1.
Angew Chem Int Ed Engl
; 59(30): 12392-12395, 2020 Jul 20.
Artículo
en Inglés
| MEDLINE
| ID: mdl-32394593
RESUMEN
A strategy for expanding the utility of chiral pyridine-2,6-bis(oxazoline) (pybox) ligands for asymmetric transition metal catalysis is introduced by adding a bidentate ligand to modulate the electronic properties and asymmetric induction. Specifically, a ruthenium(II) pybox fragment is combined with a cyclometalated N-heterocyclic carbene (NHC) ligand to generate catalysts for enantioselective transition metal nitrenoid chemistry, including ring contraction to chiral 2H-azirines (up to 97 % ee with 2000â TON) and enantioselective C(sp3 )-H aminations (up to 97 % ee with 50â TON).