RESUMEN
We used a flow cytometry assay to measure proliferation and cytokine production of self-antigen-specific T cells in individual patients during the clinical course of multiple sclerosis (MS). Myelin-associated oligodendrocytic basic protein (MOBP) was selected for proof of principles in the assay, along with myelin basic protein (MBP) to assess specific activated T cells in 10 MS patients over an 18-month period, in parallel with brain magnetic resonance imaging (MRI) scans and clinical rating scale. A positive correlation occurred between antigen-specific T cell proliferation and interferon-gamma production with clinical relapses and MRI lesion activity that was absent when the same patients were in remission.
Asunto(s)
Autoantígenos/inmunología , Epítopos de Linfocito T/inmunología , Esclerosis Múltiple/inmunología , Proteína Básica de Mielina/inmunología , Glicoproteína Asociada a Mielina/inmunología , Linfocitos T/inmunología , Adulto , Autoantígenos/sangre , Encéfalo/inmunología , Encéfalo/metabolismo , Encéfalo/patología , Femenino , Citometría de Flujo , Humanos , Masculino , Persona de Mediana Edad , Esclerosis Múltiple/sangre , Esclerosis Múltiple/patología , Proteína Básica de Mielina/sangre , Proteínas de la Mielina , Glicoproteína Asociada a Mielina/sangre , Glicoproteína Mielina-Oligodendrócito , Linfocitos T/citología , Linfocitos T/metabolismoRESUMEN
The authors present a case of multiple radiation-induced cavernous malformations of the cauda equina in a patient with a remote history of testicular cancer and extended field radiation therapy. Magnetic resonance imaging (MRI) demonstrated multiple nodular areas of enhancement coating the nerve roots of the cauda equina, mimicking an aggressive leptomeningeal process such as carcinomatous or infectious meningitis. Biopsy of one of these lesions revealed ectatic vascular channels devoid of intervening neuroglial tissue consistent with cavernous malformation.