Detalhe da pesquisa
1.
The effect of AZD9567 vs. prednisolone on glycaemic control in patients with type 2 diabetes mellitus: Results from a phase 2a clinical trial.
Br J Clin Pharmacol
; 2024 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38690606
2.
Structural insight into allosteric modulation of protease-activated receptor 2.
Nature
; 545(7652): 112-115, 2017 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28445455
3.
Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators.
J Biol Chem
; 296: 100551, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33744286
4.
Unraveling the Allosteric Cross-Talk between the Coactivator Peptide and the Ligand-Binding Site in the Glucocorticoid Receptor.
J Chem Inf Model
; 61(7): 3667-3680, 2021 07 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34156843
5.
Exploring Binding Mechanisms in Nuclear Hormone Receptors by Monte Carlo and X-ray-derived Motions.
Biophys J
; 112(6): 1147-1156, 2017 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-28355542
6.
Discovery of new selective glucocorticoid receptor agonist leads.
Bioorg Med Chem Lett
; 27(3): 437-442, 2017 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28043796
7.
Discovery of indazole ethers as novel, potent, non-steroidal glucocorticoid receptor modulators.
Bioorg Med Chem Lett
; 26(23): 5741-5748, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27810243
8.
Binding Mode and Induced Fit Predictions for Prospective Computational Drug Design.
J Chem Inf Model
; 56(4): 774-87, 2016 04 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-26974351
9.
Discovery of 9-(1-phenoxyethyl)-2-morpholino-4-oxo-pyrido[1,2-a]pyrimidine-7-carboxamides as oral PI3Kß inhibitors, useful as antiplatelet agents.
Bioorg Med Chem Lett
; 24(16): 3936-43, 2014 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25042253
10.
The discovery of potent and selective non-steroidal glucocorticoid receptor modulators, suitable for inhalation.
Bioorg Med Chem Lett
; 24(11): 2571-7, 2014 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24755427
11.
Quaternary glucocorticoid receptor structure highlights allosteric interdomain communication.
Nat Struct Mol Biol
; 30(3): 286-295, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36747092
12.
AZD9567 versus prednisolone in patients with active rheumatoid arthritis: A phase IIa, randomized, double-blind, efficacy, and safety study.
Clin Transl Sci
; 16(12): 2494-2506, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37873558
13.
Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction.
J Med Chem
; 65(24): 16818-16828, 2022 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36484727
14.
Non-covalent inhibitors of rhinovirus 3C protease.
Bioorg Med Chem Lett
; 21(2): 777-80, 2011 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21183345
15.
Effects of a selective glucocorticoid receptor modulator (AZD9567) versus prednisolone in healthy volunteers: two phase 1, single-blind, randomised controlled trials.
Lancet Rheumatol
; 2(1): e31-e41, 2020 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38258274
16.
Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection.
J Med Chem
; 62(3): 1385-1406, 2019 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30596500
17.
Novel prostaglandin D synthase inhibitors generated by fragment-based drug design.
J Med Chem
; 51(7): 2178-86, 2008 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-18341273
18.
Backbone 1H, 13C, and 15N resonance assignments of the ligand binding domain of the human wildtype glucocorticoid receptor and the F602S mutant variant.
Biomol NMR Assign
; 12(2): 263-268, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29667121
19.
Correction to "Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction".
J Med Chem
; 66(3): 2205-2207, 2023 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36708352
20.
Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion.
PLoS One
; 13(2): e0193380, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29474466