, and the corresponding reconstructive approaches are a function of complexity. These approaches proceed sequentially up rungs of the reconstructive ladder including primary repair, local flaps, grafting, regional flaps, as well as microvascular free tissue transfers. Procedures may be single stage or require multiple stages or subsequent refinement. Regardless of the defect size or location, the guiding principle of repair in the perioral region is restoring natural function and aesthetic appearance. This still-evolving area of facial plastic and reconstructive surgery lends itself to artistry and technical precision, offering opportunities for further innovation to improve the outcomes of patients with lip and perioral trauma.
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Neoplasias de los Labios , Procedimientos de Cirugía Plástica , Estética Dental , Músculos Faciales/cirugía , Humanos , Labio/cirugía , Neoplasias de los Labios/cirugía , Colgajos QuirúrgicosRESUMEN
To achieve rapid and highly efficient recovery of Li+ from seawater, a series of H2TiO3/cellulose aerogels (HTO/CA) with a porous network were prepared by a simple and effective method. The as-prepared HTO/CA were characterized and their Li+ adsorption performance was evaluated. The obtained results revealed that the maximum capacity of HTO/CA to adsorb Li+ was 28.58 ± 0.71 mg g-1. The dynamic k2 value indicated that the Li+ adsorption rate of HTO/CA was nearly five times that of HTO powder. Furthermore, the aerogel retained extremely high Li+ selectivity compared with Mg2+, Ca2+, K+, and Na+. After regeneration for five cycles, the HTO/CA retained a Li+ adsorption capacity of 22.95 mg g-1. Moreover, the HTO/CA showed an excellent adsorption efficiency of 69.93% ± 0.04% and high selectivity to Li+ in actual seawater. These findings confirm its potential as an adsorbent for recovering Li+ from seawater.
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Variability in the apparent CO2 fixation yield of four aerobic sulfur-oxidizing bacteria (Halothiobacillus neapolitanus DSM 15147, Thiobacillus thioparus DSM 505, Thiomonas intermedia DSM 18155, and Starkeya novella DSM 506) in autotrophic culturing was studied, and mutual effects of key intrinsic factors on CO2 fixation were explored. DSM 15147 and DSM 505 exhibited much higher CO2 fixation yields than DSM 18155 and DSM 506. The differences in CO2 fixation yield were determined not only by cbb gene transcription, but also by cell synthesis rate, which was determined by rRNA gene copy number; the rRNA gene copy number had a more significant effect than cbb gene transcription on the apparent CO2 fixation yield. Moreover, accumulation of EDOC was observed in all four strains during chemoautotrophic cultivation, and the proportion of EDOC accounting for total fixed organic carbon (TOC; EDOC/TOC ratio) was much higher in DSM 18155 and DSM 506 than in DSM 15147 and DSM 505. The accumulation of EDOC led to a significant decrease in the cbb gene transcription efficiency during cultivation, and a further feedback inhibitory effect on CO2 fixation.
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Dióxido de Carbono , Azufre , Alphaproteobacteria , Bacterias , Burkholderiales , Oxidación-ReducciónRESUMEN
An efficient strategy for carbazoles and 1,2,4-triarylpyrroles synthesis from anilines and cyclohexanones or acetophenones under transition-metal-free conditions is developed. A variety of disubstituted 9-arylcarbazoles were synthesized in moderate to good yields promoted by KI/I2 using anilines as the nitrogen and aryl source. Meanwhile, a variety of 1,2,4-triarylpyrroles were also selectively synthesized from anilines and acetophenones in the presence of KI alone.
