Detalhe da pesquisa
1.
Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design.
Cell
; 175(4): 1045-1058.e16, 2018 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30388443
2.
The Myxobacterial Antibiotic Myxovalargin: Biosynthesis, Structural Revision, Total Synthesis, and Molecular Characterization of Ribosomal Inhibition.
J Am Chem Soc
; 145(2): 851-863, 2023 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36603206
3.
Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis.
Chemistry
; 29(29): e202203868, 2023 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36912255
4.
Nonhydrolyzable dphenylalanine-benzoxazole derivatives retain antitubercular activity.
Bioorg Med Chem Lett
; 80: 129116, 2023 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36572353
5.
GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment.
Antimicrob Agents Chemother
; 66(6): e0013222, 2022 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35607978
6.
Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification.
Nucleic Acids Res
; 48(14): 8099-8112, 2020 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32602532
7.
Mode-of-action profiling reveals glutamine synthetase as a collateral metabolic vulnerability of M. tuberculosis to bedaquiline.
Proc Natl Acad Sci U S A
; 116(39): 19646-19651, 2019 09 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31501323
8.
Design, synthesis, in silico and in vitro evaluation of novel diphenyl ether derivatives as potential antitubercular agents.
Mol Divers
; 24(4): 1265-1279, 2020 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-31506871
9.
Synthesis, evaluation, molecular docking, and molecular dynamics studies of novel N-(4-[pyridin-2-yloxy]benzyl)arylamine derivatives as potential antitubercular agents.
Drug Dev Res
; 81(3): 315-328, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31782209
10.
Inhibition of CorA-Dependent Magnesium Homeostasis Is Cidal in Mycobacterium tuberculosis.
Antimicrob Agents Chemother
; 63(10)2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31383669
11.
C4-Phenylthio ß-lactams: Effect of the chirality of the ß-lactam ring on antimicrobial activity.
Bioorg Med Chem
; 27(20): 115050, 2019 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31474471
12.
Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site.
Proc Natl Acad Sci U S A
; 113(27): 7503-8, 2016 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27325754
13.
Caught between two proteins: a mycobacterial inhibitor challenges the mold.
Mol Microbiol
; 103(1): 2-6, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27802567
14.
Susceptibility of Mycobacterium tuberculosis Cytochrome bd Oxidase Mutants to Compounds Targeting the Terminal Respiratory Oxidase, Cytochrome c.
Antimicrob Agents Chemother
; 61(10)2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28760899
15.
Design, synthesis, and evaluation of substituted nicotinamide adenine dinucleotide (NAD+) synthetase inhibitors as potential antitubercular agents.
Bioorg Med Chem Lett
; 27(18): 4426-4430, 2017 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28827112
16.
Bioluminescent Reporters for Rapid Mechanism of Action Assessment in Tuberculosis Drug Discovery.
Antimicrob Agents Chemother
; 60(11): 6748-6757, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27572410
17.
2-Aryl-8-aza-3-deazaadenosine analogues of 5'-O-[N-(salicyl)sulfamoyl]adenosine: Nucleoside antibiotics that block siderophore biosynthesis in Mycobacterium tuberculosis.
Bioorg Med Chem
; 24(14): 3133-43, 2016 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27265685
18.
A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence.
Proc Natl Acad Sci U S A
; 110(47): 19095-100, 2013 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-24191058
19.
Correction for Singh et al., "The Three RelE Homologs of Mycobacterium tuberculosis Have Individual, Drug-Specific Effects on Bacterial Antibiotic Tolerance".
J Bacteriol
; 202(24)2020 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33214325
20.
The three Mycobacterium tuberculosis antigen 85 isoforms have unique substrates and activities determined by non-active site regions.
J Biol Chem
; 289(36): 25041-53, 2014 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25028517