AMR and Sustainable Development Goals: at a crossroads.

Antimicrobial resistance (AMR) poses a significant global health threat, primarily stemming from its misuse and overuse in both veterinary and public healthcare systems. The consequences of AMR are severe, leading to more severe infections, increased health protection costs, prolonged hospital stays, unresponsive treatments, and elevated fatality rates. The impact of AMR is direct and far-reaching, particularly affecting the Sustainable Development Goals (SDGs), underscoring the urgency for concerted global actions to achieve these objectives. Disproportionately affecting underprivileged populations, AMR compounds their vulnerabilities, pushing them further into poverty. Moreover, AMR has ramifications for food production, jeopardizing sustainable agriculture and diminishing the livelihoods of farmers. The emergence of antibiotic-resistant bacteria in underprivileged areas heightens the risk of complications and mortality. Climate change further contributes to AMR, as evidenced by increased instances of foodborne salmonellosis and the development of antibiotic resistance, resulting in substantial healthcare costs. Effectively addressing AMR demands collaboration among governments, entrepreneurs, and the public sector to establish institutions and policies across all regulatory levels. Expanding SDG 17, which focuses on partnerships for sustainable development, would facilitate global antimicrobial stewardship initiatives, technology transfer, surveillance systems, and investment in vaccine and drug research. The World Bank's SDG database, tracking progress towards sustainable development, reveals a concerning picture with only a 15% success rate till 2023 and 48% showing deviation, underscoring a global gap exacerbated by the COVID-19 pandemic. Tackling AMR's global impact necessitates international cooperation, robust monitoring, and evaluation methods. The five priorities outlined guide SDG implementation, while impoverished countries must address specific challenges in their implementation efforts. Addressing AMR and its impact on the SDGs is a multifaceted challenge that demands comprehensive and collaborative solutions on a global scale.

Navigating the sea level rise: Exploring the interplay of climate change, sea level rise, and coastal communities in india.

This research article investigates the intricate interplay between climate change, global sea level rise (SLR), and the impacts of sea level rise on the coastal regions of India. Through an interdisciplinary approach, this paper provides an overview of the global consequences of SLR on coastal communities, exploring economic, social, and environmental impacts on agriculture, communities, and coastal areas. The study examines the displacement of communities and its impact on food security, infrastructure, tourism, and ecological loss based on a comprehensive literature review. This paper emphasizes the sustainable preservation of coastal ecosystems and the development of climate-resilient infrastructure. This research aims to offer a detailed understanding of the evolving landscape of coastal livelihoods, providing valuable insights for adaptive strategies, policy formulation, and sustainable development. Ultimately, this article contributes to the scientific discourse by shedding light on the complex dynamics between climate change, SLR, and coastal communities, guiding efforts toward a resilient and sustainable future. The insights are drawn from secondary data resources, including books, scholarly journals, and reports from organizations such as the IPCC and NOAA. Based on a thorough review of the relevant literature, it critically examines the existing and potential consequences of sea level rise induced by climate change.

Knowledge, practice, and economic impacts of COVID-19 on small-scale coastal fishing communities in Bangladesh: Policy recommendations for improved livelihoods.

COVID-19 has profoundly impacted global livelihoods and disrupted the food supply chain, including the aquaculture and fisheries industries. Little is known about the response to COVID-19 and the impact it has on incomes, livelihoods and knowledge and practice in the coastal artisanal fishers communities of Bangladesh. Therefore, the aim of this study was to determine the socio-demographics of selected coastal fishers, their knowledge about COVID-19 and the preventive practice taken to reduce it. The impact on their fishing habits and income was also examined to determine potential policy areas. Data were collected via a structured questionnaire from 250 respondents from three coastal districts, Cox's Bazar, Patuakhali and Barguna, Bangladesh during April-June 2020. The research shows that the fishers' knowledge about COVID-19 and measures taken to reduce it were significantly higher in Patuakhali and Barguna than in Cox's Bazar. The pandemic caused lower consumer demand, reduced fish prices and created fish transportation issues due to movement restrictions enforced during the lockdown. Irrespective of geographical location, fishing trips were reduced by frequency and duration compared with the pre-COVID-19 period, consequently lowering the income of fishers. Fishers have received little or no support from private, non-governmental or governmental sources. Considering the evidence in this paper of economic hardship, this paper recommends artisanal fishers in Bangladesh should be provided with support to improve their health education, access to professional health facilities and financial services. This will contribute to improved food security and sustainable livelihoods that can better withstand local and/or global crises.

