RESUMEN
INTRODUCTION: The objective was to compare the short-term efficacy of methoxyflurane vs. MEOPA on acute pain during burn dressing in consultation, the secondary outcome was to assess the patient's comfort and the quality of the dressing performed. MATERIALS AND METHODS: Monocentric, prospective study from April 2018 to January 2019. Men and women>18 years presenting acute burn on<10% SCT were included. A pain≥4 on the numerical scale (from 0 to 10) at the beginning of the treatment established the indication of methoxyflurane or MEOPA, with randomization done by a nurse. The following data were collected: burn description, performed debridement, pain assessment by numerical scale: on arrival, at the beginning of care, after 6 to 10 inhalations for methoxyflurane or 3 to 4minutes of inhalation for MEOPA and at the end of care. RESULTS: Sixty patients were included, 30 in each group. There was a decrease of -2.47 points of numerical scale when initiating methoxyflurane against -1.53 points for MEOPA (P=0.08). Patients were significantly less painful when stopping treatment in the methoxyflurane group -4 points vs -2 points (P=0.001). Methoxyflurane significantly improved the debridement of the burn (P=0.018). CONCLUSION: Methoxyflurane is more effective than MEOPA in acute pain in burn dressing, improved patient comfort, and improved dressing quality.
Asunto(s)
Dolor Agudo/tratamiento farmacológico , Dolor Agudo/etiología , Anestésicos por Inhalación/uso terapéutico , Vendajes/efectos adversos , Quemaduras/terapia , Metoxiflurano/uso terapéutico , Óxido Nitroso/uso terapéutico , Compuestos de Oxígeno/uso terapéutico , Adulto , Femenino , Humanos , Masculino , Estudios ProspectivosRESUMEN
INTRODUCTION: MEOPA (equimolar mixture of oxygen and nitrous oxide) is used for its analgesic and anxiolytic properties in order to obtain conscious sedation of the patient when performing painful care. It is subject to an enhanced pharmacovigilance and addictovigilance monitoring. In this context, it is important to dispose of hospital utilization data. This work aims to assess the compliance of the use of nitrous oxide regarding the recommendations of the summary of product characteristics, in a French university hospital (Nantes) and consider possible improvements. MATERIALS AND METHODS: Transversal descriptive study, conducted in 2014 with all health professionals using MEOPA. RESULTS: Two thousand thirty-four health professionals answered the questionnaire ; durations of administrations are in conformity and the premises are generally appropriate but almost 60% of professionals have the feeling of inhaling the drug. The systematization of the prescription (always or almost always prescribed for 67% of professionals) and traceability of use (always or almost always in the patient's file for 71% of professionals) are potential source of improvement, particularly since 18% of professional health reported "abuse demands" from patients. CONCLUSION: The formation and information of health professionals are major issues of good use of nitrous oxide.
Asunto(s)
Analgésicos/administración & dosificación , Personal de Salud/estadística & datos numéricos , Óxido Nitroso/administración & dosificación , Compuestos de Oxígeno/administración & dosificación , Dolor/tratamiento farmacológico , Analgésicos/uso terapéutico , Estudios Transversales , Francia , Adhesión a Directriz , Encuestas de Atención de la Salud , Hospitales Universitarios , Humanos , Óxido Nitroso/uso terapéutico , Compuestos de Oxígeno/uso terapéutico , Guías de Práctica Clínica como Asunto , Trastornos Relacionados con Sustancias/epidemiologíaAsunto(s)
Óxido Nitroso/uso terapéutico , Compuestos de Oxígeno/uso terapéutico , Manejo del Dolor/métodos , Analgésicos no Narcóticos/administración & dosificación , Analgésicos no Narcóticos/efectos adversos , Analgésicos no Narcóticos/uso terapéutico , Anestesia por Inhalación/efectos adversos , Anestesia por Inhalación/instrumentación , Anestesia por Inhalación/métodos , Contraindicaciones , Humanos , Monitoreo Fisiológico/métodos , Monitoreo Fisiológico/enfermería , Óxido Nitroso/administración & dosificación , Óxido Nitroso/efectos adversos , Rol de la Enfermera , Compuestos de Oxígeno/administración & dosificación , Compuestos de Oxígeno/efectos adversos , Dolor/tratamiento farmacológicoAsunto(s)
