Detalhe da pesquisa
1.
Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation.
J Immunol
; 197(6): 2421-33, 2016 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27521339
2.
Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.
Chem Res Toxicol
; 30(5): 1219-1229, 2017 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28437613
3.
PF-1355, a mechanism-based myeloperoxidase inhibitor, prevents immune complex vasculitis and anti-glomerular basement membrane glomerulonephritis.
J Pharmacol Exp Ther
; 353(2): 288-98, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25698787
4.
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump.
Hepatology
; 60(3): 1015-22, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24799086
5.
From partial to full agonism: identification of a novel 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole as a full agonist of the human GPR119 receptor.
Bioorg Med Chem Lett
; 23(1): 194-7, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23177788
6.
Correction to Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.
Chem Res Toxicol
; 30(6): 1365, 2017 06 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28520417
7.
Oxidative metabolism of a quinoxaline derivative by xanthine oxidase in rodent plasma.
Chem Res Toxicol
; 24(12): 2207-16, 2011 Dec 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-21939274
8.
Design and evaluation of a 2-(2,3,6-trifluorophenyl)acetamide derivative as an agonist of the GPR119 receptor.
Bioorg Med Chem Lett
; 21(5): 1306-9, 2011 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21310611
9.
Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists.
Bioorg Med Chem Lett
; 19(9): 2400-3, 2009 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19346127
10.
Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation.
Elife
; 82019 10 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31580259
11.
Resistance mapping and mode of action of a novel class of antibacterial anthranilic acids: evidence for disruption of cell wall biosynthesis.
J Antimicrob Chemother
; 62(4): 720-9, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18567575
12.
Assessment of Bile Salt Export Pump (BSEP) Inhibition in Membrane Vesicles Using Radioactive and LC/MS-Based Detection Methods.
Curr Protoc Toxicol
; 71: 14.14.1-14.14.20, 2017 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28146280
13.
Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities.
Chem Biol
; 22(12): 1588-96, 2015 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-26670081
14.
Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases.
J Med Chem
; 58(21): 8513-28, 2015 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-26509551
15.
Design and synthesis of diazatricyclodecane agonists of the G-protein-coupled receptor 119.
J Med Chem
; 56(1): 301-19, 2013 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-23234271
16.
Adding precise nanoliter volume capabilities to liquid-handling automation for compound screening experimentation.
J Lab Autom
; 16(3): 221-8, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21609705
17.
Activation of the G-protein-coupled receptor 119: a conformation-based hypothesis for understanding agonist response.
J Med Chem
; 54(6): 1948-52, 2011 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-21361292
18.
Development of a fluorescence polarization assay for peptidyl-tRNA hydrolase.
Anal Biochem
; 306(1): 8-16, 2002 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12069408
19.
Expression, purification, and characterization of peptidyl-tRNA hydrolase from Staphylococcus aureus.
Protein Expr Purif
; 24(1): 123-30, 2002 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-11812233