Detalhe da pesquisa
1.
Deletions of Retinoblastoma 1 (Rb1) and Its Repressing Target S Phase Kinase-associated protein 2 (Skp2) Are Synthetic Lethal in Mouse Embryogenesis.
J Biol Chem
; 291(19): 10201-9, 2016 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26966181
2.
pRb is an obesity suppressor in hypothalamus and high-fat diet inhibits pRb in this location.
EMBO J
; 32(6): 844-57, 2013 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-23403926
3.
Substituting threonine 187 with alanine in p27Kip1 prevents pituitary tumorigenesis by two-hit loss of Rb1 and enhances humoral immunity in old age.
J Biol Chem
; 290(9): 5797-809, 2015 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-25583987
4.
Transmembrane protein 55B is a novel regulator of cellular cholesterol metabolism.
Arterioscler Thromb Vasc Biol
; 34(9): 1917-23, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25035345
5.
RHOA is a modulator of the cholesterol-lowering effects of statin.
PLoS Genet
; 8(11): e1003058, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23166513
6.
Disrupting Skp2-cyclin A interaction with a blocking peptide induces selective cancer cell killing.
Mol Cancer Ther
; 6(2): 684-91, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17308064
7.
Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity.
Nat Commun
; 5: 3463, 2014 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-24632684
8.
Skp2 deletion unmasks a p27 safeguard that blocks tumorigenesis in the absence of pRb and p53 tumor suppressors.
Cancer Cell
; 24(5): 645-59, 2013 Nov 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-24229711
9.
Racing to block tumorigenesis after pRb loss: an innocuous point mutation wins with synthetic lethality.
Cell Cycle
; 9(11): 2118-23, 2010 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20505340
10.
Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- mice.
Nat Genet
; 42(1): 83-8, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19966802
11.
Functional conservation of the fruitless male sex-determination gene across 250 Myr of insect evolution.
Mol Biol Evol
; 23(3): 633-43, 2006 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-16319090
12.
A comparison between Skp2 and FOXO1 for their cytoplasmic localization by Akt1.
Cell Cycle
; 9(5): 1021-2, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20160512