[A tribute to Revista Médica de Chile on its 150th Anniversary (1872-2022)]. / Homenaje a la Revista Médica de Chile en sus 150 años de vida (1872-2022).

Revista Médica de Chile was founded in 1872 by Sociedad Médica de Santiago (currently Chilean Society of Internal Medicine) and it is one out of twenty five medical journals founded during the XIX Century that still remain active. In monthly issues it presents clinical and biomedical research articles, as well as research and position papers dealing with medical education, public health or medical ethics. Special attention receive the impact on health care given by the emergence of new private medical schools in Chile, the relevance of methodologies to assess clinical competences in graduates, the certification of specialty programs and specialists, the appropiate use of simulators in clinical training, telemedicine, organ transplants, and current issues in medical ethics, such as abortions and euthanasia. Institutional and international collaboration in medical research is clearly reflected in recent years. Articles are subjected to external peer review and ICMJE Recommendations are carefully considered throughout the review process. Most articles are published in Spanish but English abstracts are mandatory and a growing number of articles are currently published in English. An Open Access electronic version is published by SciELO. Revista Médica de Chile is indexed in the most important international data bases and it is a member of the ICMJE ruling committee. The long life and prestige of this journal can be considered a testimony of the cultural heritage and progress in Chilean medicine.

Winner's curse: The sad aftermath of the discovery of insulin.

Every young researcher dreams of making a great discovery, but few achieve it. If they do, success does not guarantee happiness. There is little satisfaction in discovering something if others get the credit, and those who achieve fame must face the 'winner's curse' of living up to their reputation. Few discoveries have been more dramatic than the isolation of insulin which, as Michael Bliss said, resembled a secular miracle. And yet, as he also pointed out, this great discovery brought little happiness to those who made it. Some were sidelined, and Banting and Best were saddled with the winner's curse. Here, we look at the ways in which a great discovery can haunt its discoverers.

100 years of physiology, discrimination and wonder.

There has been 100 years of research detailing the role of insulin in glucose, protein and free fatty acid metabolism. We explore the learnings though evolution and changes in management with an understanding of how it has impacted the care of people with diabetes. The discrimination endured is described and recent advances to empower and counter this are highlighted.

Toward Historical Accountability and Remembrance: The German Society for Internal Medicine and Its Legacies From the Nazi Past.

After decades of silence, the German Society for Internal Medicine (DGIM) has made considerable efforts to come to terms with its role and actions during the Nazi era (1933 to 1945). This is particularly important because, with more than 27 000 members, the DGIM is the largest medical society in present-day Germany. Since 1882, the society's annual congress in Wiesbaden has provided a forum and focus for the key medical topics of the day. Based on ongoing historical research, this article is organized in 2 parts. The first describes how the DGIM willingly adapted to the ideology and politics of the Nazi regime, showing no solidarity with its persecuted Jewish members. To illustrate their fates, the cases of Leopold Lichtwitz, who was forced to resign as elected chairman in 1933, and committee member Julius Bauer are investigated. Both men emigrated to the United States. Light is also shed on the decisions of those who led the society during the Nazi era and on the involvement of high-ranking members in medical crimes. The second part of the article analyzes developments in the postwar period and considers why it took so long to hold up a mirror to the past. Although critical voices could be heard from both outside and within the society, they remained isolated and without consequence. Only the past 2 decades have brought about both general and specific developments toward historical accountability and an active culture of remembrance. With a declaration first published in 2015, a new website bringing history and memory together, and a strong commitment to the norms and values of liberal democracy, the DGIM has found its way to a clear position-and has lessons to teach.

[On Soviet therapeutic elite: Miron Semenovich Vovsi, the head therapist of the Red Army - portrait without retouch].

The article is devoted to the biography and scientific contribution of Miron Semyonovich Vovsi, the eminent Soviet internist, organizer of army internal medicine. For the first time, the materials of his personal records from the Yuriev (Tartu) University and verified date of his birth are publicly introduced. Miron Semyonovich (Meer Simonovic) Vovsi was born on May 12 (24) 1897, in the township of Kreslavka (actually Kraslava, Latvia). In 1915, he entered the medical faculty of Yuriev (actually Tartu) University. In 1918 he was transferred to the Moscow University. He, after serving as military doctor, studied and worked under the guidance of D. D. Pletnev, I. M. Wiechert and V. F. Zelenin. In 1934, he moved to the Botkin hospital and after defending his doctoral thesis, became the head of the Department of internal medicine in the Central institute of advanced medical training, where he worked for more than 30 years. During the Second World War, he was the chief internist of the Red Army. He was engaged in the organization and improvement of army internal medicine. In 1952, during the so-called "physicians case", he was arrested and tortured for 5 months. After his release, he returned to teaching, medical and scientific activities. He died in 1960. His major areas of scientific contribution to medicine are nephrology, cardiology and army internal medicine.

