RESUMEN
We present the case of an infant with presumed Stevens-Johnson syndrome. Through a history, physical, and histopathology, we were able to diagnose the patient with kwashiorkor. Physicians should be aware of this disorder, which is commonly thought of as a developing world problem, because it is increasing in incidence in industrialized nations because of changing dietary habits.
Asunto(s)
Vesícula/diagnóstico , Países Desarrollados , Trastornos de la Nutrición del Lactante/diagnóstico , Kwashiorkor/diagnóstico , Síndrome de Stevens-Johnson/diagnóstico , Enfermedad Aguda , Vesícula/dietoterapia , Vesícula/etiología , Diagnóstico Diferencial , Femenino , Humanos , Lactante , Fórmulas Infantiles , Trastornos de la Nutrición del Lactante/dietoterapia , Trastornos de la Nutrición del Lactante/etiología , Pacientes Internos , Kwashiorkor/dietoterapia , Kwashiorkor/etiologíaRESUMEN
Mastocytosis is characterized by an increased number of mast cells with abnormal growth and accumulation in 1 or more organs. In children, mastocytosis is commonly cutaneous and patients present with a spectrum of findings, ranging from solitary or multiple mastocytomas to urticaria pigmentosa (UP) or diffuse cutaneous mastocytosis (CM). We present a case of a 4-month-old infant with bullous UP.
Asunto(s)
Vesícula/diagnóstico , Urticaria Pigmentosa/diagnóstico , Vesícula/dietoterapia , Diagnóstico Diferencial , Antagonistas de los Receptores Histamínicos/uso terapéutico , Humanos , Lactante , Masculino , Urticaria Pigmentosa/tratamiento farmacológicoRESUMEN
Physiological events in the initial inflammatory stage of cutaneous wound healing influence subsequent stages. Proinflammatory cytokines coordinate molecular and cellular processes during the inflammatory stage. Polyunsaturated fatty acids (PUFA) alter proinflammatory cytokine production, but how this phenomenon specifically influences wound healing is not clearly understood. In the present study, effects of marine-derived omega-3 eicosapentaenoic and docosahexaenoic PUFA on proinflammatory cytokines in wound serum and time to complete healing in healthy, human skin were evaluated. We compared plasma fatty acid levels in two groups (N=30) at baseline and after 4 weeks of eicosapentaenoic/docosahexaenoic PUFA supplements (active) or placebo (control). Eight small blisters on participants' forearms were created. Proinflammatory cytokines interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha were quantified in blister fluid at 5 and 24 hours after creation. Wound area was calculated daily. Eicosapentaenoic and docosahexaenoic plasma fatty acid levels were significantly higher in the active group. Additionally, we found significantly higher IL-1beta levels in blister fluid in the active group and time to complete wound closure was somewhat longer. These results suggest that eicosapentaenoic and docosahexaenoic PUFA may increase proinflammatory cytokine production at wound sites and thus, depending on the clinical context, have noninvasive, therapeutic potential to affect cutaneous wound healing.