Livelihood impacts and governance processes of community-based wildlife conservation in Maasai Mara ecosystem, Kenya.

Community-based wildlife conservation (CBWC) programmes have been a pervasive paradigm in the conservation circles since the 1970s. The key elements of such programmes are that local communities are given ownership rights or custodianship and management responsibilities over wildlife, and that they gain social and economic benefits from conservation of the resources. However, to date, there have been only a few studies that offer in-depth analyses of the interplay between governance processes and livelihood impacts of CBWC programmes. Here, I conducted key informant interviews and focus group discussions in five wildlife conservancies in the Maasai Mara ecosystem in Kenya to address the following questions: i) What are the perceived impacts of the wildlife conservancies on livelihoods of the local people? ii) To what extent are the wildlife conservancies governed in relation to the principles of environmental governance? I assessed impacts on livelihoods by applying the Sustainable Livelihoods Framework to explore perceived conservancy-related benefits and costs (i.e. perceived changes in social, financial, human, physical, and natural capitals). I assessed governance by asking the respondents whether the following eight principles of environmental governance were applied: legitimacy, transparency, accountability, inclusiveness, fairness, integration, capability, and adaptability. Perceived benefits of participating in wildlife co-management were identified as: enhanced income from gainful employment and new business opportunities, membership to cooperative societies and participation in community work (e.g. school bursary and feeding programmes), enhanced social relations, improved access to credit and health facilities, enhanced physical infrastructure (schools, roads and bridges), improved physical security and coordinated sharing of provisioning ecosystem services like pasture and water. The principles of legitimacy, inclusiveness, and integration had reportedly been well implemented in wildlife co-management. However, the institutional mechanisms for sharing resources within the conservancies lacked transparency, accountability, and fairness, and tended to favour those who were politically connected to the leadership of the conservancies. Moreover, most of the conservancies had weak systems and few resources to facilitate delivery on responsibilities (i.e. had low capability), and had some costs associated with human-wildlife conflicts. For an improved co-management of wildlife to be achieved in these conservancies, local institutions should be reconfigured to allow active participation by conservancy landowners in decision-making, information sharing, and equitable access to conservancy-related benefits.

The role of the water tankers market in water stressed semi-arid urban areas:Implications on water quality and economic burden.

Population growth and development are associated with increased water demand that often exceeds the capacity of existing resources, resulting in water shortages, particularly in urban areas, where more than 60% of the world's population resides. In many developing communities, shortages often force households to depend on water tankers amongst other potential sources for the delivery of water for domestic and/or potable use. While water tankers have become an integral part of the water supply system in many countries, the sector is often unregulated and operates with little governmental supervision. Users are invariably unaware of the origin or the quality of purchased water. In an effort to better assess this sector, a field survey of water vending wells and tankers coupled with a water quality sampling and analysis program was implemented in a pilot semi-arid urban area (Beirut, Lebanon) to shed light on the environmental and socio-economic impacts of the water tanker sector. Total dissolved solids (TDS), chloride (Cl-), and microbial loads exceeded drinking water quality standards. While TDS and Cl- levels were mostly due to saltwater intrusion in coastal wells, tankers were found to be a significant source of total coliforms. Delivered water costs varied depending on the tanker size, the quality of the distributed water, and pre-treatment used, with a markup of nearly 8-24 folds of the public water supply and an equivalent economic burden of 16% of the average household income excluding environmental externalities of water quality. The study concludes with a management framework towards consumer protection under integrated supply and demand side measures.

People's perception on impacts of hydro-power projects in Bhagirathi river valley, India.