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BACKGROUND: Difficult airway cases can quickly become emergencies, increasing the risk of life-threatening complications or death. Emergency airway management outside the operating room is particularly challenging. METHODS: We developed a quality improvement program-the Difficult Airway Response Team (DART)-to improve emergency airway management outside the operating room. DART was implemented by a team of anesthesiologists, otolaryngologists, trauma surgeons, emergency medicine physicians, and risk managers in 2005 at The Johns Hopkins Hospital in Baltimore, Maryland. The DART program had 3 core components: operations, safety, and education. The operations component focused on developing a multidisciplinary difficult airway response team, standardizing the emergency response process, and deploying difficult airway equipment carts throughout the hospital. The safety component focused on real-time monitoring of DART activations and learning from past DART events to continuously improve system-level performance. This objective entailed monitoring the paging system, reporting difficult airway events and DART activations to a Web-based registry, and using in situ simulations to identify and mitigate defects in the emergency airway management process. The educational component included development of a multispecialty difficult airway curriculum encompassing case-based lectures, simulation, and team building/communication to ensure consistency of care. Educational materials were also developed for non-DART staff and patients to inform them about the needs of patients with difficult airways and ensure continuity of care with other providers after discharge. RESULTS: Between July 2008 and June 2013, DART managed 360 adult difficult airway events comprising 8% of all code activations. Predisposing patient factors included body mass index >40, history of head and neck tumor, prior difficult intubation, cervical spine injury, airway edema, airway bleeding, and previous or current tracheostomy. Twenty-three patients (6%) required emergent surgical airways. Sixty-two patients (17%) were stabilized and transported to the operating room for definitive airway management. There were no airway management-related deaths, sentinel events, or malpractice claims in adult patients managed by DART. Five in situ simulations conducted in the first program year improved DART's teamwork, communication, and response times and increased the functionality of the difficult airway carts. Over the 5-year period, we conducted 18 airway courses, through which >200 providers were trained. CONCLUSIONS: DART is a comprehensive program for improving difficult airway management. Future studies will examine the comparative effectiveness of the DART program and evaluate how DART has impacted patient outcomes, operational efficiency, and costs of care.
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Servicio de Urgencia en Hospital/normas , Intubación Intratraqueal/normas , Evaluación de Procesos y Resultados en Atención de Salud/normas , Grupo de Atención al Paciente/normas , Mejoramiento de la Calidad/normas , Indicadores de Calidad de la Atención de Salud/normas , Adulto , Anciano , Baltimore , Conducta Cooperativa , Análisis Costo-Beneficio , Urgencias Médicas , Servicio de Urgencia en Hospital/economía , Servicio de Urgencia en Hospital/organización & administración , Femenino , Costos de Hospital , Humanos , Capacitación en Servicio , Comunicación Interdisciplinaria , Intubación Intratraqueal/efectos adversos , Intubación Intratraqueal/economía , Intubación Intratraqueal/mortalidad , Masculino , Persona de Mediana Edad , Evaluación de Procesos y Resultados en Atención de Salud/economía , Evaluación de Procesos y Resultados en Atención de Salud/organización & administración , Grupo de Atención al Paciente/economía , Grupo de Atención al Paciente/organización & administración , Desarrollo de Programa , Evaluación de Programas y Proyectos de Salud , Mejoramiento de la Calidad/economía , Indicadores de Calidad de la Atención de Salud/economía , Medición de Riesgo , Factores de Riesgo , Factores de TiempoRESUMEN
Advocating green, nature, environmental protection, safety and the pursuit of efficacy are the trends of cosmetics in the world. In recent years, more and more Chinese herbal extracts with mild, high safety and small irritation are applied to cosmetics as the natural additives. This has become a new hot spot. The recent application advances of Chinese medicine raw materials in cosmetics are overviewed according to their main functions. This review will provide useful references for the future development and application of Chinese medicinal herbs cosmetics.
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Cosméticos/análisis , Medicamentos Herbarios Chinos/análisis , Animales , Investigación Biomédica/tendencias , Seguridad de Productos para el Consumidor , HumanosRESUMEN
As an important part of traditional Chinese medicine (TCM), mineral medicine plays an irreplaceable role. However, little has been reported on its species and valence state of heavy metals and deleterious elements, and also the relevance to pharmacological effect and toxicology. The present paper, in a new perspective, summarized the determination of the species and valence state of heavy metals and deleterious elements in recent years, discussed the progress of the pharmacological effect and toxicology, and prospected for future study which might provide reference for mineral medicine.
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Contaminación de Medicamentos , Medicina Tradicional China , Metales Pesados/análisis , Minerales/análisis , Animales , Contaminación de Medicamentos/estadística & datos numéricos , Quimioterapia , Humanos , Metales Pesados/toxicidad , Minerales/farmacologíaRESUMEN
Magnolia lotungensis is an extremely endangered endemic tree in China. To elucidate the genetic basis of M. lotungensis, we performed a comprehensive transcriptome analysis using a sample integrating the plant's bark, leaves, and flowers. De novo transcriptome assembly yielded 177,046 transcripts and 42,518 coding sequences. Notably, we identified 796 species-specific genes enriched in organelle gene regulation and defense responses. A codon usage bias analysis revealed that mutation bias appears to be the primary driver of selection in shaping the species' genetic architecture. An evolutionary analysis based on dN/dS values of paralogous and orthologous gene pairs indicated a predominance of purifying selection, suggesting strong evolutionary constraints on most genes. A comparative transcriptomic analysis with Magnolia sinica identified approximately 1000 ultra-conserved genes, enriched in essential cellular processes such as transcriptional regulation, protein synthesis, and genome stability. Interestingly, only a limited number of 511 rapidly evolving genes under positive selection were detected compared to M. sinica and Magnolia kuangsiensis. These genes were enriched in metabolic processes associated with adaptation to specific environments, potentially limiting the species' ability to expand its range. Our findings contribute to understanding the genetic architecture of M. lotungensis and suggest that an insufficient number of adaptive genes contribute to its endangered status.
