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1.
BMC Musculoskelet Disord ; 25(1): 722, 2024 Sep 07.
Artículo en Inglés | MEDLINE | ID: mdl-39244524

RESUMEN

STUDY DESIGN: A technical note and retrospective case series. OBJECTIVE: Highly upward-migrated lumbar disc herniation (LDH) is challenging due to its problematic access and incomplete removal. The most used interlaminar approach may cause extensive bony destruction. We developed a novel translaminar approach using the unilateral portal endoscopic (UBE) technique, emphasizing effective neural decompression, and preserving the facet joint's integrity. METHODS: This retrospective study included six patients receiving UBE translaminar discectomy for highly upward-migrated LDHs from May 2019 to June 2021. The migrated disc was removed through a small keyhole on the lamina of the cranial vertebra. The treatment results were evaluated by operation time, hospital stays, complications, visual analog scale (VAS), Oswestry Disability Index (ODI), Japanese Orthopaedic Association (JOA) score, and modified MacNab criteria. RESULTS: The mean pre-operative VAS for back pain (5.0 ± 4.9), VAS for leg pain (9.2 ± 1.0), JOA score (10.7 ± 6.6), and ODI (75.7 ± 25.3) were significantly improved to 0.3 ± 0.5, 1.2 ± 1.5, 27.3 ± 1.8, 5.0 ± 11.3 respectively at the final follow-up. Five patients had excellent, and one patient had good outcomes according to the Modified MacNab criteria. The hospital stay was 2.7 ± 0.5 days. No complication was recorded. The MRI follow-up showed complete disc removal, except for one patient with an asymptomatic residual disc. CONCLUSIONS: UBE translaminar discectomy is a safe and effective minimally invasive procedure for highly upward-migrated LDH with satisfactory treatment outcomes and nearly 100% facet joint preservation.


Asunto(s)
Discectomía , Endoscopía , Desplazamiento del Disco Intervertebral , Vértebras Lumbares , Humanos , Desplazamiento del Disco Intervertebral/cirugía , Desplazamiento del Disco Intervertebral/diagnóstico por imagen , Masculino , Estudios Retrospectivos , Femenino , Persona de Mediana Edad , Vértebras Lumbares/cirugía , Vértebras Lumbares/diagnóstico por imagen , Resultado del Tratamiento , Adulto , Endoscopía/métodos , Discectomía/métodos , Anciano , Dimensión del Dolor
2.
Pain Med ; 23(11): 1875-1881, 2022 10 29.
Artículo en Inglés | MEDLINE | ID: mdl-35511153

RESUMEN

INTRODUCTION: Greater trochanteric pain syndrome may often mimic pain generated from other sources. However, it is most commonly caused by gluteus medius and gluteus minimus tendinopathy or tear. The purpose of this technical report was to: 1) describe the ultrasound-guided fascial plane block technique targeting the superior gluteal nerve in the plane between gluteus medius/gluteus minimus to treat moderate-to-severe, chronic, refractory greater trochanteric pain syndrome; 2) anatomically correlate the procedure with cadaveric dissections demonstrating the structures being imaged and the tissues along the needle trajectory; 3) demonstrate the feasibility of the technique with serial dissection of one cadaveric specimen following injection with color dye. TECHNIQUE DESCRIPTION: The ultrasound-guided fascial plane block targeting the superior gluteal nerve to treat moderate-to-severe, chronic, refractory greater trochanteric pain syndrome has been outlined with supporting ultrasound scans and anatomical dissections. The cadaveric dissections are correlated to the ultrasound scans of a healthy volunteer and provide visualization of the tissues in the needle trajectory. The feasibility study in a cadaveric specimen showed adequate stain of the superior gluteal nerve without spread to the piriformis muscle belly, the sciatic nerve, or the inferior gluteal nerve. CONCLUSIONS: This ultrasound-guided fascial plane block is a feasible option for blocking the superior gluteal nerve without inadvertent involvement of the sciatic and inferior gluteal nerves. Further randomized controlled clinical trials are necessary to assess the clinical efficacy of the gluteus medius/gluteus minimus fascial plane block to treat moderate-to-severe, chronic, refractory greater trochanteric pain syndrome.