[The stages of history of national clinic of internal diseases: The Soviet medicine (stage 4)].

The publication continues the topic of previous article and develops the theme of periodization of clinical internal medicine in Russia for last 200 years. The discussion covers the fourth stage - the Soviet period of internal medicine in 1920s - 1950s that resulted in crisis. The authors, using historical examples, illustrate the need to take into account historical and social processes in studying the development of medicine.

[200 years of history of National clinic of internal diseases: issues of periodization (stages 1-3)].

The main development of the clinical internal medicine in Russia took place over the past 200 years. To understand the pattern of this process, we explored its possible subdivision into phases (periods). This article presents the first part of the proposed periodization describing the characteristics and time frame of the first three stages (from the beginning of the 19th century to the late 1910s).

Professor Samuel David Gross (1805-1884) and His Innovations in Surgery and Medicine.

Professor Samuel David Gross (1805-1884) is considered as one of the founders of American surgery. He was a skillful surgeon who could excellently perform a lithotomy, an amputation, and a cataract surgery. He introduced many new surgical techniques and designed new surgical and medical instruments. He expertise was not limited to surgery alone; he also published studies concerning internal medicine, pathology, experimental physiology, and pharmacology. His most important treatise was his 2-volume work, A System of Surgery, Pathological, Diagnostic, Therapeutic and Operative (1861), which was a standard reference book in surgery in the United States during the second half of 19th century. Gross received many honors during his life. He was active in the operating room until his death.

[Suggestions of reshaping medical education (The Hungarian medical elite at universities and the Hungarian Academy of Sciences) 1947-1948]. / Javaslatok az orvosképzés átalakítására (A magyar orvostudományi elit az egyetemeken és a Magyar Tudományos Akadémián) 1947­1948.

This study is part of the monograph entitled Scientific Elites and Politics (1945-1948) to be published soon. The relationships of political parties with several elite groups, such as groups of agronomic, human, economic, legal, technical and natural sciences, as well as the roles of these elites in scientific life, have been looked into and published in renowned periodicals. Using new sources, different specialist groups' and political powers' suggestions of reshaping medical education in 1947 and 1948, are presented. The medical elite's situation at universities and the Hungarian Academy of Sciences is also outlined. The study renders an account of the entire post-war medical elite. It will be stated who and based on what scientific achievement became member of the Hungarian Academy of Sciences, who was appointed to professor and who became a habilitated doctor. This study, which is a desideratum of research, may not only interest researchers but is aimed at a broader readership, including physicians. Orv. Hetil., 2017, 158(11), 432-437.

Wladyslaw Bieganski, MD (1857-1917)

Dr W. Bieganski was an eminent doctor of internal medicine mostly the acute infectious diseases and tuberculosis, he was scientist doing the research on the origin of the diseases and on the medical ethics, but more he was also a social activist taking care on the public health of the society in his time still living under the Russian rule. W. Bieganski living on the XIX/XX century in small provincial town, grace to his knowledge, self education and energy created the important scientific center in the municipal small hospital. His philosophic works and especially knowledge published under the shape of aphorisms on the medical ethics were several time published still after his death. The century of the death of Dr W. Bieganski the Senat of RP, the Higher Chamber of the Polish Parliament, celebrated by nominating him as one of the eminent persons for the year 2017. This publication was prepared to memorize the achievements of a medical doctor, scientists and social Dr W. Bieganski activists, that can be jugged as the precursor of the public health activist, and whose philosophical findings are still worth to be remember.

Internal medicine in the United States and Germany: mutual influences from 1870 to today.

Over the past 140 years, the close academic and clinical interactions in Internal Medicine between German-speaking countries and the United States have been through three distinct stages. From 1870 until the First World War, German medical research, teaching, and university organization served as a model for U.S. medical schools and practice. However, after World War I, medical education reforms were implemented in the U.S., and due also to radical economic and political changes at home, German medicine lost its pioneering role. Furthermore, many scientists and clinicians were forced to emigrate in the face of racial and political persecution in Germany and Austria. Since the Second World War, American medicine has grown further to become the world leader in research, training, and clinical practice. The earlier trend of American physicians studying abroad was thus reversed, with many of today's foremost German physicians completing clinical and research training in the United States.