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Especies en Peligro de Extinción , Evolución Molecular , Magnolia , Transcriptoma , Magnolia/genética , Transcriptoma/genética , Regulación de la Expresión Génica de las Plantas , Perfilación de la Expresión Génica/métodos , Selección Genética , Adaptación Fisiológica/genética , ChinaRESUMEN
OBJECTIVE: Hysteroscopic surgery will stimulate the autonomic nerves innervating the uterus, causing intense discomfort and pain in the examined person, and in severe cases, it will cause blood pressure drop, heart rate slowing, arrhythmia and even cardiac arrest, so most patients need anesthetic intervention. This study to retrospectively compare the anesthetic effect of remimazolam and propofol in minimally invasive painless hysteroscopic surgery and to explore the safety and efficacy of remimazolam. METHODS: The clinical data of 110 female patients who underwent painless hysteroscopic minimally invasive surgery in our hospital from January 2023 to June 2023 were collected. The patients were divided into the remimazolam group (group R, n = 55) and the propofol group (group P, n = 55) according to the main anesthetic drugs used during the operation. The changes in heart rate (HR), mean arterial pressure (MAP), blood oxygen saturation (SpO2), and respiratory rate (RR) at the time of entry (T0), modified vigilance/sedation score (MOAA/S) 0 (T1), cervical dilation (T2), end of the operation (T3) and anesthesia recovery (T4) were compared between the two groups. Anesthesia induction time, operation time, and anesthesia recovery time were compared between the two groups, and the incidence of intraoperative and postoperative adverse reactions was compared between the two groups. RESULTS: HR, MAP, and SpO2 in group R were significantly higher than those in group P at T1, T2, T3, and T4 (p < 0.05), and there was no significant difference in RR between the two groups (p > 0.05). HR, MAP, and SpO2 at T1 and T2 were significantly lower than those at T0 in group R (p < 0.05), and RR at different time points in the group had no significant difference (p > 0.05). HR, MAP, and SpO2 at T1, T2, T3, and T4 were significantly lower than those at T0 in group P (p < 0.01), and RR at different time points in the same group had no significant difference (p > 0.05). The anesthesia induction time in group R was more prolonged than in group P, and the anesthesia recovery time in group R was shorter than in group P (p < 0.05). The incidences of hypotension, bradycardia, low oxygen saturation, respiratory depression, and injection pain in group R were significantly lower than those in group P (p < 0.05). CONCLUSION: Intravenous induction of remimazolam at 6 mg·kg-1·h-1 and maintenance of anesthesia at 1-2 mg·kg-1·h-1 have less effect on hemodynamics, faster recovery time and lower incidence of adverse reactions compared with propofol when used in minimally invasive hysteroscopic surgery. Remimazolam can be safely and effectively used in this kind of surgery.
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Benzodiazepinas , Histeroscopía , Propofol , Humanos , Femenino , Histeroscopía/métodos , Propofol/administración & dosificación , Estudios Retrospectivos , Adulto , Periodo de Recuperación de la Anestesia , Persona de Mediana Edad , Anestésicos Intravenosos , Frecuencia Cardíaca/efectos de los fármacos , Tempo Operativo , Procedimientos Quirúrgicos Mínimamente Invasivos/métodosRESUMEN
Developing bio-based sustainable wood adhesives is significant as a substitute for petroleum-derived adhesives. However, the existing bio-based adhesives have disadvantages of complex fabrication, uncontrollable viscosity, and poor water resistance. Herein, we developed a citric acid/chitosan adhesive with viscosity-controlled and water-resistant features by one-step dissolution at room temperature based on the supramolecular self-assembly strategy. Different wood products (plywood, laminated veneer lumber and particleboard) with superior performance were prepared by applying that adhesive on veneer and wood particles (fine and rough particles). The plywood test results showed that the citric acid/chitosan adhesive had dry and wet shear strengths outperforming the China National Standard (GB/T 9846-2015, ≥0.7 MPa), reaching 2.1 and 1.1 MPa, respectively. The adhesion mechanism was mechanical interlocks and cross-linking of citric acid/chitosan in adhesives with those in the cell wall. This work provides high promise for alternatives to traditional unsustainable wood adhesives (urea-formaldehyde, melamine-urea-formaldehyde and phenolic resins) for fabricating different wood products.
