Borderline Metal Centers on Nonporous Metal-Organic Framework Nanowire Boost Fast Li-Ion Interfacial Transport of Composite Polymer Electrolyte.

Metal-organic frameworks (MOFs) fillers are emerging for composite polymer electrolytes (CPEs). Enhancing Lewis acid-base interaction (LABI) among MOFs, polymer and Li-salt is expected to promote Li+ -transport. However, it is unclear how to customize a strong LABI interface. The large surface-area of classical MOFs also interferes with clarifying the LABI influence on Li+ -transport. Herein, Bi3+ as metal centers to design colloidal-dispersed nonporous MOFs (Bi/HMT-MOFs) nanowire with a surface-area of only 17.13 m2 g-1 to prepare polyethylene oxide (PEO)-based CPEs (BMCPE) is chosen. The nonporous feature can exclude the surface-area effect on Li+ -transport. More interestingly, Bi3+ is a typical borderline acid, which can interact with both hard-basic PEO and soft-basic Li-salt anion. Accordingly, Bi/HMT-MOFs are uniformly dispersed in the BMCPE to form a strong LABI interface with PEO and Li-salt, promoting Li-salt dissociation and providing rapid Li+ -transport channels. Despite the ultralow surface-area of Bi/HMT-MOFs, BMCPE exhibits significantly enhanced ion-conductivity and Li+ transference number, which completely rival traditional MOFs-filled CPEs. BMCPE also enables symmetric and full cells with excellent high-rate performance and long-term cycling stability. In contrast, when Bi3+ sites are obscured, electrochemical performances are obviously decreased. Therefore, employing borderline metal centers will be an effective strategy to construct a LABI interface for high-performance MOFs-filled CPEs.

Na Storage Activity or Inertness of P-Configurations in N, P Dual-Doped Carbon Nanofibers: Bulk vs Surface.

Heteroatom doping is an effective method to improve the electrochemical properties of hard carbon anodes for sodium-ion batteries. However, the different roles of surface and bulk heteroatoms in Na storage have not been explored much. Herein, N, P dual-doped carbon nanofibers (NP-CNFs) with high doping contents and low surface area are designed to clarify the above issue. It is confirmed that P plays a more crucial role in Na storage compared with N. In addition, surface and bulk P not only possess different configurations but also show distinct Na storage activity. There are only oxidized POx groups on the surface, which are inactive for Na storage but promote the stability of electrochemistry interphase, while in the bulk phase, unoxidized P-C bonds also emerge except POx, which shows preeminently reversible Na storage activity, and the POx groups are activated simultaneously. Furthermore, P-doping changes the reactivity of N-configurations with Na both on the surface and in the bulk phase, exhibiting interesting synergism. As expected, the surface stability, bulk activity, and synergism enable NP-CNFs to achieve superior performance. It could deliver a prominent capacity of 105.6 mAh g-1 at 10 A g-1 after 3000 cycles in half cells and 164.3 mAh g-1 at 1 A g-1 after 200 cycles in full cells.

miR-223-3p contributes to suppressing NLRP3 inflammasome activation in Streptococcus equi ssp. zooepidemicus infection.

Streptococcus equi subsp. zooepidemicus (SEZ) is an essential pathogen in a range of species, causing a worldwide variety of diseases, such as meningitis, endocarditis, and septicaemia. Studies have shown that microRNAs (miRNAs), which regulate target genes at the post-transcriptional level, play an important regulatory role in the organism. In this study, the infection of J774A.1 murine macrophages with SEZ up-regulated NLRP3 inflammasome and downstream pathways accompanied by miR-223-3p down-regulation. Through computational prediction and experimental confirmation, we have shown that miR-223-3p directly targets the NLRP3 mRNA. Consequently, overexpression of miR-223-3p suppressed NLRP3 inflammasome activation and downstream pathways in response to SEZ infection. The miR-223-3p inhibitor exhibited the opposite effect, causing hyperactivation of NLRP3 inflammation activation and downstream pathways. Additionally, we further demonstrated that miRNA-223-3p inhibited the secretion of IL-1ß and IL-18 by regulating the NLRP3/caspase-1 pathway. Furthermore, intravenous administration of miR-223-3p significantly decreased inflammation in mice in response to SEZ. In conclusion, our results demonstrated that miR-223-3p contributes to suppressing the NLRP3 inflammasome activation in SEZ infection, contributing novel evidence to identify a therapeutic target for treating SEZ.

Progressive crushing 40Ar/39Ar dating of a gold-bearing quartz vein from the Liaotun Carlin-type gold deposit, Guangxi, southern China.

Carlin-type gold deposits are among the largest hydrothermal gold deposits in the world. However, direct dating the metallogenic age of these deposits is difficult, because not all deposits provide material suitable for conventional radiometric methods. Syn-mineralization stage quartz veins from these deposits usually contain abundant fluid inclusions, which allow fluid inclusion 40Ar/39Ar dating. In this study, progressive crushing 40Ar/39Ar dating has been performed on a gold-bearing quartz vein from the Liaotun Carlin-type gold deposit in northwestern Guangxi, China. Argon isotopes liberated from the later steps yielded an isochron age of 200.7 ± 2.1 Ma. We infer that Ar-bearing gas was extracted from the primary fluid inclusions, and that the age of ca. 200.7 Ma reflects the timing of gold mineralization. The initial 40Ar/36Ar ratio corresponding to the isochron is 298.0 ± 4.3, which is statistically indistinguishable from the value for air, indicating that the ore-forming fluids probably mainly derived from gravitational pressure flow in the basin of air-saturated water. Our preliminary study shows the feasibility and great potential of 40Ar/39Ar dating of gases from fluid inclusions by progressive crushing of quartz veins to date the mineralization age and decipher the fluid origins of Carlin-type gold deposits.