Detalhe da pesquisa
1.
Atropisomerism in Drug Discovery: A Medicinal Chemistry Perspective Inspired by Atropisomeric Class I PI3K Inhibitors.
Acc Chem Res
; 55(18): 2581-2593, 2022 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36069734
2.
Interaction of 2,4-Diaminopyrimidine-Containing Drugs Including Fedratinib and Trimethoprim with Thiamine Transporters.
Drug Metab Dispos
; 45(1): 76-85, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27803021
3.
Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency.
Bioorg Med Chem Lett
; 26(24): 5926-5930, 2016 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27876318
4.
Discovery of an Atropisomeric PI3Kß Selective Inhibitor through Optimization of the Hinge Binding Motif.
ACS Med Chem Lett
; 11(6): 1236-1243, 2020 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32551006
5.
Discovery of Lanraplenib (GS-9876): A Once-Daily Spleen Tyrosine Kinase Inhibitor for Autoimmune Diseases.
ACS Med Chem Lett
; 11(4): 506-513, 2020 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32292557
6.
Strategies and tactics for optimizing the Hit-to-Lead process and beyond--a computational chemistry perspective.
Drug Discov Today
; 13(3-4): 99-109, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18275907
7.
2-Arylpyrimidines: novel CRF-1 receptor antagonists.
Bioorg Med Chem Lett
; 18(16): 4486-90, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18672365
8.
The design, synthesis and structure-activity relationships of 1-aryl-4-aminoalkylisoquinolines: a novel series of CRF-1 receptor antagonists.
Bioorg Med Chem Lett
; 18(3): 891-6, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18180159
9.
1-Benzylbenzimidazoles: the discovery of a novel series of bradykinin B(1) receptor antagonists.
Bioorg Med Chem Lett
; 18(18): 5027-31, 2008 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18752949
10.
Aminoquinazolines as TRPV1 antagonists: modulation of drug-like properties through the exploration of 2-position substitution.
Bioorg Med Chem Lett
; 18(16): 4573-7, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18662872
11.
Atropisomerism by Design: Discovery of a Selective and Stable Phosphoinositide 3-Kinase (PI3K) ß Inhibitor.
J Med Chem
; 61(15): 6858-6868, 2018 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30015489
12.
Discovery of a Phosphoinositide 3-Kinase (PI3K) ß/δ Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3Kß Potency in a PI3Kδ-Selective Template by Targeting Nonconserved Asp856.
J Med Chem
; 60(4): 1555-1567, 2017 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28106991
13.
Discovery of Orally Efficacious Phosphoinositide 3-Kinase δ Inhibitors with Improved Metabolic Stability.
J Med Chem
; 59(19): 9228-9242, 2016 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27660855
14.
2,4,6-Triaminopyrimidine as a Novel Hinge Binder in a Series of PI3Kδ Selective Inhibitors.
J Med Chem
; 59(7): 3532-48, 2016 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26980109
15.
From arylureas to biarylamides to aminoquinazolines: discovery of a novel, potent TRPV1 antagonist.
Bioorg Med Chem Lett
; 16(19): 5217-21, 2006 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16870426
16.
Improved semiempirical heats of formation through the use of bond and group equivalents.
J Comput Chem
; 23(4): 498-510, 2002 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-11908087
17.
PDDG/PM3 and PDDG/MNDO: improved semiempirical methods.
J Comput Chem
; 23(16): 1601-22, 2002 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-12395428
18.
Contributions of conformational compression and preferential transition state stabilization to the rate enhancement by chorismate mutase.
J Am Chem Soc
; 125(23): 6892-9, 2003 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-12783541
19.
Investigation of solvent effects for the Claisen rearrangement of chorismate to prephenate: mechanistic interpretation via near attack conformations.
J Am Chem Soc
; 125(22): 6663-72, 2003 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-12769575
20.
Design, synthesis, and discovery of 5-piperazinyl-1,2,6,7-tetrahydro-5H-azepino[3,2,1-hi]indol-4-one derivatives: a novel series of mixed dopamine D2/D4 receptor antagonist.
Bioorg Med Chem Lett
; 13(4): 701-4, 2003 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-12639562