Finding the neural correlates of collaboration using a three-person fMRI hyperscanning paradigm.

Humans have an extraordinary ability to interact and cooperate with others. Despite the social and evolutionary significance of collaboration, research on finding its neural correlates has been limited partly due to restrictions on the simultaneous neuroimaging of more than one participant (also known as hyperscanning). Several studies have used dyadic fMRI hyperscanning to examine the interaction between two participants. However, to our knowledge, no study to date has aimed at revealing the neural correlates of social interactions using a three-person (or triadic) fMRI hyperscanning paradigm. Here, we simultaneously measured the blood-oxygenation level-dependent signal from 12 triads (n = 36 participants), while they engaged in a collaborative drawing task based on the social game of Pictionary General linear model analysis revealed increased activation in the brain regions previously linked with the theory of mind during the collaborative phase compared to the independent phase of the task. Furthermore, using intersubject correlation analysis, we revealed increased synchronization of the right temporo-parietal junction (R TPJ) during the collaborative phase. The increased synchrony in the R TPJ was observed to be positively associated with the overall team performance on the task. In sum, our paradigm revealed a vital role of the R TPJ among other theory-of-mind regions during a triadic collaborative drawing task.

Timing matters: disentangling the neurocognitive sequence of mentalizing.

A recent electrocorticographic study by Tan et al. makes an important contribution to understanding the processes involved in mentalizing by adding the temporal dimension to the brain network of mentalizing. Combined with multivariate methods, this approach has the potential to unveil the precise representations underlying mentalizing and their functional interplay.

The Development of Brain Network in Males with Autism Spectrum Disorders from Childhood to Adolescence: Evidence from fNIRS Study.

In the current study, functional near-infrared spectroscopy (fNIRS) was used to collect resting-state signals from 77 males with autism spectrum disorders (ASD, age: 6~16.25) and 40 typically developing (TD) males (age: 6~16.58) in the theory-of-mind (ToM) network. The graph theory analysis was used to obtain the brain network properties in ToM network, and the multiple regression analysis demonstrated that males with ASD showed a comparable global network topology, and a similar age-related decrease in the medial prefrontal cortex area (mPFC) compared to TD individuals. Nevertheless, participants with ASD showed U-shaped trajectories of nodal metrics of right temporo-parietal junction (TPJ), and an age-related decrease in the left middle frontal gyrus (MFG), while trajectories of TD participants were opposite. The nodal metrics of the right TPJ was negatively associated with the social deficits of ASD, while the nodal metrics of the left MFG was negatively associated with the communication deficits of ASD. Current findings suggested a distinct developmental trajectory of the ToM network in males with ASD from childhood to adolescence.

Discourse-level comprehension engages medial frontal Theory of Mind brain regions even for expository texts.

In addition to understanding individual word meanings and processing the syntactic and semantic dependencies among those words within a sentence, language comprehension often requires constructing a higher-order discourse structure based on the relationships among clauses and sentences in the extended context. Prior fMRI studies of discourse-level comprehension have reported greater activation for texts than unconnected sentences in what-appear-to-be regions of the Theory of Mind (ToM) network. However, those studies have generally used narratives rich in mental state content, thus confounding coherence and content. We report an fMRI experiment where ToM regions were defined functionally in each participant, and their responses were examined to texts vs. sentence lists. Critically, we used expository texts to minimize mental state content. Medial frontal but not posterior ToM regions exhibited small but reliable increases in their responses to texts relative to unconnected sentences, suggesting a role for these regions in discourse comprehension independent of content.

The Psychology of Motivated versus Rational Impression Updating.

People's beliefs about others are often impervious to new evidence: we continue to cooperate with ingroup defectors and refuse to see outgroup enemies as rehabilitated. Resistance to updating beliefs with new information has historically been interpreted as reflecting bias or motivated cognition, but recent work in Bayesian inference suggests that belief maintenance can be compatible with procedural rationality. We propose a mentalizing account of belief maintenance, which holds that protecting strong priors by generating alternative explanations for surprising information involves more mentalizing about the target than nonrational discounting. We review the neuroscientific evidence supporting this approach, and discuss how both types of processing can lead to fitness benefits.

Reduced Language Lateralization in Autism and the Broader Autism Phenotype as Assessed with Robust Individual-Subjects Analyses.

