RESUMEN
Efficient methods for the preparation of combinatorial libraries of receptors have been reported recently and, in most cases, these have led to the identification of host-like molecules that bind a particular substrate selectively. Dynamic libraries of macrocycles have also been synthesised that could open the way to a new selection approach to receptors and catalysts.
Asunto(s)
Biblioteca de Péptidos , Péptidos/química , Péptidos/síntesis química , Receptores de Superficie Celular/química , Receptores Citoplasmáticos y Nucleares/química , Receptores de Droga/química , Secuencia de Aminoácidos , Química Orgánica/métodos , Modelos MolecularesRESUMEN
A new polymer-supported chromium porphyrin has been prepared and fully characterised; its catalytic activity and recyclability were investigated for the ring-opening copolymerisation of 1,2-cyclohexene oxide (CHO) and carbon dioxide (CO2).
RESUMEN
Cement-based materials are ubiquitous in almost all built environment. In spite of this, little is known about the formation and the role played by the silicate chains always present in the cement nanostructure. By means of first principles simulations we provide compelling evidence on the pivotal role played by certain ionic species in the formation of the silicate chains inside the cementitious matrix. Moreover, we corroborate the experimental evidence which shows that the length of the most stable chains with m Si atoms follows a magic-number sequence: m = 3n-1 with n = 1,2,... Our results have been applied in the development of new higher performance cement-based materials by adding nanosilica.
RESUMEN
There are many new analytical techniques for the characterization of resin-bound substrates and solid-phase reaction monitoring. The aim of this review is to focus on applications of the different IR techniques used in solid-phase synthesis highlighting some of the recent advances in the field that allow us to obtain more than just the usual qualitative information. Many examples will be discussed where these new IR techniques have been used for mechanistic and kinetic studies of solid-phase reactions.