Detalhe da pesquisa
1.
Myeloperoxidase PET Imaging Tracks Intracellular and Extracellular Treatment Changes in Experimental Myocardial Infarction.
Int J Mol Sci
; 24(6)2023 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36982778
2.
An activatable PET imaging radioprobe is a dynamic reporter of myeloperoxidase activity in vivo.
Proc Natl Acad Sci U S A
; 116(24): 11966-11971, 2019 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31123149
3.
Examination of the Human Cytochrome P4503A4 Induction Potential of PF-06282999, an Irreversible Myeloperoxidase Inactivator: Integration of Preclinical, In Silico, and Biomarker Methodologies in the Prediction of the Clinical Outcome.
Drug Metab Dispos
; 45(5): 501-511, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28254951
4.
Species Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase Enzymes.
Drug Metab Dispos
; 44(8): 1262-9, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27079250
5.
PF-1355, a mechanism-based myeloperoxidase inhibitor, prevents immune complex vasculitis and anti-glomerular basement membrane glomerulonephritis.
J Pharmacol Exp Ther
; 353(2): 288-98, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25698787
6.
Toxicities associated with 1-month treatment with propylthiouracil (PTU) and methimazole (MMI) in male rats.
Toxicol Pathol
; 42(6): 970-83, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24067673
7.
STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts.
Cancer Discov
; 13(11): 2432-2447, 2023 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37623743
8.
Small molecule inhibitors of the Pyk2 and FAK kinases modulate chemoattractant-induced migration, adhesion and Akt activation in follicular and marginal zone B cells.
Cell Immunol
; 275(1-2): 47-54, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22507871
9.
Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors.
Bioorg Med Chem Lett
; 22(24): 7523-9, 2012 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23153798
10.
Decreased cell adhesion promotes angiogenesis in a Pyk2-dependent manner.
Exp Cell Res
; 317(13): 1860-71, 2011 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21640103
11.
Understanding the impact of the P-loop conformation on kinase selectivity.
J Chem Inf Model
; 51(6): 1199-204, 2011 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-21568278
12.
B cell receptor-induced phosphorylation of Pyk2 and focal adhesion kinase involves integrins and the Rap GTPases and is required for B cell spreading.
J Biol Chem
; 284(34): 22865-77, 2009 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-19561089
13.
Identification of novel pheno-groups in heart failure with preserved ejection fraction using machine learning.
Heart
; 106(5): 342-349, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31911501
14.
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure.
Nat Commun
; 11(1): 163, 2020 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31919418
15.
Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity.
Bioorg Med Chem Lett
; 19(12): 3253-8, 2009 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19428251
16.
Myeloperoxidase inhibition in mice alters atherosclerotic lesion composition.
PLoS One
; 14(3): e0214150, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30889221
17.
NF-kappaB RelA phosphorylation regulates RelA acetylation.
Mol Cell Biol
; 25(18): 7966-75, 2005 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16135789
18.
Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): structure-activity relationships and strategies for the elimination of reactive metabolite formation.
Bioorg Med Chem Lett
; 18(23): 6071-7, 2008 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18951788
19.
2-Aminopyridine-Based Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Inhibitors: Assessment of Mechanism-Based Safety.
J Med Chem
; 61(7): 3114-3125, 2018 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29570292
20.
Myeloperoxidase Inhibition Improves Ventricular Function and Remodeling After Experimental Myocardial Infarction.
JACC Basic Transl Sci
; 1(7): 633-643, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-30167547