Asunto(s)
Bursitis , Humanos , Correlación de Datos , Dolor , Ultrasonografía Intervencional , Cadáver
3.
Pain Med ; 21(Suppl 1): S32-S37, 2020 08 01.
Artículo en Inglés | MEDLINE | ID: mdl-32804225

RESUMEN

OBJECTIVE: This study aimed to describe and validate a novel ultrasound-guided intercostal peripheral nerve stimulator implantation technique. METHODS: The fifth to tenth ribs on both sides of an unembalmed cadaveric specimen were localized using a 15-6-MHz linear array transducer, counting distally from T-1 bilaterally. A single interventionist then implanted 12 peripheral nerve stimulators on the fifth through tenth ribs, six MicroLeads on the left side and six StimRouters on the right side, using an in-plane lateral to medial approach to the inferior border of the corresponding rib. After all the stimulators were implanted, their location was confirmed using fluoroscopy. Gross anatomic dissection was later performed for each of the stimulators placed, and the distance of the lead from the intercostal nerve and pleura was noted. RESULTS: All leads were noted in an accurate position in the plane between the inner and innermost intercostal muscle, without any intrapleural placement. The distance of the leads from the intercostal nerves was on average 2.3 mm and 1.1 mm for MicroLead and StimRouter, respectively. CONCLUSIONS: To our knowledge, this study is the first to determine the feasibility of ultrasound-guided peripheral nerve stimulator placement in close proximity to the pleura. All the stimulator leads were accurately placed using our ultrasound-guided technique and were within 0.5-3 mm from the intercostal nerve. Although this technique might prove technically challenging, the use of ultrasound for intercostal peripheral nerve stimulator implantation appears feasible and warrants further investigation to establish this as an acceptable technique for patients.


Asunto(s)
Nervios Intercostales , Ultrasonografía Intervencional , Cadáver , Estudios de Factibilidad , Humanos , Nervios Intercostales/diagnóstico por imagen , Ultrasonografía
4.
J Contemp Dent Pract ; 21(5): 593-596, 2020 May 01.
Artículo en Inglés | MEDLINE | ID: mdl-32690846

RESUMEN

AIM: To introduce an angled abutment transfer jig that splints abutments securely together to facilitate easy and quick orientation. BACKGROUND: Transferring angled abutments from cast to patients' mouth could be tasking and time-consuming. Transfer jigs are often used to facilitate orientation of abutments into implant fixtures. However, with the available jigs, abutments could move out of place and thus pose a hassle in repositioning. TECHNIQUE: This technical report introduces an angled abutment transfer jig that consists of two impression copings screwed onto angled abutments which are splinted together with red acrylic resin. Access to abutment screws is feasible through slots created in the impression copings. CONCLUSION: The introduced jig is rigid and thus ensures very accurate and easy transfer of abutments into implants followed by accurate prosthesis seating. CLINICAL SIGNIFICANCE: This transfer jig design allows clinicians to transfer the orientation of angled abutments from cast to patients' mouth with optimal speed and precision.


Asunto(s)
Pilares Dentales , Implantes Dentales , Resinas Acrílicas , Técnica de Impresión Dental , Diseño de Prótesis Dental , Prótesis Dental de Soporte Implantado , Humanos , Modelos Dentales
5.
Childs Nerv Syst ; 34(8): 1573-1577, 2018 08.
Artículo en Inglés | MEDLINE | ID: mdl-29804212

RESUMEN

3D printing has been used in several medical applications. There are no reports however of 3D printing of the brain in children for demonstrating pathology to non-medical professionals such as lawyers. We printed 3D models of the paediatric brain from volumetric MRI in cases of severe and moderate hypoxic ischaemic injury as well as a normal age matched control, as follows: MRI DICOM data was converted to NifTI (Neuroimaging Informatics Technology Initiative) format; segmentation of the brain into CSF, grey, and white matter was performed; the segmented data was converted to STL format and printed on a commercially available scanner. The characteristic volume loss and surface features of hypoxic ischaemic injury are visible in these models, which could be of value in the communication of the nature and severity of such an insult in a court setting as they can be handled and viewed from up close.


