Pesquisa | Portal de Pesquisa da BVS

1.

Signaling from RAS to RAF: The Molecules and Their Mechanisms.

Jeon, Hyesung; Tkacik, Emre; Eck, Michael J.

Annu Rev Biochem ; 2024 Feb 05.

Artigo em Inglês | MEDLINE | ID: mdl-38316136

2.

Oncogenic K-Ras suppresses global miRNA function.

Shui, Bing; Beyett, Tyler S; Chen, Zhengyi; Li, Xiaoyi; La Rocca, Gaspare; Gazlay, William M; Eck, Michael J; Lau, Ken S; Ventura, Andrea; Haigis, Kevin M.

Mol Cell ; 83(14): 2509-2523.e13, 2023 07 20.

Artigo em Inglês | MEDLINE | ID: mdl-37402366

3.

Structure of the MRAS-SHOC2-PP1C phosphatase complex.

Hauseman, Zachary J; Fodor, Michelle; Dhembi, Anxhela; Viscomi, Jessica; Egli, David; Bleu, Melusine; Katz, Stephanie; Park, Eunyoung; Jang, Dong Man; Porter, Kathryn A; Meili, Fabian; Guo, Hongqiu; Kerr, Grainne; Mollé, Sandra; Velez-Vega, Camilo; Beyer, Kim S; Galli, Giorgio G; Maira, Saveur-Michel; Stams, Travis; Clark, Kirk; Eck, Michael J; Tordella, Luca; Thoma, Claudio R; King, Daniel A.

Nature ; 609(7926): 416-423, 2022 09.

Artigo em Inglês | MEDLINE | ID: mdl-35830882

4.

EGFR in limbo.

Eck, Michael J; Hahn, William C.

Cell ; 149(4): 735-7, 2012 May 11.

Artigo em Inglês | MEDLINE | ID: mdl-22579278

5.

Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.

Park, Eunyoung; Rawson, Shaun; Li, Kunhua; Kim, Byeong-Won; Ficarro, Scott B; Pino, Gonzalo Gonzalez-Del; Sharif, Humayun; Marto, Jarrod A; Jeon, Hyesung; Eck, Michael J.

Nature ; 575(7783): 545-550, 2019 11.

Artigo em Inglês | MEDLINE | ID: mdl-31581174

6.

A Constitutive EGFR Kinase Dimer to Study Inhibitor Pharmacology.

Kim, Justin J; Schaeffner, Ilse K; Heppner, David E; To, Ciric; Jänne, Pasi A; Beyett, Tyler S; Eck, Michael J.

Mol Pharmacol ; 105(2): 97-103, 2024 Jan 10.

Artigo em Inglês | MEDLINE | ID: mdl-38164587

7.

Structure and RAF family kinase isoform selectivity of type II RAF inhibitors tovorafenib and naporafenib.

Tkacik, Emre; Li, Kunhua; Gonzalez-Del Pino, Gonzalo; Ha, Byung Hak; Vinals, Javier; Park, Eunyoung; Beyett, Tyler S; Eck, Michael J.

J Biol Chem ; 299(5): 104634, 2023 05.

Artigo em Inglês | MEDLINE | ID: mdl-36963492

8.

Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation.

Gonzalez-Del Pino, Gonzalo L; Li, Kunhua; Park, Eunyoung; Schmoker, Anna M; Ha, Byung Hak; Eck, Michael J.

Proc Natl Acad Sci U S A ; 118(36)2021 09 07.

Artigo em Inglês | MEDLINE | ID: mdl-34470822

9.

Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC.

Gero, Thomas W; Heppner, David E; Beyett, Tyler S; To, Ciric; Azevedo, Seth C; Jang, Jaebong; Bunnell, Thomas; Feru, Frederic; Li, Zhengnian; Shin, Bo Hee; Soroko, Kara M; Gokhale, Prafulla C; Gray, Nathanael S; Jänne, Pasi A; Eck, Michael J; Scott, David A.

Bioorg Med Chem Lett ; 68: 128718, 2022 07 15.

Artigo em Inglês | MEDLINE | ID: mdl-35378251

10.

The FERM domain: organizing the structure and function of FAK.

Frame, Margaret C; Patel, Hitesh; Serrels, Bryan; Lietha, Daniel; Eck, Michael J.

Nat Rev Mol Cell Biol ; 11(11): 802-14, 2010 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-20966971

11.

Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors.

Jia, Yong; Yun, Cai-Hong; Park, Eunyoung; Ercan, Dalia; Manuia, Mari; Juarez, Jose; Xu, Chunxiao; Rhee, Kevin; Chen, Ting; Zhang, Haikuo; Palakurthi, Sangeetha; Jang, Jaebong; Lelais, Gerald; DiDonato, Michael; Bursulaya, Badry; Michellys, Pierre-Yves; Epple, Robert; Marsilje, Thomas H; McNeill, Matthew; Lu, Wenshuo; Harris, Jennifer; Bender, Steven; Wong, Kwok-Kin; Jänne, Pasi A; Eck, Michael J.

