Sequestration and Destruction of Rinderpest Virus-Containing Material 10 Years after Eradication.

In 2021, the world marked 10 years free from rinderpest. The United Nations Food and Agriculture Organization and World Organisation for Animal Health have since made great strides in consolidating, sequencing, and destroying stocks of rinderpest virus-containing material, currently kept by only 14 known institutions. This progress must continue.

Rinderpest experience.

Rinderpest, the most dreaded disease of cattle, originated as far back as the domestication of cattle, occurring in Asia more than 10,000 years ago. It has been the main preoccupation of Veterinary Service activities for many centuries and was the major motivation for establishing the first veterinary school in Lyon, France, in 1761. Gaining control of the disease was the impetus for the founding of many regional and international organisations (including the World Organisation for Animal Health). Outbreaks of rinderpest have led to food shortages and starvation, economic losses and poverty, social unrest, and disrupted transport networks in regions where agriculture was dependent on draught cattle. The rinderpest virus, causative agent of the disease, has also been used as a biological weapon in the past. Many regional rinderpest eradication campaigns have been implemented, including Joint Project 15; the Pan-African Rinderpest Campaign (PARC); the South Asia Rinderpest Eradication Campaign; the West Asia Rinderpest Eradication Campaign; and the Pan African Programme for the Control of Epizootics. All of these campaigns were supported by regional and international organisations, and the disease was finally eradicated in 2011. The benefit of PARC in terms of the value of avoided losses in cattle products due to the decrease in the disease's occurrence was estimated to be between 581,000 and 35,433,000 European currency units. Currently, the world is prepared to prevent the deliberate or accidental release of the remaining infectious rinderpest virus material which exists in research and diagnostic facilities across the world.

La peste bovine, la plus redoutable des maladies bovines, existe depuis l'époque reculée de la domestication des bovins, puisqu'elle est apparue en Asie il y a plus de dix mille ans. Au fil des siècles, cette maladie a été une préoccupation centrale des services en charge de la santé animale et a été le motif principal de la création de la première école vétérinaire, à Lyon (France) en 1761. L'ambition de maîtriser la peste bovine a participé de l'élan qui a vu naître nombre d'organisations régionales et internationales (dont l'Organisation mondiale de la santé animale). Les épidémies de peste bovine ont entraîné des pénuries alimentaires et des famines, des pertes économiques et une pauvreté accrue, une instabilité sociale et l'effondrement des réseaux de transport dans les régions où l'agriculture dépendait des bovidés de trait. Le virus responsable de la peste bovine a également été utilisé en tant qu'arme biologique dans le passé. De nombreuses campagnes d'éradication de la peste bovine ont été mises en œuvre à l'échelle régionale, parmi lesquelles le Projet conjoint 15, la Campagne panafricaine de lutte contre la peste bovine (PARC), la Campagne d'éradication de la peste bovine en Asie du Sud, la Campagne d'éradication de la peste bovine en Asie occidentale et le Programme panafricain de contrôle des épizooties. Ces campagnes ont toutes reçu le soutien d'organisations régionales et internationales et la maladie a finalement été éradiquée en 2011. Les bénéfices du programme PARC en termes de pertes de production évitées dans le secteur bovin grâce au déclin de l'incidence de la maladie ont été estimés entre 581 000 et 35 433 000 ECU (unité de compte européenne). Aujourd'hui, le monde est prêt à prévenir toute libération délibérée ou accidentelle des stocks restants de produits contenant le virus de la peste bovine détenus dans différents établissements de recherche et de diagnostic répartis dans le monde.

