Detalhe da pesquisa
1.
Pharmacokinetic and pharmacodynamic properties of the novel basal insulin Fc (insulin efsitora alfa), an insulin fusion protein in development for once-weekly dosing for the treatment of patients with diabetes.
Diabetes Obes Metab
; 25(4): 1080-1090, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36541037
2.
Preclinical Characterization of LY3209590, a Novel Weekly Basal Insulin Fc-Fusion Protein.
J Pharmacol Exp Ther
; 382(3): 346-355, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35840338
3.
In Vivo and In Vitro Characterization of Basal Insulin Peglispro: A Novel Insulin Analog.
J Pharmacol Exp Ther
; 357(3): 459-65, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27026683
4.
Addition of 20-kDa PEG to Insulin Lispro Alters Absorption and Decreases Clearance in Animals.
Pharm Res
; 33(12): 2920-2929, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27528391
5.
The Basis for Weekly Insulin Therapy: Evolving Evidence With Insulin Icodec and Insulin Efsitora Alfa.
Endocr Rev
; 45(3): 379-413, 2024 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38224978
6.
Photoacoustic imaging of the dynamics of a dye-labeled IgG4 monoclonal antibody in subcutaneous tissue reveals a transient decrease in murine blood oxygenation under anesthesia.
J Biomed Opt
; 28(11): 116002, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-38078154
7.
Comprehensive insulin receptor phosphorylation dynamics profiled by mass spectrometry.
FEBS J
; 289(9): 2657-2671, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34826178
8.
Long-Duration and Non-Invasive Photoacoustic Imaging of Multiple Anatomical Structures in a Live Mouse Using a Single Contrast Agent.
Adv Sci (Weinh)
; 9(28): e2202907, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35975459
9.
Photoacoustic imaging reveals mechanisms of rapid-acting insulin formulations dynamics at the injection site.
Mol Metab
; 62: 101522, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35671972
10.
The Evolution of Insulin and How it Informs Therapy and Treatment Choices.
Endocr Rev
; 41(5)2020 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32396624
11.
Concentrated insulins: History and critical reappraisal.
J Diabetes
; 11(4): 292-300, 2019 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-30264527
12.
pI-shifted insulin analogs with extended in vivo time action and favorable receptor selectivity.
Peptides
; 28(4): 935-48, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17328992
13.
Enhancing exposure of protein therapeutics.
Drug Discov Today Technol
; 3(1): 87-94, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-24980106
14.
Novel PEGylated basal insulin LY2605541 has a preferential hepatic effect on glucose metabolism.
Diabetes
; 63(2): 494-504, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24089512
15.
Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319.
PLoS One
; 8(3): e58575, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23536797
16.
Recommendations regarding technical standards for follow-on biologics: comparability, similarity, interchangeability.
Curr Med Res Opin
; 25(7): 1655-61, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19476407
17.
In vivo deamidation characterization of monoclonal antibody by LC/MS/MS.
Anal Chem
; 77(5): 1432-9, 2005 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15732928
18.
IL-1beta epitope mapping using site-directed mutagenesis and hydrogen-deuterium exchange mass spectrometry analysis.
Biochemistry
; 44(33): 11106-14, 2005 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-16101294
19.
Glycosylation of erythropoietin affects receptor binding kinetics: role of electrostatic interactions.
Biochemistry
; 41(49): 14524-31, 2002 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-12463751