Detalhe da pesquisa
1.
Structure-activity relationship (SAR) studies on substituted N-(pyridin-3-yl)-2-amino-isonicotinamides as highly potent and selective glycogen synthase kinase-3 (GSK-3) inhibitors.
Bioorg Med Chem Lett
; 81: 129143, 2023 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36669575
2.
Macrocyclic prolinyl acyl guanidines as inhibitors of ß-secretase (BACE).
Bioorg Med Chem Lett
; 25(22): 5040-7, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26497283
3.
Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core.
Bioorg Med Chem Lett
; 25(9): 1856-63, 2015 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25845281
4.
Discovery of 2-(Anilino)pyrimidine-4-carboxamides as Highly Potent, Selective, and Orally Active Glycogen Synthase Kinase-3 (GSK-3) Inhibitors.
J Med Chem
; 66(11): 7534-7552, 2023 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37235865
5.
Design, Structure-Activity Relationships, and In Vivo Evaluation of Potent and Brain-Penetrant Imidazo[1,2-b]pyridazines as Glycogen Synthase Kinase-3ß (GSK-3ß) Inhibitors.
J Med Chem
; 66(6): 4231-4252, 2023 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36950863
6.
Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of ß-secretase (BACE).
Bioorg Med Chem Lett
; 21(22): 6916-24, 2011 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21782431
7.
Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1.
Bioorg Med Chem Lett
; 21(1): 537-41, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21078556
8.
Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors.
Bioorg Med Chem Lett
; 21(22): 6909-15, 2011 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21974952
9.
Synthesis and SAR of hydroxyethylamine based phenylcarboxyamides as inhibitors of BACE.
Bioorg Med Chem Lett
; 19(10): 2654-60, 2009 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19375914
10.
Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481.
ACS Med Chem Lett
; 10(3): 312-317, 2019 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30891132
11.
Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase-3 Inhibitors.
J Med Chem
; 59(3): 1041-51, 2016 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26751161
12.
Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 2. Probing the indeno ring substituent pattern.
J Med Chem
; 45(24): 5224-32, 2002 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12431050
13.
Synthesis and biological evaluation of 1-aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of cyclin-dependent kinases.
J Med Chem
; 47(24): 5894-911, 2004 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-15537345
14.
Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 3. Structure activity relationships at C3(1,2).
J Med Chem
; 45(24): 5233-48, 2002 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12431051
15.
Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780.
Int J Alzheimers Dis
; 2014: 431858, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25097793
16.
Acyl guanidine inhibitors of ß-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis.
J Med Chem
; 55(21): 9208-23, 2012 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23030502
17.
Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor.
ACS Med Chem Lett
; 1(3): 120-4, 2010 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900185
18.
The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression.
J Biol Chem
; 283(34): 22992-3003, 2008 Aug 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-18574238
19.
Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. Part 4: Heterocycles at C3.
Bioorg Med Chem Lett
; 14(2): 343-6, 2004 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-14698155