The people's perception on environmental and socio-economic impacts due to three hydro-electric projects (HEPs; commissioned and under construction) were studied in the north-west Indian Himalaya. Surveys among 140 project-affected people (PAPs) using a checklist of impacts indicate that among the negative impacts, decrease in flora/fauna, agriculture, flow of river, aesthetic beauty; and increase in water pollution, river bed quarrying for sand/stone, human settlement on river banks and social evils; and among the positive impacts, increase in standard of living, road connectivity, means of transport, public amenities, tourism and environmental awareness were related with HEPs. The PAPs tend to forget the negative impacts with the age of the HEPs after it becomes functional, and the positive impacts seem to outweigh the negative impacts. Study concludes that it is difficult to separate the compounding impacts due to HEP construction and other anthropogenic and natural factors, and in the absence of cause-and-effect analyses, it is hard to dispel the prevailing notion that HEPs are undesirable in the study area that led to agitations by the environmentalists and stopped construction of one of these HEPs. To overcome the situation, multi-disciplinary scientific studies involving the PAPs need to be carried out in planning and decision-making to make HEPs environment friendly and sustainable in this region. There is also a need to adopt low carbon electric power technologies and promote a decentralized energy strategy through joint ventures between public and private companies utilizing locally available renewable energy resources.

Economic appraisal of the public control and prevention strategy against the 2010 West Nile Virus outbreak in Central Macedonia, Greece.

OBJECTIVES: The aim of the present paper is to evaluate the economic efficiency of the public control and prevention strategies to tackle the 2010 West Nile Virus (WNV) outbreak in the Region of Central Macedonia, Greece. Efficiency is examined on the basis of the public prevention costs incurred and their potential in justifying the costs arising from health and nuisance impacts in the succeeding years. STUDY DESIGN: Economic appraisal of public health management interventions. METHODS: Prevention and control cost categories including control programmes, contingency planning and blood safety testing, are analyzed based on market prices. A separate cost of illness approach is conducted for the estimation of medical costs and productivity losses from 2010 to 2013 and for the calculation of averted health impacts. The averted mosquito nuisance costs to households are estimated on the basis of a contingent valuation study. Based on these findings, a limited cost-benefit analysis is employed in order to evaluate the economic efficiency of these strategies in 2010-2013. RESULTS: Results indicate that cost of illness and prevention costs fell significantly in the years following the 2010 outbreak, also as a result of the epidemic coming under control. According to the contingent valuation survey, the annual average willingness to pay to eliminate the mosquito problem in the study area ranged between 22 and 27 € per household. Cost-benefit analysis indicates that the aggregate benefit of implementing the previous 3-year strategy creates a net socio-economic benefit in 2013. However the spread of the WNV epidemic and the overall socio-economic consequences, had the various costs not been employed, remain unpredictable and extremely difficult to calculate. CONCLUSIONS: The application of a post epidemic strategy appears to be of utmost importance for public health safety. An updated well designed survey is needed for a more precise definition of the optimum prevention policies and levels and for the establishment of the various cost/benefit parameters.

Defining the impact of non-native species.

Non-native species cause changes in the ecosystems to which they are introduced. These changes, or some of them, are usually termed impacts; they can be manifold and potentially damaging to ecosystems and biodiversity. However, the impacts of most non-native species are poorly understood, and a synthesis of available information is being hindered because authors often do not clearly define impact. We argue that explicitly defining the impact of non-native species will promote progress toward a better understanding of the implications of changes to biodiversity and ecosystems caused by non-native species; help disentangle which aspects of scientific debates about non-native species are due to disparate definitions and which represent true scientific discord; and improve communication between scientists from different research disciplines and between scientists, managers, and policy makers. For these reasons and based on examples from the literature, we devised seven key questions that fall into 4 categories: directionality, classification and measurement, ecological or socio-economic changes, and scale. These questions should help in formulating clear and practical definitions of impact to suit specific scientific, stakeholder, or legislative contexts.

Global at-risk basins of socio-ecological impacts from water scarcity.