Los orígenes de la peste bovina, que es la más temida de las enfermedades del ganado vacuno, se remontan a la domesticación de los bovinos, que se dio en Asia hace más de 10 000 años. Durante muchos siglos ha sido una de las grandes preocupaciones que han guiado el trabajo de los Servicios Veterinarios, y fue uno de los principales factores que motivaron la fundación de la primera escuela de veterinaria en Lyon (Francia) en 1761. El objetivo de llegar a controlar la enfermedad fue el acicate que llevó a la creación de numerosas organizaciones de ámbito regional e internacional (entre ellas la Organización Mundial de Sanidad Animal). Los brotes de peste bovina han causado episodios de escasez de alimentos y hambruna, pérdidas económicas, pobreza y disturbios sociales, sin olvidar la desorganización de las redes de transporte en regiones donde la agricultura dependía del ganado de tiro. En el pasado el virus de la peste bovina, agente causal de la enfermedad, también ha sido utilizado como arma biológica. Numerosas campañas regionales de erradicación de la peste bovina han visto la luz, entre ellas el llamado Proyecto Conjunto 15, la Campaña panafricana contra la peste bovina (PARC), la Campaña de Erradicación de la Peste Bovina en Asia Meridional, la Campaña de Erradicación de la Peste Bovina en Asia Occidental y el Programa Panafricano de Control de Epizootias. Gracias a todas estas iniciativas, respaldadas por organizaciones regionales e internacionales, en 2011 la enfermedad quedó por fin erradicada. Según las estimaciones, basadas en el valor económico de las pérdidas de productos ganaderos evitadas gracias a la reducción de los casos de enfermedad, la PARC deparó entre 581 000 y 35 433 000 Ecus (unidades de cuenta europeas) de beneficios. En la actualidad el mundo está preparado para evitar toda liberación accidental o deliberada de las muestras infecciosas de virus de la peste bovina que aún se conservan en centros de investigación y diagnóstico de todo el planeta.

[Effects of the periodical spread of rinderpest on famine, epidemic, and tiger disasters in the late 17th Century].

This study clarifies the causes of the repetitive occurrences of such phenomena as rinderpest, epidemic, famine, and tiger disasters recorded in the Joseon Dynasty Chronicle and the Seungjeongwon Journals in the period of great catastrophe, the late 17th century in which the great Gyeongsin famine (1670~1671) and the great Eulbyeong famine (1695~1696) occurred, from the perspective that they were biological exchanges caused by the new arrival of rinderpest in the early 17th century. It is an objection to the achievements by existing studies which suggest that the great catastrophes occurring in the late 17th century are evidence of phenomena in a little ice age. First of all, rinderpest has had influence on East Asia as it had been spread from certain areas in Machuria in May 1636 through Joseon, where it raged throughout the nation, and then to the west part of Japan. The new arrival of rinderpest was indigenized in Joseon, where it was localized and spread periodically while it was adjusted to changes in the population of cattle with immunity in accordance with their life spans and reproduction rates. As the new rinderpest, which showed high pathogenicity in the early 17th century, was indigenized with its high mortality and continued until the late 17th century, it broke out periodically in general. Contrastively, epidemics like smallpox and measles that were indigenized as routine ones had occurred constantly from far past times. As a result, the rinderpest, which tried a new indigenization, and the human epidemics, which had been already indigenized long ago, were unexpectedly overlapped in their breakout, and hence great changes were noticed in the aspects of the human casualty due to epidemics. The outbreak of rinderpest resulted in famine due to lack of farming cattle, and the famine caused epidemics among people. The casualty of the human population due to the epidemics in turn led to negligence of farming cattle, which constituted factors that triggered rage and epidemics of rinderpest. The more the number of sources of infection and hosts with low immunity increased, the more lost human resources and farming cattle were lost, which led to a great famine. The periodic outbreak of the rinderpester along with the routine prevalence of various epidemics in the 17thcentury also had influenced on domestic and wild animals. Due to these phenomenon, full-fledged famines occurred that were incomparable with earlier ones. The number of domestic animals that were neglected by people who, faced with famines, were not able to take care of them was increased, and this might have brought about the rage of epidemics like rinderpest in domestic animals like cattle. The great Gyeongsin and Eulbyeong famines due to reoccurrence of the rinderpest in the late 17th century linked rinderpester, epidemics and great famines so that they interacted with each other. Furthermore, the recurring cycle of epidemics-famines-rinderpest-great famines constituted a great cycle with synergy, which resulted in eco-economic-historical great catastrophes accompanied by large scale casualties. Therefore, the Gyeongsin and Eulbyeong famines occurring in the late 17th century can be treated as events caused by the repetition of various periodic disastrous factors generated in 1670~1671 and in 1695~1696 respectively, and particularly as phenomena caused by biological exchanges based on rinderpester., rather than as little ice age phenomena due to relatively long term temperature lowering.