Asunto(s)
Recursos Audiovisuales , Encéfalo/diagnóstico por imagen , Hipoxia-Isquemia Encefálica/diagnóstico por imagen , Imagenología Tridimensional/métodos , Imagen por Resonancia Magnética/métodos , Impresión Tridimensional , Encéfalo/patología , Preescolar , Comunicación , Humanos , Hipoxia-Isquemia Encefálica/patología
6.
Neuromodulation ; 21(3): 284-289, 2018 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-29314501

RESUMEN

OBJECTIVES: Although spinal cord and dorsal root ganglia stimulation may be effective for managing regional pain syndromes, a more targeted approach is perhaps more appealing for discrete anatomical structures. Chronic shoulder pain is a common musculoskeletal problem with significant socioeconomic impact. A peripheral nerve stimulation of the axillary and suprascapular nerves may prove to be effective as a long-term solution for this indication. In anticipation of the future experimental research and clinical utilization, a sound methodology for the lead placement was developed, and its feasibility is tested in a cadaveric study. MATERIALS AND METHODS: Normal anatomy was corroborated with ultrasound scans of live models and cadaver specimens. A step-by-step ultrasound-guided implantation technique was designed. The procedure was completed targeting both the axillary and suprascapular nerves. The accuracy of the lead placement was confirmed by dissections. RESULTS: The implanted devices were found adjacent to the target nerves within 0.5-1 cm distance. CONCLUSIONS: The anatomical dissections confirmed the accuracy of ultrasound-guided placement of the lead. The described method is based on normal anatomy and appeared to be reproducible by following the outlined procedural steps.


Asunto(s)
Terapia por Estimulación Eléctrica/métodos , Manejo del Dolor/métodos , Prueba de Estudio Conceptual , Hombro/inervación , Cadáver , Dolor Crónico/terapia , Humanos , Modelos Anatómicos , Dolor de Hombro/terapia
7.
Neuromodulation ; 21(8): 755-761, 2018 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-29566288

RESUMEN

INTRODUCTION: Cervical cord stimulation is used in the treatment of chronic (neuropathic) pain syndromes refractory to conservative treatments. Several authors describe different techniques for the placement of cervical electrodes. Electrodes can be placed retrogade [Correction added on 03 April 2018 after first online publication: the word "plased" has been changed to "placed".]. In this article, we describe a refinement on how to dissect the dorsal meningo-vertebral ligaments to decrease the risk of complications. PATIENTS AND METHODS: Twenty-eight patients received a permanent cervical spinal cord stimulator. A C0-C1 retrograde insertion was performed with careful dissection of the meningo-vertebral ligaments. Complications were registered during the follow-up (mean 44.6 months [SD = 43, range 1-162 months]). RESULTS: Six complications were observed 93% of the patients reported a significant reduction in pain. CONCLUSIONS: We describe an additional surgical detail for the known procedure for retrograde placement of high cervical plate electrodes. This surgical detail might result in a lower risk of complications. We present a case series of 28 patients to support this hypothesis.


Asunto(s)
Electrodos Implantados , Neuralgia/terapia , Estimulación de la Médula Espinal/métodos , Adulto , Anciano , Vértebras Cervicales , Dolor Crónico/terapia , Electrodos , Electrodos Implantados/efectos adversos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estimulación de la Médula Espinal/efectos adversos
8.
Clin Endocrinol (Oxf) ; 87(6): 825-831, 2017 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-28718944

RESUMEN

OBJECTIVE: This study looked at the effect of a changing radiology reporting policy to routinely review the thyroid gland where visible and report on any thyroid lesion, recommending further investigation as appropriate. CONTEXT: Incidentaloma is a term used to describe a lesion found on imaging unrelated to the clinical issue under investigation. There is variability in the radiological reporting of thyroid incidentalomas and conflicting recommendations as to how these lesions should be managed. DESIGN: Data were collected retrospectively during a two-year period, including 12 months before and 12 months after the change in reporting policy and categorized according to whether the lesion under investigation was a thyroid incidentaloma or a symptomatic thyroid lesion. PATIENTS: All patients undergoing ultrasound-guided fine-needle aspiration cytology or core biopsy were included. MEASUREMENTS: The effects of the change in policy were analysed including rates of needle biopsy, rates of malignancy and subsequent surgical intervention. RESULTS: There was a 122% increase in thyroid incidentalomas undergoing needle biopsy, the majority of these were detected on computed tomography. The number of malignancies increased from 1 to 4 from year 1 to year 2. All patients were >35 years old. One patient had a positron emission tomography (PET)-detected cancer, two of four of the non-PET-detected malignancies were <1.5 cm. CONCLUSION: This study posits that routine radiological reporting of thyroid incidentalomas, with further investigation when clinically appropriate, is warranted. The results suggest that lesion size and CT characteristics are not reliable criteria to triage patients for investigation/biopsy.