Water scarcity has been increasingly impacting social and ecological systems in the context of climate change. The United Nations water conference, convened in March 2023, calls for governing water and addressing climate change in tandem to co-achieve related sustainable development goals. However, the actual (water scarcity under current climate conditions) and potential (potential water scarcity under climate change) impacts of water scarcity on these systems are rarely assessed on a global scale. Herein, we developed a framework that integrates water scarcity and climate sensitivity to assess the socio-ecological vulnerability of global basins. We found that basins that already experience water scarcity exhibit a disproportionate magnitude of climate sensitivity, exacerbating the challenges associated with managing water resources. We identified the at-risk basins by integrating socio-ecological vulnerability and found that the most at-risk basins (n = 21), which collectively accommodate 500 hundred million inhabitants, are mainly located in developing countries, implying the urgent need of international cooperation for reducing these vulnerabilities. Current Integrated Water Resources Management and Climate Change Adaptation may not be enough to alleviate the water crisis and to adapt to climate change in these at-risk basins, we thus urge policy makers in at-risk regions to integrate integrated water resources management and climate change adaptation measures to synergistically achieve related sustainable goals.

The economic impacts of house screening against malaria transmission: Experimental evidence from eastern Zambia.

Malaria imposes an economic burden for human populations in many African countries, and this burden may be reduced through house screening initiatives. We use a randomized controlled trial to measure the economic impacts of house screening against malaria infection. We use a sample of 800 households from 89 villages in rural and peri-urban Zambia to collect baseline data in August 2019 and endline data in August 2020. The main outcome variables are (self-reported) malaria prevalence rates, labor supply, and income, and consider individual and household-level outcomes. House screening reduces malaria prevalence, the number of sick days due to malaria, and the number of malaria episodes. Impacts on adults are more pronounced than on children. In terms of economic impacts, house screening increases labor supply and (household) income. We find particularly large effects on labor supply for women household members. A cost-benefit analysis, based on estimated benefits and measured costs, suggests that the private benefits of house screening exceed the costs. While not all houses are suitable for house screening, we conclude that screening is a promising and cost-effective approach to reduce malaria infections.

A comparison of three different delivery methods for achieving CRISPR/Cas9 mediated genome editing in Cichorium intybus L.

Root chicory (Cichorium intybus L. var. sativum) is used to extract inulin, a fructose polymer used as a natural sweetener and prebiotic. However, bitter tasting sesquiterpene lactones, giving chicory its known flavour, need to be removed during inulin extraction. To avoid this extraction and associated costs, recently chicory variants with a lower sesquiterpene lactone content were created by inactivating the four copies of the germacrene A synthase gene (CiGAS-S1, -S2, -S3, -L) which encode the enzyme initiating bitter sesquiterpene lactone biosynthesis in chicory. In this study, different delivery methods for CRISPR/Cas9 reagents have been compared regarding their efficiency to induce mutations in the CiGAS genes, the frequency of off-target mutations as well as their environmental and economic impacts. CRISPR/Cas9 reagents were delivered by Agrobacterium-mediated stable transformation or transient delivery by plasmid or preassembled ribonucleic complexes (RNPs) using the same sgRNA. All methods used lead to a high number of INDEL mutations within the CiGAS-S1 and CiGAS-S2 genes, which match the used sgRNA perfectly; additionally, the CiGAS-S3 and CiGAS-L genes, which have a single mismatch with the sgRNA, were mutated but with a lower mutation efficiency. While using both RNPs and plasmids delivery resulted in biallelic, heterozygous or homozygous mutations, plasmid delivery resulted in 30% of unwanted integration of plasmid fragments in the genome. Plants transformed via Agrobacteria often showed chimerism and a mixture of CiGAS genotypes. This genetic mosaic becomes more diverse when plants were grown over a prolonged period. While the genotype of the on-targets varied between the transient and stable delivery methods, no off-target activity in six identified potential off-targets with two to four mismatches was found. The environmental impacts (greenhouse gas (GHG) emissions and primary energy demand) of the methods are highly dependent on their individual electricity demand. From an economic view - like for most research and development activities - employment and value-added multiplier effects are high; particularly when compared to industrial or manufacturing processes. Considering all aspects, we conclude that using RNPs is the most suitable method for genome editing in chicory since it led to a high efficiency of editing, no off-target mutations, non-transgenic plants with no risk of unwanted integration of plasmid DNA and without needed segregation of transgenes.