Nature ; 534(7605): 129-32, 2016 06 02.

Artigo em Inglês | MEDLINE | ID: mdl-27251290

12.

A driving test for oncogenic mutations.

Heppner, David E; Beyett, Tyler S; Eck, Michael J.

J Biol Chem ; 294(24): 9390-9391, 2019 06 14.

Artigo em Inglês | MEDLINE | ID: mdl-31201242

13.

The Eya1 Phosphatase Mediates Shh-Driven Symmetric Cell Division of Cerebellar Granule Cell Precursors.

Merk, Daniel J; Zhou, Pengcheng; Cohen, Samuel M; Pazyra-Murphy, Maria F; Hwang, Grace H; Rehm, Kristina J; Alfaro, Jose; Reid, Christopher M; Zhao, Xuesong; Park, Eunyoung; Xu, Pin-Xian; Chan, Jennifer A; Eck, Michael J; Nazemi, Kellie J; Harwell, Corey C; Segal, Rosalind A.

Dev Neurosci ; 42(5-6): 170-186, 2020.

Artigo em Inglês | MEDLINE | ID: mdl-33472197

14.

Cyclic di-GMP sensing via the innate immune signaling protein STING.

Yin, Qian; Tian, Yuan; Kabaleeswaran, Venkataraman; Jiang, Xiaomo; Tu, Daqi; Eck, Michael J; Chen, Zhijian J; Wu, Hao.

Mol Cell ; 46(6): 735-45, 2012 Jun 29.

Artigo em Inglês | MEDLINE | ID: mdl-22705373

15.

Mutant-Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug-Resistant Mutations.

Jang, Jaebong; To, Ciric; De Clercq, Dries J H; Park, Eunyoung; Ponthier, Charles M; Shin, Bo Hee; Mushajiang, Mierzhati; Nowak, Radoslaw P; Fischer, Eric S; Eck, Michael J; Jänne, Pasi A; Gray, Nathanael S.

Angew Chem Int Ed Engl ; 59(34): 14481-14489, 2020 08 17.

Artigo em Inglês | MEDLINE | ID: mdl-32510788

16.

Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival.

Wang, Yubao; Begley, Michael; Li, Qing; Huang, Hai-Tsang; Lako, Ana; Eck, Michael J; Gray, Nathanael S; Mitchison, Timothy J; Cantley, Lewis C; Zhao, Jean J.

Proc Natl Acad Sci U S A ; 113(35): 9810-5, 2016 08 30.

Artigo em Inglês | MEDLINE | ID: mdl-27528663

17.

Discovery of a Highly Potent and Broadly Effective Epidermal Growth Factor Receptor and HER2 Exon 20 Insertion Mutant Inhibitor.

Jang, Jaebong; Son, Jieun; Park, Eunyoung; Kosaka, Takayuki; Saxon, Jamie A; De Clercq, Dries J H; Choi, Hwan Geun; Tanizaki, Junko; Eck, Michael J; Jänne, Pasi A; Gray, Nathanael S.

Angew Chem Int Ed Engl ; 57(36): 11629-11633, 2018 09 03.

Artigo em Inglês | MEDLINE | ID: mdl-29978938

18.

Crystal Structure of Leiomodin 2 in Complex with Actin: A Structural and Functional Reexamination.

Boczkowska, Malgorzata; Yurtsever, Zeynep; Rebowski, Grzegorz; Eck, Michael J; Dominguez, Roberto.

Biophys J ; 113(4): 889-899, 2017 Aug 22.

Artigo em Inglês | MEDLINE | ID: mdl-28834725

19.

Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes.

Goñi, Guillermina M; Epifano, Carolina; Boskovic, Jasminka; Camacho-Artacho, Marta; Zhou, Jing; Bronowska, Agnieszka; Martín, M Teresa; Eck, Michael J; Kremer, Leonor; Gräter, Frauke; Gervasio, Francesco Luigi; Perez-Moreno, Mirna; Lietha, Daniel.

Proc Natl Acad Sci U S A ; 111(31): E3177-86, 2014 Aug 05.

Artigo em Inglês | MEDLINE | ID: mdl-25049397

20.

Leveraging Gas-Phase Fragmentation Pathways for Improved Identification and Selective Detection of Targets Modified by Covalent Probes.

Ficarro, Scott B; Browne, Christopher M; Card, Joseph D; Alexander, William M; Zhang, Tinghu; Park, Eunyoung; McNally, Randall; Dhe-Paganon, Sirano; Seo, Hyuk-Soo; Lamberto, Ilaria; Eck, Michael J; Buhrlage, Sara J; Gray, Nathanael S; Marto, Jarrod A.

Anal Chem ; 88(24): 12248-12254, 2016 12 20.

Artigo em Inglês | MEDLINE | ID: mdl-28193034

Portal de Pesquisa da BVS

Informação e Conhecimento para a Saúde

Configurar filtros

Sua seleção (0)

Formato de exportação:

Exportar: