RESUMEN
The infrared reflectance spectroscopy from the sample simulating natural-rock prepared by kaolin, muscovite and montmorillonite mixed-powders was obtained by a spectrometer. Spectral data preprocessing was done using SNV. Random forest mathematical modeling was used for predicting the components of rock samples. The smallest root mean square error of the predicted three types of rock composition were 0.088 0, 0.095 6 and 0.121 2 respectively. The predictive studies showed that the application of near infrared diffuse reflectance spectroscopy to determining the content of the natural rocks and minerals of various rock composition is feasible. The study provides a theoretical basis for the rapid detection of the rock composition in the future.
RESUMEN
Chemotherapy fails to achieve an ideal gliomas therapy due to the limited delivery of chemotherapeutics across the blood brain barrier (BBB), difficult accumulation of drugs in the gliomas area, and off-target toxicity. Herein, the pH-triggered small molecule nano-prodrugs (Try-CA-NPs) emulsified from hydrophobic tryptamine (Try)-cinnamaldehyde (CA) twin drug were successfully prepared through a facile method. Try-CA-NPs exhibited long-term storage and circulation stability. Furthermore, liposoluble Try-CA-NPs could easily cross BBB and efficiently accumulate in brain, selectively target to gliomas cells via Try-mediated cellular uptake, and enhance cytotoxicity through intracellular pH-triggered endosomal escape and efficient drug release, and synergistic effect between CA and Try, therefore achieving the complete destruction of SH-SY5Y multicellular spheroids (MCs). Thus, the pH-triggered small molecule nano-prodrugs emulsified from Try-CA twin drug have the great potential for clinically targeted synergistic glioma therapy.