Characterizing the next-generation matrix and basic reproduction number in ecological epidemiology.

We address the interaction of ecological processes, such as consumer-resource relationships and competition, and the epidemiology of infectious diseases spreading in ecosystems. Modelling such interactions seems essential to understand the dynamics of infectious agents in communities consisting of interacting host and non-host species. We show how the usual epidemiological next-generation matrix approach to characterize invasion into multi-host communities can be extended to calculate R0, and how this relates to the ecological community matrix. We then present two simple examples to illustrate this approach. The first of these is a model of the rinderpest, wildebeest, grass interaction, where our inferred dynamics qualitatively matches the observed phenomena that occurred after the eradication of rinderpest from the Serengeti ecosystem in the 1980s. The second example is a prey-predator system, where both species are hosts of the same pathogen. It is shown that regions for the parameter values exist where the two host species are only able to coexist when the pathogen is present to mediate the ecological interaction.

The long journey: a brief review of the eradication of rinderpest.

In 2011, the 79th General Session of the World Assembly of the World Organisation for Animal Health (OIE) and the 37th Food and Agriculture Organization of the United Nations (FAD) Conference adopted a resolution declaring the world free from rinderpest and recommending follow-up measures to preserve the benefits of this new and hard-won situation. Eradication is an achievable objective for any livestock disease, provided that the epidemiology is uncomplicated and the necessary tools, resources and policies are available. Eradication at a national level inevitably reflects national priorities, whereas global eradication requires a level of international initiative and leadership to integrate these tools into a global framework, aimed first at suppressing transmission across all infected areas and concluding with a demonstration thatthis has been achieved. With a simple transmission chain and the environmental fragility of the virus, rinderpest has always been open to control and even eradication within a zoosanitary approach. However, in the post-1945 drive for more productive agriculture, national and global vaccination programmes became increasingly relevant and important. As rinderpest frequently spread from one region to another through trade-related livestock movements, the key to global eradication was to ensure that such vaccination programmes were carried out in a synchronised manner across all regions where the disease was endemic - an objective to which the European Union, the United States Agency for International Development, the International Atomic Energy Agency, the African Union-Interafrican Bureau of Animal Resources, FA0 and OIE fully subscribed. This article provides a review of rinderpest eradication, from the seminal work carried out by Giovanni Lancisi in the early 18th Century to the global declaration in 2011.

Disease properties, geography, and mitigation strategies in a simulation spread of rinderpest across the United States.

For the past decade, the Food and Agriculture Organization of the United Nations has been working toward eradicating rinderpest through vaccination and intense surveillance by 2012. Because of the potential severity of a rinderpest epidemic, it is prudent to prepare for an unexpected outbreak in animal populations. There is no immunity to the disease among the livestock or wildlife in the United States (US). If rinderpest were to emerge in the US, the loss in livestock could be devastating. We predict the potential spread of rinderpest using a two-stage model for the spread of a multi-host infectious disease among agricultural animals in the US. The model incorporates large-scale interactions among US counties and the small-scale dynamics of disease spread within a county. The model epidemic was seeded in 16 locations and there was a strong dependence of the overall epidemic size on the starting location. The epidemics were classified according to overall size into small epidemics of 100 to 300 animals (failed epidemics), epidemics infecting 3,000 to 30,000 animals (medium epidemics), and the large epidemics infecting around one million beef cattle. The size of the rinderpest epidemics were directly related to the origin of the disease and whether or not the disease moved into certain key counties in high-livestock-density areas of the US. The epidemic size also depended upon response time and effectiveness of movement controls.

Risk mapping of Rinderpest sero-prevalence in Central and Southern Somalia based on spatial and network risk factors.