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Metal-organic frameworks (MOFs) are characterised by high porosity levels and controllable structures, making them ideal adsorbents for wastewater. However, obtaining substrate materials with mechanical stability, excellent pore accessibility, and good processability for compositing MOF crystal powders to adsorb multiple pollutants in complex aqueous environments is challenging. In this study, porous MOFs@ modified cellulose sponge (MCS) composites were fabricated using MCS as a scaffold to provide anchoring sites for the coordination of Zr4+ ions and further in situ synthesis of MOFs, namely UiO-66@MCS and UiO-66-NH2@MCS, which effectively removed heavy metal ions and organic dyes. MOFs@MCS composites exhibit excellent water and dimensional stability, maintaining the pore structure by ambient drying during reuse. Compared with UiO-66@MCS composite, UiO-66-NH2@MCS composite exhibited a higher adsorption capacity of 224.5 mg·g-1 for Hg2+ and 400.9 mg·g-1 for methylene blue (MB). The adsorption of Hg2+ onto the MOFs@MCS composites followed the Langmuir and pseudo-second-order models, whereas the Freundlich and pseudo-second-order models were more suitable for MB adsorption. Moreover, the MOFs@MCS composites exhibited excellent reusability and were selective for the removal of Hg2+. Overall, this approach effectively combines Zr-based MOFs with mechanically and dimensionally stable porous cellulose sponges, rendering the approach suitable for purifying complex wastewater.
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Light-driven active ion transport discovered in nanomaterials (e.g., graphene, metal-organic framework, and MXene) implicates crucial applications in membrane-based technology and energy conversion systems. However, it remains a challenge to achieve bulk assembly. Herein, we employ the scalable wood as a framework for in situ growth of MoS2 nanosheets to facilitate light-responsive ion transport. Owing to the aligned and negatively charged wood nanochannels, the MoS2-decorated wood exhibits an excellent nanofluidic conductivity of 8.3 × 10-5 S cm-1 in 1 × 10-6 M KCl. Asymmetric light illumination creates the separation of electrons and holes in MoS2 nanosheets, enabling ions to move uphill against a wide range of concentration gradients. As a result, the MoS2-decorated wood can pump ions uphill against a 20-fold concentration gradient at a light intensity of 300 mW cm-2. When the illumination is applied to the opposite side, the osmotic current along the 20-fold concentration gradient can be enhanced to 75.1 nA, and the corresponding osmotic energy conversion power density increases to more than 12.6 times that of the nonilluminated state. Based on the light-responsive behaviors, we are extending the use of MoS2-decorated wood as the ionic elements for nanofluidic circuits, such as ion switches, ion diodes, and ion transistors. This work provides a facile and scalable strategy for fabricating light-controlled nanofluidic devices from biomass materials.
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Radiological science and nuclear technology have made great strides in the twenty-first century, with wide-ranging applications in various fields, including energy, medicine, and industry. However, those developments have been accompanied by the inherent risks of exposure to nuclear radiation, which is a source of concern owing to its potentially adverse effects on human health and safety and which is of particular relevance to medical personnel who may be exposed to certain cancers associated with low-dose radiation in their working environment. While medical radiation workers have seen a decrease in their occupational exposure since the 1950s thanks to improved measures for radiation protection, a concerning lack of understanding and awareness persists among medical professionals regarding these potential hazards and the required safety precautions. This issue is further compounded by insufficient capabilities in emergency response. This highlights the urgent need to strengthen radiation safety education and training to ensure the well-being of medical staff who play a critical role in radiological and nuclear emergencies. This review examines the health hazards of nuclear radiation to healthcare workers and the awareness and willingness and education of healthcare workers on radiation protection, calling for improved training programs and emergency response skills to mitigate the risks of radiation exposure in the occupational environment, providing a catalyst for future enhancement of radiation safety protocols and fostering of a culture of safety in the medical community.
