X-ray-to-visible light-field detection through pixelated colour conversion.

Light-field detection measures both the intensity of light rays and their precise direction in free space. However, current light-field detection techniques either require complex microlens arrays or are limited to the ultraviolet-visible light wavelength ranges1-4. Here we present a robust, scalable method based on lithographically patterned perovskite nanocrystal arrays that can be used to determine radiation vectors from X-rays to visible light (0.002-550 nm). With these multicolour nanocrystal arrays, light rays from specific directions can be converted into pixelated colour outputs with an angular resolution of 0.0018°. We find that three-dimensional light-field detection and spatial positioning of light sources are possible by modifying nanocrystal arrays with specific orientations. We also demonstrate three-dimensional object imaging and visible light and X-ray phase-contrast imaging by combining pixelated nanocrystal arrays with a colour charge-coupled device. The ability to detect light direction beyond optical wavelengths through colour-contrast encoding could enable new applications, for example, in three-dimensional phase-contrast imaging, robotics, virtual reality, tomographic biological imaging and satellite autonomous navigation.

Structural and Functional Sensing of Bio-Tissues Based on Compressive Sensing Spectral Domain Optical Coherence Tomography.

In this paper, a full depth 2D CS-SDOCT approach is proposed, which combines two-dimensional (2D) compressive sensing spectral-domain optical coherence tomography (CS-SDOCT) and dispersion encoding (ED) technologies, and its applications in structural imaging and functional sensing of bio-tissues are studied. Specifically, by introducing a large dispersion mismatch between the reference arm and sample arm in SD-OCT system, the reconstruction of the under-sampled A-scan data and the removal of the conjugated images can be achieved simultaneously by only two iterations. The under-sampled B-scan data is then reconstructed using the classic CS reconstruction algorithm. For a 5 mm × 3.2 mm fish-eye image, the conjugated image was reduced by 31.4 dB using 50% × 50% sampled data (250 depth scans and 480 spectral sampling points per depth scan), and all A-scan data was reconstructed in only 1.2 s. In addition, we analyze the application performance of the CS-SDOCT in functional sensing of locally homogeneous tissue. Simulation and experimental results show that this method can correctly reconstruct the extinction coefficient spectrum under reasonable iteration times. When 8 iterations were used to reconstruct the A-scan data in the imaging experiment of fisheye, the extinction coefficient spectrum calculated using 50% × 50% data was approximately consistent with that obtained with 100% data.

Dual-Channel Spectral Domain Optical Coherence Tomography Based on a Single Spectrometer Using Compressive Sensing.

Dual-channel spectral domain optical coherence tomography (SD-OCT) is one of the effective methods for improving imaging depth and imaging speed. In this paper, we design a dual-channel SD-OCT system based on a single spectrometer that can operate in two modes: (1) Increasing imaging speed and (2) expanding imaging depth. An optical path offset is preintroduced between the two channels to separate the two-channel data. However, this offset increases the requirement for the spectral resolution of the spectrometer in mode (1), so compressive sensing (CS) technology is used herein to overcome this problem. Consequently, in mode (1), when the spectral resolution of the spectrometer is the same as that used in the single-channel system, we use a dual-channel SD-OCT system combined with CS technology to double the imaging speed. In mode (2), when the spectral resolution of the spectrometer is only half of that used in a single-channel system, the imaging depth can be nearly doubled. We demonstrate the feasibility and effectiveness of the method proposed in this work by imaging a mirror, a fish fin, a fish eye, and an onion.

Periodic Nonlinear Error Analysis and Compensation of a Single-Excited Petal-Shaped Capacitive Encoder to Achieve High-Accuracy Measurement.

The measurement results of a single-excitation petal-shaped capacitive encoder show strong periodic characteristics for nonlinear errors. This paper presents the analysis of periodic nonlinear errors in a single-excitation petal-shaped encoder in terms of three main aspects-sensitive structure processing error, circuit demodulation error, and installation error. Analytical and simulation results confirm that the first-, second-, and fourth-periodic electrical errors are caused by the misalignment of circuit parameters, non-uniform segmentation of the processing error, and cross interference of the electric field, respectively. Further experimental investigation reveals that the mechanical periodic error is caused by installation misalignment. Based on these analytical, simulation, and experimental results, the design of the capacitive encoder was optimized and a method based on harmonic components was applied to compensate the periodic nonlinear error of the encoder. Measurement results shows that the prototype which has 180 petal-shaped numbers can achieve a reduction of periodic nonlinear errors to less than 0.02° and its accuracy can be improved to 0.0006° after compensation over the full measurement range.

Full-depth compressive sensing spectral-domain optical coherence tomography based on a compressive dispersion encoding method.

By combining the advantages of compressive sensing optical coherence tomography (OCT) and full-depth OCT in terms of imaging time and imaging depth, we demonstrate how compressive sampling and dispersion encoding can be simultaneously used to reconstruct a full-depth OCT image. Moreover, by considering the image processing speed, we propose a two-step compressive dispersion encoding (TCDE) method, in which a large dispersion imbalance is introduced between the reference arm and the sample arm and two iterations are performed. The first iteration selects the signals with higher intensity and then removes their conjugate items and incoherent aliasing artifacts caused by undersampling based on the least squares method. The second iteration selects the signals with lower intensity. Experimental results show that nearly the same conjugate inhibition ratio can be obtained with 50% sampled data and 100% sampled data using the TCDE method. Full-depth images of a glass slide, an onion, and a live fish eye are obtained from 50% and 100% sampled data using the TCDE method. For a 1.4 mm×3.6 mm fish eye image, the conjugate items are reduced by 33.2 and 31.7 dB using 50% sampled data and 100% sampled data, respectively.