BACKGROUND: In contrast to most pastoral systems, the Somali livestock production system is oriented towards domestic trade and export with seasonal movement patterns of herds/flocks in search of water and pasture and towards export points. Data from a rinderpest survey and other data sources have been integrated to explore the topology of a contact network of cattle herds based on a spatial proximity criterion and other attributes related to cattle herd dynamics. The objective of the study is to integrate spatial mobility and other attributes with GIS and network approaches in order to develop a predictive spatial model of presence of rinderpest. RESULTS: A spatial logistic regression model was fitted using data for 562 point locations. It includes three statistically significant continuous-scale variables that increase the risk of rinderpest: home range radius, herd density and clustering coefficient of the node of the network whose link was established if the sum of the home ranges of every pair of nodes was equal or greater than the shortest distance between the points. The sensitivity of the model is 85.1% and the specificity 84.6%, correctly classifying 84.7% of the observations. The spatial autocorrelation not accounted for by the model is negligible and visual assessment of a semivariogram of the residuals indicated that there was no undue amount of spatial autocorrelation. The predictive model was applied to a set of 6176 point locations covering the study area. Areas at high risk of having serological evidence of rinderpest are located mainly in the coastal districts of Lower and Middle Juba, the coastal area of Lower Shabele and in the regions of Middle Shabele and Bay. There are also isolated spots of high risk along the border with Kenya and the southern area of the border with Ethiopia. CONCLUSIONS: The identification of point locations and areas with high risk of presence of rinderpest and their spatial visualization as a risk map will be useful for informing the prioritization of disease surveillance and control activities for rinderpest in Somalia. The methodology applied here, involving spatial and network parameters, could also be applied to other diseases and/or species as part of a standardized approach for the design of risk-based surveillance activities in nomadic pastoral settings.

Agricultural diseases on the move early in the third millennium.

With few exceptions, the diseases that present the greatest risk to food animal production have been largely similar throughout the modern era of veterinary medicine. The current trend regarding the ever-increasing globalization of the trade of animals and animal products ensures that agricultural diseases will continue to follow legal and illegal trade patterns with increasing rapidity. Global climate changes have already had profound effects on the distribution of animal diseases, and it is an inevitable reality that continually evolving climatic parameters will further transform the ecology of numerous pathogens. In recent years, many agricultural diseases have given cause for concern regarding changes in distribution or severity. Foot-and-mouth disease, avian influenza, and African swine fever continue to cause serious problems. The expected announcement of the global eradication of rinderpest is one of the greatest successes of veterinary preventative medicine, yet the closely related disease peste des petits ruminants still spreads throughout the Middle East and Asia. The spread of novel strains of bluetongue virus across Europe is an ominous indicator that climate change is sure to influence trends in movement of agricultural diseases. Overall, veterinary practitioners and investigators are advised to not only maintain vigilance against the staple disease threats but to always be sufficiently broad-minded to expect the unexpected.

A sero-survey of rinderpest in nomadic pastoral systems in central and southern Somalia from 2002 to 2003, using a spatially integrated random sampling approach.

A cross-sectional sero-survey, using a two-stage cluster sampling design, was conducted between 2002 and 2003 in ten administrative regions of central and southern Somalia, to estimate the seroprevalence and geographic distribution of rinderpest (RP) in the study area, as well as to identify potential risk factors for the observed seroprevalence distribution. The study was also used to test the feasibility of the spatially integrated investigation technique in nomadic and semi-nomadic pastoral systems. In the absence of a systematic list of livestock holdings, the primary sampling units were selected by generating random map coordinates. A total of 9,216 serum samples were collected from cattle aged 12 to 36 months at 562 sampling sites. Two apparent clusters of RP seroprevalence were detected. Four potential risk factors associated with the observed seroprevalence were identified: the mobility of cattle herds, the cattle population density, the proximity of cattle herds to cattle trade routes and cattle herd size. Risk maps were then generated to assist in designing more targeted surveillance strategies. The observed seroprevalence in these areas declined over time. In subsequent years, similar seroprevalence studies in neighbouring areas of Kenya and Ethiopia also showed a very low seroprevalence of RP or the absence of antibodies against RP. The progressive decline in RP antibody prevalence is consistent with virus extinction. Verification of freedom from RP infection in the Somali ecosystem is currently in progress.

Perceptions and problems of disease in the one-humped camel in southern Africa in the late 19th and early 20th centuries.

