Combined 3D-tomography and 3D-power Doppler for vascular imaging of the liver.

This study aimed to investigate the role of three-dimensional color tomographic ultrasound (3D-CTU) and three-dimensional color power Doppler (3D-CPD) imaging in diagnostics of liver lesions. Based on 3D-anatomical sectional structures of the liver, we used 3D-CTU and 3D-CPD techniques to reconstitute 3D-images of lobes, segments, and intra-segmental blood vessels, and lesions of the liver. With the use of this technique, we were able to generate 3D vascular patterns of liver lobes, segments and tumor lesions, and their spatial relationship. The observed vascular patterns of intra- and peri-tumor (including surrounding lobes and segments) and the spatial relation can be used for accurate positioning of liver lesions.

Use of three-dimensional color power doppler in imaging of liver cancer.

We aimed to assess the role of three-dimensional color power Doppler (3D-CPD) imaging in diagnosis of liver cancer. First of all, we performed 2D- and 3D-CPD imaging on 96 cases of liver tumors with a total of 106 lesions to examine the characteristics of the vascular distribution patterns of the tumors, and in turn, compare the sensitivity and specificity. Also, with the use of three-dimensional volumetric measurement, we calculated the volume of tumors, quantity of intra-tumor blood vessels, and the ratio of the quantity of intra-tumor blood vessels to tumor volumes (vascular index, VI). Finally, we statistically analyzed the vascular index between benign and malignant tumors. We found that the sensitivity/specificity were 21.3%/100% for 2D-CPD, and 81.3%/100% for 3D-CPD, based on the use of type-III of blood vessels for diagnosis of the malignant lesions. In 3D-CPD, the type-III of blood vessels along with VI of > 0.3/cm3 can be used as the criteria for the diagnosis of liver cancer since we found that average VI was 0.38/cm3 in 75 malignant tumors, but 0.18/cm3 in 31 benign tumors (p less than0.05). The sensitivity and specificity in determining malignancy in the liver based on VI > 0.3/cm3 were 78.7% and 87.1%, respectively.