Asunto(s)
Glándula Tiroides/diagnóstico por imagen , Neoplasias de la Tiroides/diagnóstico por imagen , Nódulo Tiroideo/diagnóstico por imagen , Adulto , Anciano , Anciano de 80 o más Años , Biopsia con Aguja Fina/estadística & datos numéricos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Tomografía de Emisión de Positrones , Estudios Retrospectivos , Glándula Tiroides/patología , Glándula Tiroides/cirugía , Neoplasias de la Tiroides/patología , Neoplasias de la Tiroides/cirugía , Nódulo Tiroideo/patología , Nódulo Tiroideo/cirugía
9.
Neurosurg Rev ; 39(3): 449-54, 2016 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-26873745

RESUMEN

Nonshaved neurosurgery, cranial or spinal, is well reported among Caucasians but hardly among native Africans. The ungroomed scalp hairs of black Africans have unique anthropological characteristics needing special attention for shaveless cranial surgery. A technical report of the execution of this surgical procedure among an indigenous patient population in a sub-Sahara African country is presented, as well as an outcome analysis in a prospective cohort over a 7-year period. A total of 303 patients (211 males, 70 %) fulfilled the criteria for this study. The surgical procedure was primary in 278 (92 %) and redo in 8 %. It was emergency surgery in 153 (51 %). They were trauma craniotomies or decompressive craniectomies in 95 cases (31 %), craniotomies for tumour resections in 86 (28 %), and the surgical dissections for other conditions in 122 (41 %). The duration of surgery ranged from 30 min to 8.5 h, mean 2.5 (SD, 1.6), median 2. In-hospital clinical outcome was good (normal status or moderate deficit on dichotomized Glasgow outcome scale (GOS)) in 273 (90.1 %) cases while surgical site infections occurred in only 10 cases (3.3 %). The type of surgery, redo or primary, did not have any significant association with the in-hospital outcome (p = 0.5), nor with the presence of surgical site infection (SSI) (p = 0.7). The length of follow-up ranged from 2 to 63 months (mean, 7) with no untoward complications reported so far. Medium-term outcome of nonshaved neurosurgery in this indigenous black Africans remains favourable with no attendant significant adverse after-effects.


Asunto(s)
Escala de Consecuencias de Glasgow/estadística & datos numéricos , Procedimientos Neuroquirúrgicos , Cuero Cabelludo , Infección de la Herida Quirúrgica/epidemiología , Infección de la Herida Quirúrgica/etiología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Población Negra , Niño , Preescolar , Craniectomía Descompresiva/métodos , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Persona de Mediana Edad , Procedimientos Neuroquirúrgicos/métodos , Evaluación de Resultado en la Atención de Salud , Estudios Prospectivos , Adulto Joven
10.
Neuromodulation ; 18(6): 487-93; discussion 493, 2015 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-25832898

RESUMEN

OBJECTIVES: The study aims to describe an ultrasound (US)-guided peripheral nerve stimulation implant technique and describe the effect of high-frequency peripheral nerve stimulation on refractory postherpetic neuralgia. MATERIALS AND METHODS: Following a cadaver pilot trial using US and confirmatory fluoroscopic guidance, a 52-year-old man with refractory left supraorbital neuralgia underwent combined US and fluoroscopic-guided supraorbital peripheral nerve stimulator trial. The patient was subsequently implanted with a percutaneous lead over the left supraorbital and supratrochlear nerve utilizing a high-frequency stimulation paradigm. RESULTS: At 9 months follow-up, the pain intensity had declined from a weekly average of 8/10 to 1/10 on the pain visual analog scale (VAS). After implant, both nerve conduction and blink reflex studies were performed, which demonstrated herpetic nerve damage and frequency-specific peripheral nerve stimulation effects. The patient preferred analgesia in the supraorbital nerve distribution accomplished with high-frequency paresthesia-free stimulation (HFS) at an amplitude of 6.2 mA, a frequency of 100-1200 Hz, and a pulse width of 130 µsec, to paresthesia-mediated pain relief associated with low-frequency stimulation. CONCLUSION: We report the implant of a supraorbital peripheral nerve stimulating electrode that utilizes a high-frequency program resulting in sustained suppression of intractable postherpetic neuralgia.