The one-humped camel (Camelus dromedarius) was first introduced to German South West Africa (Namibia) for military purposes in 1889. Introductions to the Cape of Good Hope (South Africa) in 1897 and Rhodesia (Zimbabwe) in 1903 were initially with a view to replacing oxen that died of rinderpest. Disease risks attendant on these introductions were recognised and to some extent guarded against. There were, however, relatively few problems. One camel was diagnosed as having foot-and-mouth disease. Mange in camels from India caused some concern as did trypanosomosis from Sudan. Trypanosomosis was introduced into both the Cape of Good Hope and Transvaal. Antibodies to some common livestock disease were found in later years.

Observations on rinderpest and rinderpest-like diseases throughout West and Central African countries during rinderpest eradication projects.

Between 1998 and 2005, the Regional Reference Laboratory at Bingerville (Ivory-Coast) received samples for analysis from Western and Central African countries. From a total of 606 sera; 65 tissue samples and 75 swabs received, no rinderpest virus or specific gene products or antibodies against rinderpest were detected. Use of the PCR on the tissue and swabs (total of 140 samples) identified the genomic presence of BVD (4/140), MCF (2/140), IBR (1/140) and FMD (6/140) viruses. These cause diseases that produce similar clinical signs to rinderpest. The quality of many samples sent to the reference laboratory did not meet the laboratory requirements and this compromised analysis of some specimens.

Re-infection of wildlife populations with rinderpest virus on the periphery of the Somali ecosystem in East Africa.

We report surveillance for rinderpest virus in wildlife populations in three major ecosystems of East Africa: Great Rift Valley, Somali and Tsavo from 1994 to 2003. Three hundred and eighty wild animals were sampled for detection of rinderpest virus, antigen or genome and 1133 sampled for antibody in sera from Kenya, Uganda, Ethiopia and Tanzania from 20 species. This was done modifying for wildlife the internationally recommended standards for rinderpest investigation and diagnosis in livestock. The animals were selected according to susceptibility and preference given to gregarious species, and populations were selected according to abundance, availability and association with livestock. Rinderpest virus, antigen and/or genome were detected in Kenya; within Tsavo, Nairobi and Meru National Parks. Serological results from 864 animals (of which 65% were buffalo) from the region were selected as unequivocal; showing the temporal and spatial aspects of past epidemics. Recent infection has been only in or peripheral to the Somali ecosystem (in Kenya). Our evidence supports the hypothesis that wildlife is not important in the long-term maintenance of rinderpest and that wildlife are infected sporadically most likely from a cattle source, although this needs to be proven in the Somali ecosystem. Wildlife will continue to be a key to monitoring the remaining virus circulation in Africa.

Rinderpest seroprevalence in wildlife in Kenya and Tanzania, 1982-1993.

Eight hundred and thirty five serum samples collected from eight wild artiodactyl species in Kenya and Tanzania between 1982 and 1993 were tested for virus-neutralising (VN) antibodies to rinderpest (RP) virus. Antibodies were found in 116 of 344 buffaloes (Syncerus caffer) but not in the other species including 349 wildebeest (Connochaetes taurinus). Most of the antibody positive buffaloes were from the Maasai Mara-Serengeti ecosystem (MM-SE) and would have had opportunity for exposure to the virus during the epidemic of rinderpest in buffalo confirmed there in 1982. Buffalo born after 1985 did not have antibody indicating that virus stopped circulating in this population at or around that time. This second demonstration that RP virus disappears from the MM-SE is further evidence that these species are not permanent reservoirs of this virus. Re-infection of wildlife is transient and they remain valuable sentinels for infection in nearby domestic livestock.

[Austrian Low Countries, Europe's animal health pioneer, 1769-1776]. / Les Pays-Bas autrichiens précurseurs Européens en police sanitaire 1769-1776.

Two previously unpublished manuscripts reveal how innovative the Austrian Low Countries were when they introduced an animal health policy to control rinderpest in 1769. The policy was novel in that it replaced the slaughter of individual sick animals with herd slaughter. Unfortunately, a number of neighbouring countries failed to emulate this sure-fire method of controlling rinderpest, among them France.