[History of the 4th Department of Internal Medicine of the First Faculty of Medicine at Charles University and the General University Hospital in Prague]. / Historie IV. interní kliniky 1. LF UK a VFN.

In 2015, the doctors and nurses of the 4th Department of Internal Medicine of the First Faculty of Medicine, Charles University and the General University Hospital in Prague celebrated the 70th anniversary of its founding. The article summarizes the clinics contribution to the field of internal medicine, and particularly to angiology, hepatogastroenterology and lipidology. It comments the clinics current activities and the possibilities of its further development. Attention is also paid to the tradition of high ethical and professional standards of medical care in accordance with the norms established by the clinic's founder, prof. MUDr. Bohumil Prusík.

["On a strictly scientific basis." German constitutional medicine establishing itself, 1911­1921]. / "Auf strengster wissenschaftlicher Grundlage." Die Etablierungsphase der modernen Konstitutionslehre 1911 bis 1921.

In the years between 1911 and 1921, modern constitutional medicine established itself as an interdisciplinary research program in German-speaking countries. Untouched by later holistic interpretations and still far from the ,,crisis of medicine" of the late 1920s early constitutional medicine was very attractive due to its scientific self-characterisation. Thus, it became influential across the medical disciplines. This paper examines history and subject matter of German modern constitutional medicine in its first decade, starting in 1911, the year constitutional medicine was first publicly discussed by the Wiesbaden congress for internal medicine, including its development during World War I and closing with the first textbooks for medical students in 1921.

Raising the Academic Authority of Clinical Experience: The Department of Internal Medicine at Keijo Imperial University and Its Periodical Imsangnaegwahak.

This paper examines the periodical Clinical Internal Medicine published by the Department of Internal Medicine at Keijo Imperial University in colonial Korea. Previous studies on medical research at Keijo Imperial University have primarily focused on preclinical departments such as anatomy, hygiene, pharmacology, and microbiology which produced knowledge that supported Japan's imperialistic expansion. This approach has overlooked the research contributions of clinical departments, often viewing the roles of preclinical and clinical departments through a dichotomy between research versus clinician training. However, Clinical Internal Medicine demonstrates that the Department of Internal Medicine at Keijo Imperial University was actively engaged in research. By analyzing the purpose and content of Clinical Internal Medicine, this paper reveals that its publication was an effort by the Department of Internal Medicine to address the demand for practical knowledge among clinicians practicing outside the university. At the same time, it reflects a commitment to enhancing the academic value of clinical experience and critiques the blind pursuit of experimental medicine in the Japanese medical community in the 1920s and 1930s. The case of the Department of Internal Medicine at Keijo Imperial University illustrates the transformation of clinical experience into "worthy" academic knowledge in colonial Korea. Based on these findings, this paper provides insights into the role of clinical departments at Keijo Imperial University in research and post-graduation education.

Early achievements in cardiovascular care as reflected in the Journal of Internal Medicine.

This review mirrors progress in cardiovascular medicine as reflected by scientific contributions published in the Journal of Internal Medicine (from 1989), Acta Medica Scandinavica (from 1919 until 1989) and Nordiskt Medicinskt Arkiv (before 1919). A total of 149 articles were identified within this field since the first, published work in this field 1877-1970. The latter year was set as and end for the review since this was the year the first contribution by the author of this review was published in the journal. To cope with the large number individual publications related to different aspects of cardiovascular medicine were grouped together into fields in which Scandinavian contributions were pioneering or for other reasons of particular interest. These articles were briefly summarized together with some information of the author(s) and the contributions were put into the perspective of subsequent importance and/or scientific and clinical development. Among topics with insightful contributions published in the journal are electrophysiology, diagnostic techniques including standardization, endurance exercise and the heart, electrocardiography, myocardial infarction, atrio-ventricular block and cardiac pacing. Some of these early contributions were indeed, considering the methods available at the time for the investigations impressive and many predictions truly insightful and imaginative. Other contributions may, at least by the present day reader, seem somewhat odd.

[Moscow therapeutic schools (from the 1920s to the 1940s)].

Six leading Moscow therapeutic schools in the 1920s to the 1940s are first identified and given in this paper; their personal composition, distinctive characteristics, and role in the history of Russian internal medicine are shown.