Asunto(s)
Terapia por Estimulación Eléctrica/métodos , Neuralgia Posherpética/terapia , Nervios Periféricos/fisiología , Parpadeo/fisiología , Cadáver , Terapia por Estimulación Eléctrica/instrumentación , Electrodos Implantados , Femenino , Estudios de Seguimiento , Lateralidad Funcional , Humanos , Masculino , Persona de Mediana Edad , Conducción Nerviosa , Dimensión del Dolor , Ultrasonografía
11.
Neuromodulation ; 17(8): 766-70, 2014 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-25491786

RESUMEN

OBJECTIVE: Spinal cord stimulation can be effectively used in the treatment of low back pain and extremity pain in failed back surgery syndrome. Ideal targets for stimulation corresponding to paresthesia overlap in the low back versus the extremities may differ in cranial-caudal location. MATERIALS AND METHODS: We present here a technical report of three cases demonstrating a technique to place anterograde and retrograde epidural paddles through a single laminotomy. RESULTS: Using this technique we were able to cover five spinal levels in each patient, and different stimulation programs at different levels created paresthesia overlap in back versus lower extremity in those patients. CONCLUSION: Dual paddle placement through a single laminotomy may be a reasonable option for select patients where coverage of anatomically-separated pain regions is necessary. This technique can be performed in most patients without significantly increased morbidity.


Asunto(s)
Espacio Epidural/fisiología , Síndrome de Fracaso de la Cirugía Espinal Lumbar/terapia , Laminectomía/métodos , Dolor de la Región Lumbar/terapia , Estimulación de la Médula Espinal/métodos , Adulto , Anciano , Femenino , Humanos
12.
J Pathol Inform ; 15: 100350, 2024 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-38162951

RESUMEN

Background: Distributed ledger technology (DLT) enables the creation of tamper-resistant, decentralized, and secure digital ledgers. A non-fungible token (NFT) represents a record on-chain associated with a digital or physical asset, such as a whole-slide image (WSI). The InterPlanetary File System (IPFS) represents an off-chain network, hypermedia, and file sharing peer-to-peer protocol for storing and sharing data in a distributed file system. Today, we need cheaper, more efficient, highly scalable, and transparent solutions for WSI data storage and access of medical records and medical imaging data. Methods: WSIs were created from non-human tissues and H&E-stained sections were scanned on a Philips Ultrafast WSI scanner at 40× magnification objective lens (1 µm/pixel). TIFF images were stored on IPFS, while NFTs were minted on the Ethereum blockchain network in ERC-1155 standard. WSI-NFTs were stored on MetaMask and OpenSea was used to display the WSI-NFT collection. Filebase storage application programing interface (API) were used to create dedicated gateways and content delivery networks (CDN). Results: A total of 10 WSI-NFTs were minted on the Ethereum blockchain network, found on our collection "Whole Slide Images as Non-fungible Tokens Project" on Open Sea: https://opensea.io/collection/untitled-collection-126765644. WSI TIFF files ranged in size from 1.6 to 2.2 GB and were stored on IPFS and pinned on 3 separate nodes. Under optimal conditions, and using a dedicated CDN, WSI reached retrieved at speeds of over 10 mb/s, however, download speeds and WSI retrieval times varied significantly depending on the file and gateway used. Overall, the public IPFS gateway resulted in variably poorer WSI download retrieval performance compared to gateways provided by Filebase storage API. Conclusion: Whole-slide images, as the most complex and substantial data files in healthcare, demand innovative solutions. In this technical report, we identify pitfalls in IPFS, and demonstrate proof-of-concept using a 3-layer architecture for scalable, decentralized storage, and access. Optimized through dedicated gateways and CDNs, which can be effectively applied to all medical data and imaging modalities across the healthcare sector. DLT and off-chain network solutions present numerous opportunities for advancements in clinical care, education, and research. Such approaches uphold the principles of equitable healthcare data ownership, security, and democratization, and are poised to drive significant innovation.