Biological invasion costs reveal insufficient proactive management worldwide.

The global increase in biological invasions is placing growing pressure on the management of ecological and economic systems. However, the effectiveness of current management expenditure is difficult to assess due to a lack of standardised measurement across spatial, taxonomic and temporal scales. Furthermore, there is no quantification of the spending difference between pre-invasion (e.g. prevention) and post-invasion (e.g. control) stages, although preventative measures are considered to be the most cost-effective. Here, we use a comprehensive database of invasive alien species economic costs (InvaCost) to synthesise and model the global management costs of biological invasions, in order to provide a better understanding of the stage at which these expenditures occur. Since 1960, reported management expenditures have totalled at least US$95.3 billion (in 2017 values), considering only highly reliable and actually observed costs - 12-times less than damage costs from invasions ($1130.6 billion). Pre-invasion management spending ($2.8 billion) was over 25-times lower than post-invasion expenditure ($72.7 billion). Management costs were heavily geographically skewed towards North America (54%) and Oceania (30%). The largest shares of expenditures were directed towards invasive alien invertebrates in terrestrial environments. Spending on invasive alien species management has grown by two orders of magnitude since 1960, reaching an estimated $4.2 billion per year globally (in 2017 values) in the 2010s, but remains 1-2 orders of magnitude lower than damages. National management spending increased with incurred damage costs, with management actions delayed on average by 11 years globally following damage reporting. These management delays on the global level have caused an additional invasion cost of approximately $1.2 trillion, compared to scenarios with immediate management. Our results indicate insufficient management - particularly pre-invasion - and urge better investment to prevent future invasions and to control established alien species. Recommendations to improve reported management cost comprehensiveness, resolution and terminology are also made.

Impact of the recent Ebola epidemic with pandemic potential on the economies of Guinea, Liberia and Sierra Leone and other West African countries.

West Africa experienced its first Ebola epidemic in 2014. Its magnitude in terms of morbidity and mortality was greater than any other epidemic. It has particularly affected Guinea, Liberia and Sierra Leone. Its impact, beyond the high mortality, is also economic. The Ebola virus disease spread to several other African countries with limited resources, causing a significant financial burden to their health systems but also impacting the entire economy of the countries. The objective of this essay is to reflect on the consequences of the Ebola virus epidemics on West African economies in the short term. Estimates of the economic burden of the epidemic range from $2.8 billion to $32.6 billion in lost gross domestic product. The sectors affected by the economic crisis are the most important of the contaminated countries, namely agriculture, mining and trade. There has been a halt in socio-economic activities in the most affected regions. The decrease in the number of workers affected by the virus, the exodus to the least affected areas, and the repatriation of government employees have contributed to the decrease in the income of individuals and states. The fear of contamination by foreign countries has reduced imports, but also all tourist activities, which in turn have had an impact on the restaurant and hotel sectors. All these financial and food disruptions have exposed the population of these countries to food insecurity. The analysis of the impact of the Ebola virus on West African economies in the short term was as devastating as the health impact. This impact has directly contributed to a decrease in economic growth not only for the affected countries but also for all West African countries that depend on these same resources. A loss of about US$32.6 billion over two years in the West African region has been estimated, which is equivalent to 3.3% of the regional gross domestic product (GDP) in the absence of Ebola in 2014.

Epidemiology of Newcastle disease in Africa with emphasis on Côte d'Ivoire: A review.

