Detalhe da pesquisa
1.
Quality of Research Tools.
Handb Exp Pharmacol
; 257: 119-145, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-31620916
2.
cis-1-Oxo-heterocyclyl-4-amido cyclohexane derivatives as NPY5 receptor antagonists.
Bioorg Med Chem Lett
; 24(6): 1458-61, 2014 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24582476
3.
Discovery and structure-activity relationship of 1,3-cyclohexyl amide derivatives as novel mGluR5 negative allosteric modulators.
Bioorg Med Chem Lett
; 23(5): 1398-406, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23357634
4.
4-(1-Phenyl-1H-pyrazol-4-yl)quinolines as novel, selective and brain penetrant metabotropic glutamate receptor 4 positive allosteric modulators.
Bioorg Med Chem Lett
; 22(9): 3235-9, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22465637
5.
Design and synthesis of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl-cyclopropane carboxamide derivatives as novel melatonin receptor ligands.
Bioorg Med Chem Lett
; 21(4): 1236-42, 2011 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21237644
6.
6-Aryl-3-pyrrolidinylpyridines as mGlu5 receptor negative allosteric modulators.
Bioorg Med Chem Lett
; 21(16): 4891-9, 2011 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21757343
7.
A case study of foliglurax, the first clinical mGluR4 PAM for symptomatic treatment of Parkinson's disease: translational gaps or a failing industry innovation model?
Expert Opin Investig Drugs
; 29(12): 1323-1338, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-33074728
8.
Allosteric Modalities for Membrane-Bound Receptors: Insights from Drug Hunting for Brain Diseases.
J Med Chem
; 62(13): 5979-6002, 2019 07 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30721063
9.
2-Arylpyrimidines: novel CRF-1 receptor antagonists.
Bioorg Med Chem Lett
; 18(16): 4486-90, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18672365
10.
The design, synthesis and structure-activity relationships of 1-aryl-4-aminoalkylisoquinolines: a novel series of CRF-1 receptor antagonists.
Bioorg Med Chem Lett
; 18(3): 891-6, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18180159
11.
Metabolism-based identification of a potent thrombin receptor antagonist.
J Med Chem
; 50(1): 129-38, 2007 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-17201416
12.
The "Century of Biology" and the Evolving Role of Medicinal Chemists in Neuroscience.
ACS Chem Neurosci
; 8(1): 8-11, 2017 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28095674
13.
Recent Developments in Group I Metabotropic Glutamate Receptor Allosteric Modulators for the Treatment of Psychiatric and Neurological Disorders (2014-May 2015).
Curr Top Med Chem
; 16(29): 3470-3526, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27048271
14.
Metabotropic glutamate receptors as targets for new antipsychotic drugs: Historical perspective and critical comparative assessment.
Pharmacol Ther
; 157: 10-27, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26549541
15.
Discovery of potent orally active thrombin receptor (protease activated receptor 1) antagonists as novel antithrombotic agents.
J Med Chem
; 48(19): 5884-7, 2005 Sep 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-16161991
16.
The antipsychotic-like effects in rodents of the positive allosteric modulator Lu AF21934 involve 5-HT1A receptor signaling: mechanistic studies.
Psychopharmacology (Berl)
; 232(1): 259-73, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25012236
17.
Total Synthesis of (+)-Himbacine and (+)-Himbeline.
J Org Chem
; 64(6): 1932-1940, 1999 Mar 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-11674285
18.
Potent non-peptide thrombin receptor antagonists.
Curr Med Chem Cardiovasc Hematol Agents
; 1(1): 37-45, 2003 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15317289
19.
Chemical biology of mGlu4 receptor activation: dogmas, challenges, strategies and opportunities.
Curr Top Med Chem
; 14(15): 1755-70, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25183417
20.
Inhibitory actions of mGlu4 receptor ligands on cocaine-, but not nicotine-, induced sensitizing and conditioning locomotor responses in rats.
Pharmacol Rep
; 66(2): 205-11, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24911071