Simulation of penetration depth of Bessel beams for multifocal optical coherence tomography.

Multifocal Bessel beam optical coherence tomography (MBOCT) combines the advantages of Bessel beam OCT and multifocal OCT to increase imaging depth. For MBOCT, the penetration depth of the Bessel beam in highly scattering biological tissue limits the final imaging depth. In this paper, we theoretically analyze the penetration depth of the Bessel beams with different parameters to explore which kind of Bessel beam is more suitable for MBOCT in a scattering medium. The finite-difference time-domain method is used to simulate the field distribution of Bessel beams in the medium. We find that the MBOCT for more focus based on a Bessel beam with a smaller Fresnel number N has higher penetration depth and light intensity when its lateral resolution is fixed. Moreover, the Bessel beam with N reversely closer to unity is more advantageous for penetrating the highly scattering medium for a certain imaging depth, and the Bessel beam has larger penetration depth when its lateral size is close to the size of the object to be imaged.

Dual-sideband heterodyne of dispersion spectroscopy based on phase-sensitive detection.

A methane sensor based on dispersion spectroscopy is presented in this paper. A standard Mach-Zehnder modulator working in carrier suppression mode is adopted to generate a spectrum of a carrier and two sidebands. We aim at detecting the phase shift of the beatnote generated by the two sidebands in a methane concentration evaluation process. We put forward an analytical model to describe the dual-sideband heterodyne scheme and carry out experiments to demonstrate the model. Long-term tests show that the sensor has a minimum detection limit of 0.4 ppm·mHz-0.5 at an average time of 1 s. And in the condition of 1 atm and room temperature, a linear measurement range from 0.4 to 44955 ppm·m is achieved.

Optical Integration in Wearable, Implantable and Swallowable Healthcare Devices.

Recent advances in materials and semiconductor technologies have led to extensive research on optical integration in wearable, implantable, and swallowable health devices. These optical systems utilize the properties of light─intensity, wavelength, polarization, and phase─to monitor and potentially intervene in various biological events. The potential of these devices is greatly enhanced through the use of multifunctional optical materials, adaptable integration processes, advanced optical sensing principles, and optimized artificial intelligence algorithms. This synergy creates many possibilities for clinical applications. This Perspective discusses key opportunities, challenges, and future directions, particularly with respect to sensing modalities, multifunctionality, and the integration of miniaturized optoelectronic devices. We present fundamental insights and illustrative examples of such devices in wearable, implantable, and swallowable forms. The constant pursuit of innovation and the dedicated approach to critical challenges are poised to influence diverse fields.

A swallowable X-ray dosimeter for the real-time monitoring of radiotherapy.

Monitoring X-ray radiation in the gastrointestinal tract can enhance the precision of radiotherapy in patients with gastrointestinal cancer. Here we report the design and performance, in the gastrointestinal tract of rabbits, of a swallowable X-ray dosimeter for the simultaneous real-time monitoring of absolute absorbed radiation dose and of changes in pH and temperature. The dosimeter consists of a biocompatible optoelectronic capsule containing an optical fibre, lanthanide-doped persistent nanoscintillators, a pH-sensitive polyaniline film and a miniaturized system for the wireless readout of luminescence. The persistent luminescence of the nanoscintillators after irradiation can be used to continuously monitor pH without the need for external excitation. By using a neural-network-based regression model, we estimated the radiation dose from radioluminescence and afterglow intensity and temperature, and show that the dosimeter was approximately five times more accurate than standard methods for dose determination. Swallowable dosimeters may help to improve radiotherapy and to understand how radiotherapy affects tumour pH and temperature.

Full-depth spectral domain optical coherence tomography technology insensitive to phase disturbance.

To achieve full-depth spectral domain optical coherence tomography in the case of strong environmental disturbance, the iterative phase-shifting (IPS) method and modified dispersion-coded (MDC) method are proposed in this work. In IPS, the precise amount of phase shift is retrieved by iteration, and the direction of the phase shift is determined by dispersion compensation. Conjugate mirror items and noise can be simultaneously eliminated by two captured interferograms, whereas only one of them can be removed in the traditional phase-shift method with two interferograms. In MDC, they are removed through dispersion compensation and signal extraction with a single interferogram. Full-depth images of a glass slide, an onion, and a live fish eye are obtained by the two methods. The advantages and disadvantages of each method are analyzed and compared. IPS is found to be more effective for removing conjugate artifacts, whereas MDC is more conducive to real-time imaging. For a 2 mm × 3.6 mm image of a fish eye (200 depth scans and 1200 spectral sampling points per depth scan), the mirror image artifact is reduced by 28.55 dB in MDC and 41.53 dB in IPS. Processing times are 5.1 seconds (20 iterations) for the IPS method and 0.91 seconds for MDC.

Multifocal spectral-domain optical coherence tomography based on Bessel beam for extended imaging depth.

To advance the practical application of optical coherence tomography (OCT) in the field of biomedical imaging, the imaging depth must be extended without sacrificing resolution while maintaining sufficient sensitivity. However, there is an inherent trade-off between lateral resolution and depth of field (DOF) in OCT. To address this shortcoming, this article proposes a multifocal Bessel beam spectral-domain optical coherence tomography (MBSDOCT) capable of increasing the DOF with unchanged lateral resolution and a high signal-to-noise ratio. The proposed technique is demonstrated by simulation and experiment. A three-focal MBSDOCT with an axicon lens theoretically achieved a DOF of ∼6 mm with a lateral resolution of ∼13 µm. In imaging experiments performed on the acinar cells of orange tissue, a measured DOF of ∼4 mm was demonstrated with a sensitivity penalty of ∼18.1 dB, relative to the Gaussian beam spectral-domain OCT, with a 9-mW light source.