For decades, Newcastle disease (ND) has long been recognized as a frontline viral disease that constrains poultry production throughout Africa. The need to update on the epidemiology of the disease is rife, due to the increasing importance of poultry farming. In addition, poultry farming serves as the top animal food source globally. However, in Africa, the greater population of poultry is reared under traditional and conventional husbandry methods. This hugely impedes the ability of management practices to be correctly embraced in limiting or excluding viral pathogens in the poultry production chain. We conducted this review to consolidate recently published studies in the field and provide an overview of the disease. We reviewed original studies conducted on ND, the current taxonomic classification of the virus, clinical signs of the disease, and laboratory diagnostic methods available for virus detection and typing. This review additionally examined the control methods currently used, including available or circulating vaccines, vaccinations, recent vaccine findings, and the main variants of the virus present in West Africa. More specifically, we present a review of the current status and available information on the disease in Côte d'Ivoire. The lack of up-to-date and relevant information on the current prevalence, socio-economic impact, and ethnoveterinary medicine used against ND is probably the main limitation for appropriate and effective decision-making for better control of this disease in Côte d'Ivoire.

Dataset on the perceptions of ordinary people on the persistence of bribery practices in Nigeria.

This dataset provides the perceptions of ordinary people on the relationship between societal acceptance of bribery, anti-bribery measures, socio-economic impacts of bribery, demographic factors and persistence of bribery practices. A multi-stage sampling technique was used to target the respondents. A total of 887 grassroots respondents participated, out of which 836 responses were used for quantitative data analyses. Statistical Packages for Social Sciences (SPSS) version 23 and SmartPLS3.0 were used to determine the reliability and validity of the data. The data is useful to the authorities in formulating strategies to deal decisively with the issues of bribery practices in Nigeria.

A detailed review of the outbreak of COVID-19.

The disease COVID-19 caused by SARS-CoV-2 is the third highly infectious human Coronavirus epidemic in the 21s⁢t century due to its high transmission rate and quick evolution of its pathogenicity. Genomic studies indicate that it is zoonotic from bats. The COVID-19 has led to significant loss of lives and a tremendous economic decline in the world. Generally, the population at risk of a fatal outcome are the elderly and those who are debilitated or are immune compromised. The fatality rate is high, but now is reduced after the development of preventive vaccine although an effective treatment by drug against the virus is yet to be developed. The treatment is narrowed to the use of several anti-viral drugs, or other re-purposed drugs. Social distancing, therefore, has emerged as a putative method to decrease the rate of infection. In this review, we summarize the aspects of the disease that is so far have come to light and review the impact of the infection on our society, healthcare, economy, education, and environment.

Anxiety, Anger and Depression Amongst Low-Income Earners in Southwestern Uganda During the COVID-19 Total Lockdown.

Background: Low-income earners are particularly vulnerable to mental health, consequence of the coronavirus disease 2019 (COVID-19) lockdown restrictions, due to a temporary or permanent loss of income and livelihood, coupled with government-enforced measures of social distancing. This study evaluates the mental health status among low-income earners in southwestern Uganda during the first total COVID-19 lockdown in Uganda. Methods: A cross-sectional descriptive study was undertaken amongst earners whose income falls below the poverty threshold. Two hundred and fifty-three (n = 253) male and female low-income earners between the ages of 18 and 60 years of age were recruited to the study. Modified generalized anxiety disorder (GAD-7), Spielberger's State-Trait Anger Expression Inventory-2 (STAXI-2), and Beck Depression Inventory (BDI) tools as appropriate were used to assess anxiety, anger, and depression respectively among our respondents. Results: Severe anxiety (68.8%) followed by moderate depression (60.5%) and moderate anger (56.9%) were the most common mental health challenges experienced by low-income earners in Bushenyi district. Awareness of mental healthcare increased with the age of respondents in both males and females. A linear relationship was observed with age and depression (r = 0.154, P = 0.014) while positive correlations were observed between anxiety and anger (r = 0.254, P < 0.001); anxiety and depression (r = 0.153, P = 0.015) and anger and depression (r = 0.153, P = 0.015). Conclusion: The study shows the importance of mental health awareness in low resource settings during the current COVID-19 pandemic. Females were identified as persons at risk to mental depression, while anger was highest amongst young males.

Mass spectrometry analysis of human tear fluid biomarkers specific for ocular and systemic diseases in the context of 3P medicine.