13.
Biologicals ; 41(4): 238-46, 2013 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-23763825

RESUMEN

The neurovirulence of two new candidate 17D-204 Stamaril™ working seed lots and that of two reference preparations were compared. The Stamaril™ working seed lots have been used for more than twenty years for the manufacturing of vaccines of acceptable safety and efficacy. The preparation designated RK 168-73 and provided by the Robert Koch Institute was used as a reference. It was confirmed that RK 168-73 strain was not a good virus control in our study because it has a very low neurovirulence regarding both the clinical and histopathological scores in comparison with Stamaril™ strain and is not representative of a vaccine known to be satisfactory in use. The results were reinforced by the phenotypic characterization by plaque assay demonstrating that RK 168-73 was very different from the Stamaril™ vaccine, and by sequencing results showing 4 mutations between Stamaril™ and RK 168-73 viruses leading to amino acid differences in the NS4B and envelop proteins.


Asunto(s)
Mutación , Proteínas no Estructurales Virales , Vacuna contra la Fiebre Amarilla , Virus de la Fiebre Amarilla , Animales , Chlorocebus aethiops , Análisis Mutacional de ADN , Femenino , Ratones , Células Vero , Proteínas no Estructurales Virales/genética , Proteínas no Estructurales Virales/inmunología , Vacuna contra la Fiebre Amarilla/efectos adversos , Vacuna contra la Fiebre Amarilla/genética , Vacuna contra la Fiebre Amarilla/inmunología , Vacuna contra la Fiebre Amarilla/farmacología , Virus de la Fiebre Amarilla/genética , Virus de la Fiebre Amarilla/inmunología
14.
J Korean Assoc Oral Maxillofac Surg ; 49(4): 214-217, 2023 Aug 31.
Artículo en Inglés | MEDLINE | ID: mdl-37641904

RESUMEN

Objectives: This case series aims to introduce the nasal floor approach for extracting inverted mesiodens. Materials and Methods: Through a retrospective chart review between January 2022 and February 2023, we included the mesiodens patients using nasal floor approach, and analysis the location of mesiodens from the anterior nasal spine (ANS), total operation time, and complications. Results: Each mesiodens was located 10 to 12 mm from the ANS and was covered with a cortical layer of the nasal floor. All mesiodens were successfully extracted without exposing the adjacent incisors or nasopalatine nerve within 30 minutes from draping to postoperative dressing. Conclusion: The nasal floor approach is an efficient extraction method that reduces bone removal and prevents anatomical damage while removing the mesiodens just below the nasal floor bone.

15.
Biochem Med (Zagreb) ; 33(3): 030705, 2023 Oct 15.
Artículo en Inglés | MEDLINE | ID: mdl-37841776

RESUMEN

Introduction: This survey aims to assess the implementation of recommendations from the European Atherosclerosis Society (EAS) and the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) by clinical biochemistry laboratories in Czechia and Slovakia in their policies for reporting low-density lipoprotein cholesterol (LDL-C) concentrations. Materials and methods: The web-based survey was distributed to all 383 Czech and Slovak clinical biochemistry laboratories that measure lipids by external quality assessment provider SEKK. A total of 17 single-answer questions were included. The questionnaire was focused on the detection and decision points in familial hypercholesterolemia (FH). All survey answers were taken into account. The laboratories followed the EFLM and EAS guidelines when they reported an interpretative comment considering FH diagnosis in adults. Results: A total of 203 (53%) laboratories answered. Only 5% of laboratories added interpretative comments considering FH diagnosis when LDL-C concentrations are above 5.0 mmol/L in adults, and 3% of laboratories added interpretative comments considering FH diagnosis when LDL-C concentrations are above 4.0 mmol/L in children. Only 7% of laboratories reported goals for all cardiovascular risk categories (low, moderate, high, very high). Non-HDL cholesterol concentrations were calculated by 74% of responders. A significant number (51%) of participants did not measure apolipoprotein B, and 59% of laboratories did not measure lipoprotein(a). Conclusions: Only a small portion of laboratories from Czechia and Slovakia reported high LDL-C results with interpretative comments considering FH diagnosis in adults, the laboratories did not follow the guidelines.