One of the few replicated functional brain differences between individuals with autism spectrum disorders (ASD) and neurotypical (NT) controls is reduced language lateralization. However, most prior reports relied on comparisons of group-level activation maps or functional markers that had not been validated at the individual-subject level, and/or used tasks that do not isolate language processing from other cognitive processes, complicating interpretation. Furthermore, few prior studies have examined functional responses in other brain networks, as needed to determine the spatial selectivity of the effect. Using functional magnetic resonance imaging (fMRI), we compared language lateralization between 28 adult ASD participants and carefully pairwise-matched controls, with the language regions defined individually using a well-validated language "localizer" task. Across two language comprehension paradigms, ASD participants showed less lateralized responses due to stronger right hemisphere activity. Furthermore, this effect did not stem from a ubiquitous reduction in lateralization of function across the brain: ASD participants did not differ from controls in the lateralization of two other large-scale networks-the Theory of Mind network and the Multiple Demand network. Finally, in an exploratory study, we tested whether reduced language lateralization may also be present in NT individuals with high autism-like traits. Indeed, autistic trait load in a large set of NT participants (n = 189) was associated with less lateralized language responses. These results suggest that reduced language lateralization is robustly associated with autism and, to some extent, with autism-like traits in the general population, and this lateralization reduction appears to be restricted to the language system. LAY SUMMARY: How do brains of individuals with autism spectrum disorders (ASD) differ from those of neurotypical (NT) controls? One of the most consistently reported differences is the reduction of lateralization during language processing in individuals with ASD. However, most prior studies have used methods that made this finding difficult to interpret, and perhaps even artifactual. Using robust individual-level markers of lateralization, we found that indeed, ASD individuals show reduced lateralization for language due to stronger right-hemisphere activity. We further show that this reduction is not due to a general reduction of lateralization of function across the brain. Finally, we show that greater autistic trait load is associated with less lateralized language responses in the NT population. These results suggest that reduced language lateralization is robustly associated with autism and, to some extent, with autism-like traits in the general population. Autism Res 2020, 13: 1746-1761. © 2020 International Society for Autism Research and Wiley Periodicals LLC.

Neural and Genetic Correlates of the Social Sharing of Happiness.

Happiness is regarded as one of the most fundamental human goals. Given recent reports that positive feelings are contagious (e.g., the presence of a happy person enhances others' happiness) because of the human ability to empathize (i.e., sharing emotions), empathic ability may be a key factor in increasing one's own subjective level of happiness. Based on previous studies indicating that a single nucleotide polymorphism in the serotonin 2A receptor gene [HTR2A rs6311 guanine (G) vs. adenine (A)] is associated with sensitivity to emotional stimuli and several mental disorders such as depression, we predicted that the polymorphism might be associated with the effect of sharing happiness. To elucidate the neural and genetic correlates of the effect of sharing happiness, we first performed functional magnetic resonance imaging (fMRI) during a "happy feelings" evocation task (emotional event imagination task), during which we manipulated the valence of the imagined event (positive, neutral, or negative), as well as the presence of a friend experiencing a positive-valence event (presence or absence). We recruited young adult women for this fMRI study because empathic ability may be higher in women than in men. Participants felt happier (p < 0.01) and the mentalizing/theory-of-mind network, which spans the medial prefrontal cortex, temporoparietal junction, temporal poles, and precuneus, was significantly more active (p < 0.05) in the presence condition than in the absence condition regardless of event valence. Moreover, participants with the GG (p < 0.01) and AG (p < 0.05) genotypes of HTR2A experienced happier feelings as well as greater activation of a part of the mentalizing/theory-of-mind network (p < 0.05) during empathy for happiness (neutral/presence condition) than those with the AA genotype. In a follow-up study with a vignette-based questionnaire conducted in a relatively large sample, male and female participants were presented with the same imagined events wherein their valence and the presence of a friend were manipulated. Results showed genetic differences in happiness-related empathy regardless of sex (p < 0.05). Findings suggest that HTR2A polymorphisms are associated with the effect of sharing happiness by modulating the activity of the mentalizing/theory-of-mind network.

Propiedades psicométricas de la escala de presencia social de las mentes en red y su aplicación en el Entorno Virtual de Enseñanza Aprendizaje UTAmed / Psychometric Properties Networked Minds Social Presence Measure and its Application in the Teaching Learning Virtual Environment UTAmed

Se estudian las propiedades psicométricas de la versión en español de la medida de presencia social de las mentes en red (Networked Minds Social Presence Measure) de Harms y Biocca (2004) en una muestra de 94 estudiantes universitarios de Arica, Chile, que hacen uso del entorno virtual de enseñanza aprendizaje EVEA UTAmed. Se realizaron estudios de fiabilidad y un análisis factorial exploratorio con el método de componentes principales y rotación varimax y posteriormente un análisis factorial confirmatorio. Los resultados muestran la existencia de cinco sub escalas con un total de 23 ítems que explican 81,25 % de la varianza, un alpha de Cronbach de 0.94 y un ajuste adecuado del modelo. Se confirma además una relación positiva de la presencia social con el aprendizaje percibido. El estudio permite disponer de un instrumento más breve y adaptado a la medición de la presencia social en entornos virtuales de enseñanza aprendizaje con resultados notoriamente superiores a la de los instrumentos existentes.

The present work studies the psychometric properties of the Spanish version of the measure of social presence in Harms and Biocca (2004) minds of network (Networked Minds Social Presence Measure) in a sample of 94 university students in Arica, Chile, who make use of virtual teaching and learning environment VLE UTAmed. Reliability and an exploratory factor analysis were conducted with principal components and varimax rotation, and subsequent confirmatory factor analysis. The results show the existence of five subscales with a total of 23 items that explain 81.25% of the variance, a Cronbach's alpha of 0.94, and an adequate adjustment of the model. Additionally, the study confirms a positive relationship between social presence and perceived learning. The study allows us to have a shorter instrument, and adapted to the measurement of social presence in virtual environments for teaching and learning with better results well compared to the existing instruments.