Over the last two decades, a large number of non-communicable/chronic disorders reached an epidemic level on a global scale such as diabetes mellitus type 2, cardio-vascular disease, several types of malignancies, neurological and eye pathologies-all exerted system's enormous socio-economic burden to primary, secondary, and tertiary healthcare. The paradigm change from reactive to predictive, preventive, and personalized medicine (3PM/PPPM) has been declared as an essential transformation of the overall healthcare approach to benefit the patient and society at large. To this end, specific biomarker panels are instrumental for a cost-effective predictive approach of individualized prevention and treatments tailored to the person. The source of biomarkers is crucial for specificity and reliability of diagnostic tests and treatment targets. Furthermore, any diagnostic approach preferentially should be noninvasive to increase availability of the biomaterial, and to decrease risks of potential complications as well as concomitant costs. These requirements are clearly fulfilled by tear fluid, which represents a precious source of biomarker panels. The well-justified principle of a "sick eye in a sick body" makes comprehensive tear fluid biomarker profiling highly relevant not only for diagnostics of eye pathologies but also for prediction, prognosis, and treatment monitoring of systemic diseases. One prominent example is the Sicca syndrome linked to a cascade of severe complications that include dry eye, neurologic, and oncologic diseases. In this review, protein profiles in tear fluid are highlighted and corresponding biomarkers are exemplified for several relevant pathologies, including dry eye disease, diabetic retinopathy, cancers, and neurological disorders. Corresponding analytical approaches such as sample pre-processing, differential proteomics, electrophoretic techniques, high-performance liquid chromatography (HPLC), enzyme-linked immuno-sorbent assay (ELISA), microarrays, and mass spectrometry (MS) methodology are detailed. Consequently, we proposed the overall strategies based on the tear fluid biomarkers application for 3P medicine practice. In the context of 3P medicine, tear fluid analytical pathways are considered to predict disease development, to target preventive measures, and to create treatment algorithms tailored to individual patient profiles.

The socio-economic impacts of Covid-19 restrictions: Data from the coastal city of Mombasa, Kenya.

The novel corona virus disease (Covid-19) outbreak has caused great uncertainty in all spheres of human life. The experience has been incredibly humbling given that no country or section of society, regardless of its wealth or status, has been spared. The pandemic is not only a health crisis, but is also having serious damaging effects on societies, economies and vulnerable groups. Timely response is necessary in order to alleviate human suffering and to prevent irreversible destruction of livelihoods. This paper provides preliminary data on the socio-economic impacts of Covid-19 in the coastal city of Mombasa, Kenya, at the time of government-imposed curfews and cessation of movement. We conducted online surveys for two weeks during the restrictions period. The data was collected using online questionnaires directed at the city residents. The data highlights the mobile gender gap resulting from gender inequalities, residents' reliance on the government for Covid-19 information but lack of trust for government interventions, inadequate provisions of essential services, and the residents' lack of preparedness to tackle similar challenges in the future.

Prevalence and Socio-economic Impacts of Malnutrition Among Children in Uganda.

Malnutrition is one of the common problems that afflict the poor in low- and middle-income countries like Uganda. The rate of decline of malnutrition in the country has been very slow for the last 15 years. This problem is of utmost concern in this era of Sustainable Development Goals (SDGs) in which achieving the goals is imperative. The aim of our study was to review literature on the prevalence and socio-economic impacts of malnutrition among children under 5 in Uganda and provide recommendations to address identified gaps. This review assesses available evidences, including journal articles, country reports, the World Health Organization (WHO) reports, the United Nations International Children's Emergency Funds (UNICEF) reports, and other reports on issues pertaining to malnutrition among children in Uganda. Malnutrition, poverty, and chronic diseases are interconnected in such a way that each of the factors influences the presence and permanence of the other, resulting in a synergistic impact. The prevalence of acute and severe malnutrition among children under 5 is above the World Health Assembly target to reduce and maintain the prevalence under 5% by 2025. There are also limited studies on etiology of anemia as regards its prevalence in Uganda. The study presents a better understanding of the social and economic impact of child malnutrition on the families and the country's development. The study also strongly suggests that, for Uganda to achieve sustainable development goal 2, financial investments by the government are necessary to address nutrition in the early stages of an individual's life.