Detalhe da pesquisa
1.
Discovery and evaluation of pyrazolo[1,5-a]pyrimidines as neuropeptide Y1 receptor antagonists.
Bioorg Med Chem Lett
; 21(9): 2641-5, 2011 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21295475
2.
Pyrido[2,3-b]pyrazines, discovery of TRPV1 antagonists with reduced potential for the formation of reactive metabolites.
Bioorg Med Chem Lett
; 20(15): 4359-63, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20615696
3.
The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept.
Nat Rev Drug Discov
; 6(5): 357-72, 2007 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-17464295
4.
Aminoquinazolines as TRPV1 antagonists: modulation of drug-like properties through the exploration of 2-position substitution.
Bioorg Med Chem Lett
; 18(16): 4573-7, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18662872
5.
Crystallographic structure of a small molecule SIRT1 activator-enzyme complex.
Nat Commun
; 6: 7645, 2015 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26134520
6.
Design, synthesis, and biological evaluation of substituted 2-cyclohexyl-4-phenyl-1H-imidazoles: potent and selective neuropeptide Y Y5-receptor antagonists.
J Med Chem
; 47(9): 2318-25, 2004 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-15084130
7.
Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3.
J Med Chem
; 56(9): 3666-79, 2013 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-23570514
8.
Evidence for a common mechanism of SIRT1 regulation by allosteric activators.
Science
; 339(6124): 1216-9, 2013 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23471411
9.
Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists.
J Med Chem
; 53(8): 3330-48, 2010 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-20307063
10.
SIRT1 modulation as a novel approach to the treatment of diseases of aging.
J Med Chem
; 54(2): 417-32, 2011 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-21080630
11.
From arylureas to biarylamides to aminoquinazolines: discovery of a novel, potent TRPV1 antagonist.
Bioorg Med Chem Lett
; 16(19): 5217-21, 2006 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16870426