Asunto(s)
Aterosclerosis , Hiperlipoproteinemia Tipo II , Adulto , Niño , Humanos , LDL-Colesterol , República Checa , Eslovaquia , Laboratorios , Hiperlipoproteinemia Tipo II/diagnóstico , Colesterol
16.
J Med Phys ; 48(3): 281-288, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37969152

RESUMEN

Aim: In this study, a 6MV flattening filter (FF) and 6MV FF Free (FFF) photon beam small-field output factors (OF) were measured with various collimators using different detectors. The corrected OFs were compared with the treatment planning system (TPS) calculated OFs. Materials and Methods: OF measurements were performed with four different types of collimators: Varian Millennium multi-leaf collimator (MLC), Elekta Agility MLC, Apex micro-MLC (mMLC) and a stereotactic cone. Ten detectors (four ionization chambers and six diodes) were used to perform the OF measurements at a depth of 10 cm with a source-to-surface distance of 90 cm. The corrected OF was calculated from the measurements. The corrected OFs were compared with existing TPS-generated OFs. Results: The use of detector-specific output correction factor (OCF) in the PTW diode P detector reduced the OF uncertainty by <4.1% for 1 cm × 1 cm Sclin. The corrected OF was compared with TPS calculated OF; the maximum variation with the IBA CC01 chamber was 3.75%, 3.72%, 1.16%, and 0.90% for 5 mm stereotactic cone, 0.49 cm × 0.49 cm Apex mMLC, 1 cm × 1 cm Agility MLC, and 1 cm × 1 cm Millennium MLC, respectively. Conclusion: The technical report series-483 protocol recommends that detector-specific OCF should be used to calculate the corrected OF from the measured OF. The implementation of OCF in the TPS commissioning will reduce the small-field OF variation by <3% for any type of detector.

17.
J Korean Neurosurg Soc ; 65(1): 114-122, 2022 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-34879644

RESUMEN

OBJECTIVE: Early descent of the diaphragm sellae (DS) during endoscopic endonasal transsphenoidal surgery (EETS) for pituitary macroadenoma surgery is occasionally a troublesome event by blocking the surgical field. Here we introduce an alternative technique with the new pituitary retractor and present our clinical experiences. METHODS: We designed a simple and rigid pituitary retractor with the least space occupation in the nasal cavity to be compatible in EETS. The pituitary retractor was held by external holder system to support the herniated DS stably. We retrospectively reviewed a clinical 22 cases of pituitary macroadenomas underwent EETS using the pituitary retractor. RESULTS: The pituitary retractor stably pushed up the herniated DS in all cases, and the surgeon proceeded the procedure with bimanual maneuver. The pituitary retractor was helpful to remove tumors around the medial cavernous sinus and behind the DS in 16 and seven cases, respectively. In four cases, the meticulous hemostasis was completed with the direct visualization by the DS elevation with this retractor. Gross total tumor resection was performed in 20/22 patients (91%). The impaired visual function and hypopituitarism were improved in 18/20 (90%) and 7/14 (50%) patients after surgery, respectively. There was no complication related with the pituitary retractor. CONCLUSION: During EETS for pituitary macroadenomas, the novel pituitary retractor reported in this study is a very useful technique when the herniated DS block the surgical field and bimanual maneuver. This pituitary retractor can help to result in the excellent surgical outcomes with minimal morbidity.

18.
Dent Clin North Am ; 66(4): 673-689, 2022 10.
Artículo en Inglés | MEDLINE | ID: mdl-36216453

RESUMEN

The formal history of standards and dentistry in the United States goes back to World War I and was prompted by the government's need to buy large quantities of dental materials to treat "an army of teeth in disrepair." This article covers the use of scientific research to establish specifications and standards used to evaluate dental materials and products, and how a practitioner can use these standards to assure the safety and performance of the materials that they use in their everyday practice.