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Personal de Salud , Exposición Profesional , Protección Radiológica , Humanos , Exposición Profesional/prevención & control , Liberación de Radiactividad Peligrosa , Traumatismos por Radiación/prevención & control , Conocimientos, Actitudes y Práctica en Salud , ConcienciaciónRESUMEN
Constructing a crystalline-amorphous hybrid structure is an effective strategy to overcome the conflict between the strength and toughness of materials. However, achieving such a material structure often involves complex, energy-intensive processing. Here, we leverage the natural wood featuring coexisting crystalline and amorphous regions to achieve superstrong and ultratough wood paper (W-paper) via a dual-phase nanostructure regulation strategy. After partially removing amorphous hemicellulose and eliminating most lignin, the treated wood can self-densify through an energy-efficient air drying, resulting in a W-paper with high tensile strength, toughness, and folding endurance. Coarse-grained molecular dynamics simulations reveal the underlying deformation mechanism of the crystalline and amorphous regions inside cell walls and the failure mechanism of the W-paper under tension. Life cycle assessment reveals that W-paper shows a lower environmental impact than commercial paper and common plastics. This dual-phase nanostructure regulation based on natural wood may provide valuable insights for developing high-performance and sustainable film materials.
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Grafting thermo-responsive polymers onto cellulose nanocrystals (CNCs) and achieving critical temperature regulation has drawn significant research interest. The thermal transition behavior of CNCs can be controlled by adjusting the polymer molecular brushes on the CNCs surface. We synthesized poly((2-dimethylamino) ethyl methacrylate) (PDMAEMA) grafted CNCs via surface-initiated reversible addition-fragmentation chain transfer, followed by modifying PDMAEMA brushes into poly-3-dimethyl(methacryloyloxyethyl) ammonium propane sulfonate (PDMAPS) brushes via quaternization. The critical temperature was regulated by modifying and grafting of poly (ethylene glycol) methacrylate. Found the thermal stimulus-responsive type and transition point of CNCs can be controlled by adjusting the surface molecular brushes. Ultraviolet-visible spectroscopy and dynamic light scattering analyses indicated that CNC-PDMAEMA aggregated above 70 °C, whereas CNC-PDMAPS aggregated below 31 °C. The thermo-responsive materials based on CNCs exhibited a conversion from a lower critical aggregation temperature to an upper critical aggregation temperature (UCAT) type. CNC-PDMAPS-mPEG was obtained by modifying and grafting for UCAT to be regulated to approximately 37 °C, which is close to the human body temperature. CNC-PDMAPS and CNC-PDMAPS-mPEG exhibited only microscopic alterations and could encapsulate and release substances. Therefore, they demonstrate considerable potential for biomedical applications.
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Celulosa , Nanopartículas , Temperatura , Celulosa/química , Nanopartículas/química , Metacrilatos/química , Nylons/química , Polietilenglicoles/químicaRESUMEN
Deep vein thrombosis (DVT) is a life-threatening condition that can lead to its sequelae pulmonary embolism (PE) or post-thrombotic syndrome (PTS). Murine models of DVT are frequently used in early-stage disease research and to assess potential therapies. This creates the need for the reliable and easy quantification of blood clots. In this paper, we present a novel high-frequency 3D ultrasound approach for the quantitative evaluation of the volume of DVT in an in vitro model and an in vivo murine model. The proposed method involves the use of a high-resolution ultrasound acquisition system and semiautomatic segmentation of the clot. The measured 3D volume of blood clots was validated to be correlated with in vitro blood clot weights with an R2 of 0.89. Additionally, the method was confirmed with an R2 of 0.91 in the in vivo mouse model with a cylindrical volume from macroscopic measurement. We anticipate that the proposed method will be useful in pharmacological or therapeutic studies in murine models of DVT.
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Background: Chlamydia psittaci infections primarily cause damage to the lungs but may also affect the cardiovascular system, gastrointestinal tract, liver, kidney, and brain, resulting in a variety of extrapulmonary complications. However, reports regarding C. psittaci infection-associated pancreatitis are rare. In this report, a patient with C. psittaci pneumonia complicated by acute pancreatitis is presented. Case description: The patient presented with acute upper abdominal pain and developed severe pyrexia and dyspnoea one day later. A chest computed tomography image revealed patchy consolidation in the left lung. The disease progressed rapidly, and the patient exhibited liver and kidney damage and type 1 respiratory failure within a short period of time. Metagenomic next-generation sequencing of alveolar lavage fluid revealed the presence of C. psittaci. The patient was administered doxycycline and moxifloxacin, after which the patient's abdominal pain and lung infection significantly resolved. Conclusion: This case report demonstrates that extrapulmonary C. psittaci infections due to secondary acute pancreatitis can manifest as abdominal pain, although the exact mechanisms of C. psittaci caused by acute pancreatitis remain unclear. Timely diagnoses and treatments of such infections are necessary to achieve favorable clinical outcomes.