Quinasa de la Caseína II/antagonistas & inhibidores , Nanopartículas del Metal/química , Compuestos de Oxígeno/farmacología , Inhibidores de Proteínas Quinasas/farmacología , Elementos de Transición/farmacología , Adenosina Trifosfato/fisiología , Animales , Aniones/química , Aniones/farmacología , Antiinfecciosos/química , Antiinfecciosos/farmacología , Antiinfecciosos/uso terapéutico , Antineoplásicos/química , Antineoplásicos/farmacología , Antineoplásicos/uso terapéutico , Sitios de Unión/efectos de los fármacos , Unión Competitiva , Quinasa de la Caseína II/química , Quinasa de la Caseína II/fisiología , Dominio Catalítico/efectos de los fármacos , Ensayos Clínicos Fase II como Asunto , Técnicas Químicas Combinatorias , Humanos , Nanopartículas del Metal/uso terapéutico , Ratones , Modelos Moleculares , Proteínas de Neoplasias/antagonistas & inhibidores , Neoplasias/tratamiento farmacológico , Neoplasias/enzimología , Compuestos de Oxígeno/química , Compuestos de Oxígeno/uso terapéutico , Conformación Proteica , Inhibidores de Proteínas Quinasas/química , Elementos de Transición/química , Elementos de Transición/uso terapéutico , Ensayos Antitumor por Modelo de XenoinjertoAsunto(s)
Óxido Nitroso/uso terapéutico , Compuestos de Oxígeno/uso terapéutico , Administración por Inhalación , Analgesia/métodos , Analgesia/enfermería , Combinación de Medicamentos , Monitoreo de Drogas , Humanos , Óxido Nitroso/efectos adversos , Compuestos de Oxígeno/efectos adversos , Educación del Paciente como Asunto , Selección de PacienteAsunto(s)
Óxido Nitroso/uso terapéutico , Compuestos de Oxígeno/uso terapéutico , Dolor/tratamiento farmacológico , Administración por Inhalación , Niño , Combinación de Medicamentos , Humanos , Rol de la Enfermera , Dolor/enfermería , Dolor/psicología , Educación del Paciente como Asunto , Selección de Paciente , Psicología InfantilRESUMEN
The standard treatment of chromic skull-base osteomyelitis is antibiotics and surgical removal of sequestrums. Hyperbaric oxygen therapy has been found to be a useful method for managing refractory cases of chronic osteomyelitis. Since a minimal blood supply is needed for hyperbaric oxygen therapy, chronic osteomyelitis can produce necrotic infected areas that are not nutrified and therefore not assessable for hyperbaric oxygen therapy. Ozone is known to be an oxidizing medium with a strong bactericidal effect. We investigated the influence of locally applied ozonated oxygen on the development of chronic osteomyelitis in an experimental animal model using the femur of the rabbit. The proximal sides of the femurs of 40 rabbits were prepared and a needle inserted into the intramedullary cavity. Osteomyelitis was induced with an infusion of Staphylococcus aureus and sodium morrhuate into the bone. The needle was left in a intramedular location. After a 4-week delay animals were randomly separated into treatment and control groups. The infected femur of treated animals was flushed three times a day with 20 ml of ozonated oxygen at an ozone concentration of 107 micrograms/ml O2 over periods of 2 or 4 weeks. Clinical, radiographic and microbiological findings were documented. Chronic osteomyelitis occurred in all animals. Ten rabbits were excluded from further study during the investigation because of excessive weight loss (> 15% of the original weight). Bacterial cultures showed no significant reduction of S. aureus concentrations in the ozone-treated group, although comparison of radiographic results revealed less serious osteomyelitis-related bone damage in these animals (P < 0.01). These findings indicate that refractory osteomyelitis in the head and neck may benefit from locally applied "flush" therapy with ozonated oxygen in addition to treatment with antibiotics, surgery and hyperbaric oxygen.