Asunto(s)
Materiales Dentales , Materiales Dentales/efectos adversos , Humanos , Estados Unidos
19.
Pain Physician ; 24(2): E177-E183, 2021 03.
Artículo en Inglés | MEDLINE | ID: mdl-33740351

RESUMEN

BACKGROUND: Over the last decade, several authors have reported that percutaneous peripheral nerve stimulation (PNS) can be used to assist in verifying the position of the procedure needle tip in relation to nerve structures, and that the combined technique using both ultrasound (US) guidance and PNS may serve as a reliable method for confirmation of the correct position of the procedure needle tip. It has also been reported that, when combined with US guidance, PNS may increase the success rate of pain management interventions. OBJECTIVES: The aim of this technical report was to standardize an effective and easy to learn illustrated step-by-step technical approach to nerve identification during US-guided genicular nerve blocks, using percutaneous PNS as a verification instrument for procedure needle tip location. STUDY DESIGN: This technical protocol was developed based on the results of the authors' most recent cadaveric study on the innervation of the knee joint capsule. The technique was developed and tested by 4 different interventionists with different levels of expertise in US-guided procedures. SETTING: The cadaveric study of the knee joint capsule innervation was performed at the laboratory of the Division of Anatomy of one institution. The technical protocol using US and PNS was later developed at the medical simulation center of a different institution. METHODS: A team of anatomists from a division of anatomy of one institution performed the cadaveric study on the innervation of the knee joint capsule. A team of physicians then developed the step-by-step approach to this technical protocol at the medical simulation center of  a different institution. Finally, the illustrated step-by-step approach was tested by 4 different interventionists with different levels of expertise in US-guided procedures (1 beginner-level user; 1 intermediate-level user; 2 expert-level users), using a portable percutaneous PNS and 2 different US transducers at 2 different institutions. RESULTS: This technical protocol was successfully developed based on the results of the cadaveric study on the innervation of the knee joint capsule. Additionally, it was later successfully tested by interventionists with various levels of expertise utilizing different US equipment at separate institutions. LIMITATIONS: By combining US and nerve stimulation, this protocol requires the availability of both US equipment and necessary equipment for nerve stimulation that must all be made available in the sterile field. Another potential disadvantage is that nerve stimulation controls and the US image screen are generally located on 2 separate display panels, which could cause difficulty with visualization and simultaneous calibration for 2 individual devices. CONCLUSIONS: Our illustrated step-by-step technical protocol can be effectively and safely utilized as a reliable method of training, by which physicians with little to moderate US experience can improve their skills in accurately identifying the genicular nerves while performing US-guided examinations with the intent of executing a peripheral nerve block.


Asunto(s)
Articulación de la Rodilla/cirugía , Rodilla/cirugía , Bloqueo Nervioso/métodos , Nervios Periféricos/diagnóstico por imagen , Ultrasonografía Intervencional/métodos , Humanos , Rodilla/diagnóstico por imagen , Articulación de la Rodilla/diagnóstico por imagen , Articulación de la Rodilla/inervación , Estimulación Eléctrica Transcutánea del Nervio
20.
Cureus ; 13(3): e13916, 2021 Mar 16.
Artículo en Inglés | MEDLINE | ID: mdl-33880268

RESUMEN

Spinal cord stimulation is a safe, effective, and reversible method for the management of chronic neuropathic pain. Spinal cord stimulation was found to be superior to traditional conservative management in recent clinical trials. The superiority of this therapeutic strategy is in part due to the many benefits, such as decreased use of prescription pain medications, cost-effectiveness, and improvement in patient quality of life. With appropriate patient consent for photography during the operation per hospital policy, the technical description for percutaneous placement of a spinal cord stimulator was documented at the authors home institution. The percutaneous technique allows for decreased operative times and thus reduced anesthesia, as well as decreased post-operative pain due to less tissue and muscle dissection. Additionally, the percutaneous leads have a smaller footprint in the epidural space, allowing more patients with mild spinal canal stenosis to receive this therapeutic device, which generally precludes paddle placement. These features make the percutaneous method an appealing alternative to the traditional laminotomy technique. The traditional laminotomy approach for paddle lead placement has been well described in the literature. However, detailed and indexed techniques of the percutaneous alternative are lacking. This technical description provides the first, easily accessible technical guide for the percutaneous placement of thoracic spinal cord stimulators. The operative technique was documented with images and detailed descriptions at the authors home institution.

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